SA520412247B1 - نظم، وطرق وجهاز لتمديد مجموعة من الخلايا - Google Patents

نظم، وطرق وجهاز لتمديد مجموعة من الخلايا

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SA520412247B1
SA520412247B1 SA520412247A SA520412247A SA520412247B1 SA 520412247 B1 SA520412247 B1 SA 520412247B1 SA 520412247 A SA520412247 A SA 520412247A SA 520412247 A SA520412247 A SA 520412247A SA 520412247 B1 SA520412247 B1 SA 520412247B1
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cells
population
expanding
kits
methods
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SA520412247A
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ستيمبيرجير كريستيان
جيرميروث لوثار
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جونو ثيرابيوتكس جي إم بي اتش
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Abstract

يتعلق الاختراع الحالي بطرق في المعمل لتمديد مجموعة من الخلايا cells مثل الخلايا اللمفاوية lymphocytes ، تشتمل على تلامس عينة تشتمل على مجموعة من الخلايا بمادة كاشفة لتعدد الوحدات multimerization reagent. ثبتت المادة الكاشفة multimerization reagent لتعدد الوحدات على نحو عكسي عليها (مرتبط بها) عامل أول first agent يوفر إشارة تنشيط رئيسية primary activation signal إلى الخلايا cells واختيارياً، عامل ثاني second agent يقدم إشارة تحفيزية مشتركة co-stimulatory signal. كما يقدم الاختراع مواد كاشفة multimerization reagents ، وأطقم kits ، وترتيبات لتعدد الوحدات وجهاز لتمديد الخلايا expanding cells. شكل 1ج.
SA520412247A 2014-04-16 2016-10-16 نظم، وطرق وجهاز لتمديد مجموعة من الخلايا SA520412247B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461980506P 2014-04-16 2014-04-16
PCT/EP2015/058339 WO2015158868A2 (en) 2014-04-16 2015-04-16 Methods, kits and apparatus for expanding a population of cells

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SA520412247B1 true SA520412247B1 (ar) 2023-12-05

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SA521421882A SA521421882B1 (ar) 2014-04-16 2016-10-16 نظم، وطرق وجهاز لتمديد مجموعة من الخلايا
SA516380090A SA516380090B1 (ar) 2014-04-16 2016-10-16 نظم، وطرق وجهاز لتمديد مجموعة من الخلايا
SA520412247A SA520412247B1 (ar) 2014-04-16 2016-10-16 نظم، وطرق وجهاز لتمديد مجموعة من الخلايا

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SA516380090A SA516380090B1 (ar) 2014-04-16 2016-10-16 نظم، وطرق وجهاز لتمديد مجموعة من الخلايا

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US (2) US11274278B2 (ar)
EP (2) EP3988920A1 (ar)
JP (3) JP6696969B2 (ar)
KR (2) KR102459384B1 (ar)
CN (3) CN116656605A (ar)
AU (2) AU2015248786B2 (ar)
BR (1) BR112016024072B1 (ar)
CA (2) CA2945889C (ar)
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DK (1) DK3132247T3 (ar)
ES (1) ES2892927T3 (ar)
HR (1) HRP20211430T1 (ar)
HU (1) HUE056852T2 (ar)
IL (3) IL280738B (ar)
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MX (2) MX2016013493A (ar)
MY (1) MY184699A (ar)
PH (2) PH12016502017B1 (ar)
PL (1) PL3132247T3 (ar)
PT (1) PT3132247T (ar)
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SA (3) SA521421882B1 (ar)
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