JP2016529218A5 - - Google Patents
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- Publication number
- JP2016529218A5 JP2016529218A5 JP2016522860A JP2016522860A JP2016529218A5 JP 2016529218 A5 JP2016529218 A5 JP 2016529218A5 JP 2016522860 A JP2016522860 A JP 2016522860A JP 2016522860 A JP2016522860 A JP 2016522860A JP 2016529218 A5 JP2016529218 A5 JP 2016529218A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- solvate
- hydrate
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CPTWVPNVJXMMAV-UHFFFAOYSA-N CC(CC1)(CCC1NS(c(cc1)ccc1-c(c(C#N)c1)ccc1F)(=O)=O)O Chemical compound CC(CC1)(CCC1NS(c(cc1)ccc1-c(c(C#N)c1)ccc1F)(=O)=O)O CPTWVPNVJXMMAV-UHFFFAOYSA-N 0.000 description 1
- ZUUDKJLERCGKNN-UHFFFAOYSA-N CC(CC1)(CCC1NS(c(cc1)ccc1-c(ccc(C#N)c1)c1F)(=O)=O)O Chemical compound CC(CC1)(CCC1NS(c(cc1)ccc1-c(ccc(C#N)c1)c1F)(=O)=O)O ZUUDKJLERCGKNN-UHFFFAOYSA-N 0.000 description 1
- QHCZIGWQXAUGTL-UHFFFAOYSA-N CC(CC1)(CCC1NS(c1ccc(-c(c(F)c2)ccc2F)c(F)c1)(=O)=O)O Chemical compound CC(CC1)(CCC1NS(c1ccc(-c(c(F)c2)ccc2F)c(F)c1)(=O)=O)O QHCZIGWQXAUGTL-UHFFFAOYSA-N 0.000 description 1
- CPTWVPNVJXMMAV-MSEWRSJXSA-N C[C@](CC1)(CC[C@@H]1NS(c(cc1)ccc1-c(c(C#N)c1)ccc1F)(=O)=O)O Chemical compound C[C@](CC1)(CC[C@@H]1NS(c(cc1)ccc1-c(c(C#N)c1)ccc1F)(=O)=O)O CPTWVPNVJXMMAV-MSEWRSJXSA-N 0.000 description 1
- SIXCIFGYNGVAPI-WEHONNDLSA-N C[C@]1(CC[C@@H](CNS(c(cc2)ccc2-c(c(C#N)c2)ccc2Cl)(=O)=O)CC1)O Chemical compound C[C@]1(CC[C@@H](CNS(c(cc2)ccc2-c(c(C#N)c2)ccc2Cl)(=O)=O)CC1)O SIXCIFGYNGVAPI-WEHONNDLSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1311361.8A GB201311361D0 (en) | 2013-06-26 | 2013-06-26 | Compounds and their therapeutic use |
| GB1311361.8 | 2013-06-26 | ||
| PCT/GB2014/051921 WO2014207445A1 (en) | 2013-06-26 | 2014-06-24 | N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and their therapeutic use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016529218A JP2016529218A (ja) | 2016-09-23 |
| JP2016529218A5 true JP2016529218A5 (enExample) | 2017-07-13 |
| JP6360555B2 JP6360555B2 (ja) | 2018-07-18 |
Family
ID=48998987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016522860A Active JP6360555B2 (ja) | 2013-06-26 | 2014-06-24 | Ｎ−（４−ヒドロキシ−４−メチル−シクロヘキシル）−４−フェニル−ベンゼンスルホンアミド及びｎ−（４−ヒドロキシ−４−メチル−シクロヘキシル）−４−（２−ピリジル）ベンゼンスルホンアミド、並びにそれらの治療的使用 |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US9624167B2 (enExample) |
| EP (1) | EP3013799B1 (enExample) |
| JP (1) | JP6360555B2 (enExample) |
| KR (1) | KR102151299B1 (enExample) |
| CN (1) | CN105492426B (enExample) |
| AU (1) | AU2014300745B2 (enExample) |
| BR (1) | BR112015031527B1 (enExample) |
| CA (1) | CA2915075C (enExample) |
| CY (1) | CY1119438T1 (enExample) |
| DK (1) | DK3013799T3 (enExample) |
| EA (1) | EA028077B1 (enExample) |
| ES (1) | ES2641758T3 (enExample) |
| GB (1) | GB201311361D0 (enExample) |
| HR (1) | HRP20171611T1 (enExample) |
| HU (1) | HUE034983T2 (enExample) |
| IL (1) | IL243103B (enExample) |
| LT (1) | LT3013799T (enExample) |
| ME (1) | ME02834B (enExample) |
| MX (1) | MX374328B (enExample) |
| NZ (1) | NZ715192A (enExample) |
| PL (1) | PL3013799T3 (enExample) |
| PT (1) | PT3013799T (enExample) |
| RS (1) | RS56256B1 (enExample) |
| SG (1) | SG11201510646SA (enExample) |
| SI (1) | SI3013799T1 (enExample) |
| SM (1) | SMT201700503T1 (enExample) |
| WO (1) | WO2014207445A1 (enExample) |
| ZA (1) | ZA201600202B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
| GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
| LT3262028T (lt) * | 2014-12-17 | 2022-01-10 | Pimco 2664 Limited | N-(4-hidroksi-4-metil-cikloheksil)-4-fenil-benzensulfonamido ir n-(-4-hidroksi-4-metil-cikloheksil)-4-(2-piridil)-benzensulfonamido junginiai ir jų terapinis panaudojimas |
| GB201813312D0 (en) | 2018-08-15 | 2018-09-26 | Modern Biosciences Ltd | Compounds and their therapeutic use |
| GB201905520D0 (en) * | 2019-04-18 | 2019-06-05 | Modern Biosciences Ltd | Compounds and their therapeutic use |
| EP4431090A1 (en) | 2023-03-15 | 2024-09-18 | Istesso 1 Limited | Solfonamides acting as mitochondrial complex i modulator compounds |
| GB202308547D0 (en) | 2023-06-08 | 2023-07-26 | Istesso 2 Ltd | Tnf inhibitor combination therapies |
| GB202309515D0 (en) | 2023-06-23 | 2023-08-09 | Istesso 2 Ltd | JAK inhibitor and IL-6 inhibitor combination therapies |
| GB202315822D0 (en) | 2023-10-16 | 2023-11-29 | Istesso 3 Ltd | Anti-fibrotic combination therapeutics |
| GB202317050D0 (en) | 2023-11-07 | 2023-12-20 | Istesso 2 Ltd | Disease modifying anti-rheumatic drug combination therapies |
| EP4647071A1 (en) | 2024-05-10 | 2025-11-12 | Istesso Therapeutics Limited | Mitochondrial complex i modulator for use in the treatment of arthritis |
| GB202411554D0 (en) | 2024-08-06 | 2024-09-18 | Istesso 2 Ltd | NF-kB inhibitor combination therapies |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB597810A (en) | 1943-04-12 | 1948-02-04 | Gen Printing Ink Corp | Improvements in or relating to derivatives of diphenyl |
| DE1046220B (de) | 1956-04-21 | 1958-12-11 | Bayer Ag | Verfahren zur Herstellung von Monoazofarbstoffen und deren Metallkomplexverbindungen |
| US4119784A (en) | 1977-07-01 | 1978-10-10 | American Cyanamid Company | Anionic substituted sulfonamido biphenyls |
| DE3000519A1 (de) | 1979-02-01 | 1980-08-14 | Byk Gulden Lomberg Chem Fab | Sulfonamido-alkansaeuren, ihre verwendung und herstellung sowie sie enthaltende arzneimittel |
| DE3535167A1 (de) | 1985-10-02 | 1987-04-09 | Boehringer Mannheim Gmbh | Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel |
| IL118325A0 (en) | 1995-05-25 | 1996-10-31 | Pont Merck And Pharmaceutical | Integrin receptor antagonists and pharmaceutical compositions containing them |
| CZ132798A3 (cs) | 1995-10-30 | 1999-02-17 | Smithkline Beecham Corporation | Inhibitory proteázy |
| US5760028A (en) | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
| EP0888344A1 (en) | 1996-03-15 | 1999-01-07 | The Du Pont Merck Pharmaceutical Company | Spirocycle integrin inhibitors |
| WO1998003166A1 (en) | 1996-07-22 | 1998-01-29 | Monsanto Company | Thiol sulfonamide metalloprotease inhibitors |
| HUP0000641A3 (en) | 1996-10-16 | 2001-02-28 | American Cyanamid Company Madi | Ortho-sulfonamido aryl hydroxamic acid derivatives, their use, as matrix metalloproteinase and tace inhibitors and pharmaceutical compositions containing them |
| WO1998023608A1 (en) | 1996-11-27 | 1998-06-04 | Dupont Pharmaceuticals Company | Novel integrin receptor antagonists |
| WO1998043962A1 (en) | 1997-03-28 | 1998-10-08 | Du Pont Pharmaceuticals Company | Heterocyclic integrin inhibitor prodrugs |
| AU734302B2 (en) | 1997-05-08 | 2001-06-07 | Smithkline Beecham Corporation | Protease inhibitors |
| DE19719621A1 (de) | 1997-05-09 | 1998-11-12 | Hoechst Ag | Sulfonylaminocarbonsäuren |
| PT877019E (pt) | 1997-05-09 | 2002-05-31 | Hoechst Ag | Acidos diaminocarboxilicos substituidos |
| US6291425B1 (en) | 1999-09-01 | 2001-09-18 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage |
| JP2002501054A (ja) | 1998-01-23 | 2002-01-15 | アヴェンティス ファルマ ドイチェラント ゲーエムベーハー | 骨吸収の阻害剤として及び細胞接着の阻害剤としての新規のスルホンアミド誘導体 |
| EP1053226A1 (en) | 1998-02-04 | 2000-11-22 | Novartis AG | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
| JPH11246527A (ja) | 1998-03-02 | 1999-09-14 | Shionogi & Co Ltd | Ｍｍｐ−８阻害剤 |
| DE19815547C1 (de) | 1998-04-07 | 1999-12-02 | Joachim Schmidt | Haftmittel für Zahnprothesen |
| EP0960882A1 (en) | 1998-05-19 | 1999-12-01 | Hoechst Marion Roussel Deutschland GmbH | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists |
| CN1418210A (zh) | 2000-03-21 | 2003-05-14 | 宝洁公司 | 含有碳环侧链的n－取代金属蛋白酶抑制剂 |
| WO2001090077A1 (en) | 2000-05-19 | 2001-11-29 | Guilford Pharmaceuticals, Inc. | Sulfonamide and carbamide derivatives of 6(5h)phenanthridinones and their uses |
| AU2002228316A1 (en) | 2001-01-29 | 2002-08-12 | Insight Strategy And Marketing Ltd | Carbazole derivatives and their uses as heparanase inhibitors |
| JPWO2002074298A1 (ja) | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Ｉｌ−６産生阻害剤 |
| US6849635B2 (en) | 2001-05-07 | 2005-02-01 | Smithkline Beecham Corporation | Sulfonamides |
| NZ531153A (en) | 2001-08-09 | 2005-10-28 | Ono Pharmaceutical Co | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
| GB0126157D0 (en) | 2001-10-31 | 2002-01-02 | Univ Aberdeen | Therapeutic compounds |
| TW200305396A (en) | 2002-03-27 | 2003-11-01 | Shionogi & Co | Cartilage extracellular matrix degradation |
| MXPA05002571A (es) | 2002-09-04 | 2005-09-08 | Schering Corp | Pirazolopirimidinas como inhibidores de cinasa dependientes de ciclina. |
| DE10251170A1 (de) | 2002-10-31 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| WO2004073619A2 (en) | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Ccr8 antagonists |
| ES2298753T3 (es) | 2003-05-07 | 2008-05-16 | The University Court Of The University Of Aberdeen | Cetonas y cetonas reducidas como agentes terapeuticos para el tratamiento de enfermedades oseas. |
| JPWO2004106290A1 (ja) | 2003-05-14 | 2006-07-20 | キッセイ薬品工業株式会社 | アミノアルコール誘導体、それを含有する医薬組成物およびそれらの用途 |
| AR046330A1 (es) | 2003-09-09 | 2005-12-07 | Japan Tobacco Inc | Inhibidor de dipeptidilpeptidasa iv |
| GB0324792D0 (en) | 2003-10-23 | 2003-11-26 | Sterix Ltd | Compound |
| BRPI0417687A (pt) | 2003-12-19 | 2007-04-03 | Pfizer | derivados de benzenossulfonilamino-piridin-2-ila e compostos relacionados como inibidores de 11-beta-hidroxiesteróide desidrogenase tipo 1 (11-beta-hsd-1) para o tratamento de diabetes e obesidade |
| EP1723132A1 (en) | 2004-02-12 | 2006-11-22 | Asterand Uk Limited | Ep2 receptor agonists |
| GB0405193D0 (en) | 2004-03-08 | 2004-04-21 | Medical Res Council | Compounds |
| US20080255240A1 (en) | 2004-05-05 | 2008-10-16 | Novo Nordisk A/S | Sulfonamide Derivatives |
| GB0412553D0 (en) | 2004-06-04 | 2004-07-07 | Univ Aberdeen | Therapeutic agents for the treatment of bone conditions |
| WO2005123089A2 (en) | 2004-06-10 | 2005-12-29 | Kalypsys, Inc. | Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease |
| CA2584413A1 (en) | 2004-10-29 | 2006-05-04 | Astrazeneca Ab | Novel sulphonamide derivatives as glucocorticoid receptor modulators for the treatment of inflammatory diseases |
| EP1659113A1 (en) | 2004-11-08 | 2006-05-24 | Evotec AG | Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) |
| EA200702498A1 (ru) | 2005-06-16 | 2008-06-30 | Пфайзер Инк. | N-(пиридин-2-ил)сульфонамидные производные |
| WO2007008541A2 (en) | 2005-07-08 | 2007-01-18 | Kalypsys, Inc. | Cellular cholesterol absorption modifiers |
| TW200720261A (en) | 2005-08-31 | 2007-06-01 | Sankyo Co | Phenylene derivatives |
| EP2774925B1 (en) | 2005-11-08 | 2016-12-28 | Vertex Pharmaceuticals Incorporated | Heterocyclic modulators of ATP-binding cassette transporters |
| EA019879B1 (ru) | 2005-12-29 | 2014-07-30 | Лексикон Фармасьютикалз, Инк. | Полициклические производные аминокислот, содержащая их фармацевтическая композиция и способ лечения, использующий эти производные |
| US7560597B2 (en) | 2007-03-08 | 2009-07-14 | The University Court Of The University Of Aberdeen | 2′,4′-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds and their use as therapeutic agents |
| GB0705400D0 (en) | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
| WO2010025235A1 (en) | 2008-08-29 | 2010-03-04 | Regents Of The University Of Michigan | Selective ligands for the dopamine 3 (d3) receptor and methods of using the same |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| GB0817208D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
| GB0817207D0 (en) * | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
| GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
| LT3262028T (lt) | 2014-12-17 | 2022-01-10 | Pimco 2664 Limited | N-(4-hidroksi-4-metil-cikloheksil)-4-fenil-benzensulfonamido ir n-(-4-hidroksi-4-metil-cikloheksil)-4-(2-piridil)-benzensulfonamido junginiai ir jų terapinis panaudojimas |
-
2013
- 2013-06-26 GB GBGB1311361.8A patent/GB201311361D0/en not_active Ceased
-
2014
- 2014-06-24 SM SM20170503T patent/SMT201700503T1/it unknown
- 2014-06-24 JP JP2016522860A patent/JP6360555B2/ja active Active
- 2014-06-24 DK DK14735642.2T patent/DK3013799T3/en active
- 2014-06-24 PL PL14735642T patent/PL3013799T3/pl unknown
- 2014-06-24 EA EA201592308A patent/EA028077B1/ru unknown
- 2014-06-24 SI SI201430364T patent/SI3013799T1/sl unknown
- 2014-06-24 CA CA2915075A patent/CA2915075C/en active Active
- 2014-06-24 RS RS20170876A patent/RS56256B1/sr unknown
- 2014-06-24 NZ NZ715192A patent/NZ715192A/en unknown
- 2014-06-24 EP EP14735642.2A patent/EP3013799B1/en active Active
- 2014-06-24 LT LTEP14735642.2T patent/LT3013799T/lt unknown
- 2014-06-24 ME MEP-2017-208A patent/ME02834B/me unknown
- 2014-06-24 MX MX2015016914A patent/MX374328B/es active IP Right Grant
- 2014-06-24 HU HUE14735642A patent/HUE034983T2/en unknown
- 2014-06-24 CN CN201480047140.2A patent/CN105492426B/zh active Active
- 2014-06-24 KR KR1020167002015A patent/KR102151299B1/ko active Active
- 2014-06-24 BR BR112015031527-5A patent/BR112015031527B1/pt active IP Right Grant
- 2014-06-24 AU AU2014300745A patent/AU2014300745B2/en active Active
- 2014-06-24 ES ES14735642.2T patent/ES2641758T3/es active Active
- 2014-06-24 US US14/899,422 patent/US9624167B2/en active Active
- 2014-06-24 WO PCT/GB2014/051921 patent/WO2014207445A1/en not_active Ceased
- 2014-06-24 PT PT147356422T patent/PT3013799T/pt unknown
- 2014-06-24 SG SG11201510646SA patent/SG11201510646SA/en unknown
- 2014-06-24 HR HRP20171611TT patent/HRP20171611T1/hr unknown
-
2015
- 2015-12-14 IL IL243103A patent/IL243103B/en active IP Right Grant
-
2016
- 2016-01-11 ZA ZA2016/00202A patent/ZA201600202B/en unknown
-
2017
- 2017-04-11 US US15/484,256 patent/US9796670B2/en active Active
- 2017-10-11 CY CY20171101060T patent/CY1119438T1/el unknown
- 2017-10-17 US US15/786,021 patent/US10029979B2/en active Active
-
2018
- 2018-07-17 US US16/037,048 patent/US10233147B2/en active Active
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