JP2018193382A5 - - Google Patents
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- JP2018193382A5 JP2018193382A5 JP2018135444A JP2018135444A JP2018193382A5 JP 2018193382 A5 JP2018193382 A5 JP 2018193382A5 JP 2018135444 A JP2018135444 A JP 2018135444A JP 2018135444 A JP2018135444 A JP 2018135444A JP 2018193382 A5 JP2018193382 A5 JP 2018193382A5
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- xrpd pattern
- Prior art date
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- 0 O=*(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2[C@@](CCC(N1)=O)C1=O Chemical compound O=*(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2[C@@](CCC(N1)=O)C1=O 0.000 description 2
- VOEDQAONRWQWFZ-NRFANRHFSA-N O=C(C1=C(C2)C(OCc3ccc(CN4CCOCC4)cc3)=CCC1)N2[C@@H](CCC(N1)=O)C1=O Chemical compound O=C(C1=C(C2)C(OCc3ccc(CN4CCOCC4)cc3)=CCC1)N2[C@@H](CCC(N1)=O)C1=O VOEDQAONRWQWFZ-NRFANRHFSA-N 0.000 description 2
- IXZOHGPZAQLIBH-UHFFFAOYSA-N O=C(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2C(CCC(N1)=O)C1=O Chemical compound O=C(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2C(CCC(N1)=O)C1=O IXZOHGPZAQLIBH-UHFFFAOYSA-N 0.000 description 2
- IXZOHGPZAQLIBH-NRFANRHFSA-N O=C(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2[C@@H](CCC(N1)=O)C1=O Chemical compound O=C(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2[C@@H](CCC(N1)=O)C1=O IXZOHGPZAQLIBH-NRFANRHFSA-N 0.000 description 2
- KDODKCNOLNSRCI-DEOSSOPVSA-N CC(C1=C(CN[C@@H](CCC(N2)=O)C2=O)C(OCc2ccc(CN3CCOCC3)cc2)=CCC#C1)=O Chemical compound CC(C1=C(CN[C@@H](CCC(N2)=O)C2=O)C(OCc2ccc(CN3CCOCC3)cc2)=CCC#C1)=O KDODKCNOLNSRCI-DEOSSOPVSA-N 0.000 description 1
- OZHXLPTYODOEFI-UHFFFAOYSA-N O=C(C(C=CC1)=C(C2)C1OCc1ccc(CN3CCOCC3)cc1)N2C(CCC(N1)=O)C1=O Chemical compound O=C(C(C=CC1)=C(C2)C1OCc1ccc(CN3CCOCC3)cc1)N2C(CCC(N1)=O)C1=O OZHXLPTYODOEFI-UHFFFAOYSA-N 0.000 description 1
- VEJUANQWUJGECH-YFPLAWBCSA-N O=C(CC[C@@H]1N(C2)C3OC3c3c2c(OCc2ccc(CN4CCOCC4)cc2)ccc3)NC1=O Chemical compound O=C(CC[C@@H]1N(C2)C3OC3c3c2c(OCc2ccc(CN4CCOCC4)cc2)ccc3)NC1=O VEJUANQWUJGECH-YFPLAWBCSA-N 0.000 description 1
- FSAIPDALTWLINA-UHFFFAOYSA-N O=C(c1c(C2)c(OCC3=CCC(CN4CCOCC4)C=C3)ccc1)N2C(CCC(N1)=O)C1=O Chemical compound O=C(c1c(C2)c(OCC3=CCC(CN4CCOCC4)C=C3)ccc1)N2C(CCC(N1)=O)C1=O FSAIPDALTWLINA-UHFFFAOYSA-N 0.000 description 1
- RVCQPJFZKRZBQK-QFIPXVFZSA-N O=C(c1c(C2)c(OCCc3ccc(CN4CCOCC4)cc3)ccc1)N2[C@@H](CCC(N1)=O)C1=O Chemical compound O=C(c1c(C2)c(OCCc3ccc(CN4CCOCC4)cc3)ccc1)N2[C@@H](CCC(N1)=O)C1=O RVCQPJFZKRZBQK-QFIPXVFZSA-N 0.000 description 1
- URNOWHKBGQPDIJ-XEGCMXMBSA-N OC([C@H](CC1)N(Cc2c3cccc2OCc2ccc(CN4CCOCC4)cc2)C3=O)NC1=O Chemical compound OC([C@H](CC1)N(Cc2c3cccc2OCc2ccc(CN4CCOCC4)cc2)C3=O)NC1=O URNOWHKBGQPDIJ-XEGCMXMBSA-N 0.000 description 1
- XMDMKYZTWXTUTD-UHFFFAOYSA-N OC(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2C(CCC(N1)=O)C1=O Chemical compound OC(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2C(CCC(N1)=O)C1=O XMDMKYZTWXTUTD-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261681484P | 2012-08-09 | 2012-08-09 | |
| US61/681,484 | 2012-08-09 | ||
| JP2015526692A JP6419072B2 (ja) | 2012-08-09 | 2013-08-08 | （ｓ）−３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526692A Division JP6419072B2 (ja) | 2012-08-09 | 2013-08-08 | （ｓ）−３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081266A Division JP7174735B2 (ja) | 2012-08-09 | 2020-05-01 | （ｓ）－３－（４－（（４－（モルホリノメチル）ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018193382A JP2018193382A (ja) | 2018-12-06 |
| JP2018193382A5 true JP2018193382A5 (enExample) | 2019-01-31 |
| JP6954869B2 JP6954869B2 (ja) | 2021-10-27 |
Family
ID=49054882
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526692A Active JP6419072B2 (ja) | 2012-08-09 | 2013-08-08 | （ｓ）−３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
| JP2018135444A Active JP6954869B2 (ja) | 2012-08-09 | 2018-07-19 | （ｓ）−３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
| JP2020081266A Active JP7174735B2 (ja) | 2012-08-09 | 2020-05-01 | （ｓ）－３－（４－（（４－（モルホリノメチル）ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
| JP2022127689A Active JP7431900B2 (ja) | 2012-08-09 | 2022-08-10 | （ｓ）－３－（４－（（４－（モルホリノメチル）ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526692A Active JP6419072B2 (ja) | 2012-08-09 | 2013-08-08 | （ｓ）−３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081266A Active JP7174735B2 (ja) | 2012-08-09 | 2020-05-01 | （ｓ）－３－（４－（（４－（モルホリノメチル）ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
| JP2022127689A Active JP7431900B2 (ja) | 2012-08-09 | 2022-08-10 | （ｓ）－３－（４－（（４－（モルホリノメチル）ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオンの塩及び固体形態、並びにそれらを含有する組成物及び使用方法 |
Country Status (38)
Families Citing this family (23)
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| EP2699091B1 (en) | 2011-03-28 | 2017-06-21 | DeuteRx, LLC | 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds |
| ES2885769T3 (es) | 2012-08-09 | 2021-12-15 | Celgene Corp | Una forma sólida de clorhidrato de (s)-3-(4-((4-morpholinometil)bencil)oxi)-1-oxoisoindolin-2-il)piperidina-2,6-diona |
| JP6359563B2 (ja) | 2013-01-14 | 2018-07-18 | デュートルクス・リミテッド・ライアビリティ・カンパニーＤｅｕｔｅＲｘ， ＬＬＣ | ３−（５置換−４−オキソキナゾリン−３（４ｈ）−イル）−３−ジュウテロピペリジン−２，６−ジオン誘導体 |
| WO2014116573A1 (en) | 2013-01-22 | 2014-07-31 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
| CA2941560A1 (en) | 2013-03-14 | 2014-09-25 | Deuterx, Llc | 3-(substituted-4-oxo-quinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| US9809603B1 (en) | 2015-08-18 | 2017-11-07 | Deuterx, Llc | Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same |
| BR112019011200B1 (pt) | 2016-12-01 | 2021-12-28 | Arvinas Operations, Inc | Derivados de tetrahidronaftaleno e tetrahidroisoquinolina como degradadores do receptor de estrogênio |
| WO2018140671A1 (en) * | 2017-01-27 | 2018-08-02 | Celgene Corporation | 3-(1-oxo-4-((4-((3-oxomorpholino) methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione and isotopologues thereof |
| TWI787284B (zh) | 2017-06-22 | 2022-12-21 | 美商西建公司 | 以b型肝炎病毒感染表徵之肝細胞癌之治療 |
| IL281845B2 (en) | 2018-10-01 | 2025-06-01 | Celgene Corp | Combination therapy comprising 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and daratumumab for the treatment multiple myeloma |
| CA3117978A1 (en) | 2018-11-08 | 2020-05-14 | Juno Therapeutics, Inc. | Methods and combinations for treatment and t cell modulation |
| KR20220054347A (ko) | 2019-08-26 | 2022-05-02 | 아비나스 오퍼레이션스, 인코포레이티드 | 에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 유도체로 유방암을 치료하는 방법 |
| WO2021080931A1 (en) | 2019-10-21 | 2021-04-29 | Celgene Corporation | Solid forms comprising (s)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dioneand salts thereof, and compositions comprising the same and their use |
| IL292667B1 (en) * | 2019-11-07 | 2026-02-01 | Juno Therapeutics Inc | Combination of T-cell therapy and (s)-3-[4-(4-morpholin-4-ylmethyl-benzyloxy)-l-oxo-3,l-dihydro-isoindol-2-yl]-piperidine-6,2-dione |
| WO2022056368A1 (en) * | 2020-09-14 | 2022-03-17 | Arvinas Operations, Inc. | Crystalline forms of a compound for the targeted degradation of estrogen receptor |
| CA3227425A1 (en) * | 2021-07-26 | 2023-02-02 | Arvinas Operations, Inc. | Methods of manufacturing a bifunctional compound |
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