EA201891870A1 - Производные иминотиадиазинандиоксида в качестве ингибиторов плазмепсина v - Google Patents
Производные иминотиадиазинандиоксида в качестве ингибиторов плазмепсина vInfo
- Publication number
- EA201891870A1 EA201891870A1 EA201891870A EA201891870A EA201891870A1 EA 201891870 A1 EA201891870 A1 EA 201891870A1 EA 201891870 A EA201891870 A EA 201891870A EA 201891870 A EA201891870 A EA 201891870A EA 201891870 A1 EA201891870 A1 EA 201891870A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- inhibitors
- plasmexin
- iminothiadasinandoxide
- substituted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Настоящее изобретение относится к производным 3-имино-5-метил-1,2,4-тиадиазинан-1,1-диоксида, замещенных в 5-м положении фенильным фрагментом, который, в свою очередь, является замещенным в мета-положении необязательно замещенной ненасыщенной конденсированной бициклической гетероароматической кольцевой системой, содержащей по меньшей мере один атом азота, которые являются селективными ингибиторами активности плазмепсина V, полезными для применения в качестве фармацевтических средств, в особенности для лечения малярии.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1603104.9A GB201603104D0 (en) | 2016-02-23 | 2016-02-23 | Therapeutic agents |
| PCT/EP2017/054023 WO2017144517A1 (en) | 2016-02-23 | 2017-02-22 | Iminothiadiazinane dioxide derivatives as plasmepsin v inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201891870A1 true EA201891870A1 (ru) | 2019-03-29 |
| EA034537B1 EA034537B1 (ru) | 2020-02-18 |
Family
ID=55753038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201891870A EA034537B1 (ru) | 2016-02-23 | 2017-02-22 | Производные иминотиадиазинандиоксида в качестве ингибиторов плазмепсина v |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10464932B2 (ru) |
| EP (1) | EP3419975B1 (ru) |
| JP (1) | JP6831400B2 (ru) |
| CN (1) | CN109153674B (ru) |
| BR (1) | BR112018016196A2 (ru) |
| CA (1) | CA3015271C (ru) |
| EA (1) | EA034537B1 (ru) |
| ES (1) | ES2886449T3 (ru) |
| GB (1) | GB201603104D0 (ru) |
| WO (1) | WO2017144517A1 (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201805816D0 (en) * | 2018-04-06 | 2018-05-23 | Ucb Biopharma Sprl | Therapeutic agents |
| CA3115472A1 (en) | 2018-10-05 | 2020-04-09 | Annapurna Bio, Inc. | Compounds and compositions for treating conditions associated with apj receptor activity |
| CN110156608B (zh) * | 2019-04-24 | 2022-04-01 | 深圳市第二人民医院 | 绿卡色林中间体对氯苯乙胺的合成方法 |
| GB201906804D0 (en) | 2019-05-14 | 2019-06-26 | Ucb Biopharma Sprl | Therapeutic agents |
| WO2021026884A1 (en) * | 2019-08-15 | 2021-02-18 | Merck Sharp & Dohme Corp. | Antimalarial agents |
| CN114206856A (zh) | 2019-08-19 | 2022-03-18 | Ucb生物制药有限责任公司 | 抗疟疾的六氢嘧啶类似物 |
| WO2021155612A1 (en) * | 2020-02-09 | 2021-08-12 | Merck Sharp & Dohme Corp. | Antimalarial agents |
| GB202010606D0 (en) | 2020-07-10 | 2020-08-26 | Ucb Biopharma Sprl | Therapeutic agents |
| WO2023102747A1 (en) * | 2021-12-07 | 2023-06-15 | Merck Sharp & Dohme Llc | Antimalarial agents |
| WO2023152042A1 (en) | 2022-02-08 | 2023-08-17 | UCB Biopharma SRL | Antimalarial hexahydropyrimidine analogues |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060122173A1 (en) * | 2003-06-06 | 2006-06-08 | Jakob Busch-Petersen | Il-8 receptor antagonists |
| US7592348B2 (en) * | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| AU2004299040A1 (en) | 2003-12-15 | 2005-06-30 | Pharmacopeia, Inc. | Heterocyclic aspartyl protease inhibitors |
| US7763609B2 (en) * | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| UA108363C2 (uk) * | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| RS54339B1 (en) * | 2010-01-18 | 2016-02-29 | Mmv Medicines For Malaria Venture | NEW ANTIMALARIAN AGENTS |
| WO2014093190A1 (en) | 2012-12-14 | 2014-06-19 | Merck Sharp & Dohme Corp. | Bace inhibitors of iminothiadiazine dioxides |
-
2016
- 2016-02-23 GB GBGB1603104.9A patent/GB201603104D0/en not_active Ceased
-
2017
- 2017-02-22 EA EA201891870A patent/EA034537B1/ru not_active IP Right Cessation
- 2017-02-22 CN CN201780012863.2A patent/CN109153674B/zh active Active
- 2017-02-22 WO PCT/EP2017/054023 patent/WO2017144517A1/en active Application Filing
- 2017-02-22 CA CA3015271A patent/CA3015271C/en active Active
- 2017-02-22 US US16/076,387 patent/US10464932B2/en active Active
- 2017-02-22 JP JP2018562713A patent/JP6831400B2/ja active Active
- 2017-02-22 EP EP17706753.5A patent/EP3419975B1/en active Active
- 2017-02-22 ES ES17706753T patent/ES2886449T3/es active Active
- 2017-02-22 BR BR112018016196A patent/BR112018016196A2/pt active Search and Examination
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017144517A1 (en) | 2017-08-31 |
| EA034537B1 (ru) | 2020-02-18 |
| US10464932B2 (en) | 2019-11-05 |
| JP2019509337A (ja) | 2019-04-04 |
| CN109153674B (zh) | 2022-03-22 |
| CA3015271C (en) | 2023-08-01 |
| EP3419975A1 (en) | 2019-01-02 |
| JP6831400B2 (ja) | 2021-02-17 |
| BR112018016196A2 (pt) | 2018-12-18 |
| CN109153674A (zh) | 2019-01-04 |
| US20190040053A1 (en) | 2019-02-07 |
| ES2886449T3 (es) | 2021-12-20 |
| EP3419975B1 (en) | 2021-06-23 |
| CA3015271A1 (en) | 2017-08-31 |
| GB201603104D0 (en) | 2016-04-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201891870A1 (ru) | Производные иминотиадиазинандиоксида в качестве ингибиторов плазмепсина v | |
| EA201891222A1 (ru) | Производные иминотетрагидропиримидинона в качестве ингибиторов плазмепсина v | |
| CY1120635T1 (el) | Βενζαμιδια αμινοετεροαρυλιου ως αναστολεις κινασης | |
| BR112017019286A2 (pt) | composto de fórmula (i) ou um sal farmaceuticamente aceitável deste | |
| PH12016501813A1 (en) | 1,3-benzodioxole derivative | |
| MX2017006266A (es) | Compuestos de heteroarilo como inhibidores de cinasas asociadas al receptor de interleucina 1(irak) y sus usos. | |
| MD3464249T2 (ro) | Derivați carbonucleozidici substituiţi utili în calitate de agenți anticanceroşi | |
| EA201690848A1 (ru) | Производные бициклического пиридила с конденсированными кольцами в качестве ингибиторов fgfr4 | |
| EA201791684A1 (ru) | Селективные ингибиторы bace1 | |
| RS54730B1 (sr) | Inhibitori beta sekretaze | |
| PH12019501178A1 (en) | Thiopene derivatives as antiviral agents | |
| EA202090368A1 (ru) | Соединения-ингибиторы рецептора лизофосфатидной кислоты 1 (lpar1) | |
| TW201613938A (en) | Selective inhibitors for protein kinases, a pharmaceutical composition and an use thereof | |
| MX2017005422A (es) | Inhibidores de histona desacetilasa y sus usos en terapia. | |
| EA201790016A1 (ru) | АНАЛОГ ПИРИДИНО[1,2-a]ПИРИМИДОНА, ПРИМЕНЯЕМЫЙ В КАЧЕСТВЕ ИНГИБИТОРА PI3K | |
| EA201892264A1 (ru) | Производные тетрагидроизохинолина | |
| EA201591915A1 (ru) | Соединения феноксиэтил дигидро-1h-изохинолина | |
| EA201791645A1 (ru) | Новые соли и полиморфы scy-078 | |
| EA201892449A1 (ru) | Конденсированные гетероциклические соединения | |
| EA201692140A1 (ru) | Производные аминопиридина в качестве ингибиторов фосфатидилинозитол 3-киназы | |
| PH12019500370A1 (en) | Triazolopyrazinone derivative useful as a human pde1 inhibitor | |
| EA201792109A1 (ru) | Конденсированные с тетрагидрофураном производные аминогидротиазина, пригодные для лечения болезни альцгеймера | |
| EA201690908A1 (ru) | Пиразолопиримидиновые соединения | |
| EA201690593A1 (ru) | Новые соединения мочевины | |
| TH179088A (th) | อนุพันธ์ของกรดบอรอนิค |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |