CY1124717T1 - Μεθοδοι, kit και συσκευη για επεκταση πληθυσμου κυτταρων - Google Patents
Μεθοδοι, kit και συσκευη για επεκταση πληθυσμου κυτταρωνInfo
- Publication number
- CY1124717T1 CY1124717T1 CY20211100943T CY211100943T CY1124717T1 CY 1124717 T1 CY1124717 T1 CY 1124717T1 CY 20211100943 T CY20211100943 T CY 20211100943T CY 211100943 T CY211100943 T CY 211100943T CY 1124717 T1 CY1124717 T1 CY 1124717T1
- Authority
- CY
- Cyprus
- Prior art keywords
- kits
- cells
- provides
- expansion
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/12—Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/52—CD40, CD40-ligand (CD154)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2537/00—Supports and/or coatings for cell culture characterised by physical or chemical treatment
- C12N2537/10—Cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Sustainable Development (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Computer Hardware Design (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461980506P | 2014-04-16 | 2014-04-16 | |
| PCT/EP2015/058339 WO2015158868A2 (en) | 2014-04-16 | 2015-04-16 | Methods, kits and apparatus for expanding a population of cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124717T1 true CY1124717T1 (el) | 2022-07-22 |
Family
ID=53052805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100943T CY1124717T1 (el) | 2014-04-16 | 2021-11-02 | Μεθοδοι, kit και συσκευη για επεκταση πληθυσμου κυτταρων |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US11274278B2 (enExample) |
| EP (2) | EP3132247B1 (enExample) |
| JP (4) | JP6696969B2 (enExample) |
| KR (2) | KR102714469B1 (enExample) |
| CN (3) | CN106414724A (enExample) |
| AU (2) | AU2015248786B2 (enExample) |
| BR (1) | BR112016024072B1 (enExample) |
| CA (2) | CA2945889C (enExample) |
| CY (1) | CY1124717T1 (enExample) |
| DK (1) | DK3132247T3 (enExample) |
| ES (1) | ES2892927T3 (enExample) |
| HR (1) | HRP20211430T1 (enExample) |
| HU (1) | HUE056852T2 (enExample) |
| IL (3) | IL280738B (enExample) |
| LT (1) | LT3132247T (enExample) |
| MX (2) | MX380519B (enExample) |
| MY (1) | MY184699A (enExample) |
| PH (2) | PH12016502017B1 (enExample) |
| PL (1) | PL3132247T3 (enExample) |
| PT (1) | PT3132247T (enExample) |
| RS (1) | RS62471B1 (enExample) |
| RU (2) | RU2020133435A (enExample) |
| SA (3) | SA521421882B1 (enExample) |
| SG (2) | SG11201608557UA (enExample) |
| SI (1) | SI3132247T1 (enExample) |
| SM (1) | SMT202100600T1 (enExample) |
| WO (1) | WO2015158868A2 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6362543B2 (ja) | 2012-02-23 | 2018-07-25 | ジュノ セラピューティクス ゲーエムベーハー | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| LT3132247T (lt) | 2014-04-16 | 2021-12-10 | Juno Therapeutics Gmbh | Ląstelių populiacijos padauginimo būdai, rinkiniai ir priemonės |
| IL313845A (en) | 2014-04-23 | 2024-08-01 | Juno Therapeutics Inc | Methods for enriching or producing immune cell populations for adoptive therapy |
| US11466253B2 (en) | 2015-10-22 | 2022-10-11 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| CN108474791B (zh) | 2015-10-22 | 2022-07-08 | 朱诺治疗学有限公司 | 培养细胞的方法及用于该方法的试剂盒和设备 |
| HK1258932A1 (zh) | 2015-10-22 | 2019-11-22 | Juno Therapeutics Gmbh | 用於转导的方法、反应剂盒、反应剂和设备 |
| EP3192810A1 (en) | 2016-01-14 | 2017-07-19 | Deutsches Krebsforschungszentrum | Psma binding antibody and uses thereof |
| CN107129988A (zh) * | 2016-02-29 | 2017-09-05 | 广西医科大学 | 一种特异性结合cd3的核酸适配体及其筛选方法和应用 |
| CN116478907A (zh) * | 2016-06-02 | 2023-07-25 | 克洛索治疗有限公司 | 治疗性重组klotho蛋白及其组合物和方法 |
| WO2018023100A2 (en) | 2016-07-29 | 2018-02-01 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies and related methods |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| MA46998A (fr) * | 2016-12-05 | 2019-10-09 | Juno Therapeutics Inc | Production de cellules modifiées pour une thérapie cellulaire adoptive |
| US12234441B2 (en) * | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US11624046B2 (en) * | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| WO2018184028A2 (en) * | 2017-03-31 | 2018-10-04 | Terumo Bct, Inc. | Cell expansion |
| MA49288A (fr) * | 2017-04-27 | 2020-03-04 | Juno Therapeutics Gmbh | Reactifs particulaires oligomères et leurs méthodes d'utilisation |
| MA50855A (fr) | 2017-11-01 | 2020-09-09 | Juno Therapeutics Inc | Procédé de génération de compositions thérapeutiques de cellules modifiées |
| CA3084445A1 (en) | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Process for producing a composition of engineered t cells |
| JP7433230B2 (ja) | 2017-12-08 | 2024-02-19 | ジュノー セラピューティクス インコーポレイテッド | 細胞を培養するための無血清培地配合物およびその使用の方法 |
| MA51154A (fr) * | 2017-12-15 | 2020-10-21 | Aleta Biotherapeutics Inc | Variants de cd19 |
| CN107904278B (zh) * | 2017-12-25 | 2021-07-20 | 北昊干细胞与再生医学研究院有限公司 | 检测药物对细胞增殖影响的方法 |
| US11149244B2 (en) * | 2018-04-04 | 2021-10-19 | Southwest Research Institute | Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy |
| EP3790958A1 (en) * | 2018-05-08 | 2021-03-17 | Life Technologies Corporation | Compositions and methods for culturing and expanding cells |
| WO2019226529A1 (en) * | 2018-05-21 | 2019-11-28 | Bioprocessia Technologies Llc | Multivalent protein complexes |
| SG11202101204TA (en) | 2018-08-09 | 2021-03-30 | Juno Therapeutics Inc | Processes for generating engineered cells and compositions thereof |
| EP3623383A1 (en) | 2018-09-11 | 2020-03-18 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Improved bispecific flt3xcd3 antigen binding proteins |
| US12195543B2 (en) | 2018-09-11 | 2025-01-14 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Anti-FLT3 antigen binding proteins |
| SG11202102986XA (en) * | 2018-09-24 | 2021-04-29 | Southwest Res Inst | Three-dimensional bioreactors |
| EP3874024A1 (en) * | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
| KR20200132147A (ko) * | 2019-05-15 | 2020-11-25 | 의료법인 성광의료재단 | 자연 살해 세포의 배양용 조성물 및 이를 이용한 방법 |
| CN114127561A (zh) * | 2019-05-24 | 2022-03-01 | 索尔生物公司 | 使用开关样结合反应的亲和分离系统和方法 |
| MX2021015125A (es) * | 2019-06-07 | 2022-04-06 | Juno Therapeutics Inc | Cultivo automatizado de celulas t. |
| WO2021084050A1 (en) | 2019-10-30 | 2021-05-06 | Juno Therapeutics Gmbh | Cell selection and/or stimulation devices and methods of use |
| EP3822288A1 (en) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
| CN115335399A (zh) | 2019-12-06 | 2022-11-11 | 朱诺治疗学股份有限公司 | 针对gprc5d靶结合结构域的抗独特型抗体以及相关组合物和方法 |
| KR20220122653A (ko) | 2019-12-06 | 2022-09-02 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ｂｃｍａ-표적 결합 도메인에 대한 항-이디오타입 항체 및 관련 조성물 및 방법 |
| JP7502451B2 (ja) | 2020-01-31 | 2024-06-18 | セル．コペディア ゲーエムベーハー | 生物学的実体を単離する方法 |
| IL295381B1 (en) | 2020-02-12 | 2026-04-01 | Juno Therapeutics Inc | BCMA-directed chimeric T-cell antigen receptor compounds and methods and uses thereof |
| IL295384B1 (en) | 2020-02-12 | 2026-04-01 | Juno Therapeutics Inc | T-cell preparations with chimeric antigen receptor directed against CD19 and methods and uses thereof |
| US12241086B2 (en) | 2020-04-15 | 2025-03-04 | Amgen Inc. | Process for generating genetically engineered autologous T cells |
| US12378521B2 (en) | 2020-04-15 | 2025-08-05 | Amgen Inc. | Method for enhancing production of genetically engineered autologous T cells |
| JP2023536326A (ja) | 2020-08-05 | 2023-08-24 | ジュノー セラピューティクス インコーポレイテッド | Ｒｏｒ１標的結合ドメインに対する抗イディオタイプ抗体ならびに関連する組成物および方法 |
| WO2022098787A1 (en) | 2020-11-04 | 2022-05-12 | Juno Therapeutics, Inc. | Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| KR20230159851A (ko) | 2021-03-22 | 2023-11-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 치료 세포 조성물의 효력을 결정하는 방법 |
| JP2024517863A (ja) | 2021-05-06 | 2024-04-23 | ジュノ・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞を刺激し、形質導入する方法 |
| CN117957313A (zh) | 2021-07-19 | 2024-04-30 | 修复免疫股份有限公司 | 从多能干细胞生产免疫细胞群的方法 |
| CN116286659A (zh) * | 2021-10-25 | 2023-06-23 | 黄�俊 | 多聚体在car表达细胞检测和细胞制备中的应用 |
| WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| EP4615960A1 (en) | 2022-11-09 | 2025-09-17 | C3S2 GmbH | Methods for manufacturing engineered immune cells |
| CN121100267A (zh) | 2022-12-09 | 2025-12-09 | 朱诺治疗学股份有限公司 | 使用全息成像预测细胞表型的机器学习方法 |
| CN121002052A (zh) | 2023-02-03 | 2025-11-21 | C3S2 有限公司 | 用于非病毒生产工程化免疫细胞的方法 |
| WO2024182516A1 (en) | 2023-02-28 | 2024-09-06 | Juno Therapeutics, Inc. | Cell therapy for treating systemic autoimmune diseases |
| EP4698902A1 (en) | 2023-04-18 | 2026-02-25 | Juno Therapeutics, Inc. | Cytotoxicity assay for assessing potency of therapeutic cell compositions |
| EP4716851A2 (en) | 2023-05-23 | 2026-04-01 | Juno Therapeutics, Inc. | Activation markers of t cells and method for assessing t cell activation |
| CN117448255B (zh) * | 2023-09-28 | 2024-12-31 | 深圳市龙华区人民医院 | S2饲养细胞、制备方法及其应用 |
| WO2025109111A1 (en) * | 2023-11-22 | 2025-05-30 | Immudex Aps | Immune cell activating multimers |
| KR102824339B1 (ko) * | 2024-07-01 | 2025-06-26 | 현대자동차주식회사 | 배터리 제어 장치 및 그 방법 |
| WO2026020055A2 (en) | 2024-07-18 | 2026-01-22 | Juno Therapeutics, Inc. | Methods for assessing exosomes in a cell composition and related uses |
| WO2026050426A2 (en) | 2024-08-28 | 2026-03-05 | Juno Therapeutics, Inc. | Cd19-directed chimeric antigen receptor cell therapy for treating autoimmune and neurological diseases |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
| DE3583940D1 (de) | 1984-10-02 | 1991-10-02 | Harry M Meade | Herstellung von streptavidinaehnlichen polypeptiden. |
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| DE4237113B4 (de) | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| WO1994029436A1 (en) | 1993-06-04 | 1994-12-22 | The United States Of America Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of t cells |
| WO1996023879A1 (en) | 1995-01-30 | 1996-08-08 | Terrapin Technologies, Inc. | Glubodies - multiplicities of proteins capable of binding a variety of small molecules |
| WO1996024606A1 (en) | 1995-02-09 | 1996-08-15 | University Of Washington | Modified-affinity streptavidin |
| AU5917796A (en) | 1995-04-11 | 1997-04-09 | Trustees Of Boston University | Streptavidin mutants |
| DE19641876B4 (de) * | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| WO1998040396A1 (en) | 1997-03-14 | 1998-09-17 | Trustees Of Boston University | Multiflavor streptavidin |
| US5985658A (en) | 1997-11-14 | 1999-11-16 | Health Research Incorporated | Calmodulin-based cell separation technique |
| US6664042B1 (en) | 1999-01-26 | 2003-12-16 | Cornell Research Foundation, Inc. | Determining viral load in double negative T cells |
| EP2332978B1 (en) * | 1999-02-03 | 2014-04-02 | Amgen, Inc | Novel polypeptides involved in immune response |
| WO2000046349A1 (en) | 1999-02-04 | 2000-08-10 | Technion Research & Development Foundation Ltd. | Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| US20030235908A1 (en) | 2000-02-24 | 2003-12-25 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| EP1227321A1 (en) | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| JP2005536184A (ja) | 2002-03-01 | 2005-12-02 | エルドマン，ヴォルカー，エー． | ストレプトアビジン結合ペプチド |
| US7754155B2 (en) | 2002-03-15 | 2010-07-13 | Ross Amelia A | Devices and methods for isolating target cells |
| AU2003234194A1 (en) | 2002-04-23 | 2003-11-10 | Meir Strahilevitz | Methods and devices for targeting a site in a mammal and for removing species from a mammal |
| FR2841905B1 (fr) | 2002-07-05 | 2004-09-03 | Centre Nat Rech Scient | Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications |
| CA2500392C (en) | 2002-09-27 | 2012-11-27 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
| WO2004096975A2 (en) | 2003-05-02 | 2004-11-11 | Insception Bioscience, Inc. | Apparatus and methods for amplification of blood stem cell numbers |
| DE60334250D1 (de) | 2003-05-08 | 2010-10-28 | Life Technologies Corp | Erzeugung und isolierung antigenspezifischer t-zellen |
| WO2005050209A1 (en) | 2003-11-20 | 2005-06-02 | Biosensor Applications Sweden (Publ) | Mixture of at least two different antibodies specific for predetermined antigens and use of the mixture |
| SE0400181D0 (sv) | 2004-01-29 | 2004-01-29 | Gyros Ab | Segmented porous and preloaded microscale devices |
| US7776583B2 (en) | 2004-06-03 | 2010-08-17 | Meso Scale Technologies, Llc | Methods and apparatuses for conducting assays |
| JP5255841B2 (ja) | 2004-10-15 | 2013-08-07 | ジェネンコー・インターナショナル・インク | 競合示差スクリーニング |
| WO2006058226A2 (en) * | 2004-11-24 | 2006-06-01 | The Trustees Of Boston University | Modified dimeric streptavidins and uses thereof |
| US20060252087A1 (en) | 2005-01-18 | 2006-11-09 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
| US7704708B2 (en) * | 2006-02-13 | 2010-04-27 | Uti Limited Partnership | Monomeric streptavidin muteins |
| US7855057B2 (en) | 2006-03-23 | 2010-12-21 | Millipore Corporation | Protein splice variant/isoform discrimination and quantitative measurements thereof |
| WO2007117602A2 (en) | 2006-04-07 | 2007-10-18 | Biogen Idec Ma Inc. | Isolation and use of human regulatory t cells |
| US20070238169A1 (en) * | 2006-04-11 | 2007-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Cell sorter and culture system |
| US20080085532A1 (en) | 2006-09-18 | 2008-04-10 | Jorn Gorlach | Method for determining the immune status of a subject |
| EP2687540A1 (en) | 2006-10-17 | 2014-01-22 | Oncotherapy Science, Inc. | Peptide vaccines for cancers expressing MPHOSPH1 or DEPDC1 polypeptides |
| EP2085782B1 (en) | 2006-11-02 | 2017-03-08 | Kyowa Medex CO., LTD. | Method of immunoassaying a component to be measured |
| EP2518193A3 (en) | 2006-11-15 | 2013-01-23 | Invitrogen Dynal AS | Methods for reversibly binding a biotin compound to a support |
| US20080131415A1 (en) | 2006-11-30 | 2008-06-05 | Riddell Stanley R | Adoptive transfer of cd8 + t cell clones derived from central memory cells |
| CN101226118B (zh) | 2007-01-19 | 2010-06-16 | 中国医学科学院肿瘤研究所 | 一种兼容免疫荧光分析的细胞化学染色方法及其用途 |
| US8709980B2 (en) * | 2007-03-26 | 2014-04-29 | Celexion, Llc | Cell surface display, screening and production of proteins of interest |
| EP2167537A2 (en) | 2007-07-03 | 2010-03-31 | Dako Denmark A/S | Compiled methods for analysing and sorting samples |
| CN101802195B (zh) | 2007-08-20 | 2012-10-24 | 内克斯特伊拉股份公司 | pⅦ噬菌体展示 |
| ES2640216T3 (es) | 2007-12-07 | 2017-11-02 | Miltenyi Biotec Gmbh | Sistemas y métodos para procesamiento de células |
| EP3358354B1 (en) | 2008-01-18 | 2020-07-15 | President and Fellows of Harvard College | Methods of detecting signatures of disease or conditions in bodily fluids |
| ES2666667T3 (es) | 2008-01-29 | 2018-05-07 | Fred Hutchinson Cancer Research Center | Identificación de células T CD8+ que son CD161 hi y/o IL-18R (alfa) hi y tienen una capacidad de evacuación rápida de fármacos |
| CN101446576B (zh) | 2008-12-29 | 2011-06-22 | 江苏省苏微微生物研究有限公司 | 一种微囊藻毒素-lr单抗免疫亲和柱的制备和使用方法 |
| WO2010080032A2 (en) | 2009-01-09 | 2010-07-15 | Stichting Het Nederlands Kanker Instituut | Bead-assisted viral transduction |
| US20110070581A1 (en) | 2009-04-27 | 2011-03-24 | Amit Gupta | Separation of Leukocytes |
| WO2011053971A2 (en) * | 2009-11-02 | 2011-05-05 | Fina Biosolutions, Llc | Method for enhancing the sensitivity of antibody based assays |
| US20120321665A1 (en) * | 2009-12-14 | 2012-12-20 | Benaroya Research Institute At Virginia Mason | Compositions and methods for treating airway inflammatory diseases |
| EP2363501A1 (en) | 2010-03-02 | 2011-09-07 | Universitätsklinikum Hamburg-Eppendorf | Method for isolating target cells |
| EP2982766B1 (en) | 2010-08-06 | 2018-05-23 | Ludwig-Maximilians-Universität München | Identification of t cell target antigens |
| WO2012058627A2 (en) | 2010-10-29 | 2012-05-03 | Miqin Zhang | Pre-targeted nanoparticle system and method for labeling biological particles |
| US9987308B2 (en) | 2011-03-23 | 2018-06-05 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| US9023604B2 (en) * | 2011-07-18 | 2015-05-05 | Iba Gmbh | Method of reversibly staining a target cell |
| WO2013038272A2 (en) | 2011-09-13 | 2013-03-21 | Uti Limited Partnership | Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins |
| JP6362543B2 (ja) | 2012-02-23 | 2018-07-25 | ジュノ セラピューティクス ゲーエムベーハー | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| UA114108C2 (uk) * | 2012-07-10 | 2017-04-25 | Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем | Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання |
| CN112375846A (zh) | 2012-07-13 | 2021-02-19 | 宾夕法尼亚大学董事会 | 评估用于施用的转导t细胞的适用性的方法 |
| PL3824905T3 (pl) | 2012-08-20 | 2025-05-05 | Fred Hutchinson Cancer Center | Sposób i kompozycje do immunoterapii komórkowej |
| CA2891820A1 (en) | 2012-11-16 | 2014-05-22 | Iba Gmbh | Streptavidin muteins and methods of using them |
| CN103305464B (zh) | 2013-06-05 | 2015-04-15 | 南昌大学 | 直接分离cd4+和cd8+淋巴细胞的方法 |
| US9698876B2 (en) | 2013-07-23 | 2017-07-04 | Telefonaktiebolaget Lm Ericsson (Publ) | Transmission mode allocation in LTE networks |
| AU2014368892B2 (en) | 2013-12-20 | 2019-06-13 | Fred Hutchinson Cancer Center | Tagged chimeric effector molecules and receptors thereof |
| IL322264A (en) | 2014-04-07 | 2025-09-01 | Novartis Ag | Cancer treatment using chimeric antigen receptor (CAR) against CD19 |
| LT3132247T (lt) | 2014-04-16 | 2021-12-10 | Juno Therapeutics Gmbh | Ląstelių populiacijos padauginimo būdai, rinkiniai ir priemonės |
| IL313845A (en) | 2014-04-23 | 2024-08-01 | Juno Therapeutics Inc | Methods for enriching or producing immune cell populations for adoptive therapy |
| WO2015162211A1 (en) | 2014-04-24 | 2015-10-29 | Miltenyi Biotec Gmbh | Method for automated generation of genetically modified t cells |
| EP3738597A1 (en) | 2014-04-25 | 2020-11-18 | Bluebird Bio, Inc. | Improved methods for manufacturing adoptive cell therapies |
| WO2015166049A1 (en) * | 2014-04-30 | 2015-11-05 | Iba Gmbh | Method of isolating a target cell |
| MX2017012939A (es) | 2015-04-08 | 2018-05-22 | Novartis Ag | Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19. |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| US11466253B2 (en) | 2015-10-22 | 2022-10-11 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| HK1258932A1 (zh) | 2015-10-22 | 2019-11-22 | Juno Therapeutics Gmbh | 用於转导的方法、反应剂盒、反应剂和设备 |
| CN108474791B (zh) | 2015-10-22 | 2022-07-08 | 朱诺治疗学有限公司 | 培养细胞的方法及用于该方法的试剂盒和设备 |
| CN108884140B (zh) | 2015-12-03 | 2022-10-25 | 朱诺治疗学股份有限公司 | 修饰的嵌合受体及相关组合物和方法 |
| MA49288A (fr) | 2017-04-27 | 2020-03-04 | Juno Therapeutics Gmbh | Reactifs particulaires oligomères et leurs méthodes d'utilisation |
| SG11202101204TA (en) | 2018-08-09 | 2021-03-30 | Juno Therapeutics Inc | Processes for generating engineered cells and compositions thereof |
| EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
-
2015
- 2015-04-16 LT LTEPPCT/EP2015/058339T patent/LT3132247T/lt unknown
- 2015-04-16 KR KR1020227036837A patent/KR102714469B1/ko active Active
- 2015-04-16 CN CN201580032543.4A patent/CN106414724A/zh active Pending
- 2015-04-16 CA CA2945889A patent/CA2945889C/en active Active
- 2015-04-16 SG SG11201608557UA patent/SG11201608557UA/en unknown
- 2015-04-16 KR KR1020167031915A patent/KR102459384B1/ko active Active
- 2015-04-16 WO PCT/EP2015/058339 patent/WO2015158868A2/en not_active Ceased
- 2015-04-16 PT PT157206202T patent/PT3132247T/pt unknown
- 2015-04-16 MX MX2016013493A patent/MX380519B/es unknown
- 2015-04-16 US US15/304,045 patent/US11274278B2/en active Active
- 2015-04-16 AU AU2015248786A patent/AU2015248786B2/en active Active
- 2015-04-16 CA CA3176848A patent/CA3176848A1/en active Pending
- 2015-04-16 BR BR112016024072-3A patent/BR112016024072B1/pt active IP Right Grant
- 2015-04-16 SG SG10201808491UA patent/SG10201808491UA/en unknown
- 2015-04-16 HU HUE15720620A patent/HUE056852T2/hu unknown
- 2015-04-16 CN CN202310417528.8A patent/CN116656605A/zh active Pending
- 2015-04-16 PL PL15720620T patent/PL3132247T3/pl unknown
- 2015-04-16 ES ES15720620T patent/ES2892927T3/es active Active
- 2015-04-16 RS RS20211143A patent/RS62471B1/sr unknown
- 2015-04-16 IL IL280738A patent/IL280738B/en unknown
- 2015-04-16 JP JP2017505717A patent/JP6696969B2/ja active Active
- 2015-04-16 EP EP15720620.2A patent/EP3132247B1/en active Active
- 2015-04-16 RU RU2020133435A patent/RU2020133435A/ru unknown
- 2015-04-16 SM SM20210600T patent/SMT202100600T1/it unknown
- 2015-04-16 MY MYPI2016703777A patent/MY184699A/en unknown
- 2015-04-16 SI SI201531727T patent/SI3132247T1/sl unknown
- 2015-04-16 CN CN202010423347.2A patent/CN111961647A/zh active Pending
- 2015-04-16 HR HRP20211430TT patent/HRP20211430T1/hr unknown
- 2015-04-16 EP EP21191440.3A patent/EP3988920A1/en active Pending
- 2015-04-16 RU RU2016144724A patent/RU2735640C9/ru active
- 2015-04-16 IL IL293587A patent/IL293587B2/en unknown
- 2015-04-16 DK DK15720620.2T patent/DK3132247T3/da active
-
2016
- 2016-10-11 PH PH12016502017A patent/PH12016502017B1/en unknown
- 2016-10-13 IL IL248360A patent/IL248360B/en active IP Right Grant
- 2016-10-13 MX MX2020014089A patent/MX2020014089A/es unknown
- 2016-10-16 SA SA521421882A patent/SA521421882B1/ar unknown
- 2016-10-16 SA SA520412247A patent/SA520412247B1/ar unknown
- 2016-10-16 SA SA516380090A patent/SA516380090B1/ar unknown
-
2020
- 2020-04-23 JP JP2020076705A patent/JP7762499B2/ja active Active
- 2020-07-01 PH PH12020551028A patent/PH12020551028A1/en unknown
-
2021
- 2021-11-02 CY CY20211100943T patent/CY1124717T1/el unknown
-
2022
- 2022-01-27 AU AU2022200527A patent/AU2022200527B9/en active Active
- 2022-03-11 US US17/693,292 patent/US20220195388A1/en active Pending
-
2023
- 2023-02-20 JP JP2023024443A patent/JP2023062124A/ja active Pending
-
2024
- 2024-12-20 JP JP2024225388A patent/JP2025060756A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12020551028A1 (en) | Methods, kits and apparatus for expanding a population of cells | |
| CY1123220T1 (el) | Πρωτεϊνες συνδεσης anti-lag-3 | |
| BR112014025384A8 (pt) | método e sistema para executar ensaio automatizado e métodos para executar teste reflexivo em vários exemplares | |
| JOP20170041B1 (ar) | اجسام مضادة ضد vista (b7h5) | |
| CL2017002604A1 (es) | Sondas duales silenciadoras | |
| MX2020000481A (es) | Uso de proteína cas, método para detectar moléculas de ácido nucleico objetivo y kit. | |
| CL2016001867A1 (es) | Sistema y dispositivo para la generación de alto rendimiento de gotitas y métodos de uso combinatorios. | |
| CA2873099C (en) | Aptamer-based multiplexed assays | |
| BR112017009728A2 (pt) | anticorpos isolados, ácido nucleico isolado, vetor, célula hospedeira, método para produzir o anticorpo, composição, usos de um anticorpo e métodos de tratamento de um distúrbio | |
| CL2017000278A1 (es) | Moléculas biespecíficas de unión a antígeno activadoras de células t | |
| EP4300100A3 (en) | Reagent storage in an assay device | |
| SA518400078B1 (ar) | مصفوفة مولد ضد | |
| BR112016008970A2 (pt) | Método de ativação ex vivo e para avaliar ativação plasmática em um indivíduo, ensaio ex vivo para determinar atividade de calicreína plasmática em uma amostra | |
| EP3757225A3 (en) | Pancreatic cancer detection kit or device, and detection method | |
| BR112016019836A2 (pt) | método para analisar uma amostra de um sujeito, dispositivo de diagnóstico para utilização no diagnóstico da endometriose, kit, uso de um biomarcador, e, método para aumentar uma resposta de anticorpos em um sujeito | |
| EA201692157A1 (ru) | Синтез двухцепочечных нуклеиновых кислот | |
| BR112014018995A2 (pt) | Sistemas para executar ensaio automatizado | |
| AR102517A1 (es) | Ensayos para detectar subgrupos inmunes de células t y sus métodos de uso | |
| MX2017001134A (es) | Composiciones y metodos para la deteccion y analisis de tuberculosis micobacteriana. | |
| TR201907737T4 (tr) | Test numunesi desteği ve çarpışma testi aparatı ve destek kullanılarak yapısal elemanın çarpışma testi yöntemi. | |
| GB2542576A (en) | Method and kit of detecting the absence of micro-oranisms | |
| BR112019006862A2 (pt) | dispositivo de análise e método para testagem de uma amostra | |
| CY1123180T1 (el) | Συστημα ανιχνευσης που αξιοποιει αλυσιδωτη αντιδραση πολυμερασης | |
| EP4242663A3 (en) | Methods for characterizing compositions comprising peanut antigens | |
| BR112017008393A2 (pt) | aparelho e sistema para amplificação de ácido nucleico |