JP2018135394A5 - - Google Patents
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- Publication number
- JP2018135394A5 JP2018135394A5 JP2018108448A JP2018108448A JP2018135394A5 JP 2018135394 A5 JP2018135394 A5 JP 2018135394A5 JP 2018108448 A JP2018108448 A JP 2018108448A JP 2018108448 A JP2018108448 A JP 2018108448A JP 2018135394 A5 JP2018135394 A5 JP 2018135394A5
- Authority
- JP
- Japan
- Prior art keywords
- trienyl
- dione
- diene
- hydroxy
- tetramethylhexadec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229940064063 alpha tocotrienol Drugs 0.000 claims 15
- RZFHLOLGZPDCHJ-DLQZEEBKSA-N alpha-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(/CC/C=C(\CC/C=C(\C)/C)/C)\C)(C)CCc2c1C RZFHLOLGZPDCHJ-DLQZEEBKSA-N 0.000 claims 15
- RZFHLOLGZPDCHJ-XZXLULOTSA-N α-Tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C RZFHLOLGZPDCHJ-XZXLULOTSA-N 0.000 claims 15
- 239000011730 α-tocotrienol Substances 0.000 claims 15
- 235000019145 α-tocotrienol Nutrition 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 239000002243 precursor Substances 0.000 claims 6
- VPXVPJQOPRBXPO-UHFFFAOYSA-N 2,5-bis[6-[ethyl-[(2-methoxyphenyl)methyl]amino]hexylamino]cyclohexa-2,5-diene-1,4-dione Chemical compound C=1C=CC=C(OC)C=1CN(CC)CCCCCCNC(C(C=1)=O)=CC(=O)C=1NCCCCCCN(CC)CC1=CC=CC=C1OC VPXVPJQOPRBXPO-UHFFFAOYSA-N 0.000 claims 5
- 238000004587 chromatography analysis Methods 0.000 claims 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- 239000000741 silica gel Substances 0.000 claims 4
- 229910002027 silica gel Inorganic materials 0.000 claims 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 4
- DFUSDJMZWQVQSF-XLGIIRLISA-N (2r)-2-methyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol Chemical class OC1=CC=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 DFUSDJMZWQVQSF-XLGIIRLISA-N 0.000 claims 3
- 239000012535 impurity Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229940087168 alpha tocopherol Drugs 0.000 claims 2
- 238000001704 evaporation Methods 0.000 claims 2
- 230000008020 evaporation Effects 0.000 claims 2
- -1 hexadeca-6,10,14-trienyl Chemical group 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 229960000984 tocofersolan Drugs 0.000 claims 2
- 239000002076 α-tocopherol Substances 0.000 claims 2
- 235000004835 α-tocopherol Nutrition 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000419 plant extract Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19758508P | 2008-10-28 | 2008-10-28 | |
| US61/197,585 | 2008-10-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015140302A Division JP2015187169A (ja) | 2008-10-28 | 2015-07-14 | α−トコトリエノールおよび誘導体の産生のためのプロセス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019008496A Division JP2019065041A (ja) | 2008-10-28 | 2019-01-22 | α−トコトリエノールおよび誘導体の産生のためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018135394A JP2018135394A (ja) | 2018-08-30 |
| JP2018135394A5 true JP2018135394A5 (enExample) | 2019-03-07 |
| JP7181708B2 JP7181708B2 (ja) | 2022-12-01 |
Family
ID=42118126
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011534678A Active JP5775459B2 (ja) | 2008-10-28 | 2009-10-27 | α−トコトリエノールおよび誘導体の産生のためのプロセス |
| JP2014177733A Active JP6001025B2 (ja) | 2008-10-28 | 2014-09-02 | α−トコトリエノールおよび誘導体の産生のためのプロセス |
| JP2015140302A Withdrawn JP2015187169A (ja) | 2008-10-28 | 2015-07-14 | α−トコトリエノールおよび誘導体の産生のためのプロセス |
| JP2018108448A Active JP7181708B2 (ja) | 2008-10-28 | 2018-06-06 | α－トコトリエノールおよび誘導体の産生のためのプロセス |
| JP2019008496A Withdrawn JP2019065041A (ja) | 2008-10-28 | 2019-01-22 | α−トコトリエノールおよび誘導体の産生のためのプロセス |
| JP2021016310A Withdrawn JP2021066745A (ja) | 2008-10-28 | 2021-02-04 | α−トコトリエノールおよび誘導体の産生のためのプロセス |
| JP2023057343A Withdrawn JP2023073469A (ja) | 2008-10-28 | 2023-03-31 | α－トコトリエノールおよび誘導体の産生のためのプロセス |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011534678A Active JP5775459B2 (ja) | 2008-10-28 | 2009-10-27 | α−トコトリエノールおよび誘導体の産生のためのプロセス |
| JP2014177733A Active JP6001025B2 (ja) | 2008-10-28 | 2014-09-02 | α−トコトリエノールおよび誘導体の産生のためのプロセス |
| JP2015140302A Withdrawn JP2015187169A (ja) | 2008-10-28 | 2015-07-14 | α−トコトリエノールおよび誘導体の産生のためのプロセス |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019008496A Withdrawn JP2019065041A (ja) | 2008-10-28 | 2019-01-22 | α−トコトリエノールおよび誘導体の産生のためのプロセス |
| JP2021016310A Withdrawn JP2021066745A (ja) | 2008-10-28 | 2021-02-04 | α−トコトリエノールおよび誘導体の産生のためのプロセス |
| JP2023057343A Withdrawn JP2023073469A (ja) | 2008-10-28 | 2023-03-31 | α－トコトリエノールおよび誘導体の産生のためのプロセス |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US8106223B2 (enExample) |
| EP (3) | EP2362875B1 (enExample) |
| JP (7) | JP5775459B2 (enExample) |
| CN (2) | CN105753829B (enExample) |
| BR (1) | BRPI0920414B1 (enExample) |
| CA (2) | CA2741767C (enExample) |
| DK (2) | DK2963006T3 (enExample) |
| EA (2) | EA201692046A1 (enExample) |
| ES (2) | ES2701260T3 (enExample) |
| HU (1) | HUE041714T2 (enExample) |
| MX (1) | MX2011004440A (enExample) |
| MY (2) | MY185183A (enExample) |
| PL (2) | PL2963006T3 (enExample) |
| PT (2) | PT2963006T (enExample) |
| SI (1) | SI2963006T1 (enExample) |
| TR (1) | TR201819154T4 (enExample) |
| WO (1) | WO2010051277A1 (enExample) |
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| CA2777479C (en) | 2009-04-28 | 2017-10-17 | Ptc Therapeutics, Inc. | Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones |
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