JP2004525354A5 - - Google Patents

Download PDF

Info

Publication number
JP2004525354A5
JP2004525354A5 JP2002554713A JP2002554713A JP2004525354A5 JP 2004525354 A5 JP2004525354 A5 JP 2004525354A5 JP 2002554713 A JP2002554713 A JP 2002554713A JP 2002554713 A JP2002554713 A JP 2002554713A JP 2004525354 A5 JP2004525354 A5 JP 2004525354A5
Authority
JP
Japan
Prior art keywords
binding
cell
receptor
reversible
biotin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002554713A
Other languages
English (en)
Japanese (ja)
Other versions
JP4416400B2 (ja
JP2004525354A (ja
Filing date
Publication date
Priority claimed from EP00128634A external-priority patent/EP1227321A1/en
Application filed filed Critical
Publication of JP2004525354A publication Critical patent/JP2004525354A/ja
Publication of JP2004525354A5 publication Critical patent/JP2004525354A5/ja
Application granted granted Critical
Publication of JP4416400B2 publication Critical patent/JP4416400B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2002554713A 2000-12-28 2001-12-28 抗原特異的t−細胞の機能的精製のための可逆的mhc多量体染色法 Expired - Lifetime JP4416400B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00128634A EP1227321A1 (en) 2000-12-28 2000-12-28 Reversible MHC multimer staining for functional purification of antigen-specific T cells
PCT/EP2001/015353 WO2002054065A2 (en) 2000-12-28 2001-12-28 Reversible mhc multimer staining for functional purification of antigen-specific t cells

Publications (3)

Publication Number Publication Date
JP2004525354A JP2004525354A (ja) 2004-08-19
JP2004525354A5 true JP2004525354A5 (enExample) 2008-12-18
JP4416400B2 JP4416400B2 (ja) 2010-02-17

Family

ID=8170850

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002554713A Expired - Lifetime JP4416400B2 (ja) 2000-12-28 2001-12-28 抗原特異的t−細胞の機能的精製のための可逆的mhc多量体染色法

Country Status (5)

Country Link
US (2) US7776562B2 (enExample)
EP (2) EP1227321A1 (enExample)
JP (1) JP4416400B2 (enExample)
CA (1) CA2467434C (enExample)
WO (1) WO2002054065A2 (enExample)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
EP1982176A1 (en) * 2006-01-30 2008-10-22 Dako Denmark A/S High-speed quantification of antigen specific t-cells in whole blood by flow cytometry
EP1878744A1 (en) 2006-07-13 2008-01-16 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Epitope-tag for surface-expressed T-cell receptor proteins, uses thereof and method of selecting host cells expressing them
EP2518193A3 (en) * 2006-11-15 2013-01-23 Invitrogen Dynal AS Methods for reversibly binding a biotin compound to a support
WO2008116468A2 (en) 2007-03-26 2008-10-02 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
WO2009003493A2 (en) 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US12529164B2 (en) 2007-09-14 2026-01-20 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
JP5933894B2 (ja) 2007-09-14 2016-06-15 アディマブ, エルエルシー 合理的に設計された、合成抗体ライブラリおよびその使用
EP2197908A2 (en) 2007-09-27 2010-06-23 Dako Denmark A/S Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
US10722562B2 (en) 2008-07-23 2020-07-28 Immudex Aps Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
US10369204B2 (en) 2008-10-02 2019-08-06 Dako Denmark A/S Molecular vaccines for infectious disease
WO2011034115A1 (ja) * 2009-09-17 2011-03-24 Jsr株式会社 アビジンとビオチン誘導体の解離方法及び解離剤
AU2011249041B2 (en) 2010-05-06 2014-10-30 Adaptive Biotechnologies Corp. Monitoring health and disease status using clonotype profiles
PT2619223T (pt) * 2010-09-21 2019-07-11 Us Health Recetores de células t anti-ssx-2 e materiais e métodos de utilização relacionados
WO2012044999A2 (en) * 2010-10-01 2012-04-05 Ludwig Institute For Cancer Research Ltd. Reversible protein multimers, methods for their production and use
PT2734538T (pt) * 2011-07-18 2018-08-02 Iba Gmbh Processo para corar, de forma reversível, uma célula-alvo
WO2013056090A1 (en) * 2011-10-12 2013-04-18 University Of Connecticut Affinity-based materials for the non-destructive separation and recovery of cells
WO2013124474A2 (en) 2012-02-23 2013-08-29 Stage Cell Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
CN102662054B (zh) * 2012-05-10 2014-08-13 东南大学 一种同步检测特异性胸腺依赖性淋巴细胞数量和功能的方法
EP2920204B1 (en) 2012-11-16 2019-09-18 IBA GmbH Streptavidin muteins and methods of using them
SG11201605046YA (en) * 2013-12-20 2016-07-28 Hutchinson Fred Cancer Res Tagged chimeric effector molecules and receptors thereof
CA2936914C (en) 2014-01-21 2020-08-18 Stemcell Technologies Inc. Method for separating target entities from a sample using a composition of mono-specific tetrameric antibody complexes coupled to a surface
EP3132247B1 (en) 2014-04-16 2021-08-18 Juno Therapeutics GmbH Methods, kits and apparatus for expanding a population of cells
ES2995052T3 (en) 2014-04-23 2025-02-05 Juno Therapeutics Inc Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy
CA2945414C (en) 2014-04-30 2023-05-09 Iba Gmbh Method of isolating a target cell
EP3037820A1 (en) 2014-12-27 2016-06-29 Miltenyi Biotec GmbH Cell detection methods and reagents having a releasable labelling moiety
WO2016166568A1 (en) 2015-04-16 2016-10-20 Juno Therapeutics Gmbh Methods, kits and apparatus for expanding a population of cells
WO2016176652A2 (en) 2015-04-29 2016-11-03 Fred Hutchinson Cancer Research Center Modified stem cells and uses thereof
JP6657721B2 (ja) 2015-09-30 2020-03-04 ソニー株式会社 細胞の分析方法、細胞分析用チップ、細胞分析用試薬、細胞分析用キット及び細胞分析用装置
EP3365678A1 (en) 2015-10-22 2018-08-29 Juno Therapeutics GmbH Methods for culturing cells and kits and apparatus for same
EP3365453A2 (en) 2015-10-22 2018-08-29 Juno Therapeutics GmbH Methods, kits, agents and apparatuses for transduction
IL258844B2 (en) 2015-10-22 2024-03-01 Juno Therapeutics Gmbh Methods for culturing cells and kits and apparatus for same
WO2017180420A1 (en) 2016-04-11 2017-10-19 Board Of Regents, The University Of Texas System Methods and compositions for detecting single t cell receptor affinity and sequence
JP7165060B2 (ja) * 2016-06-28 2022-11-02 テクニッシェ ウニヴェルズィテート ミュンヘン 受容体-リガンドkoff速度を分析するための可逆的細胞標識および不可逆的細胞標識の組み合わせ
WO2018029350A2 (en) 2016-08-11 2018-02-15 Kite Pharma Eu B.V. Methods of making and using soluble mhc molecules
US10294454B2 (en) 2016-08-24 2019-05-21 General Electric Company Methods and kits for cell activation
EP3336545A1 (en) 2016-12-13 2018-06-20 Miltenyi Biotec GmbH Reversible labeling of antigens in biological specimens
EP3336546B1 (en) 2016-12-13 2020-07-01 Miltenyi Biotec B.V. & Co. KG Reversible cell labelling with conjugates having two releasable binding sites
CA3050085A1 (en) 2017-01-20 2018-07-26 Juno Therapeutics Gmbh Cell surface conjugates and related cell compositions and methods
EP4647493A3 (en) 2017-04-27 2026-01-14 Juno Therapeutics, Inc. Oligomeric particle reagents and methods of use thereof
ES3009018T3 (en) 2017-07-29 2025-03-25 Juno Therapeutics Inc Reagents for expanding cells expressing recombinant receptors
EP3489684B1 (en) 2017-11-27 2024-06-26 Miltenyi Biotec B.V. & Co. KG Method for photobleaching stained cells
WO2019113557A1 (en) 2017-12-08 2019-06-13 Juno Therapeutics, Inc. Process for producing a composition of engineered t cells
CN116148467A (zh) * 2017-12-12 2023-05-23 清华大学 检测翻译后修饰蛋白质与其配体间相互作用的成套试剂
CA3108657A1 (en) 2018-08-09 2020-02-13 Juno Therapeutics, Inc. Processes for generating engineered cells and compositions thereof
WO2020048876A1 (en) 2018-09-03 2020-03-12 Technische Universitaet Muenchen A double peptide tag combining reversibility and flexible functionalization
JP7504891B2 (ja) 2018-09-11 2024-06-24 ジュノー セラピューティクス インコーポレイテッド 操作された細胞組成物のマススペクトロメトリー分析のための方法
US12522660B2 (en) 2018-10-31 2026-01-13 C3S2 Gmbh Methods for selection and stimulation of cells and apparatus for same
CA3117720A1 (en) 2018-11-06 2020-05-14 Juno Therapeutics, Inc. Process for producing genetically engineered t cells
EP3898666A2 (en) 2018-12-17 2021-10-27 Immudex ApS Panel comprising borrelia mhc multimers
MX2021012285A (es) 2019-04-09 2021-12-15 Nurix Therapeutics Inc Compuestos de piperidina 3-sustituidos para inhibicion del protooncogen-b de linfoma de linea b de casitas (cbl-b) y uso de un inhibidor de cbl-b en combinacion con una vacuna contra el cancer y/o con un virus oncolitico.
EP3953489A1 (en) 2019-04-12 2022-02-16 Miltenyi Biotec B.V. & Co. KG Conjugates having an enzymatically releasable detection moiety and a barcode moiety
AU2020278592B2 (en) 2019-05-17 2024-10-10 Nurix Therapeutics, Inc. Cyano cyclobutyl compounds for Cbl-b inhibition and uses thereof
US20220220504A1 (en) 2019-05-28 2022-07-14 Miltenyi Biotec B.V. & Co. KG Method for Generation of Genetically Modified T Cells
CA3139965A1 (en) 2019-06-07 2020-12-10 Ivie AIFUWA Automated t cell culture
MX2021015675A (es) 2019-06-26 2022-02-03 Nurix Therapeutics Inc Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos.
CA3148769A1 (en) 2019-07-30 2021-02-04 Nurix Therapeutics, Inc. Urea, amide, and substituted heteroaryl compounds for cbl-b inhibition
US12444491B2 (en) 2019-08-30 2025-10-14 Juno Therapeutics, Inc. Machine learning methods for classifying cells
US20220315894A1 (en) 2019-09-11 2022-10-06 Miltenyi Biotec B.V. & Co. KG Method for Transduction of T Cells in the Presence of Malignant Cells
IL292319B2 (en) 2019-10-30 2026-01-01 C3S2 Gmbh Cell selection and/or stimulation devices and methods of use
WO2021122185A1 (en) 2019-12-20 2021-06-24 Miltenyi Biotec B.V. & Co. KG Reversible cell detection via mhc with conjugates having an enzymatically cleavable detection moiety
US20230090117A1 (en) 2020-01-28 2023-03-23 Juno Therapeutics, Inc. Methods for t cell transduction
US11965882B2 (en) 2020-01-31 2024-04-23 Cell.Copedia GmbH Methods of isolating a biological entity
MX2022009830A (es) 2020-02-12 2022-10-28 Juno Therapeutics Inc Composiciones de celulas t que expresan receptores de antigenos quimericos dirigidos a bcma y metodos y usos de las mismas.
IL295384A (en) 2020-02-12 2022-10-01 Juno Therapeutics Inc Cd19-directed chimeric antigen receptor t cell compositions and methods and uses thereof
JP2023526278A (ja) 2020-05-13 2023-06-21 ジュノー セラピューティクス インコーポレイテッド 組み換え受容体を発現しているドナーバッチ細胞を産生するための方法
EP3916393B1 (en) 2020-05-27 2023-01-25 Miltenyi Biotec B.V. & Co. KG Method for detection of cells by repetitive staining and destaining
EP4204809A1 (en) 2020-08-27 2023-07-05 Miltenyi Biotec B.V. & Co. KG Releasable reagents for cell separation
JP7612841B2 (ja) 2020-09-07 2025-01-14 ミルテニー バイオテック ベー.フェー. ウント コー. カー・ゲー 酵素的に放出可能な検出部分およびバーコード部分を有するコンジュゲート
KR20240018454A (ko) 2021-05-06 2024-02-13 주노 테라퓨틱스 게엠베하 T 세포의 자극 및 형질도입 방법
WO2023017115A1 (en) 2021-08-11 2023-02-16 Iba Lifesciences Gmbh Fractionation of cells based on a marker protein
EP4227423A1 (en) 2022-02-09 2023-08-16 Technische Universität München Means and methods for identifying high affinity t-cells
US20250297282A1 (en) 2022-05-05 2025-09-25 Juno Therapeutics Gmbh Viral-binding protein and related reagents, articles, and methods of use
WO2023230581A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Methods of manufacturing t cell therapies
EP4615960A1 (en) 2022-11-09 2025-09-17 C3S2 GmbH Methods for manufacturing engineered immune cells
JP2026501122A (ja) 2022-12-09 2026-01-14 ジュノー セラピューティクス インコーポレイテッド ホログラフィックイメージングを使用して細胞表現型を予測するための機械学習方法
CN121002052A (zh) 2023-02-03 2025-11-21 C3S2 有限公司 用于非病毒生产工程化免疫细胞的方法
CN121127253A (zh) 2023-02-28 2025-12-12 朱诺治疗学股份有限公司 治疗系统性自身免疫性疾病的细胞疗法
EP4484441A1 (en) 2023-06-26 2025-01-01 Eberhard-Karls-Universität Tübingen Mhc-class i derived polypeptide
WO2025083196A1 (en) 2023-10-18 2025-04-24 Tq Therapeutics Gmbh A method of manufacturing a cellular therapy product and respective kits and devices

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948590A (en) * 1987-06-09 1990-08-14 Yale University Avidin or streptavidin conjugated liposomes
DE4237113B4 (de) * 1992-11-03 2006-10-12 "Iba Gmbh" Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins
US5595881A (en) * 1994-08-09 1997-01-21 Anergen, Inc. Method for the detection of antigen presenting cells
WO1997011183A1 (en) * 1995-04-11 1997-03-27 Trustees Of Boston University Streptavidin mutants
EP0851768B1 (en) * 1995-09-01 2002-04-24 University of Washington Interactive molecular conjugates
DE19641876B4 (de) * 1996-10-10 2011-09-29 Iba Gmbh Streptavidinmuteine
US5985658A (en) * 1997-11-14 1999-11-16 Health Research Incorporated Calmodulin-based cell separation technique
FR2841905B1 (fr) 2002-07-05 2004-09-03 Centre Nat Rech Scient Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications

Similar Documents

Publication Publication Date Title
JP2004525354A5 (enExample)
US11761956B2 (en) Nanopore biosensors for detection of proteins and nucleic acids
JP2017513524A5 (enExample)
CA2907050C (en) Methods for detecting peptide/mhc/tcr binding
Mazumdar et al. Easy-to-use dipstick tests for detection of lead in paints using non-cross-linked gold nanoparticle–DNAzyme conjugates
Zuccaro et al. Real-time label-free direct electronic monitoring of topoisomerase enzyme binding kinetics on graphene
CN103797028B (zh) 使靶细胞可逆染色的方法
CN101495656B (zh) 采用带修饰的核苷酸通过纳米通道进行dna序列测定
Walker et al. A pore-forming protein with a metal-actuated switch
CN106662584B (zh) 分离靶细胞的方法
Nagase et al. Thermally Modulated Retention of Lymphoctytes on Polymer‐Brush‐Grafted Glass Beads
CN107735686A (zh) 具有内部蛋白质衔接子的纳米孔
EP2725359B1 (en) Cell separation method using a release system for cell-antibody-substrate conjugates containing a polyethylene glycol spacer unit
WO2002083937A3 (en) Methods using o6-alkylguanine-dna alkyltransferases
JP2017514481A5 (enExample)
CA2423979A1 (en) Method for quantifying phosphokinase activity on proteins
US20260072019A1 (en) Method of determining the presence or absence of a target analyte comprising using a reporter polynucleotide and a transmembrane pore
Mooney et al. Use of phage display methods to identify heptapeptide sequences for use as affinity purification ‘tags’ with novel chelating ligands in immobilized metal ion affinity chromatography
JP2006007204A5 (enExample)
CN101995463A (zh) 用于斑点金免疫渗滤法检测类风湿关节炎免疫抗体的组合物
CA2432995A1 (en) Immunogenic hla-a2 supermotif-restricted peptides
Moring et al. Target specific sample preparation from aqueous extracts with molecular imprinted polymers
Mann et al. Epitope-specific binder design by yeast surface display
WO2024138565A1 (zh) 纳米孔蛋白及其突变体和应用
EP3548621A1 (en) Methods and systems for identifying candidate nucleic acid agent