JP2002332277A5 - - Google Patents
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- Publication number
- JP2002332277A5 JP2002332277A5 JP2001390810A JP2001390810A JP2002332277A5 JP 2002332277 A5 JP2002332277 A5 JP 2002332277A5 JP 2001390810 A JP2001390810 A JP 2001390810A JP 2001390810 A JP2001390810 A JP 2001390810A JP 2002332277 A5 JP2002332277 A5 JP 2002332277A5
- Authority
- JP
- Japan
- Prior art keywords
- methylpiperazine
- optically active
- enantiomer
- separating
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- JOMNTHCQHJPVAZ-UHFFFAOYSA-N 2-methylpiperazine Chemical compound CC1CNCCN1 JOMNTHCQHJPVAZ-UHFFFAOYSA-N 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 9
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- SXERGJJQSKIUIC-UHFFFAOYSA-N 2-Phenoxypropionic acid Chemical compound OC(=O)C(C)OC1=CC=CC=C1 SXERGJJQSKIUIC-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 239000007810 chemical reaction solvent Substances 0.000 claims 4
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 4
- 239000011707 mineral Substances 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000012452 mother liquor Substances 0.000 claims 3
- JOMNTHCQHJPVAZ-RXMQYKEDSA-N (2r)-2-methylpiperazine Chemical compound C[C@@H]1CNCCN1 JOMNTHCQHJPVAZ-RXMQYKEDSA-N 0.000 claims 2
- SCQIWGPTHVBTHC-UHFFFAOYSA-N 2-methylpiperazin-1-ium;2-phenoxypropanoate Chemical compound CC1CNCC[NH2+]1.[O-]C(=O)C(C)OC1=CC=CC=C1 SCQIWGPTHVBTHC-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 1
- 125000006165 cyclic alkyl group Chemical group 0.000 claims 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 claims 1
- XCIXKGXIYUWCLL-UHFFFAOYSA-N cyclopentanol Chemical compound OC1CCCC1 XCIXKGXIYUWCLL-UHFFFAOYSA-N 0.000 claims 1
- 150000002168 ethanoic acid esters Chemical class 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001390810A JP2002332277A (ja) | 2001-03-06 | 2001-12-25 | 光学活性２−メチルピペラジンの製造方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001061394 | 2001-03-06 | ||
| JP2001-61394 | 2001-03-06 | ||
| JP2001390810A JP2002332277A (ja) | 2001-03-06 | 2001-12-25 | 光学活性２−メチルピペラジンの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002332277A JP2002332277A (ja) | 2002-11-22 |
| JP2002332277A5 true JP2002332277A5 (enExample) | 2005-07-14 |
Family
ID=26610673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001390810A Pending JP2002332277A (ja) | 2001-03-06 | 2001-12-25 | 光学活性２−メチルピペラジンの製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2002332277A (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4768145B2 (ja) * | 2001-04-18 | 2011-09-07 | 大東化学株式会社 | 光学活性２−フェノキシプロピオン酸の光学精製方法 |
| JP4728636B2 (ja) * | 2004-12-15 | 2011-07-20 | 大東化学株式会社 | 光学活性アミノ酸類の製造方法 |
| JP2011057619A (ja) * | 2009-09-10 | 2011-03-24 | Tokai Univ | 光学活性アミン化合物の製造方法、並びに、ジアステレオマー塩及びその製造方法 |
| JP6473952B2 (ja) * | 2014-08-08 | 2019-02-27 | 東レ・ファインケミカル株式会社 | 光学活性２−メチルピペラジンの製造方法 |
-
2001
- 2001-12-25 JP JP2001390810A patent/JP2002332277A/ja active Pending
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