JP2013529647A5 - - Google Patents
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- JP2013529647A5 JP2013529647A5 JP2013516840A JP2013516840A JP2013529647A5 JP 2013529647 A5 JP2013529647 A5 JP 2013529647A5 JP 2013516840 A JP2013516840 A JP 2013516840A JP 2013516840 A JP2013516840 A JP 2013516840A JP 2013529647 A5 JP2013529647 A5 JP 2013529647A5
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 19
- 201000010099 disease Diseases 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- 208000035475 disorder Diseases 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 6
- 201000008383 nephritis Diseases 0.000 claims 5
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 208000026106 cerebrovascular disease Diseases 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 208000010247 contact dermatitis Diseases 0.000 claims 2
- 230000002526 effect on cardiovascular system Effects 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 206010025135 lupus erythematosus Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000005590 Anaphylatoxin C5a Receptor Human genes 0.000 claims 1
- 108010059426 Anaphylatoxin C5a Receptor Proteins 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010011091 Coronary artery thrombosis Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
- 206010018910 Haemolysis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000004852 Lung Injury Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
- 208000034486 Multi-organ failure Diseases 0.000 claims 1
- 208000010718 Multiple Organ Failure Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 241000721454 Pemphigus Species 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 1
- 206010069363 Traumatic lung injury Diseases 0.000 claims 1
- 206010052568 Urticaria chronic Diseases 0.000 claims 1
- 206010053648 Vascular occlusion Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000024376 chronic urticaria Diseases 0.000 claims 1
- 208000002528 coronary thrombosis Diseases 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000008588 hemolysis Effects 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 1
- 231100000515 lung injury Toxicity 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 206010043554 thrombocytopenia Diseases 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 208000021331 vascular occlusion disease Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/823,039 | 2010-06-24 | ||
| US12/823,039 US20100311753A1 (en) | 2008-12-22 | 2010-06-24 | C5aR ANTAGONISTS |
| US13/072,616 US20110275639A1 (en) | 2008-12-22 | 2011-03-25 | C5aR ANTAGONISTS |
| US13/072,616 | 2011-03-25 | ||
| PCT/US2011/041910 WO2011163640A1 (en) | 2010-06-24 | 2011-06-24 | C5ar antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016053725A Division JP6189989B2 (ja) | 2010-06-24 | 2016-03-17 | Ｃ５ａＲアンタゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013529647A JP2013529647A (ja) | 2013-07-22 |
| JP2013529647A5 true JP2013529647A5 (enExample) | 2014-08-14 |
Family
ID=47996916
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516840A Withdrawn JP2013529647A (ja) | 2010-06-24 | 2011-06-24 | Ｃ５ａＲアンタゴニスト |
| JP2016053725A Active JP6189989B2 (ja) | 2010-06-24 | 2016-03-17 | Ｃ５ａＲアンタゴニスト |
| JP2017150928A Active JP6438086B2 (ja) | 2010-06-24 | 2017-08-03 | Ｃ５ａＲアンタゴニスト |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016053725A Active JP6189989B2 (ja) | 2010-06-24 | 2016-03-17 | Ｃ５ａＲアンタゴニスト |
| JP2017150928A Active JP6438086B2 (ja) | 2010-06-24 | 2017-08-03 | Ｃ５ａＲアンタゴニスト |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US9126939B2 (enExample) |
| EP (1) | EP2585064B1 (enExample) |
| JP (3) | JP2013529647A (enExample) |
| CN (1) | CN103068385B (enExample) |
| BR (1) | BR112012033075B1 (enExample) |
| DK (1) | DK2585064T3 (enExample) |
| ES (1) | ES2632975T3 (enExample) |
| HR (1) | HRP20171176T1 (enExample) |
| HU (1) | HUE033644T2 (enExample) |
| PL (1) | PL2585064T3 (enExample) |
| PT (1) | PT2585064T (enExample) |
| RS (1) | RS56332B1 (enExample) |
| SI (1) | SI2585064T1 (enExample) |
| WO (1) | WO2011163640A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5819730B2 (ja) | 2008-12-22 | 2015-11-24 | ケモセントリックス，インコーポレイティド | Ｃ５ａＲアンタゴニスト |
| US20110275639A1 (en) * | 2008-12-22 | 2011-11-10 | Chemocentryx, Inc. | C5aR ANTAGONISTS |
| DK2585064T3 (en) * | 2010-06-24 | 2017-07-24 | Chemocentryx Inc | C5aR antagonists |
| IL311677B2 (en) | 2014-01-13 | 2025-06-01 | Aurigene Oncology Ltd | Bicyclic heterocyclyl derivatives as irak4 inhibitors |
| CA2952188A1 (en) * | 2014-06-20 | 2015-12-23 | Aurigene Discovery Technologies Limited | Substituted indazole compounds as irak4 inhibitors |
| JP6898229B6 (ja) | 2014-09-29 | 2021-07-28 | ケモセントリックス，インコーポレイティド | Ｃ５ａＲアンタゴニスト製造における方法及び中間体 |
| SG11201805828YA (en) * | 2016-01-14 | 2018-08-30 | Chemocentryx Inc | Method of treating c3 glomerulopathy |
| SG11201808625QA (en) * | 2016-04-04 | 2018-10-30 | Chemocentryx Inc | SOLUBLE C5aR ANTAGONISTS |
| CN120267671A (zh) | 2017-03-31 | 2025-07-08 | 奥锐金肿瘤有限公司 | 用于治疗血液病的化合物和组合物 |
| DK3411400T3 (da) | 2017-04-03 | 2021-10-11 | Inflarx Gmbh | Behandling af inflammatoriske sygdomme med hæmmere af c5a-aktivitet |
| JP7141129B2 (ja) | 2017-05-31 | 2022-09-22 | ケモセントリックス，インコーポレイティド | Ｃ５ａ阻害剤としての５－５融合環 |
| KR102638253B1 (ko) | 2017-05-31 | 2024-02-16 | 케모센트릭스, 인크. | C5a 억제제로서의 6-5 융합 고리 |
| AU2018286754A1 (en) * | 2017-06-23 | 2019-12-19 | Inflarx Gmbh | Treatment of inflammatory diseases with inhibitors of C5A activity |
| CN111741754A (zh) * | 2017-10-30 | 2020-10-02 | 凯莫森特里克斯股份有限公司 | 作为免疫调节剂的氘代化合物 |
| EP4410377A3 (en) | 2017-10-31 | 2024-11-13 | Curis, Inc. | Compounds and compositions for treating hematological disorders |
| KR20200109297A (ko) * | 2017-10-31 | 2020-09-22 | 케모센트릭스, 인크. | 소변 sCD163의 C5aR 억제제 감소 |
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| MA51327A (fr) | 2017-12-22 | 2021-05-26 | Chemocentryx Inc | Composés cycliques fusionnés en 5,5 à substitution diaryle, utilisés en tant qu'inhibiteurs du c5ar |
| UA124694C2 (uk) * | 2018-01-10 | 2021-10-27 | Ідорсія Фармасьютікалз Лтд | 2,4,6,7-ТЕТРАГІДРОПІРАЗОЛО[4,3-d]ПІРИМІДИН-5-ОНОВІ ПОХІДНІ ТА СПОРІДНЕНІ СПОЛУКИ ЯК МОДУЛЯТОРИ РЕЦЕПТОРА C5A ДЛЯ ЛІКУВАННЯ ВАСКУЛІТУ ТА ЗАПАЛЬНИХ ЗАХВОРЮВАНЬ |
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| CN108727354A (zh) * | 2018-05-16 | 2018-11-02 | 张玉叶 | 一种甲酰胺类衍生物及其在抗肿瘤药物中的应用 |
| CN108440513A (zh) * | 2018-05-16 | 2018-08-24 | 张玉叶 | 一种甲酰胺类衍生物及其在抗肿瘤药物中的应用 |
| CN108440514A (zh) * | 2018-05-16 | 2018-08-24 | 张玉叶 | 一种甲酰胺类衍生物、制备方法及其在抗肿瘤药物中的应用 |
| CN108727355A (zh) * | 2018-05-16 | 2018-11-02 | 张玉叶 | 一种甲酰胺类衍生物、制备方法及其在抗肿瘤药物中的应用 |
| JP2021527062A (ja) | 2018-06-07 | 2021-10-11 | ケモセントリックス，インコーポレイティド | ＡＮＣＡ関連血管炎に対するｃ５ａアンタゴニストの投薬及び効果 |
| CN113164403A (zh) | 2018-11-30 | 2021-07-23 | 凯莫森特里克斯股份有限公司 | 胶囊制剂 |
| KR102890201B1 (ko) | 2019-07-10 | 2025-11-24 | 케모센트릭스, 인크. | Pd-l1 억제제로서의 인단 |
| ES3068390T3 (en) | 2019-10-16 | 2026-05-29 | Chemocentryx Inc | Heteroaryl-biphenyl amides for the treatment of pd-l1 diseases |
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| KR20220098754A (ko) * | 2019-11-08 | 2022-07-12 | 케모센트릭스, 인크. | 보체 성분 C5a 수용체의 비정질 형태 |
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| DK2585064T3 (en) | 2010-06-24 | 2017-07-24 | Chemocentryx Inc | C5aR antagonists |
| CA2877526A1 (en) | 2012-06-20 | 2013-12-27 | Novartis Ag | Complement pathway modulators and uses thereof |
| JP6898229B6 (ja) * | 2014-09-29 | 2021-07-28 | ケモセントリックス，インコーポレイティド | Ｃ５ａＲアンタゴニスト製造における方法及び中間体 |
| SG11201805828YA (en) | 2016-01-14 | 2018-08-30 | Chemocentryx Inc | Method of treating c3 glomerulopathy |
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2011
- 2011-06-24 DK DK11799027.5T patent/DK2585064T3/en active
- 2011-06-24 PL PL11799027T patent/PL2585064T3/pl unknown
- 2011-06-24 HR HRP20171176TT patent/HRP20171176T1/hr unknown
- 2011-06-24 SI SI201131229T patent/SI2585064T1/sl unknown
- 2011-06-24 EP EP11799027.5A patent/EP2585064B1/en active Active
- 2011-06-24 HU HUE11799027A patent/HUE033644T2/en unknown
- 2011-06-24 PT PT117990275T patent/PT2585064T/pt unknown
- 2011-06-24 CN CN201180039245.XA patent/CN103068385B/zh active Active
- 2011-06-24 ES ES11799027.5T patent/ES2632975T3/es active Active
- 2011-06-24 RS RS20170761A patent/RS56332B1/sr unknown
- 2011-06-24 WO PCT/US2011/041910 patent/WO2011163640A1/en not_active Ceased
- 2011-06-24 JP JP2013516840A patent/JP2013529647A/ja not_active Withdrawn
- 2011-06-24 US US13/806,339 patent/US9126939B2/en active Active
- 2011-06-24 BR BR112012033075-6A patent/BR112012033075B1/pt active IP Right Grant
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2015
- 2015-09-04 US US14/846,487 patent/US9573897B2/en active Active
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2016
- 2016-03-17 JP JP2016053725A patent/JP6189989B2/ja active Active
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2017
- 2017-01-06 US US15/400,820 patent/US20170114017A1/en not_active Abandoned
- 2017-08-03 JP JP2017150928A patent/JP6438086B2/ja active Active
- 2017-10-02 US US15/722,819 patent/US10035768B2/en active Active
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2018
- 2018-06-27 US US16/020,139 patent/US20190062275A1/en not_active Abandoned
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2020
- 2020-10-20 US US17/075,131 patent/US20210269398A1/en not_active Abandoned
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2022
- 2022-09-26 US US17/935,434 patent/US20230102258A1/en not_active Abandoned
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2026
- 2026-03-16 US US19/568,426 patent/US20260209179A1/en active Pending
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