|
US3507866A
(en)
|
1967-08-08 |
1970-04-21 |
Merck & Co Inc |
1h - imidazo(4,5-b)pyrazin - 2 - one and processes for their preparation
|
|
US3567725A
(en)
|
1968-11-20 |
1971-03-02 |
Merck & Co Inc |
Process for preparation of 1h-imidazo-(4,5-b)pyrazin-2-ones
|
|
US4294836A
(en)
|
1980-03-24 |
1981-10-13 |
Sterling Drug Inc. |
1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use
|
|
US4294837A
(en)
|
1980-03-28 |
1981-10-13 |
Sterling Drug Inc. |
1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use
|
|
US4317909A
(en)
|
1980-03-24 |
1982-03-02 |
Sterling Drug Inc. |
Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones
|
|
US4309537A
(en)
|
1980-03-28 |
1982-01-05 |
Sterling Drug Inc. |
Production of imidazo[4,5-b]pyridin-2-ones or thiones
|
|
GB8709448D0
(en)
|
1987-04-21 |
1987-05-28 |
Pfizer Ltd |
Heterobicyclic quinoline derivatives
|
|
JPS63275582A
(ja)
|
1987-05-02 |
1988-11-14 |
Naade Kenkyusho:Kk |
２−アミノイミダゾ〔４，５−ｂ〕ピリジン誘導体の製造方法
|
|
DD262026A1
(de)
|
1987-07-10 |
1988-11-16 |
Akad Wissenschaften Ddr |
Verfahren zur herstellung von 4-substituierten 6-(pyrid-4-yl)-2,4-dihydro-1h-imidazo[4,5-b]pyrid-2-onen
|
|
FR2643903A1
(fr)
|
1989-03-03 |
1990-09-07 |
Union Pharma Scient Appl |
Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux
|
|
US4963561A
(en)
|
1990-02-28 |
1990-10-16 |
Sterling Drug Inc. |
Imidazopyridines, their preparation and use
|
|
TW274550B
(enExample)
|
1992-09-26 |
1996-04-21 |
Hoechst Ag |
|
|
DE19601627A1
(de)
|
1996-01-18 |
1997-07-24 |
Bayer Ag |
Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
|
|
US6031105A
(en)
|
1996-04-09 |
2000-02-29 |
Pfizer Inc |
Substituted pyridines
|
|
CA2305370C
(en)
|
1997-09-26 |
2006-11-28 |
Gerald Mcmahon |
Azabenzimidazole-based compounds for modulating serine/threonine protein kinase function
|
|
CA2311414A1
(en)
|
1997-11-27 |
1999-06-10 |
Chugai Research Institute For Molecular Medicine, Inc. |
Diagnostic method, diagnostic reagent and therapeutic preparation for diseases caused by variation in lkb1 gene
|
|
ZA9810490B
(en)
|
1997-12-03 |
1999-05-20 |
Dainippon Pharmaceutical Co |
2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor
|
|
WO2000072670A1
(en)
|
1999-05-31 |
2000-12-07 |
Chugai Research Institute For Molecular Medicine, Inc. |
Lkb1 gene knockout animals
|
|
JP2003146987A
(ja)
|
1999-05-31 |
2003-05-21 |
Dainippon Pharmaceut Co Ltd |
２−アリールプリン−９−アセトアミド誘導体
|
|
JP3814125B2
(ja)
|
1999-06-02 |
2006-08-23 |
大日本住友製薬株式会社 |
２−アリール−８−オキソジヒドロプリン誘導体からなる医薬
|
|
JP2002100363A
(ja)
|
2000-09-25 |
2002-04-05 |
Mitsubishi Chemicals Corp |
リチウム二次電池用正極材料、リチウム二次電池用正極及びリチウム二次電池
|
|
JP2002167387A
(ja)
|
2000-11-29 |
2002-06-11 |
Dainippon Pharmaceut Co Ltd |
２−（７，８−ジヒドロ−８−オキソ−９ｈ−プリン−９−イル）酢酸誘導体
|
|
ES2249384T3
(es)
|
2000-12-12 |
2006-04-01 |
Neurogen Corporation |
Espiro(isobenzofuran-1,4'-piperadin)-3-onas y 3h-espirobenzofuran-1,4-piperidinas.
|
|
WO2002076954A1
(en)
|
2001-03-23 |
2002-10-03 |
Smithkline Beecham Corporation |
Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
|
|
RS51012B
(sr)
|
2001-09-04 |
2010-10-31 |
Boehringer Ingelheim Pharma Gmbh. & Co.Kg. |
Novi dihidropteridinoni, postupak za njihovo dobijanje i njihova primena kao lekova
|
|
CA2462441A1
(en)
|
2001-10-18 |
2003-04-24 |
Pier F. Cirillo |
1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors
|
|
MY156407A
(en)
|
2002-02-28 |
2016-02-26 |
Novartis Ag |
5-phenylthiazole derivatives and use as p13 kinase inhibitors
|
|
US7247621B2
(en)
|
2002-04-30 |
2007-07-24 |
Valeant Research & Development |
Antiviral phosphonate compounds and methods therefor
|
|
KR20050006221A
(ko)
|
2002-05-06 |
2005-01-15 |
제네랩스 테크놀로지스, 인코포레이티드 |
Ｃ형 간염 바이러스 감염 치료용의 뉴클레오시드 유도체
|
|
US20040204420A1
(en)
|
2002-08-05 |
2004-10-14 |
Rana Tariq M. |
Compounds for modulating RNA interference
|
|
JP2006512313A
(ja)
|
2002-10-31 |
2006-04-13 |
アムジェン インコーポレイテッド |
抗炎症剤
|
|
KR101052482B1
(ko)
|
2002-11-21 |
2011-07-28 |
노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 |
포스포티딜이노시톨(ｐｉ) 3-키나제 억제제인 2,4,6-삼치환피리미딘 및 암의 치료에서 이들의 사용
|
|
EP1590341B1
(en)
|
2003-01-17 |
2009-06-17 |
Warner-Lambert Company LLC |
2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation
|
|
ES2287583T3
(es)
|
2003-02-26 |
2007-12-16 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG |
Dihidropteridinonas, procedimiento para su preparacion y su uso como medicamenteos.
|
|
GB0305152D0
(en)
|
2003-03-06 |
2003-04-09 |
Novartis Ag |
Organic compounds
|
|
GB2400101A
(en)
|
2003-03-28 |
2004-10-06 |
Biofocus Discovery Ltd |
Compounds capable of binding to the active site of protein kinases
|
|
TW200519106A
(en)
|
2003-05-02 |
2005-06-16 |
Novartis Ag |
Organic compounds
|
|
EP2345658A1
(en)
|
2003-05-30 |
2011-07-20 |
Pharmasset, Inc. |
Modified fluorinated nucleoside analogues
|
|
AU2004263080B2
(en)
|
2003-06-26 |
2008-12-18 |
Merck Sharp & Dohme Corp. |
Benzodiazepine CGRP receptor antagonists
|
|
EP1651673B1
(en)
|
2003-07-17 |
2008-04-16 |
University of Dundee |
Methods for use of an lkb1/strad/mo25 complex
|
|
GB0320197D0
(en)
|
2003-08-28 |
2003-10-01 |
Novartis Ag |
Organic compounds
|
|
US20080194019A1
(en)
|
2003-09-09 |
2008-08-14 |
Beth Israel Deaconess Medical Center, Inc. |
Tumor Suppressor Lkb1 Kinase Directly Activates Amp-Activated Kinase
|
|
JP2008501707A
(ja)
|
2004-06-04 |
2008-01-24 |
アイコス、コーポレーション |
マスト細胞障害を処置するための方法
|
|
DE102004029784A1
(de)
|
2004-06-21 |
2006-01-05 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
|
|
WO2006001266A1
(ja)
|
2004-06-23 |
2006-01-05 |
Banyu Pharmaceutical Co., Ltd. |
２－アリールプリン誘導体の製造方法
|
|
US20060058311A1
(en)
|
2004-08-14 |
2006-03-16 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation
|
|
GB0420719D0
(en)
|
2004-09-17 |
2004-10-20 |
Addex Pharmaceuticals Sa |
Novel allosteric modulators
|
|
JP2008514628A
(ja)
|
2004-09-24 |
2008-05-08 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
蛋白質キナーゼ類のイミダゾ｛４，５−ｂ｝ピラジノン阻害剤
|
|
GB0423653D0
(en)
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
US8153640B2
(en)
|
2004-10-29 |
2012-04-10 |
Tibotec Pharmaceuticals Ltd. |
HIV inhibiting bicyclic pyrimdine derivatives
|
|
US7855205B2
(en)
|
2004-10-29 |
2010-12-21 |
Janssen Pharmaceutica Nv |
Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
|
|
SE0403006D0
(sv)
|
2004-12-09 |
2004-12-09 |
Biovitrum Ab |
New compounds
|
|
US7767687B2
(en)
|
2004-12-13 |
2010-08-03 |
Biogen Idec Ma Inc. |
Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
|
|
AU2006215386B2
(en)
|
2005-02-16 |
2009-06-11 |
Astrazeneca Ab |
Chemical compounds
|
|
WO2006091737A1
(en)
|
2005-02-24 |
2006-08-31 |
Kemia, Inc. |
Modulators of gsk-3 activity
|
|
JP2008531538A
(ja)
|
2005-02-25 |
2008-08-14 |
クドス ファーマシューティカルズ リミテッド |
２，４−ジアミノ−ピリドピリミジン誘導体とｍＴＯＲ阻害剤としてのその使用
|
|
KR20070108916A
(ko)
|
2005-02-25 |
2007-11-13 |
쿠도스 파마슈티칼스 리미티드 |
Ｍｔｏｒ 억제제로서 작용하는 하이드라지노메틸,하이드라조노메틸 및 5-원 복소환 화합물 및 이의항암제로서의 용도
|
|
US20070021443A1
(en)
|
2005-04-05 |
2007-01-25 |
Ohlmeyer Michael J |
Purine and imidazopyridine derivatives for immunosuppression
|
|
EA016945B1
(ru)
|
2005-10-07 |
2012-08-30 |
Экселиксис, Инк. |
ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
|
|
AU2006302148B2
(en)
|
2005-10-07 |
2012-12-06 |
Exelixis, Inc. |
Pyridopyrimidinone inhibitors of PI3Kalpha
|
|
UA116188C2
(uk)
|
2005-10-07 |
2018-02-26 |
Екселіксіс, Інк. |
Інгібітори фосфатидилінозит-3-кінази і способи їх застосування
|
|
US8628931B2
(en)
|
2005-10-18 |
2014-01-14 |
George Mason Intellectual Properties, Inc. |
mTOR pathway theranostic
|
|
DK1951724T3
(da)
|
2005-11-17 |
2011-08-15 |
Osi Pharmaceuticals Llc |
Sammensmeltede bicykliske mTOR-inhibitorer
|
|
WO2007060404A1
(en)
|
2005-11-22 |
2007-05-31 |
Kudos Pharmaceuticals Limited |
PYRIDO-,PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
|
GB0525080D0
(en)
|
2005-12-09 |
2006-01-18 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
GB0525083D0
(en)
|
2005-12-09 |
2006-01-18 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
KR20080083188A
(ko)
|
2006-01-11 |
2008-09-16 |
아스트라제네카 아베 |
모르폴리노 피리미딘 유도체 및 요법에서의 그 유도체의용도
|
|
US20090281075A1
(en)
|
2006-02-17 |
2009-11-12 |
Pharmacopeia, Inc. |
Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors
|
|
EP3719018B1
(en)
|
2006-04-25 |
2025-08-27 |
Astex Therapeutics Ltd |
Purine and deazapurine derivatives as pharmaceutical compounds
|
|
DK2024372T3
(da)
|
2006-04-26 |
2010-09-20 |
Hoffmann La Roche |
Thieno[3,2-d]pyrimidin-derivat, der er egnet som P13K inhibitor
|
|
JP2009535386A
(ja)
|
2006-05-03 |
2009-10-01 |
アストラゼネカ アクチボラグ |
チアゾール誘導体および抗腫瘍剤としてのその使用
|
|
US20090118336A1
(en)
|
2006-05-03 |
2009-05-07 |
Laurent David |
Pyrazole derivatives and their use as pi3k inhibitors
|
|
JP2009537621A
(ja)
|
2006-05-22 |
2009-10-29 |
アストラゼネカ アクチボラグ |
インドール誘導体
|
|
CN102993204A
(zh)
|
2006-08-02 |
2013-03-27 |
赛特凯恩蒂克公司 |
特定的化学个体、组合物和方法
|
|
WO2008023161A1
(en)
|
2006-08-23 |
2008-02-28 |
Kudos Pharmaceuticals Limited |
2-methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors
|
|
WO2008079460A2
(en)
|
2006-09-05 |
2008-07-03 |
Emory University |
Tyrosine kinase inhibitors for prevention or treatment of infection
|
|
US20100144738A1
(en)
|
2006-09-05 |
2010-06-10 |
William Bornmann |
Inhibitors of c-met and uses thereof
|
|
WO2008032089A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidaz0lyl-2-m0rph0lin0-6-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032036A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
6-benzimidaz0lyl-2-m0rph0lin0-4- (azetidine, pyrrolidine, piperidine or azepine) pyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
CN101563340A
(zh)
|
2006-09-14 |
2009-10-21 |
阿斯利康(瑞典)有限公司 |
用作pi3k和mtor抑制剂用于治疗增殖性疾病的2-苯并咪唑基-6-吗啉代-4-哌啶-4-基嘧啶衍生物
|
|
WO2008032060A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidaz0lyl-6-m0rph0lin0-2-piperazinylpyrimidine derivatives as p13k and mtor inhibitors for the treatment of proliferative disorders
|
|
US20090270390A1
(en)
|
2006-09-14 |
2009-10-29 |
Astrazeneca |
Pyrimidine derivatives
|
|
WO2008032091A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidaz0lyl-6-m0rph0lin0-2-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032027A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
WO2008032077A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
WO2008032033A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032028A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
2 -benzimidazolyl- 6 -morpholino-4- (azetidine, pyrrolidine, piperidine or azepine) pyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008043031A1
(en)
|
2006-10-04 |
2008-04-10 |
Pharmacopeia, Inc. |
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
|
|
US7902187B2
(en)
|
2006-10-04 |
2011-03-08 |
Wyeth Llc |
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
|
|
MX337906B
(es)
|
2006-10-19 |
2016-03-28 |
Signal Pharm Llc |
Compuestos de heteroarilo, composiciones de los mismos, y su uso como inhibidores de proteina cinasas.
|
|
EP2078018B1
(en)
|
2006-10-19 |
2012-03-14 |
Signal Pharmaceuticals LLC |
Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors
|
|
CN102993202A
(zh)
|
2006-11-20 |
2013-03-27 |
诺瓦提斯公司 |
2-甲基-2-[4-(3-甲基-2-氧代-8-喹啉-3-基-2,3-二氢-咪唑并[4,5-c]喹啉-1-基)-苯基]-丙腈的盐和晶型
|
|
US20080234262A1
(en)
|
2007-03-21 |
2008-09-25 |
Wyeth |
Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
|
|
UA99284C2
(ru)
|
2007-05-11 |
2012-08-10 |
Елі Ліллі Енд Компані |
ИНГИБИТОРЫ р70 S6-КИНАЗЫ
|
|
CA2692720A1
(en)
|
2007-07-09 |
2009-01-15 |
Astrazeneca Ab |
Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k
|
|
JP2010533161A
(ja)
|
2007-07-09 |
2010-10-21 |
アストラゼネカ アクチボラグ |
化合物−９４６
|
|
WO2009007748A2
(en)
|
2007-07-09 |
2009-01-15 |
Astrazeneca Ab |
Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
|
|
FR2920428B1
(fr)
*
|
2007-08-29 |
2012-06-15 |
Univ Rouen |
Procede de dedoublement de sels de l'omeprazole
|
|
KR20100083170A
(ko)
|
2007-10-16 |
2010-07-21 |
와이어쓰 엘엘씨 |
티에노피리미딘 및 피라졸로피리미딘 화합물 및 이의 ｍＴＯＲ 키나제 및 ＰＩ3 키나제 억제제로서의 용도
|
|
AU2008345225A1
(en)
|
2007-12-21 |
2009-07-09 |
University Of Rochester |
Method for altering the lifespan of eukaryotic organisms
|
|
CN102014914A
(zh)
|
2008-01-15 |
2011-04-13 |
惠氏有限责任公司 |
3h-[1,2,3]三唑并[4,5-d]嘧啶化合物、其作为mtor激酶和pi3激酶抑制剂的用途、以及它们的合成
|
|
WO2009102986A1
(en)
|
2008-02-15 |
2009-08-20 |
Catholic Healthcare West (D/B/A St. Joseph's Hospital And Medical Center) |
Treatment of adenocarcinoma expressing lkb1 with mtor inhibitor in combination with cox1 inhibitor
|
|
WO2010006072A2
(en)
|
2008-07-08 |
2010-01-14 |
The Regents Of The University Of California |
Mtor modulators and uses thereof
|
|
US8110578B2
(en)
|
2008-10-27 |
2012-02-07 |
Signal Pharmaceuticals, Llc |
Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
|
|
CA2744498C
(en)
|
2008-11-25 |
2017-10-24 |
University Of Rochester |
Mlk inhibitors and methods of use
|
|
EP2424845A4
(en)
*
|
2009-04-27 |
2014-03-05 |
Reddys Lab Ltd Dr |
PREPARATION OF DECITABIN
|
|
SI2477987T1
(en)
|
2009-09-14 |
2018-03-30 |
Gilead Sciences, Inc. |
MODULATORS TO TOLL OF LIKE RECEPTORS
|
|
CN102686225A
(zh)
|
2009-10-26 |
2012-09-19 |
西格诺药品有限公司 |
杂芳基化合物的合成和纯化方法
|
|
MX2012007273A
(es)
|
2009-12-23 |
2012-12-17 |
Elan Pharm Inc |
Pteridinonas como inhibidores de la quinasa tipo polo.
|
|
PH12012501581A1
(en)
|
2010-02-03 |
2012-10-22 |
Signal Pharm Llc |
Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors
|
|
US20110318336A1
(en)
|
2010-03-29 |
2011-12-29 |
George Mason Intellectual Properties, Inc. |
Identification and Treatment of Aggressive Lung Cancer Tumors
|
|
US20120028972A1
(en)
|
2010-07-30 |
2012-02-02 |
Lilly Wong |
Biomarker assays for detecting or measuring inhibition of tor kinase activity
|
|
CN103857804A
(zh)
|
2011-08-03 |
2014-06-11 |
西格诺药品有限公司 |
作为lkb1状态的预测性生物标志物的基因表达谱的鉴定
|
|
SG10201912850WA
(en)
|
2011-10-19 |
2020-02-27 |
Signal Pharm Llc |
Treatment Of Cancer With TOR Kinase Inhibitors
|
|
WO2013082344A1
(en)
*
|
2011-12-02 |
2013-06-06 |
Signal Pharmaceuticals, Llc |
Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
|
|
MX358303B
(es)
|
2012-02-24 |
2018-08-14 |
Signal Pharm Llc |
Uso de 7-(6-(2-hidroxipropan-2il) piridin-3-il)-1-((1r,4r)4-metoxi ciclohexil)-3, 4-dihidropirazin-[2,3-b] pirazin-2(1h)-ona o una sal, estereoisómero o tautómero aceptable farmaceuticamente del mismo, en combinación con una cantidad efectiva de erlotinib o azacitidina para preparar un composición farmacéutica en el tratamiento de cáncer de pulmón de cédula no pequeña, avanzado.
|
|
MX360877B
(es)
|
2012-03-15 |
2018-11-21 |
Signal Pharm Llc |
Compuesto 1-etil-7-(2-metil-6-(1h-1,2,4-triazol-3-il)piridin-3-il) -3,4-dihidropirazino[2,3-b]pirazin-(1h)-ona para usarse en el tratamiento de sarcoma de ewing que sobreexpresa e-veintiseis(ets).
|
|
SG11201405724RA
(en)
|
2012-03-15 |
2014-10-30 |
Signal Pharm Llc |
Treatment of cancer with tor kinase inhibitors
|
|
EA028062B1
(ru)
|
2012-03-15 |
2017-10-31 |
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
Лечение рака ингибиторами tor киназы
|
|
NZ628416A
(en)
|
2012-03-15 |
2016-04-29 |
Signal Pharm Llc |
Treatment of cancer with tor kinase inhibitors
|
|
AR094997A1
(es)
*
|
2012-08-09 |
2015-09-16 |
Celgene Corp |
Sales y formas sólidas de (s)-3-(4-((4-(morfolinometil)bencil)oxi)-1-oxoisoindolin-2-il)piperidin-2,6-diona y composiciones que las comprenden y sus usos
|
|
AU2013203714B2
(en)
|
2012-10-18 |
2015-12-03 |
Signal Pharmaceuticals, Llc |
Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
|
|
BR112015026292B1
(pt)
|
2013-04-17 |
2022-04-12 |
Signal Pharmaceuticals, Llc |
Uso de 1-etil-7-(2-metil-6-(1h-1,2,4-triazol-3-il)piridin-3-il)-3,4-dihidropirazino [2,3-b]pirazin-2(1h)- ona e métodos in vitro
|
|
US20140314673A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Treatment of cancer with dihydropyrazino-pyrazines
|
|
MX2015014455A
(es)
|
2013-04-17 |
2016-07-21 |
Signal Pharm Llc |
Terapia de combinacion que comprende un inhibidor de tor cinasa y n-(3-(5-fluoro-2-(4-(2-metoxietoxi)fenilamino)pirimidin-4-ilamino )fenil)acrilamida para tratar cancer.
|
|
EP2986609B1
(en)
|
2013-04-17 |
2019-06-19 |
Signal Pharmaceuticals, LLC |
Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
|
|
JP6389241B2
(ja)
|
2013-04-17 |
2018-09-12 |
シグナル ファーマシューティカルズ，エルエルシー |
癌を治療するためのＴＯＲキナーゼ阻害剤及びＩＭｉＤ化合物を含む組合せ療法
|
|
MY189663A
(en)
|
2013-04-17 |
2022-02-23 |
Signal Pharm Llc |
Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
|
|
NZ631082A
(en)
|
2013-04-17 |
2017-06-30 |
Signal Pharm Llc |
Methods for treating cancer using tor kinase inhibitor combination therapy
|
|
EA030808B1
(ru)
|
2013-04-17 |
2018-09-28 |
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
ПРИМЕНЕНИЕ 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1Н-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1Н)-ОНА В ЛЕЧЕНИИ МУЛЬТИФОРМНОЙ ГЛИОБЛАСТОМЫ
|
|
US9474757B2
(en)
|
2013-04-17 |
2016-10-25 |
Signal Pharmaceuticals, Llc |
Methods for treating cancer using TOR kinase inhibitor combination therapy
|