CN100448866C - 具有光学活性的2-羟甲基-3-取代苯基丙酸化合物及其拆分方法 - Google Patents
具有光学活性的2-羟甲基-3-取代苯基丙酸化合物及其拆分方法 Download PDFInfo
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- CN100448866C CN100448866C CNB2005100297381A CN200510029738A CN100448866C CN 100448866 C CN100448866 C CN 100448866C CN B2005100297381 A CNB2005100297381 A CN B2005100297381A CN 200510029738 A CN200510029738 A CN 200510029738A CN 100448866 C CN100448866 C CN 100448866C
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Abstract
Description
拆分剂 | 溶剂 | 成盐收率(%) | [α]<sub>D</sub><sup>20</sup>(c=1,甲醇) | 成盐熔点(℃) |
(+)-α-苯乙胺 | 乙醇 | 75.2 | +29.2 | 172 |
(-)-α-苯乙胺 | 乙醇 | 119.2 | -29.0 | 158~160 |
葡辛胺 | 乙醇 | 70.5 | +29.4 | 112~114 |
辛可尼定 | 乙醇 | 77.3 | +29.1 | 176 |
奎宁 | 乙醇 | 78.8 | -28.7 | 150~152 |
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CNB2005100297381A CN100448866C (zh) | 2005-09-16 | 2005-09-16 | 具有光学活性的2-羟甲基-3-取代苯基丙酸化合物及其拆分方法 |
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CN1931855A CN1931855A (zh) | 2007-03-21 |
CN100448866C true CN100448866C (zh) | 2009-01-07 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103012280B (zh) * | 2011-09-22 | 2015-04-29 | 江苏康缘药业股份有限公司 | 一种制备安立生坦的方法 |
CN105130794A (zh) * | 2015-09-02 | 2015-12-09 | 彭静 | S-1-苯乙胺拆分制备s-4-甲氧基扁桃酸的方法 |
CN107759623B (zh) * | 2016-08-23 | 2020-08-14 | 苏州旺山旺水生物医药有限公司 | Jak抑制剂的中间体及其制备方法 |
CN107759601B (zh) * | 2016-08-23 | 2020-09-11 | 苏州旺山旺水生物医药有限公司 | 一种jak抑制剂及其盐的制备方法 |
CN106349144B (zh) * | 2016-08-30 | 2019-05-24 | 山东默得森生物制药有限公司 | 一种(s)-奥拉西坦中间体的制备方法 |
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WO2004060885A1 (ja) * | 2002-12-27 | 2004-07-22 | Kaneka Corporation | 光学活性2−チオメチル−3−フェニルプロピオン酸誘導体およびその合成中間体の製造法 |
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WO2004060885A1 (ja) * | 2002-12-27 | 2004-07-22 | Kaneka Corporation | 光学活性2−チオメチル−3−フェニルプロピオン酸誘導体およびその合成中間体の製造法 |
Non-Patent Citations (2)
Title |
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法西多曲原料药的合成. 刘丰良,王文革,阳卫军.合成化学,第5期. 2004 |
法西多曲原料药的合成. 刘丰良,王文革,阳卫军.合成化学,第5期. 2004 * |
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