PE20180160A1 - Sulfonilureas y compuestos relacionados y uso de estos - Google Patents

Sulfonilureas y compuestos relacionados y uso de estos

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Publication number
PE20180160A1
PE20180160A1 PE2017001395A PE2017001395A PE20180160A1 PE 20180160 A1 PE20180160 A1 PE 20180160A1 PE 2017001395 A PE2017001395 A PE 2017001395A PE 2017001395 A PE2017001395 A PE 2017001395A PE 20180160 A1 PE20180160 A1 PE 20180160A1
Authority
PE
Peru
Prior art keywords
sulfonylureas
compounds
furan
heteroaryl
aryl
Prior art date
Application number
PE2017001395A
Other languages
English (en)
Inventor
Luke ONEILL
Rebecca Coll
Matt Cooper
Avril Robertson
Kate Schroder
Original Assignee
Univ Queensland
Provost Fellows Found Scholars & Other Members Board College Holy & Und
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56691944&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20180160(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from AU2015900507A external-priority patent/AU2015900507A0/en
Application filed by Univ Queensland, Provost Fellows Found Scholars & Other Members Board College Holy & Und filed Critical Univ Queensland
Publication of PE20180160A1 publication Critical patent/PE20180160A1/es

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    • C07—ORGANIC CHEMISTRY
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE SULFONILUREAS DE FORMULA (I) DONDE W ES O, S O Se; J ES S Y Se; R1 ES CICLOALQUILO, ARILO, HETEROARILO, ENTRE OTROS; R2 ES ARILO, HETEROARILO, HETEROCICLILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-((2,5-DIMETOXIFENIL)CARBAMOIL)-4-(2-HIDROXIPROPAN-2-IL)FURAN-2-SULFONAMIDA; N-((4-CLORO-2,6-DIMETILFENIL)CARBAMOIL)-4-(2-HIDROXIPROPAN-2-IL)FURAN-2-SULFONAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVACION DEL INFLAMASOMA DE LA PROTEINA 3 QUE CONTIENE DOMINIO DE PIRINA (NLRP3) SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS QUE IMPLICAN INFLAMACION
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