ES2148616T3 - Aminometilacion de los tocoferoles. - Google Patents

Aminometilacion de los tocoferoles.

Info

Publication number
ES2148616T3
ES2148616T3 ES96104467T ES96104467T ES2148616T3 ES 2148616 T3 ES2148616 T3 ES 2148616T3 ES 96104467 T ES96104467 T ES 96104467T ES 96104467 T ES96104467 T ES 96104467T ES 2148616 T3 ES2148616 T3 ES 2148616T3
Authority
ES
Spain
Prior art keywords
formaldehyde
mannich
prepd
mixt
tocopherol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96104467T
Other languages
English (en)
Inventor
Robert Karl Mueller
Heinz Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2148616T3 publication Critical patent/ES2148616T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN PROCEDIMIENTO PARA LA OBTENCION DE UN REACTIVO DE MANNICH, QUE CONSISTE EN HACER REACCIONAR FORMALDEHIDO, ESPECIALMENTE PARAFORMALDEHIDO, CON UNA AMINA SECUNDARIA EN AUSENCIA TOTAL O CASI, DE UN DISOLVENTE. UNA ALTERNATIVA CONSISTE EN HACER REACCIONAR EN CANTIDADES CASI EQUIMOLARES, UNA AMINA SECUNDARIA OBTENIDA DE UN AMINOMETANO, FORMALDEHIDO, ESPECIALMENTE PARAFORMALDEHIDO, Y AGUA. LA INVENCION COMPRENDE ADEMAS UN PROCEDIMIENTO PARA LA AMINOMETILACION DE {DE}-TOCOFEROL O MEZCLAS DE ESTE TOCOFEROL, QUE CONSISTE EN UTILIZAR UN REACTIVO DE MANNICH, OBTENIDO DE LA MANERA ANTES EXPLICADA. DESPUES DE ACABAR ESTA AMINOMETILACION, SE PUEDE SEPARAR DE FORMA DESTILATIVA EL REACTIVO DE MANNICH SOBRANTE, Y HACERLO REACCIONAR CON FORMALDEHIDO, ESPECIALMENTE PARAFORMALDEHIDO, PARA REGENERARLO Y VOLVERLO A UTILIZAR, LO QUE TAMBIEN ES OTRO ASPECTO DE LA INVENCION. FINALMENTE, LA INVENCION TAMBIEN COMPRENDE NUEVOS Y DETERMINADOS BIS(AMINOMETIL)-{DE}-TOCOFEROLES.
ES96104467T 1995-03-28 1996-03-21 Aminometilacion de los tocoferoles. Expired - Lifetime ES2148616T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH87895 1995-03-28

Publications (1)

Publication Number Publication Date
ES2148616T3 true ES2148616T3 (es) 2000-10-16

Family

ID=4197282

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96104467T Expired - Lifetime ES2148616T3 (es) 1995-03-28 1996-03-21 Aminometilacion de los tocoferoles.

Country Status (8)

Country Link
US (3) US6066731A (es)
EP (1) EP0735033B1 (es)
JP (1) JPH08269040A (es)
CN (1) CN1159284C (es)
AT (1) ATE194609T1 (es)
DE (1) DE59605564D1 (es)
DK (1) DK0735033T3 (es)
ES (1) ES2148616T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10316375A1 (de) * 2003-04-10 2004-11-04 Celanese Chemicals Europe Gmbh Verfahren zur Herstellung von N-Methyl-dialkylaminen aus sekundären Dialkylaminen und Formaldehyd
EP3450431B1 (en) * 2008-10-28 2023-09-13 PTC Therapeutics, Inc. Process for the production of alpha-tocotrienol and derivatives
CN103080084B (zh) 2010-08-26 2017-07-07 帝斯曼知识产权资产管理有限公司 Tmhq的制备方法
CN102675275A (zh) * 2012-05-18 2012-09-19 江南大学 一种甲基化与柱层析相结合制备高含量α-生育酚的方法
CN107001209B (zh) 2014-12-17 2021-02-19 帝斯曼知识产权资产管理有限公司 在金(i)络合物存在的情况下基于炔烃与二甲基呋喃的分子间反应形成色满
CN105801551B (zh) * 2014-12-29 2018-11-30 浙江新和成药业有限公司 一种维生素e醋酸酯的清洁生产方法
JP7117241B2 (ja) 2015-12-16 2022-08-12 ピーティーシー セラピューティクス， インコーポレイテッド 混合されたトコール組成物からアルファ－トコトリエノールを富化するための改良された方法
CN111675677B (zh) * 2020-07-13 2022-07-19 江苏富比亚化学品有限公司 一种n-甲基吗啉的合成工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2486539A (en) * 1946-07-19 1949-11-01 Distillation Products Inc Conversion of beta-, gamma-, and delta-tocopherol to alph-tocopherol
US2519863A (en) * 1949-05-14 1950-08-22 Eastman Kodak Co Conversion of beta-, gamma-, and delta-tocopherol to alpha-tocopherol by aminoalkylation and reduction
US4977282A (en) * 1984-04-17 1990-12-11 Henkel Corporation Production of d-alpha-tocopherol from natural plant sources
AU581216B2 (en) * 1984-04-17 1989-02-16 Henkel Corporation Production of d-alpha-tocopherol from natural plant sources
DE3741661A1 (de) * 1987-12-09 1989-06-22 Basf Lacke & Farben Bindemittel fuer die kathodische elektrotauchlackierung
US5229521A (en) * 1990-12-11 1993-07-20 Ciba-Geigy Corporation Process for the preparation of symmetrical 2,2-methylenebisbenzotriazolyl phenols
DE59103040D1 (de) * 1990-12-11 1994-10-27 Ciba Geigy Ag Verfahren zur Herstellung von symmetrischen 2,2'-Methylen-bis-benztriazolylphenolen.

Also Published As

Publication number Publication date
JPH08269040A (ja) 1996-10-15
US6066731A (en) 2000-05-23
EP0735033B1 (de) 2000-07-12
DK0735033T3 (da) 2000-10-23
EP0735033A1 (de) 1996-10-02
US6252071B1 (en) 2001-06-26
ATE194609T1 (de) 2000-07-15
DE59605564D1 (de) 2000-08-17
US6359132B1 (en) 2002-03-19
CN1138026A (zh) 1996-12-18
CN1159284C (zh) 2004-07-28

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