CN111386268A - 一种urat1抑制剂的晶型及其制备方法 - Google Patents

一种urat1抑制剂的晶型及其制备方法 Download PDF

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Publication number
CN111386268A
CN111386268A CN201880076152.6A CN201880076152A CN111386268A CN 111386268 A CN111386268 A CN 111386268A CN 201880076152 A CN201880076152 A CN 201880076152A CN 111386268 A CN111386268 A CN 111386268A
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degrees
compound
solution
reaction
uric acid
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CN111386268B (zh
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王建非
张杨
朱文元
黎健
陈曙辉
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Dongbao Zixing Hangzhou Biomedical Co ltd
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Medshine Discovery Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

本发明公开了一种URAT1抑制剂的晶型及其制备方法。

Description

PCT国内申请，说明书已公开。

Claims (14)

  1. PCT国内申请，权利要求书已公开。
CN201880076152.6A 2017-11-23 2018-11-20 一种urat1抑制剂的晶型及其制备方法 Active CN111386268B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2017111819602 2017-11-23
CN201711181960 2017-11-23
PCT/CN2018/116351 WO2019101058A1 (zh) 2017-11-23 2018-11-20 一种urat1抑制剂的晶型及其制备方法

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CN111386268A true CN111386268A (zh) 2020-07-07
CN111386268B CN111386268B (zh) 2022-04-19

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US (1) US10995087B2 (zh)
EP (1) EP3712148B1 (zh)
JP (1) JP6892968B2 (zh)
KR (1) KR102246619B1 (zh)
CN (1) CN111386268B (zh)
AU (1) AU2018370811B2 (zh)
CA (1) CA3083295C (zh)
NZ (1) NZ765226A (zh)
TW (1) TWI774881B (zh)
WO (1) WO2019101058A1 (zh)
ZA (1) ZA202003581B (zh)

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CN115561367B (zh) * 2022-11-09 2023-06-30 山东海雅医药科技有限公司 痛风药物有关物质的高效液相色谱检测方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104470898A (zh) * 2013-05-13 2015-03-25 上海恒瑞医药有限公司 环烷基甲酸类衍生物、其制备方法及其在医药上的应用
CN106032377A (zh) * 2015-03-12 2016-10-19 天津药物研究院有限公司 四氮唑类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途
CN107266377A (zh) * 2016-04-08 2017-10-20 浙江京新药业股份有限公司 一种urat1抑制剂的轴手性对映体的多晶型

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101411806B1 (ko) 2007-11-27 2014-06-24 아디아 바이오사이언스즈 인크. 신규한 화합물 및 조성물과 사용 방법
CN105399694B (zh) * 2015-12-11 2017-09-15 浙江京新药业股份有限公司 药物Lesinurad轴手性对映体
RU2709473C9 (ru) 2016-05-23 2020-06-16 Систоун Фармасьютикал (Сучжоу) Ко., Лтд. Тиофеновое соединение, способ его получения и его фармацевтическое применение

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104470898A (zh) * 2013-05-13 2015-03-25 上海恒瑞医药有限公司 环烷基甲酸类衍生物、其制备方法及其在医药上的应用
CN106032377A (zh) * 2015-03-12 2016-10-19 天津药物研究院有限公司 四氮唑类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途
CN107266377A (zh) * 2016-04-08 2017-10-20 浙江京新药业股份有限公司 一种urat1抑制剂的轴手性对映体的多晶型

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Publication number Publication date
US20200361917A1 (en) 2020-11-19
AU2018370811B2 (en) 2021-01-21
JP6892968B2 (ja) 2021-06-23
ZA202003581B (en) 2021-08-25
JP2021504353A (ja) 2021-02-15
TWI774881B (zh) 2022-08-21
US10995087B2 (en) 2021-05-04
EP3712148A4 (en) 2020-12-30
EP3712148B1 (en) 2021-07-07
CA3083295C (en) 2021-05-04
CN111386268B (zh) 2022-04-19
CA3083295A1 (en) 2019-05-31
KR20200084357A (ko) 2020-07-10
WO2019101058A1 (zh) 2019-05-31
KR102246619B1 (ko) 2021-04-30
EP3712148A1 (en) 2020-09-23
TW201925192A (zh) 2019-07-01
NZ765226A (en) 2022-11-25
AU2018370811A1 (en) 2020-06-25

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