JP2014221842A5 - - Google Patents

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JP2014221842A5
JP2014221842A5 JP2014177733A JP2014177733A JP2014221842A5 JP 2014221842 A5 JP2014221842 A5 JP 2014221842A5 JP 2014177733 A JP2014177733 A JP 2014177733A JP 2014177733 A JP2014177733 A JP 2014177733A JP 2014221842 A5 JP2014221842 A5 JP 2014221842A5
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tetramethylhexadec
trienyl
diene
hydroxy
dione
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JP2014177733A
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JP6001025B2 (ja
JP2014221842A (ja
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JP2014177733A 2008-10-28 2014-09-02 α−トコトリエノールおよび誘導体の産生のためのプロセス Active JP6001025B2 (ja)

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US19758508P 2008-10-28 2008-10-28
US61/197,585 2008-10-28

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JP2011534678A Division JP5775459B2 (ja) 2008-10-28 2009-10-27 α−トコトリエノールおよび誘導体の産生のためのプロセス

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JP2015140302A Division JP2015187169A (ja) 2008-10-28 2015-07-14 α−トコトリエノールおよび誘導体の産生のためのプロセス

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JP2014221842A JP2014221842A (ja) 2014-11-27
JP2014221842A5 true JP2014221842A5 (enExample) 2015-08-27
JP6001025B2 JP6001025B2 (ja) 2016-10-05

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JP2011534678A Active JP5775459B2 (ja) 2008-10-28 2009-10-27 α−トコトリエノールおよび誘導体の産生のためのプロセス
JP2014177733A Active JP6001025B2 (ja) 2008-10-28 2014-09-02 α−トコトリエノールおよび誘導体の産生のためのプロセス
JP2015140302A Withdrawn JP2015187169A (ja) 2008-10-28 2015-07-14 α−トコトリエノールおよび誘導体の産生のためのプロセス
JP2018108448A Active JP7181708B2 (ja) 2008-10-28 2018-06-06 α-トコトリエノールおよび誘導体の産生のためのプロセス
JP2019008496A Withdrawn JP2019065041A (ja) 2008-10-28 2019-01-22 α−トコトリエノールおよび誘導体の産生のためのプロセス
JP2021016310A Withdrawn JP2021066745A (ja) 2008-10-28 2021-02-04 α−トコトリエノールおよび誘導体の産生のためのプロセス
JP2023057343A Withdrawn JP2023073469A (ja) 2008-10-28 2023-03-31 α-トコトリエノールおよび誘導体の産生のためのプロセス

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JP2015140302A Withdrawn JP2015187169A (ja) 2008-10-28 2015-07-14 α−トコトリエノールおよび誘導体の産生のためのプロセス
JP2018108448A Active JP7181708B2 (ja) 2008-10-28 2018-06-06 α-トコトリエノールおよび誘導体の産生のためのプロセス
JP2019008496A Withdrawn JP2019065041A (ja) 2008-10-28 2019-01-22 α−トコトリエノールおよび誘導体の産生のためのプロセス
JP2021016310A Withdrawn JP2021066745A (ja) 2008-10-28 2021-02-04 α−トコトリエノールおよび誘導体の産生のためのプロセス
JP2023057343A Withdrawn JP2023073469A (ja) 2008-10-28 2023-03-31 α-トコトリエノールおよび誘導体の産生のためのプロセス

Country Status (17)

Country Link
US (6) US8106223B2 (enExample)
EP (3) EP2362875B1 (enExample)
JP (7) JP5775459B2 (enExample)
CN (2) CN105753829B (enExample)
BR (1) BRPI0920414B1 (enExample)
CA (2) CA2741767C (enExample)
DK (2) DK2963006T3 (enExample)
EA (2) EA201692046A1 (enExample)
ES (2) ES2553557T3 (enExample)
HU (1) HUE041714T2 (enExample)
MX (1) MX2011004440A (enExample)
MY (2) MY185183A (enExample)
PL (2) PL2362875T3 (enExample)
PT (2) PT2963006T (enExample)
SI (1) SI2963006T1 (enExample)
TR (1) TR201819154T4 (enExample)
WO (1) WO2010051277A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2583087C (en) 2003-09-19 2012-07-10 Galileo Pharmaceuticals, Inc. Chroman derivatives
HUE033304T2 (en) * 2005-06-01 2017-11-28 Bioelectron Tech Corp Redoxactive therapeutic agents for the treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
WO2007100652A2 (en) 2006-02-22 2007-09-07 Edison Pharmaceuticals, Inc. Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
EA038941B1 (ru) 2007-11-06 2021-11-12 ПиТиСи ТЕРАПЬЮТИКС, ИНК. ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ
US8952071B2 (en) 2008-01-08 2015-02-10 Edison Pharmaceuticals, Inc. (Het)aryl-p-quinone derivatives for treatment of mitochondrial diseases
US8716527B2 (en) 2008-03-05 2014-05-06 Edison Pharmaceuticals, Inc. 2-substituted-p-quinone derivatives for treatment of oxidative stress diseases
US8716486B2 (en) * 2008-06-25 2014-05-06 Edison Pharmaceuticals, Inc. 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases
EP3827815B1 (en) 2008-09-10 2023-09-06 PTC Therapeutics, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
EP2362726B1 (en) 2008-10-14 2018-08-08 Bioelectron Technology Corporation Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells
ES2553557T3 (es) 2008-10-28 2015-12-10 Edison Pharmaceuticals, Inc. Proceso para la producción de alfa-tocotrienol y derivados
DK2424495T3 (en) 2009-04-28 2018-04-30 Bioelectron Tech Corp TREATMENT OF LEVERS HEREDIC OPTICAL NEUROPATHY AND DOMINANT OPTICAL ATROPHY WITH TOCOTRIENOL QUINONES
EP2470168B1 (en) 2009-08-26 2018-01-31 BioElectron Technology Corporation Methods for the prevention and treatment of cerebral ischemia
WO2012154613A1 (en) * 2011-05-06 2012-11-15 Edison Pharmaceuticals, Inc. Improved process for the preparation of d-alpha-tocotrienol from natural extracts
WO2012174286A1 (en) 2011-06-14 2012-12-20 Edison Pharmaceuticals, Inc. Catechol derivatives for treatment of oxidative stress diseases
EP2734512B1 (en) 2011-07-19 2019-11-20 Bioelectron Technology Corporation Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
MY162508A (en) * 2011-07-21 2017-06-15 Sime Darby Malaysia Berhad External preparation for skin
CA2883882A1 (en) 2012-09-07 2014-03-13 Edison Pharmaceuticals, Inc. Benzoquinone derivatives for treating oxidative stress disorders
US8937191B2 (en) * 2012-12-20 2015-01-20 Orochem Technologies, Inc. Recovery of highly pure alpha-tocotrienol from crude palm oil extract
US9670170B2 (en) 2013-03-15 2017-06-06 Bioelectron Technology Corporation Resorufin derivatives for treatment of oxidative stress disorders
US9868711B2 (en) 2013-03-15 2018-01-16 Bioelectron Technology Corporation Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
US9296712B2 (en) 2013-03-15 2016-03-29 Edison Pharmaceuticals, Inc. Resorufin derivatives for treatment of oxidative stress disorders
HK1220451A1 (zh) 2013-03-15 2017-05-05 Bioelectron Technology Corporation 用於治疗氧化应激障碍的烷基-杂芳基取代醌衍生物
WO2015078886A1 (en) * 2013-11-29 2015-06-04 Saudi Basic Industries Corporation Stabilised polyolefin composition
US9512098B1 (en) 2014-02-03 2016-12-06 Board Of Trustees Of The University Of Arkansas Process of producing purified gamma- and delta-tocotrienols from tocol-rich oils or distillates
CN104262315A (zh) * 2014-09-05 2015-01-07 宁波大红鹰生物工程股份有限公司 一种生育三烯酚的分离提纯方法
SG10202003299PA (en) 2014-12-16 2020-05-28 Ptc Therapeutics Inc Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide
WO2016114860A1 (en) 2015-01-12 2016-07-21 Edison Pharmaceuticals, Inc. Quinones for protection against radiation exposure
EP3390377A1 (en) * 2015-12-16 2018-10-24 BioElectron Technology Corporation Improved methods for enriching alpha-tocotrienol from mixed tocol compositions
MX391378B (es) 2015-12-17 2025-03-21 Ptc Therapeutics Inc Derivados de fluoroalquil-, fluoroalcoxi-, fenoxi-, heteroariloxi-, alcoxi- y amina-1,4-benzoquinona para tratamiento de trastornos de estres oxidativo.
CA3011293A1 (en) 2016-01-12 2017-07-20 Bioelectron Technology Corporation Tocopherol and tocotrienol quinone derivatives for increasing thiosulfate levels or decreasing hydrogen sulfide levels
JP2018083799A (ja) 2016-11-15 2018-05-31 バイオエレクトロン テクノロジー コーポレイション 2−置換アミノ−ナフト[1,2−d]イミダゾール−5−オン化合物またはその製薬学上許容される塩
WO2018191732A1 (en) 2017-04-14 2018-10-18 Bioelectron Technology Corporation Methods and compositions for treatment of inflammation and oxidative stress
JP7586815B2 (ja) 2018-10-17 2024-11-19 ピーティーシー セラピューティクス, インコーポレイテッド α-シヌクレイノパチー、タウオパチー、および他の障害を抑制および処置するための2,3,5-トリメチル-6-ノニルシクロヘキサ-2,5-ジエン-1,4-ジオン
IL291898A (en) 2019-10-04 2022-06-01 Stealth Biotherapeutics Inc Quinone-, hydroquinone- and naphthoquinone-analogues of vatiquinone for treatment of mitochondrial disorder diseases
CN120554211A (zh) 2020-04-03 2025-08-29 康德生物医疗有限公司 用于预防和/或治疗线粒体疾病的组合物和方法
PE20240893A1 (es) 2021-07-08 2024-04-24 Ptc Therapeutics Inc Composiciones farmaceuticas que comprenden 2,3,5-trimetil-6-nonilciclohexa-2,5-dien-1,4-diona

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2519863A (en) 1949-05-14 1950-08-22 Eastman Kodak Co Conversion of beta-, gamma-, and delta-tocopherol to alpha-tocopherol by aminoalkylation and reduction
US4977282A (en) * 1984-04-17 1990-12-11 Henkel Corporation Production of d-alpha-tocopherol from natural plant sources
EP0159018A3 (en) * 1984-04-17 1986-10-01 HENKEL CORPORATION (a Delaware corp.) Production of d-alpha-tocopherol from natural plant sources
US4603142A (en) 1984-06-01 1986-07-29 Wisconsin Alumni Research Foundation Cholesterol lowering method of use
JPS636186A (ja) 1986-06-23 1988-01-12 タツタ電線株式会社 点滴監視装置
JPH0788376B2 (ja) 1986-09-02 1995-09-27 エーザイ株式会社 光学活性α−トコトリエノ−ルの製造方法
JP2685785B2 (ja) 1988-03-11 1997-12-03 エーザイ株式会社 光学活性α−トコトリエノールの製造方法
EP0333472B1 (en) 1988-03-16 1997-10-08 PALM OIL RESEARCH & DEVELOPMENT BOARD Production of high concentration tocopherols and tocotrienols from palm oil by-products
US5157132A (en) * 1990-05-18 1992-10-20 Carotech Associates Integrated process for recovery of carotenoids and tocotrienols from oil
CA2124086A1 (en) 1991-11-22 1993-05-27 Ronald H. Lane Tocotrienols and tocotrienol-like compounds and methods for their use
ATE194609T1 (de) 1995-03-28 2000-07-15 Hoffmann La Roche Aminomethylierung von tocopherolen
US5660691A (en) 1995-11-13 1997-08-26 Eastman Chemical Company Process for the production of tocotrienol/tocopherol blend concentrates
US6232060B1 (en) 1996-01-19 2001-05-15 Galileo Laboratories, Inc. Assay system for anti-stress agents
US5801159A (en) 1996-02-23 1998-09-01 Galileo Laboratories, Inc. Method and composition for inhibiting cellular irreversible changes due to stress
US5932748A (en) 1997-06-06 1999-08-03 Roche Vitamins Inc. Process for permethylating non-α-tocopherols to produce α-tocopherol
EP1042269B1 (en) * 1997-10-29 2003-05-02 Flexsys America L.P. Preparation of quinonediimines from phenylenediamines using hydrogen peroxide and a catalyst
US6224717B1 (en) 1998-01-29 2001-05-01 Eastman Chemical Company Methods for separating a tocotrienol from a tocol-containing mixture and compositions thereof
KR20010033917A (ko) * 1998-11-06 2001-04-25 니시다 야스마사 토코트리엔올류 함유 분말, 이의 제조방법 및 이를 압축성형하여 제조한 정제
US6395915B1 (en) 1999-09-10 2002-05-28 Technikrom, Inc. Method for producing purified tocotrienols and tocopherols using liquid chromatography
MY127451A (en) 1999-11-04 2006-12-29 Malaysian Palm Oil Board A method of chromatographic isolation for vitamin e isomers
DE10034233A1 (de) * 2000-07-14 2002-01-24 Basf Ag Tocotrienolchinon-Cyclisierungsprodukte
US7034054B2 (en) 2000-12-15 2006-04-25 Galileo Pharmaceuticals, Inc. Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols
US6838104B2 (en) 2000-12-20 2005-01-04 Archer Daniels Midland Company Process for the production of tocotrienols
US6608196B2 (en) 2001-05-03 2003-08-19 Galileo Pharmaceuticals, Inc. Process for solid supported synthesis of pyruvate-derived compounds
JP4842455B2 (ja) 2001-06-13 2011-12-21 コマツNtc株式会社 半導体単結晶引上げ装置及びそのライン構成
JP2003171376A (ja) 2001-09-27 2003-06-20 Lion Corp トコフェロール類及びトコトリエノール類濃縮物、その製造方法
US6667330B2 (en) 2002-01-31 2003-12-23 Galileo Pharmaceuticals, Inc. Furanone derivatives
US6653346B1 (en) 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives
US6590113B1 (en) 2002-03-26 2003-07-08 Ronald T. Sleeter Process for treating oils containing antioxidant compounds
AU2003287250B9 (en) 2002-10-30 2010-01-28 Ptc Therapeutics, Inc. Identifying therapeutic compounds based on their physical-chemical properties
MY130618A (en) * 2002-11-27 2007-07-31 Malaysian Palm Oil Board A method of extracting and isolating minor components from vegetable oil
CA2583087C (en) 2003-09-19 2012-07-10 Galileo Pharmaceuticals, Inc. Chroman derivatives
WO2005035491A2 (en) 2003-10-10 2005-04-21 Yasoo Health, Inc. PROCESS FOR SYNTHESIZING d-TOCOTRIENOLS FROM 2- VINYLCHROMANE COMPOUND
MY173044A (en) 2003-11-19 2019-12-20 Carotech Bhd Recovery of phytonutriens from oils
US7393662B2 (en) 2004-09-03 2008-07-01 Centocor, Inc. Human EPO mimetic hinge core mimetibodies, compositions, methods and uses
HUE033304T2 (en) * 2005-06-01 2017-11-28 Bioelectron Tech Corp Redoxactive therapeutic agents for the treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
EA021818B1 (ru) 2005-09-15 2015-09-30 Эдисон Фармасьютикалз, Инк. Варианты хвостовой части редокс-активных лекарственных средств для лечения митохондриальных болезней и модуляция биомаркера энергетического обмена q10
WO2007100652A2 (en) 2006-02-22 2007-09-07 Edison Pharmaceuticals, Inc. Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
WO2007105297A1 (ja) * 2006-03-13 2007-09-20 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo メチン系色素とその用途
JP2010515736A (ja) 2007-01-10 2010-05-13 エジソン ファーマシューティカルズ, インコーポレイテッド エリスロポイエチン活性またはトロンボポイエチン活性を有する化合物を用いる呼吸鎖障害の治療
KR101481197B1 (ko) 2007-05-24 2015-01-09 로더스 크로클란 비.브이. 토코페롤 및 토코트리에놀을 함유하는 조성물의 제조방법
EA038941B1 (ru) 2007-11-06 2021-11-12 ПиТиСи ТЕРАПЬЮТИКС, ИНК. ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ
CA2710253A1 (en) 2008-01-07 2009-07-16 Centocor Ortho Biotech Inc. Method of treating erythropoietin hyporesponsive anemias
US8952071B2 (en) 2008-01-08 2015-02-10 Edison Pharmaceuticals, Inc. (Het)aryl-p-quinone derivatives for treatment of mitochondrial diseases
CA2717741C (en) * 2008-03-05 2018-04-03 Edison Pharmaceuticals, Inc. Treatment of hearing and balance impairments with redox-active therapeutics
US8716527B2 (en) 2008-03-05 2014-05-06 Edison Pharmaceuticals, Inc. 2-substituted-p-quinone derivatives for treatment of oxidative stress diseases
US20110142834A1 (en) 2008-05-15 2011-06-16 Edison Pharmaceuticals, Inc. Treatment of hearing and balance impairments using compounds having erythropoietin activity
EP2303309A2 (en) 2008-05-22 2011-04-06 Edison Pharmaceuticals, Inc. Treatment of mitochondrial diseases with an erythropoietin mimetic
US8716486B2 (en) 2008-06-25 2014-05-06 Edison Pharmaceuticals, Inc. 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases
US20100010100A1 (en) 2008-07-09 2010-01-14 Hinman Andrew W Dermatological compositions with anti-aging and skin even-toning properties
WO2010014361A1 (en) 2008-07-30 2010-02-04 Edison Pharmaceuticals, Inc. Naphthoquinone compositions with anti-aging, anti- inflammatory and skin even-toning properties
US20100029706A1 (en) 2008-07-30 2010-02-04 Edison Parmaceuticals, Inc. a Delaware Corporation HYDROGENATED PYRIDO[4,3-b]INDOLES FOR THE TREATMENT OF OXIDATIVE STRESS
EP3827815B1 (en) 2008-09-10 2023-09-06 PTC Therapeutics, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
EP2362726B1 (en) 2008-10-14 2018-08-08 Bioelectron Technology Corporation Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells
ES2553557T3 (es) * 2008-10-28 2015-12-10 Edison Pharmaceuticals, Inc. Proceso para la producción de alfa-tocotrienol y derivados
DK2424495T3 (en) 2009-04-28 2018-04-30 Bioelectron Tech Corp TREATMENT OF LEVERS HEREDIC OPTICAL NEUROPATHY AND DOMINANT OPTICAL ATROPHY WITH TOCOTRIENOL QUINONES
JP2012525398A (ja) 2009-04-28 2012-10-22 アンペア ライフ サイエンシーズ,インコーポレイテッド 眼科障害を治療するためのトコトリエノールの局所、眼周囲または眼内使用
JP2012525397A (ja) 2009-04-28 2012-10-22 エジソン ファーマシューティカルズ, インコーポレイテッド 眼科疾患を治療するためのトコトリエノールキノンの製剤
US20120122969A1 (en) 2009-06-25 2012-05-17 Ampere Life Sciences, Inc. Treatment of pervasive developmental disorders with tocotrienols or tocotrienol enriched extracts
EP2470168B1 (en) 2009-08-26 2018-01-31 BioElectron Technology Corporation Methods for the prevention and treatment of cerebral ischemia
EA201200977A1 (ru) 2009-12-31 2013-01-30 Эдисон Фармасьютикалз, Инк. Лечение синдрома ли и ли-подобного синдрома токотриенолхинонами
CN102884037A (zh) 2010-03-09 2013-01-16 爱迪生制药有限公司 α-生育醌衍生物的合成,及其使用方法
WO2011113018A1 (en) 2010-03-12 2011-09-15 Ampere Life Sciences, Inc. Measurement and control of biological time
BR112012025558A2 (pt) 2010-04-06 2016-06-28 Edison Pharmaceuticals Inc tratamento para a ataxia-telangiectasia
CN105147651A (zh) 2010-04-27 2015-12-16 爱迪生药物公司 治疗眼科疾病的醌类的制剂
US20120101169A1 (en) 2010-07-14 2012-04-26 Penwest Pharmaceuticals Co. Methods of providing anticoagulation effects in subjects
EP2600857A4 (en) 2010-08-06 2014-06-11 Edison Pharmaceuticals Inc TREATMENT OF OCHONDRIAL DISEASES WITH NAPHTHOCHINONES
US20120295985A1 (en) 2010-11-19 2012-11-22 Miller Guy M Methods for improving blood glucose control
WO2012154613A1 (en) 2011-05-06 2012-11-15 Edison Pharmaceuticals, Inc. Improved process for the preparation of d-alpha-tocotrienol from natural extracts
WO2012170773A1 (en) 2011-06-08 2012-12-13 Edison Pharmaceuticals, Inc. Adjunctive therapy for the treatment of mitochondrial disorders with quinones and naphthoquinones
WO2012174286A1 (en) 2011-06-14 2012-12-20 Edison Pharmaceuticals, Inc. Catechol derivatives for treatment of oxidative stress diseases
EP2729004B1 (en) 2011-07-06 2020-03-25 PTC Therapeutics, Inc. Treatment of methylmalonic aciduria, isovaleric aciduria, and other organic acidurias with tocotrienol quinones
WO2013006736A1 (en) 2011-07-06 2013-01-10 Edison Pharmaceuticals, Inc Treatment of leigh syndrome and leigh-like syndrome, including complications of sucla2 mutations, with tocotrienol quinones
EP2734512B1 (en) 2011-07-19 2019-11-20 Bioelectron Technology Corporation Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
CA2883882A1 (en) 2012-09-07 2014-03-13 Edison Pharmaceuticals, Inc. Benzoquinone derivatives for treating oxidative stress disorders
US8937191B2 (en) 2012-12-20 2015-01-20 Orochem Technologies, Inc. Recovery of highly pure alpha-tocotrienol from crude palm oil extract
US20140256830A1 (en) 2013-03-08 2014-09-11 Ampere Life Sciences, Inc. Resorcinol compounds for dermatological use
US9296712B2 (en) 2013-03-15 2016-03-29 Edison Pharmaceuticals, Inc. Resorufin derivatives for treatment of oxidative stress disorders
HK1220451A1 (zh) 2013-03-15 2017-05-05 Bioelectron Technology Corporation 用於治疗氧化应激障碍的烷基-杂芳基取代醌衍生物
US9868711B2 (en) 2013-03-15 2018-01-16 Bioelectron Technology Corporation Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
US20140275045A1 (en) 2013-03-15 2014-09-18 Edison Pharmaceuticals, Inc. Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
US9670170B2 (en) 2013-03-15 2017-06-06 Bioelectron Technology Corporation Resorufin derivatives for treatment of oxidative stress disorders
WO2014194292A1 (en) 2013-05-31 2014-12-04 Edison Pharmaceuticals, Inc. Carboxylic acid derivatives for treatment of oxidative stress disorders
US20180002247A1 (en) 2014-12-16 2018-01-04 Bioelectron Technology Corporation Methods for chiral resolution of trolox
SG10202003299PA (en) 2014-12-16 2020-05-28 Ptc Therapeutics Inc Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide
WO2016114860A1 (en) 2015-01-12 2016-07-21 Edison Pharmaceuticals, Inc. Quinones for protection against radiation exposure
EP3390377A1 (en) 2015-12-16 2018-10-24 BioElectron Technology Corporation Improved methods for enriching alpha-tocotrienol from mixed tocol compositions
MX391378B (es) 2015-12-17 2025-03-21 Ptc Therapeutics Inc Derivados de fluoroalquil-, fluoroalcoxi-, fenoxi-, heteroariloxi-, alcoxi- y amina-1,4-benzoquinona para tratamiento de trastornos de estres oxidativo.
WO2017123823A1 (en) 2016-01-12 2017-07-20 Bioelectron Technology Corporation Alkyl-, acyl-, urea-, and aza-uracil sulfide:quinone oxidoreductase inhibitors
CA3011293A1 (en) 2016-01-12 2017-07-20 Bioelectron Technology Corporation Tocopherol and tocotrienol quinone derivatives for increasing thiosulfate levels or decreasing hydrogen sulfide levels
WO2018081644A1 (en) 2016-10-28 2018-05-03 Bioelectron Technology Corporation Methods of analyzing p-hydroquinone levels and ratios
WO2018093957A1 (en) 2016-11-15 2018-05-24 Bioelectron Technology Corporation 2-substituted amino-naphth[1,2-d]imidazol-5-one compounds or pharmaceutically acceptable salts thereof cross reference to related applications
WO2018129411A1 (en) 2017-01-06 2018-07-12 Bioelectron Technology Corporation Aryl- and heteroaryl-resorufin derivatives for treatment of oxidative stress disorders and liver and kidney disorders
WO2018191732A1 (en) 2017-04-14 2018-10-18 Bioelectron Technology Corporation Methods and compositions for treatment of inflammation and oxidative stress

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