BR112018016671A2 - sulfonilureias e compostos relacionados e uso do mesmo - Google Patents

sulfonilureias e compostos relacionados e uso do mesmo

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Publication number
BR112018016671A2
BR112018016671A2 BR112018016671A BR112018016671A BR112018016671A2 BR 112018016671 A2 BR112018016671 A2 BR 112018016671A2 BR 112018016671 A BR112018016671 A BR 112018016671A BR 112018016671 A BR112018016671 A BR 112018016671A BR 112018016671 A2 BR112018016671 A2 BR 112018016671A2
Authority
BR
Brazil
Prior art keywords
present
compounds
independently selected
relates
sulfonylureas
Prior art date
Application number
BR112018016671A
Other languages
English (en)
Inventor
O'neill Luke
Coll Rebecca
Cooper Matthew
Robertson Avril
Schroder Kate
Murray Macleod Angus
John Miller David
Original Assignee
The University Of Queensland
The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2016900535A external-priority patent/AU2016900535A0/en
Application filed by The University Of Queensland, The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin filed Critical The University Of Queensland
Publication of BR112018016671A2 publication Critical patent/BR112018016671A2/pt

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

a presente invenção refere-se a compostos de fórmula (i), e sais, solvatos e pró-fármacos farmaceuticamente aceitáveis dos mesmos: em que q é selecionado dentre o, s e se; j é s ou se; w1 e w2, quando presentes, são independentemente selecionados dentre n e c; r1 e r2 são selecionados independentemente do grupo que consiste em hidrogênio, alquila c1-c12, alcenila c2-c12, alcinila c2-c12, arila, heterociclila, heteroarila, cicloalquila, cicloalcenila, amino, amido, alquiltio, acila, arilalquila e acilamido, todos os quais podem ser opcionalmente substituídos; e em que pelo menos um de w1 e w2 está presente e é um átomo de nitrogênio e quando r1 ou r2 são cíclicos, então o respectivo w1 ou w2 pode fazer parte da estrutura do anel. a presente invenção também se refere a composições farmacêuticas incluindo tais compostos, a métodos de tratamento que utilizam tais compostos, em particular em relação a distúrbios mediados por inflamassomas de nlrp3, e a utilizações de diagnóstico associadas.
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Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20180160A1 (es) 2015-02-16 2018-01-18 Univ Queensland Sulfonilureas y compuestos relacionados y uso de estos
CN109071454B (zh) 2016-02-16 2023-02-17 昆士兰大学 磺酰脲和相关化合物及其用途
WO2018048871A1 (en) 2016-09-06 2018-03-15 Jazz Pharmaceuticals International Iii Limited Solvate form of (r)-2-amino-3-phenylpropyl carbamate
BR112019014549A2 (pt) 2017-01-23 2020-02-18 Genentech, Inc. Compostos de fórmulas i, ig, ih, ie, compostos, composição farmacêutica, métodos de tratamento, de modulação da atividade de um alvo biológico, de inibição da ativação de um inflamassoma e utilização de um composto
US11840543B2 (en) 2017-05-24 2023-12-12 The University Of Queensland Compounds and uses
LT3661925T (lt) 2017-07-07 2022-03-10 Inflazome Limited Naujieji sulfonamido karboksamido junginiai
EP3649112A1 (en) 2017-07-07 2020-05-13 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
WO2019034690A1 (en) 2017-08-15 2019-02-21 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
MA49904A (fr) 2017-08-15 2020-06-24 Inflazome Ltd Nouveaux composés de sulfonamide carboxamide
US11926600B2 (en) 2017-08-15 2024-03-12 Inflazome Limited Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
TW201910317A (zh) 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 新穎化合物
US11518739B2 (en) 2017-08-15 2022-12-06 Inflazome Limited Sulfonamide carboxamide compounds
JP6984818B2 (ja) * 2017-09-01 2021-12-22 学校法人近畿大学 ゼルンボン誘導化合物と癌細胞増殖抑制剤およびそれらの製造方法
WO2019068772A1 (en) * 2017-10-03 2019-04-11 Inflazome Limited NEW COMPOUNDS
GB201721185D0 (en) * 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
US11905252B2 (en) 2018-03-02 2024-02-20 Inflazome Limited Compounds
US11884645B2 (en) 2018-03-02 2024-01-30 Inflazome Limited Sulfonyl acetamides as NLRP3 inhibitors
US11834433B2 (en) 2018-03-02 2023-12-05 Inflazome Limited Compounds
US11530200B2 (en) 2018-03-02 2022-12-20 Inflazome Limited Compounds
US20200407340A1 (en) 2018-03-02 2020-12-31 Inflazome Limited Sulfonamide derivates as nlrp3 inhibitors
GB201806578D0 (en) 2018-04-23 2018-06-06 Inflazome Ltd Novel compound
MA52489A (fr) 2018-05-04 2021-03-10 Inflazome Ltd Nouveaux composés
CN108404117B (zh) * 2018-05-29 2020-06-30 广东龙帆生物科技有限公司 核苷酸结合寡聚化结构域样受体蛋白在治疗寨卡病毒感染药物中的应用
BR112021001012A2 (pt) 2018-07-20 2021-04-20 F. Hoffmann-La Roche Ag compostos de sulfonilureia como inibidores da atividade de interleucina-1
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
CN112672995A (zh) 2018-08-15 2021-04-16 英夫拉索姆有限公司 新型磺酰胺脲化合物
GB201819083D0 (en) 2018-11-23 2019-01-09 Inflazome Ltd Novel compounds
EP3914351A1 (en) * 2019-01-25 2021-12-01 Nodthera Limited Carbamate derivatives and uses thereof
GB201905265D0 (en) 2019-04-12 2019-05-29 Inflazome Ltd Inflammasome inhibition
WO2020249669A1 (en) * 2019-06-12 2020-12-17 NodThera Limited Sulfonamide derivatives and uses thereof
US20230083495A1 (en) * 2019-06-12 2023-03-16 NodThera Limited Sulfonylurea derivatives and uses thereof
EP3983387B1 (en) * 2019-06-12 2024-04-24 Nodthera Limited Sulfonylurea derivatives and uses thereof
EP3986879A1 (en) 2019-06-21 2022-04-27 AC Immune SA Fused 1,2 thiazoles and 1,2 thiazines which act as nl3p3 modulators
WO2021002887A1 (en) 2019-07-02 2021-01-07 Novartis Inflammasome Research, Inc. Gut-targeted nlrp3 antagonists and their use in therapy
CN110183433B (zh) * 2019-07-11 2021-06-04 华东理工大学 吡唑类化合物及其制备方法与用途
CN114401971A (zh) 2019-08-16 2022-04-26 英夫拉索姆有限公司 用作nlrp3抑制剂的大环磺酰脲衍生物
WO2021043966A1 (en) 2019-09-06 2021-03-11 Inflazome Limited Nlrp3 inhibitors
EP4082614A4 (en) * 2019-12-27 2024-01-24 Japan Tobacco Inc ACYLSULFAMIDE COMPOUND AND PHARMACEUTICAL USE THEREOF
JP7072260B2 (ja) * 2019-12-27 2022-05-20 国立大学法人愛媛大学 マックル・ウェルズ症候群の治療用医薬組成物
EP4107153A1 (en) 2020-02-18 2022-12-28 Inflazome Limited Compounds
US20230096220A1 (en) * 2020-02-28 2023-03-30 Zydus Lifesciences Limited Novel subtituted sulfonylurea and sulfoximineurea derivatives
CN115605209A (zh) 2020-03-16 2023-01-13 祖玛珍生物科学有限公司（Gb） Nlrp3调节剂
AU2021291065A1 (en) 2020-06-19 2022-12-15 Ac Immune Sa Dihydrooxazole and thiourea derivatives modulating the NLRP3 inflammasome pathway
WO2022023907A1 (en) 2020-07-31 2022-02-03 Novartis Ag Methods of selecting and treating patients at elevated risk of major adverse cardiac events
CN117279903A (zh) * 2021-02-10 2023-12-22 杭州英创医药科技有限公司 作为nlrp3抑制剂的化合物
WO2023118521A1 (en) 2021-12-22 2023-06-29 Ac Immune Sa Dihydro-oxazol derivative compounds
CN114469940B (zh) * 2022-03-15 2023-03-31 温州医科大学附属第一医院 小分子化合物aq-390在制备抵抗细胞焦亡药物及抑制剂的应用
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
WO2024013395A1 (en) 2022-07-14 2024-01-18 Ac Immune Sa Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway
US20240101563A1 (en) 2022-07-28 2024-03-28 Ac Immune Sa Novel compounds

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1064284B (de) 1958-01-11 1959-08-27 Bayer Ag Fungizide Mittel
US3242174A (en) 1962-02-06 1966-03-22 Pfizer & Co C 1-(tertiary aminosulfonyl)-3-(hydrocarbon) ureas
DE1165012B (de) * 1962-04-05 1964-03-12 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylsemicarbaziden
DE1168415B (de) * 1962-04-06 1964-04-23 Boehringer & Soehne Gmbh Verfahren zur Herstellung neuer Benzolsulfonyl-semicarbazide
DE1670121A1 (de) * 1966-08-02 1970-10-29 Boehringer Mannheim Gmbh Verfahren zur Herstellung neuer antidiabetisch wirksamer Benzolsulfonyl-semicarbazide
NL131473C (pt) 1966-10-28
US3856786A (en) 1972-07-25 1974-12-24 Pennwalt Corp Sulfonyldiisocyanate adducts
US4401816A (en) * 1980-04-29 1983-08-30 E. I. Du Pont De Nemours And Company Sulfamoyl chlorides
GB2110689A (en) 1981-12-03 1983-06-22 Sandoz Ltd Herbicidal heterocyclic aminosulfonyl ureas and isoureas
CH649081A5 (de) * 1982-01-12 1985-04-30 Ciba Geigy Ag Triaza-verbindungen.
CA2019260C (en) 1989-06-22 1999-06-29 Hirokazu Ochiai Penam derivatives and salts thereof, processes for producing the same and antibacterial agent comprising the same
US5214206A (en) 1990-11-07 1993-05-25 Warner-Lambert Company Aminosulfonyl urea acat inhibitors
DE4039733A1 (de) 1990-12-13 1992-06-17 Basf Ag Substituierte 5-aminopyrazole
JP3573757B2 (ja) 1997-01-29 2004-10-06 ファイザー・インク スルホニルウレア誘導体、およびインターロイキン−１の活性を制御する上でのスルホニルウレア誘導体の使用
JP2000302783A (ja) 1999-04-22 2000-10-31 Fuji Photo Film Co Ltd ピロロピリミジンオン化合物及びそれを用いた感熱記録材料
JP4112127B2 (ja) 1999-08-31 2008-07-02 株式会社リコー 感熱記録材料
AU6464400A (en) 1999-09-14 2001-04-17 Pfizer Products Inc. Combination treatment with il-1ra and diaryl sulphonyl urea compounds
JP2004503534A (ja) * 2000-06-14 2004-02-05 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー １５−リポキシゲナーゼの阻害剤としての１，２，４−三置換ベンゼン
US7531576B2 (en) 2000-12-26 2009-05-12 Pola Chemical Industries, Inc. Biphenyl derivatives
CA2369967A1 (en) 2001-02-12 2002-08-12 Joseph Anthony Cornicelli Methods of treating nuclear factor-kappa b mediated diseases and disorders
US20020127263A1 (en) * 2001-02-27 2002-09-12 Wenda Carlyle Peroxisome proliferator-acitvated receptor gamma ligand eluting medical device
EP1281399A3 (en) 2001-08-01 2004-02-11 Warner-Lambert Company Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production
KR20090121832A (ko) * 2008-05-23 2009-11-26 인제대학교 산학협력단 2-(2-히드록시벤조일)히드라진카르복시아미드 유도체 또는이의 약학적으로 허용가능한 염, 이의 제조방법, 및 이를유효 성분으로 함유하는 선택적 면역 억제용 약학적 조성물
CN103159651B (zh) * 2011-12-14 2015-06-17 安徽贝克联合制药有限公司 磺酰脲胍及其制备方法和用途
PE20180160A1 (es) 2015-02-16 2018-01-18 Univ Queensland Sulfonilureas y compuestos relacionados y uso de estos
DE102015104306B4 (de) 2015-03-23 2018-05-03 Papierfabrik August Koehler Se Wärmeempfindliches Aufzeichnungsmaterial
FR3046933B1 (fr) 2016-01-25 2018-03-02 Galderma Research & Development Inhibiteurs nlrp3 pour le traitement des pathologies cutanees inflammatoires
CN109071454B (zh) 2016-02-16 2023-02-17 昆士兰大学 磺酰脲和相关化合物及其用途
WO2017189651A1 (en) 2016-04-26 2017-11-02 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as fxr agonists and methods of use thereof
WO2017189652A1 (en) 2016-04-26 2017-11-02 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as fxr agonists and methods of use thereof
US10080743B2 (en) 2016-04-26 2018-09-25 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as FXR agonists and methods of use thereof
US10138228B2 (en) 2016-05-18 2018-11-27 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as FXR agonists and methods of use therof
US10144729B2 (en) 2016-05-18 2018-12-04 Enanta Pharmaceuticals, Inc. Isoxazole analogs as FXR agonists and methods of use thereof
EP3272739A1 (en) 2016-07-20 2018-01-24 NodThera Limited Sulfonyl urea derivatives and their use in the control of interleukin-1 activity
US11840543B2 (en) 2017-05-24 2023-12-12 The University Of Queensland Compounds and uses
WO2019034690A1 (en) 2017-08-15 2019-02-21 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
EP3668862A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Novel sulfonamide carboxamide compounds
US11926600B2 (en) 2017-08-15 2024-03-12 Inflazome Limited Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
US20200361895A1 (en) 2017-08-15 2020-11-19 Inflazome Limited Novel sulfonamide carboxamide compounds
TW201910317A (zh) 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 新穎化合物
WO2019092171A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
WO2019092172A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
US11905252B2 (en) 2018-03-02 2024-02-20 Inflazome Limited Compounds
WO2019166629A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
US20200407340A1 (en) 2018-03-02 2020-12-31 Inflazome Limited Sulfonamide derivates as nlrp3 inhibitors
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
CN112672995A (zh) * 2018-08-15 2021-04-16 英夫拉索姆有限公司 新型磺酰胺脲化合物

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