JP2018193382A5 - - Google Patents
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- JP2018193382A5 JP2018193382A5 JP2018135444A JP2018135444A JP2018193382A5 JP 2018193382 A5 JP2018193382 A5 JP 2018193382A5 JP 2018135444 A JP2018135444 A JP 2018135444A JP 2018135444 A JP2018135444 A JP 2018135444A JP 2018193382 A5 JP2018193382 A5 JP 2018193382A5
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- Prior art keywords
- degrees
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- xrpd pattern
- Prior art date
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- 0 O=*(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2[C@@](CCC(N1)=O)C1=O Chemical compound O=*(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2[C@@](CCC(N1)=O)C1=O 0.000 description 2
- VOEDQAONRWQWFZ-NRFANRHFSA-N O=C(C1=C(C2)C(OCc3ccc(CN4CCOCC4)cc3)=CCC1)N2[C@@H](CCC(N1)=O)C1=O Chemical compound O=C(C1=C(C2)C(OCc3ccc(CN4CCOCC4)cc3)=CCC1)N2[C@@H](CCC(N1)=O)C1=O VOEDQAONRWQWFZ-NRFANRHFSA-N 0.000 description 2
- IXZOHGPZAQLIBH-UHFFFAOYSA-N O=C(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2C(CCC(N1)=O)C1=O Chemical compound O=C(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2C(CCC(N1)=O)C1=O IXZOHGPZAQLIBH-UHFFFAOYSA-N 0.000 description 2
- IXZOHGPZAQLIBH-NRFANRHFSA-N O=C(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2[C@@H](CCC(N1)=O)C1=O Chemical compound O=C(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2[C@@H](CCC(N1)=O)C1=O IXZOHGPZAQLIBH-NRFANRHFSA-N 0.000 description 2
- KDODKCNOLNSRCI-DEOSSOPVSA-N CC(C1=C(CN[C@@H](CCC(N2)=O)C2=O)C(OCc2ccc(CN3CCOCC3)cc2)=CCC#C1)=O Chemical compound CC(C1=C(CN[C@@H](CCC(N2)=O)C2=O)C(OCc2ccc(CN3CCOCC3)cc2)=CCC#C1)=O KDODKCNOLNSRCI-DEOSSOPVSA-N 0.000 description 1
- OZHXLPTYODOEFI-UHFFFAOYSA-N O=C(C(C=CC1)=C(C2)C1OCc1ccc(CN3CCOCC3)cc1)N2C(CCC(N1)=O)C1=O Chemical compound O=C(C(C=CC1)=C(C2)C1OCc1ccc(CN3CCOCC3)cc1)N2C(CCC(N1)=O)C1=O OZHXLPTYODOEFI-UHFFFAOYSA-N 0.000 description 1
- VEJUANQWUJGECH-YFPLAWBCSA-N O=C(CC[C@@H]1N(C2)C3OC3c3c2c(OCc2ccc(CN4CCOCC4)cc2)ccc3)NC1=O Chemical compound O=C(CC[C@@H]1N(C2)C3OC3c3c2c(OCc2ccc(CN4CCOCC4)cc2)ccc3)NC1=O VEJUANQWUJGECH-YFPLAWBCSA-N 0.000 description 1
- FSAIPDALTWLINA-UHFFFAOYSA-N O=C(c1c(C2)c(OCC3=CCC(CN4CCOCC4)C=C3)ccc1)N2C(CCC(N1)=O)C1=O Chemical compound O=C(c1c(C2)c(OCC3=CCC(CN4CCOCC4)C=C3)ccc1)N2C(CCC(N1)=O)C1=O FSAIPDALTWLINA-UHFFFAOYSA-N 0.000 description 1
- RVCQPJFZKRZBQK-QFIPXVFZSA-N O=C(c1c(C2)c(OCCc3ccc(CN4CCOCC4)cc3)ccc1)N2[C@@H](CCC(N1)=O)C1=O Chemical compound O=C(c1c(C2)c(OCCc3ccc(CN4CCOCC4)cc3)ccc1)N2[C@@H](CCC(N1)=O)C1=O RVCQPJFZKRZBQK-QFIPXVFZSA-N 0.000 description 1
- URNOWHKBGQPDIJ-XEGCMXMBSA-N OC([C@H](CC1)N(Cc2c3cccc2OCc2ccc(CN4CCOCC4)cc2)C3=O)NC1=O Chemical compound OC([C@H](CC1)N(Cc2c3cccc2OCc2ccc(CN4CCOCC4)cc2)C3=O)NC1=O URNOWHKBGQPDIJ-XEGCMXMBSA-N 0.000 description 1
- XMDMKYZTWXTUTD-UHFFFAOYSA-N OC(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2C(CCC(N1)=O)C1=O Chemical compound OC(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2C(CCC(N1)=O)C1=O XMDMKYZTWXTUTD-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261681484P | 2012-08-09 | 2012-08-09 | |
| US61/681,484 | 2012-08-09 | ||
| JP2015526692A JP6419072B2 (ja) | 2012-08-09 | 2013-08-08 | （ｓ）−３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526692A Division JP6419072B2 (ja) | 2012-08-09 | 2013-08-08 | （ｓ）−３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081266A Division JP7174735B2 (ja) | 2012-08-09 | 2020-05-01 | （ｓ）－３－（４－（（４－（モルホリノメチル）ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018193382A JP2018193382A (ja) | 2018-12-06 |
| JP2018193382A5 true JP2018193382A5 (enExample) | 2019-01-31 |
| JP6954869B2 JP6954869B2 (ja) | 2021-10-27 |
Family
ID=49054882
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526692A Active JP6419072B2 (ja) | 2012-08-09 | 2013-08-08 | （ｓ）−３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
| JP2018135444A Active JP6954869B2 (ja) | 2012-08-09 | 2018-07-19 | （ｓ）−３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
| JP2020081266A Active JP7174735B2 (ja) | 2012-08-09 | 2020-05-01 | （ｓ）－３－（４－（（４－（モルホリノメチル）ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
| JP2022127689A Active JP7431900B2 (ja) | 2012-08-09 | 2022-08-10 | （ｓ）－３－（４－（（４－（モルホリノメチル）ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526692A Active JP6419072B2 (ja) | 2012-08-09 | 2013-08-08 | （ｓ）−３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081266A Active JP7174735B2 (ja) | 2012-08-09 | 2020-05-01 | （ｓ）－３－（４－（（４－（モルホリノメチル）ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
| JP2022127689A Active JP7431900B2 (ja) | 2012-08-09 | 2022-08-10 | （ｓ）－３－（４－（（４－（モルホリノメチル）ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
Country Status (38)
Families Citing this family (23)
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| TR201904785T4 (tr) | 2012-08-09 | 2019-05-21 | Celgene Corp | (S)-3-(4-((4-MORFOLINOMETİL)BENZİL)OKSİ)-1-OKSOİZOİNDOLİN-2-il)PİPERİDİN-2,6-DİON HİDROKLORİDİN BİR KATI FORMU. |
| CA2935495C (en) | 2013-01-14 | 2021-04-20 | Deuterx, Llc | 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
| US9695145B2 (en) | 2013-01-22 | 2017-07-04 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4- morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
| US9290475B2 (en) | 2013-03-14 | 2016-03-22 | Deuterx, Llc | 3-(substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same |
| NZ714742A (en) * | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| US9809603B1 (en) | 2015-08-18 | 2017-11-07 | Deuterx, Llc | Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same |
| WO2018102725A1 (en) | 2016-12-01 | 2018-06-07 | Arvinas, Inc. | Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders |
| EP3573979A1 (en) * | 2017-01-27 | 2019-12-04 | Celgene Corporation | 3-(1-oxo-4-((4-((3-oxomorpholino) methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione and isotopologues thereof |
| ES2959860T3 (es) | 2017-06-22 | 2024-02-28 | Celgene Corp | Tratamiento del carcinoma hepatocelular caracterizado por la infección por el virus de la hepatitis B |
| AU2019351811B2 (en) | 2018-10-01 | 2025-01-02 | Celgene Corporation | Combination therapy for the treatment of cancer |
| CA3117978A1 (en) | 2018-11-08 | 2020-05-14 | Juno Therapeutics, Inc. | Methods and combinations for treatment and t cell modulation |
| ES3061133T3 (en) | 2019-08-26 | 2026-03-31 | Arvinas Operations Inc | Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders |
| BR112022007580A2 (pt) * | 2019-10-21 | 2022-07-05 | Celgene Corp | Formas sólidas que compreendem (s)-2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-morfolinoazetidin-1-il)metil)benzil)amino)isoindolino-1,3-diona e seus sais e composições que compreendem as mesmas e seus usos |
| IL292667B1 (en) | 2019-11-07 | 2026-02-01 | Juno Therapeutics Inc | Combination of T-cell therapy and (s)-3-[4-(4-morpholin-4-ylmethyl-benzyloxy)-l-oxo-3,l-dihydro-isoindol-2-yl]-piperidine-6,2-dione |
| AU2021342287A1 (en) * | 2020-09-14 | 2023-04-13 | Arvinas Operations, Inc. | Crystalline forms of a compound for the targeted degradation of estrogen receptor |
| JP2024527934A (ja) * | 2021-07-26 | 2024-07-26 | アルビナス・オペレーションズ・インコーポレイテッド | 二官能性化合物を製造する方法 |
| US11964979B2 (en) * | 2022-06-27 | 2024-04-23 | Abion Inc. | Camsylate salts of triazolopyrazine derivatives |
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