MX2020001778A - Nuevos compuestos de sulfonamida carboxamida. - Google Patents
Nuevos compuestos de sulfonamida carboxamida.Info
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- MX2020001778A MX2020001778A MX2020001778A MX2020001778A MX2020001778A MX 2020001778 A MX2020001778 A MX 2020001778A MX 2020001778 A MX2020001778 A MX 2020001778A MX 2020001778 A MX2020001778 A MX 2020001778A MX 2020001778 A MX2020001778 A MX 2020001778A
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/55—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to acyclic carbon atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
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- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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Abstract
La presente invención se refiere a compuestos de la fórmula (I): Fórmula (I) donde Q se selecciona de O o S; L es un grupo hidrocarbileno C1-C12 saturado o insaturado, opcionalmente sustituido que incluye opcionalmente uno o más heteroátomos N, O o S; R1 es -NR3 R4, -OR5, -(C=NR6 )R7, - (CO)R8, -CN, -N3, un grupo de amonio cuaternario o un heterociclo opcionalmente sustituido; R3, R4, R5, R6, R7 y R8 son cada uno independientemente hidrógeno o un grupo hidrocarbilo C1-C10 saturado o insaturado, opcionalmente sustituido que incluye opcionalmente uno o más heteroátomos N, O o S; donde opcionalmente L y R3, o L y R4, o R3 y R4, or L y R5, o L y R6, o L y R7, o R6 y R7, o L y R8 junto con el o los átomos al cual se encuentran unidos pueden formar un 10 grupo cíclico de 3 a 12 miembros, saturado o insaturado, opcionalmente sustituido; y R2 es un grupo cíclico sustituido en la posición a, donde R2 puede opcionalmente ser sustituido de forma adicional; siempre que el átomo de L que se encuentre unido al átomo de azufre del grupo sulfonilurea es un átomo de carbono y no sea un átomo de anillo de un grupo heterocíclico o aromático. La presente invención también hace referencia a sales, solvatos y profármacos de 15 dichos compuestos, a composiciones farmacéuticas de dichos compuestos y al uso de dichos compuestos en el tratamiento y prevención de trastornos médicos y enfermedades, especialmente mediante la inhibición de NLRP3.
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GBGB1713083.2A GB201713083D0 (en) | 2017-08-15 | 2017-08-15 | Novel compounds |
GBGB1713079.0A GB201713079D0 (en) | 2017-08-15 | 2017-08-15 | Novel Compounds |
GBGB1713082.4A GB201713082D0 (en) | 2017-08-15 | 2017-08-15 | Novel compounds |
GBGB1718563.8A GB201718563D0 (en) | 2017-11-09 | 2017-11-09 | Novel compounds |
GBGB1718561.2A GB201718561D0 (en) | 2017-11-09 | 2017-11-09 | Novel compounds |
GBGB1718564.6A GB201718564D0 (en) | 2017-11-09 | 2017-11-09 | Novel compounds |
GBGB1721726.6A GB201721726D0 (en) | 2017-12-22 | 2017-12-22 | Novel compounds |
GBGB1810983.5A GB201810983D0 (en) | 2018-07-04 | 2018-07-04 | Novel compounds |
GBGB1812225.9A GB201812225D0 (en) | 2018-07-26 | 2018-07-26 | Novel compounds |
PCT/EP2018/072133 WO2019034696A1 (en) | 2017-08-15 | 2018-08-15 | NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS |
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CA3078195A1 (en) | 2017-11-09 | 2019-05-16 | Inflazome Limited | Novel sulfonamide carboxamide compounds |
WO2019166629A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
EP3759089A1 (en) | 2018-03-02 | 2021-01-06 | Inflazome Limited | Novel compounds |
WO2019166633A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Sulfonamide derivates as nlrp3 inhibitors |
EP3759077A1 (en) | 2018-03-02 | 2021-01-06 | Inflazome Limited | Novel compounds |
US11530200B2 (en) | 2018-03-02 | 2022-12-20 | Inflazome Limited | Compounds |
WO2019166627A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
US11884645B2 (en) | 2018-03-02 | 2024-01-30 | Inflazome Limited | Sulfonyl acetamides as NLRP3 inhibitors |
GB201803394D0 (en) | 2018-03-02 | 2018-04-18 | Inflazome Ltd | Novel compounds |
GB201803393D0 (en) | 2018-03-02 | 2018-04-18 | Inflazome Ltd | Novel compounds |
GB201806578D0 (en) | 2018-04-23 | 2018-06-06 | Inflazome Ltd | Novel compound |
MX2020011501A (es) | 2018-05-04 | 2020-12-07 | Inflazome Ltd | Compuestos novedosos. |
GB201902327D0 (en) | 2019-02-20 | 2019-04-03 | Inflazome Ltd | Novel compounds |
CA3108948A1 (en) | 2018-08-15 | 2020-02-20 | Inflazome Limited | Novel sulfonamideurea compounds |
GB201817038D0 (en) | 2018-10-19 | 2018-12-05 | Inflazome Ltd | Novel processes |
GB201819083D0 (en) | 2018-11-23 | 2019-01-09 | Inflazome Ltd | Novel compounds |
GB201905265D0 (en) | 2019-04-12 | 2019-05-29 | Inflazome Ltd | Inflammasome inhibition |
CN114555609A (zh) | 2019-08-16 | 2022-05-27 | 英夫拉索姆有限公司 | 用作nlrp3抑制剂的大环磺酰胺衍生物 |
CN114401971A (zh) | 2019-08-16 | 2022-04-26 | 英夫拉索姆有限公司 | 用作nlrp3抑制剂的大环磺酰脲衍生物 |
CN114302876A (zh) | 2019-09-06 | 2022-04-08 | 英夫拉索姆有限公司 | Nlrp3抑制剂 |
WO2021089781A1 (en) | 2019-11-07 | 2021-05-14 | Inflazome Limited | Treatment or prevention of psychiatric brain disorders using the nlrp3 inhibitor n-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1 -isopropyl-1 h-pyrazole-3-sulfonamide |
CN114630664A (zh) | 2019-11-07 | 2022-06-14 | 英夫拉索姆有限公司 | 神经炎症或炎性脑部病症的治疗和预防 |
EP4054564A1 (en) | 2019-11-07 | 2022-09-14 | Inflazome Limited | Treatment of autoinflammatory disorders |
CN114641287A (zh) | 2019-11-07 | 2022-06-17 | 英夫拉索姆有限公司 | 神经退行性病症的治疗和预防 |
WO2021089776A1 (en) | 2019-11-07 | 2021-05-14 | Inflazome Limited | Treatment and prevention of a traumatic brain disorder |
GB201916237D0 (en) | 2019-11-07 | 2019-12-25 | Inflazome Ltd | Novel treatment |
-
2018
- 2018-08-15 WO PCT/EP2018/072133 patent/WO2019034696A1/en unknown
- 2018-08-15 AU AU2018317800A patent/AU2018317800A1/en not_active Abandoned
- 2018-08-15 CA CA3071145A patent/CA3071145A1/en active Pending
- 2018-08-15 MA MA049904A patent/MA49904A/fr unknown
- 2018-08-15 KR KR1020207006637A patent/KR20200041337A/ko not_active Application Discontinuation
- 2018-08-15 US US16/638,646 patent/US11773058B2/en active Active
- 2018-08-15 EP EP18759581.4A patent/EP3668601A1/en active Pending
- 2018-08-15 CN CN201880059147.4A patent/CN111107903A/zh active Pending
- 2018-08-15 RU RU2020110394A patent/RU2020110394A/ru unknown
- 2018-08-15 SG SG11202001112RA patent/SG11202001112RA/en unknown
- 2018-08-15 JP JP2020508545A patent/JP2020531448A/ja active Pending
- 2018-08-15 BR BR112020002906-8A patent/BR112020002906A2/pt not_active Application Discontinuation
- 2018-08-15 MX MX2020001778A patent/MX2020001778A/es unknown
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2020
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JP2020531448A (ja) | 2020-11-05 |
IL272550A (en) | 2020-03-31 |
BR112020002906A2 (pt) | 2020-08-04 |
US20200331850A1 (en) | 2020-10-22 |
US11773058B2 (en) | 2023-10-03 |
MA49904A (fr) | 2020-06-24 |
SG11202001112RA (en) | 2020-03-30 |
AU2018317800A1 (en) | 2020-02-13 |
EP3668601A1 (en) | 2020-06-24 |
RU2020110394A (ru) | 2022-01-20 |
WO2019034696A1 (en) | 2019-02-21 |
KR20200041337A (ko) | 2020-04-21 |
CN111107903A (zh) | 2020-05-05 |
RU2020110394A3 (es) | 2022-02-22 |
CA3071145A1 (en) | 2019-02-21 |
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