JP2017513524A5 - - Google Patents
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- Publication number
- JP2017513524A5 JP2017513524A5 JP2017505717A JP2017505717A JP2017513524A5 JP 2017513524 A5 JP2017513524 A5 JP 2017513524A5 JP 2017505717 A JP2017505717 A JP 2017505717A JP 2017505717 A JP2017505717 A JP 2017505717A JP 2017513524 A5 JP2017513524 A5 JP 2017513524A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- streptavidin
- analog
- avidin
- biotin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010090804 Streptavidin Proteins 0.000 claims 23
- 239000003153 chemical reaction reagent Substances 0.000 claims 22
- 238000000034 method Methods 0.000 claims 20
- 108090001008 Avidin Proteins 0.000 claims 19
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 14
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 229960002685 biotin Drugs 0.000 claims 9
- 235000020958 biotin Nutrition 0.000 claims 9
- 239000011616 biotin Substances 0.000 claims 9
- 150000001615 biotins Chemical class 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 230000002441 reversible effect Effects 0.000 claims 3
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 102000000584 Calmodulin Human genes 0.000 claims 2
- 108010041952 Calmodulin Proteins 0.000 claims 2
- 108010078791 Carrier Proteins Proteins 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 2
- 102000005720 Glutathione transferase Human genes 0.000 claims 2
- 108010070675 Glutathione transferase Proteins 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 229910001428 transition metal ion Inorganic materials 0.000 claims 2
- 108010028230 Trp-Ser- His-Pro-Gln-Phe-Glu-Lys Proteins 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 108010018381 streptavidin-binding peptide Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020076705A JP7762499B2 (ja) | 2014-04-16 | 2020-04-23 | 細胞の集団を拡大する方法、キット、及び装置 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461980506P | 2014-04-16 | 2014-04-16 | |
| US61/980,506 | 2014-04-16 | ||
| PCT/EP2015/058339 WO2015158868A2 (en) | 2014-04-16 | 2015-04-16 | Methods, kits and apparatus for expanding a population of cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020076705A Division JP7762499B2 (ja) | 2014-04-16 | 2020-04-23 | 細胞の集団を拡大する方法、キット、及び装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513524A JP2017513524A (ja) | 2017-06-01 |
| JP2017513524A5 true JP2017513524A5 (enExample) | 2018-05-31 |
| JP6696969B2 JP6696969B2 (ja) | 2020-05-20 |
Family
ID=53052805
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505717A Active JP6696969B2 (ja) | 2014-04-16 | 2015-04-16 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2020076705A Active JP7762499B2 (ja) | 2014-04-16 | 2020-04-23 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2023024443A Pending JP2023062124A (ja) | 2014-04-16 | 2023-02-20 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2024225388A Pending JP2025060756A (ja) | 2014-04-16 | 2024-12-20 | 細胞の集団を拡大する方法、キット、及び装置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020076705A Active JP7762499B2 (ja) | 2014-04-16 | 2020-04-23 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2023024443A Pending JP2023062124A (ja) | 2014-04-16 | 2023-02-20 | 細胞の集団を拡大する方法、キット、及び装置 |
| JP2024225388A Pending JP2025060756A (ja) | 2014-04-16 | 2024-12-20 | 細胞の集団を拡大する方法、キット、及び装置 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US11274278B2 (enExample) |
| EP (2) | EP3132247B1 (enExample) |
| JP (4) | JP6696969B2 (enExample) |
| KR (2) | KR102714469B1 (enExample) |
| CN (3) | CN106414724A (enExample) |
| AU (2) | AU2015248786B2 (enExample) |
| BR (1) | BR112016024072B1 (enExample) |
| CA (2) | CA2945889C (enExample) |
| CY (1) | CY1124717T1 (enExample) |
| DK (1) | DK3132247T3 (enExample) |
| ES (1) | ES2892927T3 (enExample) |
| HR (1) | HRP20211430T1 (enExample) |
| HU (1) | HUE056852T2 (enExample) |
| IL (3) | IL293587B2 (enExample) |
| LT (1) | LT3132247T (enExample) |
| MX (2) | MX380519B (enExample) |
| MY (1) | MY184699A (enExample) |
| PH (2) | PH12016502017A1 (enExample) |
| PL (1) | PL3132247T3 (enExample) |
| PT (1) | PT3132247T (enExample) |
| RS (1) | RS62471B1 (enExample) |
| RU (2) | RU2735640C9 (enExample) |
| SA (3) | SA516380090B1 (enExample) |
| SG (2) | SG11201608557UA (enExample) |
| SI (1) | SI3132247T1 (enExample) |
| SM (1) | SMT202100600T1 (enExample) |
| WO (1) | WO2015158868A2 (enExample) |
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| SG10201606970UA (en) | 2012-02-23 | 2016-10-28 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| SG11201608557UA (en) | 2014-04-16 | 2016-11-29 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| ES2759260T3 (es) | 2014-04-23 | 2020-05-08 | Juno Therapeutics Inc | Métodos para aislar, cultivar y modificar genéticametne poblaciones de células inmunes para la terapia adoptiva |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| RU2761555C2 (ru) | 2015-10-22 | 2021-12-09 | Джуно Терапьютикс Гмбх | Способы, наборы, средства и устройства для трансдукции |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| EP3192810A1 (en) | 2016-01-14 | 2017-07-19 | Deutsches Krebsforschungszentrum | Psma binding antibody and uses thereof |
| CN107129988A (zh) * | 2016-02-29 | 2017-09-05 | 广西医科大学 | 一种特异性结合cd3的核酸适配体及其筛选方法和应用 |
| KR102840156B1 (ko) * | 2016-06-02 | 2025-07-31 | 클로토 테라퓨틱스, 아이엔씨. | 치료학적 재조합 클로토 단백질 및 이를 수반하는 조성물 및 방법 |
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