JP2013529647A - Ｃ５ａＲアンタゴニスト - Google Patents

Ｃ５ａＲアンタゴニスト Download PDF

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JP2013529647A
JP2013529647A JP2013516840A JP2013516840A JP2013529647A JP 2013529647 A JP2013529647 A JP 2013529647A JP 2013516840 A JP2013516840 A JP 2013516840A JP 2013516840 A JP2013516840 A JP 2013516840A JP 2013529647 A JP2013529647 A JP 2013529647A
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alkyl
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heteroaryl
disease
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JP2013529647A5 (enExample
Inventor
ファン ピンチェン
ロイド グリーンマン ケビン
レディ レレティ マンモハン
ヤンドン リ
パワーズ ジェイ
裕子 田中
チュ ヤン
イービン ツェン
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ケモセントリックス，インコーポレイティド
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Priority claimed from US12/823,039 external-priority patent/US20100311753A1/en
Priority claimed from US13/072,616 external-priority patent/US20110275639A1/en
Application filed by ケモセントリックス，インコーポレイティド filed Critical ケモセントリックス，インコーポレイティド
Publication of JP2013529647A publication Critical patent/JP2013529647A/ja
Publication of JP2013529647A5 publication Critical patent/JP2013529647A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Diabetes (AREA)
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JP2013516840A 2010-06-24 2011-06-24 Ｃ５ａＲアンタゴニスト Withdrawn JP2013529647A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/823,039 2010-06-24
US12/823,039 US20100311753A1 (en) 2008-12-22 2010-06-24 C5aR ANTAGONISTS
US13/072,616 US20110275639A1 (en) 2008-12-22 2011-03-25 C5aR ANTAGONISTS
US13/072,616 2011-03-25
PCT/US2011/041910 WO2011163640A1 (en) 2010-06-24 2011-06-24 C5ar antagonists

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JP2016053725A Division JP6189989B2 (ja) 2010-06-24 2016-03-17 Ｃ５ａＲアンタゴニスト

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JP2013529647A true JP2013529647A (ja) 2013-07-22
JP2013529647A5 JP2013529647A5 (enExample) 2014-08-14

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JP6438086B2 (ja) 2018-12-12
US10035768B2 (en) 2018-07-31
EP2585064B1 (en) 2017-05-03
PT2585064T (pt) 2017-08-08
EP2585064A1 (en) 2013-05-01
US20170114017A1 (en) 2017-04-27
US20180179160A1 (en) 2018-06-28
JP2017193586A (ja) 2017-10-26
US20160229802A1 (en) 2016-08-11
US20130172347A1 (en) 2013-07-04
US20190062275A1 (en) 2019-02-28
BR112012033075B1 (pt) 2021-06-01
JP2016130249A (ja) 2016-07-21
HUE033644T2 (en) 2017-12-28
EP2585064A4 (en) 2014-01-15

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