|
US2519863A
(en)
|
1949-05-14 |
1950-08-22 |
Eastman Kodak Co |
Conversion of beta-, gamma-, and delta-tocopherol to alpha-tocopherol by aminoalkylation and reduction
|
|
US4977282A
(en)
*
|
1984-04-17 |
1990-12-11 |
Henkel Corporation |
Production of d-alpha-tocopherol from natural plant sources
|
|
EP0159018A3
(en)
*
|
1984-04-17 |
1986-10-01 |
HENKEL CORPORATION (a Delaware corp.) |
Production of d-alpha-tocopherol from natural plant sources
|
|
US4603142A
(en)
|
1984-06-01 |
1986-07-29 |
Wisconsin Alumni Research Foundation |
Cholesterol lowering method of use
|
|
JPS636186A
(ja)
|
1986-06-23 |
1988-01-12 |
タツタ電線株式会社 |
点滴監視装置
|
|
JPH0788376B2
(ja)
|
1986-09-02 |
1995-09-27 |
エーザイ株式会社 |
光学活性α−トコトリエノ−ルの製造方法
|
|
JP2685785B2
(ja)
|
1988-03-11 |
1997-12-03 |
エーザイ株式会社 |
光学活性α−トコトリエノールの製造方法
|
|
EP0333472B1
(en)
|
1988-03-16 |
1997-10-08 |
PALM OIL RESEARCH & DEVELOPMENT BOARD |
Production of high concentration tocopherols and tocotrienols from palm oil by-products
|
|
US5157132A
(en)
*
|
1990-05-18 |
1992-10-20 |
Carotech Associates |
Integrated process for recovery of carotenoids and tocotrienols from oil
|
|
CA2124086A1
(en)
|
1991-11-22 |
1993-05-27 |
Ronald H. Lane |
Tocotrienols and tocotrienol-like compounds and methods for their use
|
|
ATE194609T1
(de)
|
1995-03-28 |
2000-07-15 |
Hoffmann La Roche |
Aminomethylierung von tocopherolen
|
|
US5660691A
(en)
|
1995-11-13 |
1997-08-26 |
Eastman Chemical Company |
Process for the production of tocotrienol/tocopherol blend concentrates
|
|
US6232060B1
(en)
|
1996-01-19 |
2001-05-15 |
Galileo Laboratories, Inc. |
Assay system for anti-stress agents
|
|
US5801159A
(en)
|
1996-02-23 |
1998-09-01 |
Galileo Laboratories, Inc. |
Method and composition for inhibiting cellular irreversible changes due to stress
|
|
US5932748A
(en)
|
1997-06-06 |
1999-08-03 |
Roche Vitamins Inc. |
Process for permethylating non-α-tocopherols to produce α-tocopherol
|
|
EP1042269B1
(en)
*
|
1997-10-29 |
2003-05-02 |
Flexsys America L.P. |
Preparation of quinonediimines from phenylenediamines using hydrogen peroxide and a catalyst
|
|
US6224717B1
(en)
|
1998-01-29 |
2001-05-01 |
Eastman Chemical Company |
Methods for separating a tocotrienol from a tocol-containing mixture and compositions thereof
|
|
KR20010033917A
(ko)
*
|
1998-11-06 |
2001-04-25 |
니시다 야스마사 |
토코트리엔올류 함유 분말, 이의 제조방법 및 이를 압축성형하여 제조한 정제
|
|
US6395915B1
(en)
|
1999-09-10 |
2002-05-28 |
Technikrom, Inc. |
Method for producing purified tocotrienols and tocopherols using liquid chromatography
|
|
MY127451A
(en)
|
1999-11-04 |
2006-12-29 |
Malaysian Palm Oil Board |
A method of chromatographic isolation for vitamin e isomers
|
|
DE10034233A1
(de)
*
|
2000-07-14 |
2002-01-24 |
Basf Ag |
Tocotrienolchinon-Cyclisierungsprodukte
|
|
US7034054B2
(en)
|
2000-12-15 |
2006-04-25 |
Galileo Pharmaceuticals, Inc. |
Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols
|
|
US6838104B2
(en)
|
2000-12-20 |
2005-01-04 |
Archer Daniels Midland Company |
Process for the production of tocotrienols
|
|
US6608196B2
(en)
|
2001-05-03 |
2003-08-19 |
Galileo Pharmaceuticals, Inc. |
Process for solid supported synthesis of pyruvate-derived compounds
|
|
JP4842455B2
(ja)
|
2001-06-13 |
2011-12-21 |
コマツNtc株式会社 |
半導体単結晶引上げ装置及びそのライン構成
|
|
JP2003171376A
(ja)
|
2001-09-27 |
2003-06-20 |
Lion Corp |
トコフェロール類及びトコトリエノール類濃縮物、その製造方法
|
|
US6667330B2
(en)
|
2002-01-31 |
2003-12-23 |
Galileo Pharmaceuticals, Inc. |
Furanone derivatives
|
|
US6653346B1
(en)
|
2002-02-07 |
2003-11-25 |
Galileo Pharmaceuticals, Inc. |
Cytoprotective benzofuran derivatives
|
|
US6590113B1
(en)
|
2002-03-26 |
2003-07-08 |
Ronald T. Sleeter |
Process for treating oils containing antioxidant compounds
|
|
AU2003287250B9
(en)
|
2002-10-30 |
2010-01-28 |
Ptc Therapeutics, Inc. |
Identifying therapeutic compounds based on their physical-chemical properties
|
|
MY130618A
(en)
*
|
2002-11-27 |
2007-07-31 |
Malaysian Palm Oil Board |
A method of extracting and isolating minor components from vegetable oil
|
|
CA2583087C
(en)
|
2003-09-19 |
2012-07-10 |
Galileo Pharmaceuticals, Inc. |
Chroman derivatives
|
|
WO2005035491A2
(en)
|
2003-10-10 |
2005-04-21 |
Yasoo Health, Inc. |
PROCESS FOR SYNTHESIZING d-TOCOTRIENOLS FROM 2- VINYLCHROMANE COMPOUND
|
|
MY173044A
(en)
|
2003-11-19 |
2019-12-20 |
Carotech Bhd |
Recovery of phytonutriens from oils
|
|
US7393662B2
(en)
|
2004-09-03 |
2008-07-01 |
Centocor, Inc. |
Human EPO mimetic hinge core mimetibodies, compositions, methods and uses
|
|
HUE033304T2
(en)
*
|
2005-06-01 |
2017-11-28 |
Bioelectron Tech Corp |
Redoxactive therapeutic agents for the treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
|
|
EA021818B1
(ru)
|
2005-09-15 |
2015-09-30 |
Эдисон Фармасьютикалз, Инк. |
Варианты хвостовой части редокс-активных лекарственных средств для лечения митохондриальных болезней и модуляция биомаркера энергетического обмена q10
|
|
WO2007100652A2
(en)
|
2006-02-22 |
2007-09-07 |
Edison Pharmaceuticals, Inc. |
Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
|
|
WO2007105297A1
(ja)
*
|
2006-03-13 |
2007-09-20 |
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo |
メチン系色素とその用途
|
|
JP2010515736A
(ja)
|
2007-01-10 |
2010-05-13 |
エジソン ファーマシューティカルズ, インコーポレイテッド |
エリスロポイエチン活性またはトロンボポイエチン活性を有する化合物を用いる呼吸鎖障害の治療
|
|
KR101481197B1
(ko)
|
2007-05-24 |
2015-01-09 |
로더스 크로클란 비.브이. |
토코페롤 및 토코트리에놀을 함유하는 조성물의 제조방법
|
|
EA038941B1
(ru)
|
2007-11-06 |
2021-11-12 |
ПиТиСи ТЕРАПЬЮТИКС, ИНК. |
ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ
|
|
CA2710253A1
(en)
|
2008-01-07 |
2009-07-16 |
Centocor Ortho Biotech Inc. |
Method of treating erythropoietin hyporesponsive anemias
|
|
US8952071B2
(en)
|
2008-01-08 |
2015-02-10 |
Edison Pharmaceuticals, Inc. |
(Het)aryl-p-quinone derivatives for treatment of mitochondrial diseases
|
|
CA2717741C
(en)
*
|
2008-03-05 |
2018-04-03 |
Edison Pharmaceuticals, Inc. |
Treatment of hearing and balance impairments with redox-active therapeutics
|
|
US8716527B2
(en)
|
2008-03-05 |
2014-05-06 |
Edison Pharmaceuticals, Inc. |
2-substituted-p-quinone derivatives for treatment of oxidative stress diseases
|
|
US20110142834A1
(en)
|
2008-05-15 |
2011-06-16 |
Edison Pharmaceuticals, Inc. |
Treatment of hearing and balance impairments using compounds having erythropoietin activity
|
|
EP2303309A2
(en)
|
2008-05-22 |
2011-04-06 |
Edison Pharmaceuticals, Inc. |
Treatment of mitochondrial diseases with an erythropoietin mimetic
|
|
US8716486B2
(en)
|
2008-06-25 |
2014-05-06 |
Edison Pharmaceuticals, Inc. |
2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases
|
|
US20100010100A1
(en)
|
2008-07-09 |
2010-01-14 |
Hinman Andrew W |
Dermatological compositions with anti-aging and skin even-toning properties
|
|
WO2010014361A1
(en)
|
2008-07-30 |
2010-02-04 |
Edison Pharmaceuticals, Inc. |
Naphthoquinone compositions with anti-aging, anti- inflammatory and skin even-toning properties
|
|
US20100029706A1
(en)
|
2008-07-30 |
2010-02-04 |
Edison Parmaceuticals, Inc. a Delaware Corporation |
HYDROGENATED PYRIDO[4,3-b]INDOLES FOR THE TREATMENT OF OXIDATIVE STRESS
|
|
EP3827815B1
(en)
|
2008-09-10 |
2023-09-06 |
PTC Therapeutics, Inc. |
Treatment of pervasive developmental disorders with redox-active therapeutics
|
|
EP2362726B1
(en)
|
2008-10-14 |
2018-08-08 |
Bioelectron Technology Corporation |
Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells
|
|
ES2553557T3
(es)
*
|
2008-10-28 |
2015-12-10 |
Edison Pharmaceuticals, Inc. |
Proceso para la producción de alfa-tocotrienol y derivados
|
|
DK2424495T3
(en)
|
2009-04-28 |
2018-04-30 |
Bioelectron Tech Corp |
TREATMENT OF LEVERS HEREDIC OPTICAL NEUROPATHY AND DOMINANT OPTICAL ATROPHY WITH TOCOTRIENOL QUINONES
|
|
JP2012525398A
(ja)
|
2009-04-28 |
2012-10-22 |
アンペア ライフ サイエンシーズ,インコーポレイテッド |
眼科障害を治療するためのトコトリエノールの局所、眼周囲または眼内使用
|
|
JP2012525397A
(ja)
|
2009-04-28 |
2012-10-22 |
エジソン ファーマシューティカルズ, インコーポレイテッド |
眼科疾患を治療するためのトコトリエノールキノンの製剤
|
|
US20120122969A1
(en)
|
2009-06-25 |
2012-05-17 |
Ampere Life Sciences, Inc. |
Treatment of pervasive developmental disorders with tocotrienols or tocotrienol enriched extracts
|
|
EP2470168B1
(en)
|
2009-08-26 |
2018-01-31 |
BioElectron Technology Corporation |
Methods for the prevention and treatment of cerebral ischemia
|
|
EA201200977A1
(ru)
|
2009-12-31 |
2013-01-30 |
Эдисон Фармасьютикалз, Инк. |
Лечение синдрома ли и ли-подобного синдрома токотриенолхинонами
|
|
CN102884037A
(zh)
|
2010-03-09 |
2013-01-16 |
爱迪生制药有限公司 |
α-生育醌衍生物的合成,及其使用方法
|
|
WO2011113018A1
(en)
|
2010-03-12 |
2011-09-15 |
Ampere Life Sciences, Inc. |
Measurement and control of biological time
|
|
BR112012025558A2
(pt)
|
2010-04-06 |
2016-06-28 |
Edison Pharmaceuticals Inc |
tratamento para a ataxia-telangiectasia
|
|
CN105147651A
(zh)
|
2010-04-27 |
2015-12-16 |
爱迪生药物公司 |
治疗眼科疾病的醌类的制剂
|
|
US20120101169A1
(en)
|
2010-07-14 |
2012-04-26 |
Penwest Pharmaceuticals Co. |
Methods of providing anticoagulation effects in subjects
|
|
EP2600857A4
(en)
|
2010-08-06 |
2014-06-11 |
Edison Pharmaceuticals Inc |
TREATMENT OF OCHONDRIAL DISEASES WITH NAPHTHOCHINONES
|
|
US20120295985A1
(en)
|
2010-11-19 |
2012-11-22 |
Miller Guy M |
Methods for improving blood glucose control
|
|
WO2012154613A1
(en)
|
2011-05-06 |
2012-11-15 |
Edison Pharmaceuticals, Inc. |
Improved process for the preparation of d-alpha-tocotrienol from natural extracts
|
|
WO2012170773A1
(en)
|
2011-06-08 |
2012-12-13 |
Edison Pharmaceuticals, Inc. |
Adjunctive therapy for the treatment of mitochondrial disorders with quinones and naphthoquinones
|
|
WO2012174286A1
(en)
|
2011-06-14 |
2012-12-20 |
Edison Pharmaceuticals, Inc. |
Catechol derivatives for treatment of oxidative stress diseases
|
|
EP2729004B1
(en)
|
2011-07-06 |
2020-03-25 |
PTC Therapeutics, Inc. |
Treatment of methylmalonic aciduria, isovaleric aciduria, and other organic acidurias with tocotrienol quinones
|
|
WO2013006736A1
(en)
|
2011-07-06 |
2013-01-10 |
Edison Pharmaceuticals, Inc |
Treatment of leigh syndrome and leigh-like syndrome, including complications of sucla2 mutations, with tocotrienol quinones
|
|
EP2734512B1
(en)
|
2011-07-19 |
2019-11-20 |
Bioelectron Technology Corporation |
Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
|
|
CA2883882A1
(en)
|
2012-09-07 |
2014-03-13 |
Edison Pharmaceuticals, Inc. |
Benzoquinone derivatives for treating oxidative stress disorders
|
|
US8937191B2
(en)
|
2012-12-20 |
2015-01-20 |
Orochem Technologies, Inc. |
Recovery of highly pure alpha-tocotrienol from crude palm oil extract
|
|
US20140256830A1
(en)
|
2013-03-08 |
2014-09-11 |
Ampere Life Sciences, Inc. |
Resorcinol compounds for dermatological use
|
|
US9296712B2
(en)
|
2013-03-15 |
2016-03-29 |
Edison Pharmaceuticals, Inc. |
Resorufin derivatives for treatment of oxidative stress disorders
|
|
HK1220451A1
(zh)
|
2013-03-15 |
2017-05-05 |
Bioelectron Technology Corporation |
用於治疗氧化应激障碍的烷基-杂芳基取代醌衍生物
|
|
US9868711B2
(en)
|
2013-03-15 |
2018-01-16 |
Bioelectron Technology Corporation |
Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
|
|
US20140275045A1
(en)
|
2013-03-15 |
2014-09-18 |
Edison Pharmaceuticals, Inc. |
Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
|
|
US9670170B2
(en)
|
2013-03-15 |
2017-06-06 |
Bioelectron Technology Corporation |
Resorufin derivatives for treatment of oxidative stress disorders
|
|
WO2014194292A1
(en)
|
2013-05-31 |
2014-12-04 |
Edison Pharmaceuticals, Inc. |
Carboxylic acid derivatives for treatment of oxidative stress disorders
|
|
US20180002247A1
(en)
|
2014-12-16 |
2018-01-04 |
Bioelectron Technology Corporation |
Methods for chiral resolution of trolox
|
|
SG10202003299PA
(en)
|
2014-12-16 |
2020-05-28 |
Ptc Therapeutics Inc |
Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide
|
|
WO2016114860A1
(en)
|
2015-01-12 |
2016-07-21 |
Edison Pharmaceuticals, Inc. |
Quinones for protection against radiation exposure
|
|
EP3390377A1
(en)
|
2015-12-16 |
2018-10-24 |
BioElectron Technology Corporation |
Improved methods for enriching alpha-tocotrienol from mixed tocol compositions
|
|
MX391378B
(es)
|
2015-12-17 |
2025-03-21 |
Ptc Therapeutics Inc |
Derivados de fluoroalquil-, fluoroalcoxi-, fenoxi-, heteroariloxi-, alcoxi- y amina-1,4-benzoquinona para tratamiento de trastornos de estres oxidativo.
|
|
WO2017123823A1
(en)
|
2016-01-12 |
2017-07-20 |
Bioelectron Technology Corporation |
Alkyl-, acyl-, urea-, and aza-uracil sulfide:quinone oxidoreductase inhibitors
|
|
CA3011293A1
(en)
|
2016-01-12 |
2017-07-20 |
Bioelectron Technology Corporation |
Tocopherol and tocotrienol quinone derivatives for increasing thiosulfate levels or decreasing hydrogen sulfide levels
|
|
WO2018081644A1
(en)
|
2016-10-28 |
2018-05-03 |
Bioelectron Technology Corporation |
Methods of analyzing p-hydroquinone levels and ratios
|
|
WO2018093957A1
(en)
|
2016-11-15 |
2018-05-24 |
Bioelectron Technology Corporation |
2-substituted amino-naphth[1,2-d]imidazol-5-one compounds or pharmaceutically acceptable salts thereof cross reference to related applications
|
|
WO2018129411A1
(en)
|
2017-01-06 |
2018-07-12 |
Bioelectron Technology Corporation |
Aryl- and heteroaryl-resorufin derivatives for treatment of oxidative stress disorders and liver and kidney disorders
|
|
WO2018191732A1
(en)
|
2017-04-14 |
2018-10-18 |
Bioelectron Technology Corporation |
Methods and compositions for treatment of inflammation and oxidative stress
|