SA521421882B1 - نظم، وطرق وجهاز لتمديد مجموعة من الخلايا - Google Patents

نظم، وطرق وجهاز لتمديد مجموعة من الخلايا

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SA521421882B1
SA521421882B1 SA521421882A SA521421882A SA521421882B1 SA 521421882 B1 SA521421882 B1 SA 521421882B1 SA 521421882 A SA521421882 A SA 521421882A SA 521421882 A SA521421882 A SA 521421882A SA 521421882 B1 SA521421882 B1 SA 521421882B1
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cells
population
expanding
kits
methods
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SA521421882A
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ستيمبيرجير كريستيان
جيرميروث لوثار
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جونو ثيرابيوتكس جي إم بي اتش
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Abstract

يتعلق الاختراع الحالي بطرق في المعمل لتمديد مجموعة من الخلايا مثل الخلايا اللمفاوية lymphocytes ، تشتمل على تلامس عينة تشتمل على مجموعة من الخلايا بمادة كاشفة لتعدد الوحدات multimerization reagent. ثبتت المادة الكاشفة لتعدد الوحدات على نحو عكسي عليها (مرتبط بها) عامل أول يوفر إشارة تنشيط رئيسية primary activation signal إلى الخلايا واختيارياً، عامل ثاني يقدم إشارة تحفيزية مشتركة co-stimulatory signal . كما يقدم الاختراع مواد كاشفة، وأطقم، وترتيبات لتعدد الوحدات وجهاز لتمديد الخلايا apparatus for expanding cells. شكل 1ج.
SA521421882A 2014-04-16 2016-10-16 نظم، وطرق وجهاز لتمديد مجموعة من الخلايا SA521421882B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461980506P 2014-04-16 2014-04-16
PCT/EP2015/058339 WO2015158868A2 (en) 2014-04-16 2015-04-16 Methods, kits and apparatus for expanding a population of cells

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SA521421882B1 true SA521421882B1 (ar) 2023-11-19

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SA521421882A SA521421882B1 (ar) 2014-04-16 2016-10-16 نظم، وطرق وجهاز لتمديد مجموعة من الخلايا
SA516380090A SA516380090B1 (ar) 2014-04-16 2016-10-16 نظم، وطرق وجهاز لتمديد مجموعة من الخلايا
SA520412247A SA520412247B1 (ar) 2014-04-16 2016-10-16 نظم، وطرق وجهاز لتمديد مجموعة من الخلايا

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SA520412247A SA520412247B1 (ar) 2014-04-16 2016-10-16 نظم، وطرق وجهاز لتمديد مجموعة من الخلايا

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US (2) US11274278B2 (ar)
EP (2) EP3988920A1 (ar)
JP (3) JP6696969B2 (ar)
KR (2) KR102459384B1 (ar)
CN (3) CN116656605A (ar)
AU (2) AU2015248786B2 (ar)
BR (1) BR112016024072B1 (ar)
CA (2) CA2945889C (ar)
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HR (1) HRP20211430T1 (ar)
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IL (3) IL280738B (ar)
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MX (2) MX2016013493A (ar)
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PH (2) PH12016502017B1 (ar)
PL (1) PL3132247T3 (ar)
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RU (2) RU2735640C9 (ar)
SA (3) SA521421882B1 (ar)
SG (2) SG11201608557UA (ar)
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