EA201891222A1 - Производные иминотетрагидропиримидинона в качестве ингибиторов плазмепсина v - Google Patents

Производные иминотетрагидропиримидинона в качестве ингибиторов плазмепсина v

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Publication number
EA201891222A1
EA201891222A1 EA201891222A EA201891222A EA201891222A1 EA 201891222 A1 EA201891222 A1 EA 201891222A1 EA 201891222 A EA201891222 A EA 201891222A EA 201891222 A EA201891222 A EA 201891222A EA 201891222 A1 EA201891222 A1 EA 201891222A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
plasmexin
iminotetrahydropyrimidinon
inhibitors
substituted
Prior art date
Application number
EA201891222A
Other languages
English (en)
Other versions
EA034196B1 (ru
Inventor
Ребекка Луиза Чарлтон
Тереса Де Аро Гарсия
Мартин Александер Лоу
Малькольм Маккосс
Тревор Морган
Ричард Дэвид Тейлор
Чжаонин Чжу
Original Assignee
Юсб Байофарма Спрл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1520808.5A external-priority patent/GB201520808D0/en
Priority claimed from GBGB1612944.7A external-priority patent/GB201612944D0/en
Application filed by Юсб Байофарма Спрл filed Critical Юсб Байофарма Спрл
Publication of EA201891222A1 publication Critical patent/EA201891222A1/ru
Publication of EA034196B1 publication Critical patent/EA034196B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В заявке описана серия производных 2-имино-6-метилтетрагидропиримидин-4(1H)-она, замещенных в положении 6 фенильным фрагментом, который, в свою очередь, является замещенным в мета-положении необязательно замещенной ненасыщенной конденсированной бициклической кольцевой системой, содержащей по меньшей мере один атом азота, являющихся селективными ингибиторами активности плазмепсина V, полезных для применения в качестве фармацевтических средств, в особенности для лечения малярии.
EA201891222A 2015-11-25 2016-11-24 Производные иминотетрагидропиримидинона в качестве ингибиторов плазмепсина v EA034196B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1520808.5A GB201520808D0 (en) 2015-11-25 2015-11-25 Therapeutic agents
GBGB1612944.7A GB201612944D0 (en) 2016-07-26 2016-07-26 Therapeutic agents
PCT/EP2016/078664 WO2017089453A1 (en) 2015-11-25 2016-11-24 Iminotetrahydropyrimidinone derivatives as plasmepsin v inhibitors

Publications (2)

Publication Number Publication Date
EA201891222A1 true EA201891222A1 (ru) 2018-10-31
EA034196B1 EA034196B1 (ru) 2020-01-16

Family

ID=57391986

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891222A EA034196B1 (ru) 2015-11-25 2016-11-24 Производные иминотетрагидропиримидинона в качестве ингибиторов плазмепсина v

Country Status (8)

Country Link
US (1) US11136310B2 (ru)
EP (1) EP3380464B1 (ru)
JP (1) JP6826116B2 (ru)
CN (1) CN108290860B (ru)
CA (1) CA3005809A1 (ru)
EA (1) EA034196B1 (ru)
ES (1) ES2811329T3 (ru)
WO (1) WO2017089453A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10793563B2 (en) 2018-01-29 2020-10-06 Merck Patent Gmbh GCN2 inhibitors and uses thereof
GB201805816D0 (en) 2018-04-06 2018-05-23 Ucb Biopharma Sprl Therapeutic agents
EA202190952A1 (ru) 2018-10-05 2021-12-22 Аннапурна Байо, Инк. Соединения и композиции для лечения патологических состояний, связанных с активностью рецептора apj
GB201906804D0 (en) 2019-05-14 2019-06-26 Ucb Biopharma Sprl Therapeutic agents
WO2021026884A1 (en) * 2019-08-15 2021-02-18 Merck Sharp & Dohme Corp. Antimalarial agents
CA3141524A1 (en) 2019-08-19 2021-02-25 UCB Biopharma SRL Antimalarial hexahydropyrimidine analogues
CN110642720B (zh) * 2019-10-12 2022-09-27 浙江吉泰新材料股份有限公司 一种2,4-二氟-3,5-二氯硝基苯的制备方法
WO2021155612A1 (en) * 2020-02-09 2021-08-12 Merck Sharp & Dohme Corp. Antimalarial agents
GB202010606D0 (en) 2020-07-10 2020-08-26 Ucb Biopharma Sprl Therapeutic agents
WO2023102747A1 (en) * 2021-12-07 2023-06-15 Merck Sharp & Dohme Llc Antimalarial agents
CN113717053B (zh) * 2021-09-02 2023-10-27 合肥利夫生物科技有限公司 一种酪氨酸激酶抑制剂关键中间体的合成方法
WO2023152042A1 (en) 2022-02-08 2023-08-17 UCB Biopharma SRL Antimalarial hexahydropyrimidine analogues
CN114591338B (zh) * 2022-03-31 2023-05-09 苏州欧康维视生物科技有限公司 一种Syk和VEGFR2双靶点抑制剂的制备方法及其用途
EP4434972A1 (en) * 2023-03-22 2024-09-25 Eberhard-Karls-Universität Tübingen Atm kinase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
PT1699455E (pt) * 2003-12-15 2013-08-27 Merck Sharp & Dohme Inibidores de protease de aspartilo heterocíclicos
EP1802588A4 (en) * 2004-10-15 2010-02-17 Astrazeneca Ab SUBSTITUTED AMINOPYRIMIDONE AND APPLICATIONS THEREOF
JP2008516945A (ja) * 2004-10-15 2008-05-22 アストラゼネカ・アクチエボラーグ 置換されたアミノ化合物およびそれらの使用
AR058381A1 (es) * 2005-12-19 2008-01-30 Astrazeneca Ab Compuestos derivados de 2-aminopiridin-4-onas y una composicion farmaceutica
RU2009100074A (ru) * 2006-06-12 2010-07-20 Шеринг Корпорейшн (US) Гетероциклические ингибиторы аспартильной протеазы

Also Published As

Publication number Publication date
BR112018010473A8 (pt) 2019-02-26
EP3380464B1 (en) 2020-05-27
CN108290860A (zh) 2018-07-17
CN108290860B (zh) 2021-08-10
WO2017089453A1 (en) 2017-06-01
JP6826116B2 (ja) 2021-02-03
EA034196B1 (ru) 2020-01-16
ES2811329T3 (es) 2021-03-11
EP3380464A1 (en) 2018-10-03
US20200283416A1 (en) 2020-09-10
BR112018010473A2 (pt) 2018-11-21
US11136310B2 (en) 2021-10-05
CA3005809A1 (en) 2017-06-01
JP2019501138A (ja) 2019-01-17

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