BR112017022654A2 - derivado heterocíclico de 6 membros e composição farmacêutica compreendendo o mesmo - Google Patents
derivado heterocíclico de 6 membros e composição farmacêutica compreendendo o mesmoInfo
- Publication number
- BR112017022654A2 BR112017022654A2 BR112017022654-5A BR112017022654A BR112017022654A2 BR 112017022654 A2 BR112017022654 A2 BR 112017022654A2 BR 112017022654 A BR112017022654 A BR 112017022654A BR 112017022654 A2 BR112017022654 A2 BR 112017022654A2
- Authority
- BR
- Brazil
- Prior art keywords
- similar
- same
- pharmaceutical composition
- membered heterocyclic
- heterocyclic derivative
- Prior art date
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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Abstract
fornecido é o composto representado pela fórmula (i) [fórmula química 1] em que [fórmula química 2] é ou similares y1 é o ou similares; z1 é c(r4) ou n; z2a é c(r5a) ou simila-res; z3a é c(r6) ou similares; r4, r5a e r6 são cada qual independen-temente átomos de hidrogênio ou similares; r1 é grupo carbocíclico aromático substituído ou não substituído ou similares; r2a, r2b, r2c e r2d são cada qual independentemente átomos de hidrogênio ou similares; x é n(r7a) ou similares; r7a é um átomo de hidrogênio ou similares; r3 é [fórmula química 3] ou similares; anel b é um carbociclo aromático de 6 membros ou similares; r9a e r10a são cada qual independentemente um halogênio ou similares; n é um número inteiro de 1 a 5; m é um número inteiro de 0 a 4; e p1 é um número inteiro de 0 a 3) ou um sal farmaceuticamente aceitável dos mesmos.
Applications Claiming Priority (5)
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PCT/JP2016/062759 WO2016171249A1 (ja) | 2015-04-24 | 2016-04-22 | 6員複素環誘導体およびそれらを含有する医薬組成物 |
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JP6358639B2 (ja) * | 2015-04-24 | 2018-07-18 | 塩野義製薬株式会社 | 6員複素環誘導体およびそれらを含有する医薬組成物 |
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JP6716711B2 (ja) | 2016-03-24 | 2020-07-01 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Apjアゴニストとしての6−ヒドロキシ−4−オキソ−1,4−ジヒドロピリミジン−5−カルボキシアミド |
WO2017204316A1 (ja) * | 2016-05-27 | 2017-11-30 | 塩野義製薬株式会社 | 5-オキソ-1,2,4-トリアジン誘導体およびその医薬組成物 |
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TW201821411A (zh) * | 2016-10-21 | 2018-06-16 | 日商鹽野義製藥股份有限公司 | 含氮六員雜環衍生物及含有此等之醫藥組成物 |
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CN113666914B (zh) * | 2021-09-27 | 2022-06-07 | 成都施贝康生物医药科技有限公司 | 二氢嘧啶类化合物及其制备方法和用途 |
CN113801097B (zh) * | 2021-09-27 | 2022-11-22 | 成都施贝康生物医药科技有限公司 | 二氢嘧啶类化合物、其制备方法及用途 |
CN113735838B (zh) * | 2021-09-27 | 2022-07-08 | 成都施贝康生物医药科技有限公司 | 二氢嘧啶类化合物、其制备方法及用途 |
CN113620888B (zh) * | 2021-09-27 | 2023-06-06 | 成都施贝康生物医药科技有限公司 | 二氢嘧啶类化合物及其制备方法和应用 |
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- 2016-04-22 AU AU2016252686A patent/AU2016252686B2/en not_active Ceased
- 2016-04-22 ES ES16783270T patent/ES2905399T3/es active Active
- 2016-04-22 US US15/568,822 patent/US10774051B2/en active Active
- 2016-04-22 KR KR1020177033887A patent/KR102059333B1/ko active IP Right Grant
- 2016-04-22 DK DK16783270.8T patent/DK3287443T3/da active
- 2016-04-22 PL PL16783270T patent/PL3287443T3/pl unknown
- 2016-04-22 WO PCT/JP2016/062759 patent/WO2016171249A1/ja active Application Filing
- 2016-04-22 BR BR112017022654-5A patent/BR112017022654A2/pt not_active Application Discontinuation
- 2016-04-22 MX MX2017013678A patent/MX2017013678A/es unknown
- 2016-04-22 RU RU2017140830A patent/RU2683245C1/ru active
- 2016-04-22 TW TW105112745A patent/TWI715569B/zh not_active IP Right Cessation
- 2016-04-22 CN CN201680037127.8A patent/CN107709299B/zh active Active
- 2016-04-22 CA CA2983721A patent/CA2983721A1/en active Pending
- 2016-04-22 EP EP16783270.8A patent/EP3287443B1/en active Active
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AU2016252686A1 (en) | 2017-10-26 |
CN107709299A (zh) | 2018-02-16 |
TW201643140A (zh) | 2016-12-16 |
PL3287443T3 (pl) | 2022-02-21 |
JP6358639B2 (ja) | 2018-07-18 |
KR20170139144A (ko) | 2017-12-18 |
ES2905399T3 (es) | 2022-04-08 |
EP3957627A1 (en) | 2022-02-23 |
US20200262796A1 (en) | 2020-08-20 |
EP3287443A4 (en) | 2018-09-26 |
KR20190123812A (ko) | 2019-11-01 |
EP3287443B1 (en) | 2021-10-27 |
US11124486B2 (en) | 2021-09-21 |
CN107709299B (zh) | 2021-07-16 |
CA2983721A1 (en) | 2016-10-27 |
MX2017013678A (es) | 2018-03-15 |
AU2016252686B2 (en) | 2019-03-14 |
RU2683245C1 (ru) | 2019-03-27 |
DK3287443T3 (da) | 2022-02-07 |
WO2016171249A1 (ja) | 2016-10-27 |
US20180118694A1 (en) | 2018-05-03 |
JP2018162273A (ja) | 2018-10-18 |
US10774051B2 (en) | 2020-09-15 |
EP3287443A1 (en) | 2018-02-28 |
JPWO2016171249A1 (ja) | 2018-03-01 |
US20210292283A1 (en) | 2021-09-23 |
KR102059333B1 (ko) | 2019-12-26 |
TWI715569B (zh) | 2021-01-11 |
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