JP2017513524A5 - - Google Patents
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- Publication number
- JP2017513524A5 JP2017513524A5 JP2017505717A JP2017505717A JP2017513524A5 JP 2017513524 A5 JP2017513524 A5 JP 2017513524A5 JP 2017505717 A JP2017505717 A JP 2017505717A JP 2017505717 A JP2017505717 A JP 2017505717A JP 2017513524 A5 JP2017513524 A5 JP 2017513524A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- streptavidin
- analog
- avidin
- biotin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010090804 Streptavidin Proteins 0.000 claims 23
- 239000003153 chemical reaction reagent Substances 0.000 claims 22
- 238000000034 method Methods 0.000 claims 20
- 108090001008 Avidin Proteins 0.000 claims 19
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 14
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 229960002685 biotin Drugs 0.000 claims 9
- 235000020958 biotin Nutrition 0.000 claims 9
- 239000011616 biotin Substances 0.000 claims 9
- 150000001615 biotins Chemical class 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 230000002441 reversible effect Effects 0.000 claims 3
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 102000000584 Calmodulin Human genes 0.000 claims 2
- 108010041952 Calmodulin Proteins 0.000 claims 2
- 108010078791 Carrier Proteins Proteins 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 2
- 102000005720 Glutathione transferase Human genes 0.000 claims 2
- 108010070675 Glutathione transferase Proteins 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 229910001428 transition metal ion Inorganic materials 0.000 claims 2
- 108010028230 Trp-Ser- His-Pro-Gln-Phe-Glu-Lys Proteins 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 108010018381 streptavidin-binding peptide Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020076705A JP7762499B2 (ja) | 2014-04-16 | 2020-04-23 | 細胞の集団を拡大する方法、キット、及び装置 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461980506P | 2014-04-16 | 2014-04-16 | |
| US61/980,506 | 2014-04-16 | ||
| PCT/EP2015/058339 WO2015158868A2 (en) | 2014-04-16 | 2015-04-16 | Methods, kits and apparatus for expanding a population of cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020076705A Division JP7762499B2 (ja) | 2014-04-16 | 2020-04-23 | 細胞の集団を拡大する方法、キット、及び装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513524A JP2017513524A (ja) | 2017-06-01 |
| JP2017513524A5 true JP2017513524A5 (enExample) | 2018-05-31 |
| JP6696969B2 JP6696969B2 (ja) | 2020-05-20 |
Family
ID=53052805
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505717A Active JP6696969B2 (ja) | 2014-04-16 | 2015-04-16 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2020076705A Active JP7762499B2 (ja) | 2014-04-16 | 2020-04-23 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2023024443A Pending JP2023062124A (ja) | 2014-04-16 | 2023-02-20 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2024225388A Pending JP2025060756A (ja) | 2014-04-16 | 2024-12-20 | 細胞の集団を拡大する方法、キット、及び装置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020076705A Active JP7762499B2 (ja) | 2014-04-16 | 2020-04-23 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2023024443A Pending JP2023062124A (ja) | 2014-04-16 | 2023-02-20 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2024225388A Pending JP2025060756A (ja) | 2014-04-16 | 2024-12-20 | 細胞の集団を拡大する方法、キット、及び装置 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US11274278B2 (enExample) |
| EP (2) | EP3988920A1 (enExample) |
| JP (4) | JP6696969B2 (enExample) |
| KR (2) | KR102459384B1 (enExample) |
| CN (3) | CN111961647A (enExample) |
| AU (2) | AU2015248786B2 (enExample) |
| BR (1) | BR112016024072B1 (enExample) |
| CA (2) | CA3176848A1 (enExample) |
| CY (1) | CY1124717T1 (enExample) |
| DK (1) | DK3132247T3 (enExample) |
| ES (1) | ES2892927T3 (enExample) |
| HR (1) | HRP20211430T1 (enExample) |
| HU (1) | HUE056852T2 (enExample) |
| IL (3) | IL280738B (enExample) |
| LT (1) | LT3132247T (enExample) |
| MX (2) | MX380519B (enExample) |
| MY (1) | MY184699A (enExample) |
| PH (2) | PH12016502017A1 (enExample) |
| PL (1) | PL3132247T3 (enExample) |
| PT (1) | PT3132247T (enExample) |
| RS (1) | RS62471B1 (enExample) |
| RU (2) | RU2735640C9 (enExample) |
| SA (3) | SA520412247B1 (enExample) |
| SG (2) | SG10201808491UA (enExample) |
| SI (1) | SI3132247T1 (enExample) |
| SM (1) | SMT202100600T1 (enExample) |
| WO (1) | WO2015158868A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013224027B2 (en) | 2012-02-23 | 2019-01-24 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| JP6696969B2 (ja) | 2014-04-16 | 2020-05-20 | ユノ・セラピューティクス・ゲーエムベーハーＪｕｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｇｍｂｈ | 細胞の集団を拡大する方法、キット、及び装置 |
| SG11201608862SA (en) | 2014-04-23 | 2016-11-29 | Juno Therapeutics Inc | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| KR20180108567A (ko) | 2015-10-22 | 2018-10-04 | 주노 테라퓨틱스 게엠베하 | 형질도입을 위한 방법, 키트, 제제 및 장치 |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| MA45488A (fr) * | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| EP3192810A1 (en) | 2016-01-14 | 2017-07-19 | Deutsches Krebsforschungszentrum | Psma binding antibody and uses thereof |
| CN107129988A (zh) * | 2016-02-29 | 2017-09-05 | 广西医科大学 | 一种特异性结合cd3的核酸适配体及其筛选方法和应用 |
| BR112018073909A2 (pt) * | 2016-06-02 | 2019-02-26 | Klotho Therapeutics, Inc. | proteínas klotho recombinantes terapêuticas e composições e métodos envolvendo as mesmas |
| WO2018023100A2 (en) | 2016-07-29 | 2018-02-01 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies and related methods |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| EP3548611A1 (en) * | 2016-12-05 | 2019-10-09 | Juno Therapeutics, Inc. | Production of engineered cells for adoptive cell therapy |
| US11624046B2 (en) * | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US11629332B2 (en) * | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) * | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| WO2018197949A1 (en) * | 2017-04-27 | 2018-11-01 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| MX2020004240A (es) | 2017-11-01 | 2020-09-25 | Juno Therapeutics Inc | Proceso para generar composiciones terapeuticas de celulas modificadas. |
| MA51154A (fr) * | 2017-12-15 | 2020-10-21 | Aleta Biotherapeutics Inc | Variants de cd19 |
| CN107904278B (zh) * | 2017-12-25 | 2021-07-20 | 北昊干细胞与再生医学研究院有限公司 | 检测药物对细胞增殖影响的方法 |
| US11149244B2 (en) * | 2018-04-04 | 2021-10-19 | Southwest Research Institute | Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy |
| EP3790958A1 (en) * | 2018-05-08 | 2021-03-17 | Life Technologies Corporation | Compositions and methods for culturing and expanding cells |
| CN112912103B (zh) * | 2018-05-21 | 2025-08-29 | 广州邦定生物技术有限公司 | 多价蛋白质复合物 |
| EP3833742A2 (en) | 2018-08-09 | 2021-06-16 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| EP3623383A1 (en) | 2018-09-11 | 2020-03-18 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Improved bispecific flt3xcd3 antigen binding proteins |
| MY205658A (en) | 2018-09-11 | 2024-11-04 | Deutsches Krebsforschungszentrumstiftung Des Ffentlichen Rechts | Improved anti-flt₃ antigen binding proteins |
| US11447731B2 (en) * | 2018-09-24 | 2022-09-20 | Southwest Research Institute | Three-dimensional bioreactors |
| MX2021005013A (es) | 2018-10-31 | 2021-07-21 | Juno Therapeutics Gmbh | Métodos para la selección y estimulación de células y aparatos para los mismos. |
| KR20200132147A (ko) * | 2019-05-15 | 2020-11-25 | 의료법인 성광의료재단 | 자연 살해 세포의 배양용 조성물 및 이를 이용한 방법 |
| CN114127561A (zh) * | 2019-05-24 | 2022-03-01 | 索尔生物公司 | 使用开关样结合反应的亲和分离系统和方法 |
| CN114207136A (zh) * | 2019-06-07 | 2022-03-18 | 朱诺治疗学股份有限公司 | 自动化t细胞培养 |
| CA3159380A1 (en) | 2019-10-30 | 2021-05-06 | Juno Therapeutics Gmbh | Cell selection and/or stimulation devices and methods of use |
| EP3822288A1 (en) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
| BR112022010627A2 (pt) | 2019-12-06 | 2022-08-16 | Juno Therapeutics Inc | Anticorpos anti-idiotípicos para domínios de ligação alvejados por bcma e composições e métodos relacionados |
| CN115335399A (zh) | 2019-12-06 | 2022-11-11 | 朱诺治疗学股份有限公司 | 针对gprc5d靶结合结构域的抗独特型抗体以及相关组合物和方法 |
| CA3163761C (en) | 2020-01-31 | 2023-07-11 | Herbert Stadler | Methods of isolating a biological entity |
| JP2023519098A (ja) | 2020-02-12 | 2023-05-10 | ジュノー セラピューティクス インコーポレイテッド | Ｃｄ１９指向性キメラ抗原受容体ｔ細胞組成物ならびにその方法および使用 |
| CA3170153A1 (en) | 2020-02-12 | 2021-08-19 | Juno Therapeutics, Inc. | Bcma-directed chimeric antigen receptor t cell compositions and methods and uses thereof |
| US12378521B2 (en) | 2020-04-15 | 2025-08-05 | Amgen Inc. | Method for enhancing production of genetically engineered autologous T cells |
| US12241086B2 (en) | 2020-04-15 | 2025-03-04 | Amgen Inc. | Process for generating genetically engineered autologous T cells |
| KR20230095918A (ko) | 2020-08-05 | 2023-06-29 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ror1-표적 결합 도메인에 대한 항이디오타입 항체 및 관련 조성물 및 방법 |
| JP2023549780A (ja) | 2020-11-04 | 2023-11-29 | ジュノー セラピューティクス インコーポレイテッド | 改変されたインバリアントｃｄ３免疫グロブリンスーパーファミリー鎖遺伝子座からキメラ受容体を発現する細胞ならびに関連するポリヌクレオチドおよび方法 |
| AU2021401052A1 (en) | 2020-12-18 | 2023-06-22 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| WO2022204070A1 (en) | 2021-03-22 | 2022-09-29 | Juno Therapeutics, Inc. | Methods of determining potency of a therapeutic cell composition |
| JP2024517863A (ja) | 2021-05-06 | 2024-04-23 | ジュノ・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞を刺激し、形質導入する方法 |
| CN117957313A (zh) | 2021-07-19 | 2024-04-30 | 修复免疫股份有限公司 | 从多能干细胞生产免疫细胞群的方法 |
| US20250297282A1 (en) | 2022-05-05 | 2025-09-25 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| EP4615960A1 (en) | 2022-11-09 | 2025-09-17 | C3S2 GmbH | Methods for manufacturing engineered immune cells |
| WO2024124132A1 (en) | 2022-12-09 | 2024-06-13 | Juno Therapeutics, Inc. | Machine learning methods for predicting cell phenotype using holographic imaging |
| AU2024214593A1 (en) | 2023-02-03 | 2025-08-07 | C3S2 Gmbh | Methods for non-viral manufacturing of engineered immune cells |
| US20240285762A1 (en) | 2023-02-28 | 2024-08-29 | Juno Therapeutics, Inc. | Cell therapy for treating systemic autoimmune diseases |
| KR20250169631A (ko) | 2023-04-18 | 2025-12-03 | 주노 쎄러퓨티크스 인코퍼레이티드 | 치료 세포 조성물의 효력을 평가하기 위한 세포독성 검정 |
| WO2024243365A2 (en) | 2023-05-23 | 2024-11-28 | Juno Therapeutics, Inc. | Activation markers of t cells and method for assessing t cell activation |
| CN117448255B (zh) * | 2023-09-28 | 2024-12-31 | 深圳市龙华区人民医院 | S2饲养细胞、制备方法及其应用 |
| WO2025109111A1 (en) * | 2023-11-22 | 2025-05-30 | Immudex Aps | Immune cell activating multimers |
| KR102824339B1 (ko) * | 2024-07-01 | 2025-06-26 | 현대자동차주식회사 | 배터리 제어 장치 및 그 방법 |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
| WO1986002077A1 (en) | 1984-10-02 | 1986-04-10 | Meade Harry M | Production of streptavidin-like polypeptides |
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| DE4237113B4 (de) | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| AU7052194A (en) | 1993-06-04 | 1995-01-03 | Regents Of The University Of Michigan, The | Methods for selectively stimulating proliferation of t cells |
| WO1996023879A1 (en) | 1995-01-30 | 1996-08-08 | Terrapin Technologies, Inc. | Glubodies - multiplicities of proteins capable of binding a variety of small molecules |
| JPH11501008A (ja) | 1995-02-09 | 1999-01-26 | ユニバーシティ オブ ワシントン | 改変−アフィニティーストレプトアビジン |
| US6022951A (en) | 1995-04-11 | 2000-02-08 | Univ Boston | Streptavidin mutants |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| WO1998040396A1 (en) | 1997-03-14 | 1998-09-17 | Trustees Of Boston University | Multiflavor streptavidin |
| US5985658A (en) | 1997-11-14 | 1999-11-16 | Health Research Incorporated | Calmodulin-based cell separation technique |
| US6664042B1 (en) | 1999-01-26 | 2003-12-16 | Cornell Research Foundation, Inc. | Determining viral load in double negative T cells |
| HUP0105337A3 (en) * | 1999-02-03 | 2011-01-28 | Amgen Inc | Polypeptides involved in immune response |
| BR0009403A (pt) * | 1999-02-04 | 2001-11-27 | Technion Res & Dev Foundation | Método de expansão/conservação das células detronco hemopoiéticas indiferenciadas ou dascélulas progenitoras, método de preparação deum meio condicionado de célula estomacal útil naexpansão/conservação das células de troncohemopoiéticas indiferenciadas ou das célulasprogenitoras, método de transplante de célulasde tronco hemopoiéticas indiferenciadas ou decélulas progenitoras em um recipiente, tampão debiorreator e biorreator |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| US20030235908A1 (en) * | 2000-02-24 | 2003-12-25 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| EP1227321A1 (en) | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| ATE370159T1 (de) | 2002-03-01 | 2007-09-15 | Volker A Erdmann | Streptavidin-bindungspeptid |
| US7754155B2 (en) | 2002-03-15 | 2010-07-13 | Ross Amelia A | Devices and methods for isolating target cells |
| WO2003090781A1 (en) | 2002-04-23 | 2003-11-06 | Meir Strahilevitz | Methods and devices for targeting a site in a mammal and for removing species from a mammal |
| FR2841905B1 (fr) | 2002-07-05 | 2004-09-03 | Centre Nat Rech Scient | Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications |
| CA2500392C (en) | 2002-09-27 | 2012-11-27 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
| SG150387A1 (en) | 2003-05-02 | 2009-03-30 | Insception Bioscience Inc | Apparatus and methods for amplification of blood stem cell numbers |
| EP1623017B1 (en) | 2003-05-08 | 2010-09-15 | Life Technologies Corporation | Generation and isolation of antigen-specific t cells |
| AU2004292131A1 (en) | 2003-11-20 | 2005-06-02 | Biosensor Applications Sweden (Publ) | Mixture of at least two different antibodies specific for predetermined antigens and use of the mixture |
| SE0400181D0 (sv) | 2004-01-29 | 2004-01-29 | Gyros Ab | Segmented porous and preloaded microscale devices |
| WO2005121798A1 (en) | 2004-06-03 | 2005-12-22 | Meso Scale Technologies, Llc | Methods and apparatuses for conducting assays |
| DK1800136T3 (da) | 2004-10-15 | 2012-03-26 | Danisco Us Inc | Kompetitiv differentiel screening |
| WO2006058226A2 (en) * | 2004-11-24 | 2006-06-01 | The Trustees Of Boston University | Modified dimeric streptavidins and uses thereof |
| US20060252087A1 (en) | 2005-01-18 | 2006-11-09 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
| US7704708B2 (en) * | 2006-02-13 | 2010-04-27 | Uti Limited Partnership | Monomeric streptavidin muteins |
| US7855057B2 (en) | 2006-03-23 | 2010-12-21 | Millipore Corporation | Protein splice variant/isoform discrimination and quantitative measurements thereof |
| US20090208471A1 (en) | 2006-04-07 | 2009-08-20 | Yun Theodore J | Isolation and Use of Human Regulatory T Cells |
| US20070238169A1 (en) * | 2006-04-11 | 2007-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Cell sorter and culture system |
| US20080085532A1 (en) | 2006-09-18 | 2008-04-10 | Jorn Gorlach | Method for determining the immune status of a subject |
| KR101527473B1 (ko) | 2006-10-17 | 2015-06-17 | 온코세라피 사이언스 가부시키가이샤 | Ｍｐｈｏｓｐｈ1 또는 ｄｅｐｄｃ1 폴리펩티드를 발현하는 암에 대한 펩티드 백신 |
| CN105866401A (zh) | 2006-11-02 | 2016-08-17 | 协和梅迪克斯株式会社 | 免疫测定待测组分的方法 |
| CA2671326A1 (en) | 2006-11-15 | 2008-11-20 | Invitrogen Dynal As | Methods of reversibly binding a biotin compound to a support |
| US20080131415A1 (en) | 2006-11-30 | 2008-06-05 | Riddell Stanley R | Adoptive transfer of cd8 + t cell clones derived from central memory cells |
| CN101226118B (zh) | 2007-01-19 | 2010-06-16 | 中国医学科学院肿瘤研究所 | 一种兼容免疫荧光分析的细胞化学染色方法及其用途 |
| WO2008118476A2 (en) * | 2007-03-26 | 2008-10-02 | Codon Devices, Inc. | Cell surface display, screening and production of proteins of interest |
| WO2009003493A2 (en) | 2007-07-03 | 2009-01-08 | Dako Denmark A/S | Mhc multimers, methods for their generation, labeling and use |
| PT2193199E (pt) | 2007-08-20 | 2014-02-14 | Nextera As | Apresentação em fagos por intermédio de pvii |
| EP2227334B1 (en) | 2007-12-07 | 2011-10-12 | Miltenyi Biotec GmbH | A centrifuge for separating a sample into at least two components |
| WO2009092068A1 (en) | 2008-01-18 | 2009-07-23 | President And Fellows Of Harvard College | Methods of detecting signatures of disease or conditions in bodily fluids |
| WO2009097119A2 (en) | 2008-01-29 | 2009-08-06 | Fred Hutchinson Cancer Research Center | Identification of cd8+ t cells that are cd161hi and/or il18r(alpha)hi and have rapid drug efflux capacity |
| CN101446576B (zh) | 2008-12-29 | 2011-06-22 | 江苏省苏微微生物研究有限公司 | 一种微囊藻毒素-lr单抗免疫亲和柱的制备和使用方法 |
| WO2010080032A2 (en) | 2009-01-09 | 2010-07-15 | Stichting Het Nederlands Kanker Instituut | Bead-assisted viral transduction |
| US20110070581A1 (en) | 2009-04-27 | 2011-03-24 | Amit Gupta | Separation of Leukocytes |
| US20120214187A1 (en) * | 2009-11-02 | 2012-08-23 | Ffina Biolutions, Llc | Method for Enhancing the Sensitivity of Antibody Based Assays |
| US20120321665A1 (en) * | 2009-12-14 | 2012-12-20 | Benaroya Research Institute At Virginia Mason | Compositions and methods for treating airway inflammatory diseases |
| EP2363501A1 (en) | 2010-03-02 | 2011-09-07 | Universitätsklinikum Hamburg-Eppendorf | Method for isolating target cells |
| JP6192537B2 (ja) | 2010-08-06 | 2017-09-06 | ルードヴィヒ−マクシミリアン−ウニヴェルズィテート ミュンヘン | Ｔ細胞の標的抗原の同定 |
| WO2012058627A2 (en) | 2010-10-29 | 2012-05-03 | Miqin Zhang | Pre-targeted nanoparticle system and method for labeling biological particles |
| JP6203705B2 (ja) | 2011-03-23 | 2017-09-27 | フレッド ハッチンソン キャンサー リサーチ センター | 細胞免疫療法のための方法および組成物 |
| EP3418295B1 (en) * | 2011-07-18 | 2020-09-02 | IBA GmbH | Method of reversibly staining a target cell |
| US9353161B2 (en) | 2011-09-13 | 2016-05-31 | Uti Limited Partnership | Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins |
| AU2013224027B2 (en) | 2012-02-23 | 2019-01-24 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| UA114108C2 (uk) * | 2012-07-10 | 2017-04-25 | Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем | Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання |
| WO2014011996A1 (en) | 2012-07-13 | 2014-01-16 | The Trustees Of The University Of Pennsylvania | Methods of assessing the suitability of transduced t cells for administration |
| PH12019550223A1 (en) | 2012-08-20 | 2024-02-19 | Fred Hutchinson Cancer Center | Method and compositions for cellular immunotherapy |
| CN105073770B (zh) | 2012-11-16 | 2019-08-06 | Iba股份有限公司 | 链霉亲和素突变蛋白及其使用方法 |
| CN103305464B (zh) | 2013-06-05 | 2015-04-15 | 南昌大学 | 直接分离cd4+和cd8+淋巴细胞的方法 |
| US9698876B2 (en) | 2013-07-23 | 2017-07-04 | Telefonaktiebolaget Lm Ericsson (Publ) | Transmission mode allocation in LTE networks |
| WO2015095895A1 (en) | 2013-12-20 | 2015-06-25 | Fred Hutchinson Cancer Research Center | Tagged chimeric effector molecules and receptors thereof |
| CN111514283B (zh) | 2014-04-07 | 2025-10-14 | 诺华股份有限公司 | 使用抗cd19嵌合抗原受体治疗癌症 |
| JP6696969B2 (ja) | 2014-04-16 | 2020-05-20 | ユノ・セラピューティクス・ゲーエムベーハーＪｕｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｇｍｂｈ | 細胞の集団を拡大する方法、キット、及び装置 |
| SG11201608862SA (en) | 2014-04-23 | 2016-11-29 | Juno Therapeutics Inc | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| US10131876B2 (en) | 2014-04-24 | 2018-11-20 | Miltenyi Biotec Gmbh | Method for automated generation of genetically modified T cells |
| CA2946552A1 (en) | 2014-04-25 | 2015-10-29 | Bluebird Bio, Inc. | Improved methods for manufacturing adoptive cell therapies |
| CA2945414C (en) * | 2014-04-30 | 2023-05-09 | Iba Gmbh | Method of isolating a target cell |
| CA2981751A1 (en) | 2015-04-08 | 2016-10-13 | Novartis Ag | Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car)- expressing cell |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| KR20180108567A (ko) | 2015-10-22 | 2018-10-04 | 주노 테라퓨틱스 게엠베하 | 형질도입을 위한 방법, 키트, 제제 및 장치 |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| EP4212547A1 (en) | 2015-12-03 | 2023-07-19 | Juno Therapeutics, Inc. | Modified chimeric receptors and related compositions and methods |
| WO2018197949A1 (en) | 2017-04-27 | 2018-11-01 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| EP3833742A2 (en) | 2018-08-09 | 2021-06-16 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| MX2021005013A (es) | 2018-10-31 | 2021-07-21 | Juno Therapeutics Gmbh | Métodos para la selección y estimulación de células y aparatos para los mismos. |
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