JP2016523301A5 - - Google Patents
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- Publication number
- JP2016523301A5 JP2016523301A5 JP2016522246A JP2016522246A JP2016523301A5 JP 2016523301 A5 JP2016523301 A5 JP 2016523301A5 JP 2016522246 A JP2016522246 A JP 2016522246A JP 2016522246 A JP2016522246 A JP 2016522246A JP 2016523301 A5 JP2016523301 A5 JP 2016523301A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- inhibitor
- pharmaceutically acceptable
- acceptable salt
- acid sulfate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 claims 13
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 10
- 239000003112 inhibitor Substances 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 102000007469 Actins Human genes 0.000 claims 4
- 108010085238 Actins Proteins 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 239000003638 chemical reducing agent Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000006277 sulfonation reaction Methods 0.000 claims 3
- 230000004614 tumor growth Effects 0.000 claims 3
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 229940122588 Heparanase inhibitor Drugs 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229940125532 enzyme inhibitor Drugs 0.000 claims 2
- 239000002532 enzyme inhibitor Substances 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 230000029115 microtubule polymerization Effects 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- KEQGZUUPPQEDPF-UHFFFAOYSA-N 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione Chemical group CC1(C)N(Cl)C(=O)N(Cl)C1=O KEQGZUUPPQEDPF-UHFFFAOYSA-N 0.000 claims 1
- IAJILQKETJEXLJ-SQOUGZDYSA-N L-guluronic acid Chemical group O=C[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O IAJILQKETJEXLJ-SQOUGZDYSA-N 0.000 claims 1
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 1
- 239000002257 antimetastatic agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- XTHPWXDJESJLNJ-UHFFFAOYSA-N chlorosulfonic acid Substances OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229910000652 nickel hydride Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 230000035484 reaction time Effects 0.000 claims 1
- 239000012279 sodium borohydride Substances 0.000 claims 1
- 229910000033 sodium borohydride Inorganic materials 0.000 claims 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310275323.7 | 2013-07-02 | ||
| CN201310275323.7A CN104277130A (zh) | 2013-07-02 | 2013-07-02 | 一种硫酸酯化聚古洛糖酸多糖或其可药用盐及其制备方法和用途 |
| PCT/CN2014/081472 WO2015000411A1 (zh) | 2013-07-02 | 2014-07-02 | 一种硫酸酯化聚古洛糖酸多糖或其可药用盐及其制备方法和用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019030255A Division JP6772318B2 (ja) | 2013-07-02 | 2019-02-22 | 硫酸化ポリグルロン酸多糖又はその薬学的塩、その調製方法及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016523301A JP2016523301A (ja) | 2016-08-08 |
| JP2016523301A5 true JP2016523301A5 (enExample) | 2017-08-10 |
| JP6757249B2 JP6757249B2 (ja) | 2020-09-16 |
Family
ID=52143111
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016522246A Expired - Fee Related JP6757249B2 (ja) | 2013-07-02 | 2014-07-02 | 硫酸化ポリグルロン酸多糖又はその薬学的塩、その調製方法及びその使用 |
| JP2019030255A Expired - Fee Related JP6772318B2 (ja) | 2013-07-02 | 2019-02-22 | 硫酸化ポリグルロン酸多糖又はその薬学的塩、その調製方法及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019030255A Expired - Fee Related JP6772318B2 (ja) | 2013-07-02 | 2019-02-22 | 硫酸化ポリグルロン酸多糖又はその薬学的塩、その調製方法及びその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10058566B2 (enExample) |
| EP (1) | EP3018147B1 (enExample) |
| JP (2) | JP6757249B2 (enExample) |
| KR (1) | KR102258569B1 (enExample) |
| CN (2) | CN104277130A (enExample) |
| AU (1) | AU2014286711B2 (enExample) |
| BR (1) | BR112015032849B1 (enExample) |
| CA (1) | CA2916749C (enExample) |
| DK (1) | DK3018147T3 (enExample) |
| EA (1) | EA028655B1 (enExample) |
| ES (1) | ES2674976T3 (enExample) |
| HU (1) | HUE038981T2 (enExample) |
| MX (1) | MX373099B (enExample) |
| PL (1) | PL3018147T3 (enExample) |
| PT (1) | PT3018147T (enExample) |
| SG (1) | SG11201510717SA (enExample) |
| TR (1) | TR201809674T4 (enExample) |
| WO (1) | WO2015000411A1 (enExample) |
| ZA (1) | ZA201509353B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104277130A (zh) * | 2013-07-02 | 2015-01-14 | 中国科学院上海药物研究所 | 一种硫酸酯化聚古洛糖酸多糖或其可药用盐及其制备方法和用途 |
| CN107904240A (zh) * | 2017-12-04 | 2018-04-13 | 辽东学院 | 一种抗肝癌细胞转移的抑制剂组合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3228231A1 (de) | 1982-07-28 | 1984-02-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München | Arzneimittel, calciummischsalze von polymeren, anionischen carbonsaeuren und/oder schwefelsaeureestern, verfahren zu ihrer herstellung und ihre verwendung |
| JPH0625304A (ja) | 1992-07-06 | 1994-02-01 | Higeta Shoyu Co Ltd | ガラクトサミン重合体硫酸化物及び該物質を 含有する抗ウイルス剤 |
| CN1132209A (zh) | 1995-03-27 | 1996-10-02 | 青岛海洋大学 | 一种新药多聚甘露糖醛酸硫酸盐 |
| GB2317182B (en) | 1996-09-11 | 2000-11-01 | Johnson & Johnson Medical | Sulfated polysaccharides and uses thereof in medical treatment |
| CN1473836A (zh) | 2003-08-04 | 2004-02-11 | 中国海洋大学 | 还原端1位为羧基的古罗糖醛酸寡糖及其衍生物 |
| CN1213071C (zh) * | 2003-11-25 | 2005-08-03 | 中国海洋大学 | 一种古糖酯及其制备方法和应用 |
| JP4897310B2 (ja) | 2006-02-28 | 2012-03-14 | 理研食品株式会社 | Ｌ−グルロン酸金属塩又はｄ−マンヌロン酸金属塩の製造方法 |
| JP2008027767A (ja) | 2006-07-21 | 2008-02-07 | Aomori Prefecture | 固体高分子電解質膜及び燃料電池 |
| CN101691410B (zh) * | 2009-09-18 | 2011-12-28 | 中国海洋大学 | 一种具有防治胰岛素抵抗作用的海洋寡糖铬配合物 |
| RU2553348C2 (ru) | 2010-03-10 | 2015-06-10 | Айновобайолоджик, Инк. | Продукт, содержащий глюкоманнан, ксантановую камедь и альгинат для лечения метаболических нарушений |
| CN102743409B (zh) | 2012-06-18 | 2013-11-20 | 中国海洋大学 | 聚甘露糖醛酸丙酯硫酸盐在制备抗甲型h1n1流感病毒药物中的应用 |
| CN104277130A (zh) * | 2013-07-02 | 2015-01-14 | 中国科学院上海药物研究所 | 一种硫酸酯化聚古洛糖酸多糖或其可药用盐及其制备方法和用途 |
-
2013
- 2013-07-02 CN CN201310275323.7A patent/CN104277130A/zh active Pending
-
2014
- 2014-07-02 CN CN201480038171.1A patent/CN105358582B/zh not_active Expired - Fee Related
- 2014-07-02 KR KR1020167002769A patent/KR102258569B1/ko not_active Expired - Fee Related
- 2014-07-02 DK DK14819337.8T patent/DK3018147T3/en active
- 2014-07-02 US US14/901,297 patent/US10058566B2/en not_active Expired - Fee Related
- 2014-07-02 WO PCT/CN2014/081472 patent/WO2015000411A1/zh not_active Ceased
- 2014-07-02 BR BR112015032849-0A patent/BR112015032849B1/pt not_active IP Right Cessation
- 2014-07-02 HU HUE14819337A patent/HUE038981T2/hu unknown
- 2014-07-02 MX MX2016000043A patent/MX373099B/es active IP Right Grant
- 2014-07-02 ES ES14819337.8T patent/ES2674976T3/es active Active
- 2014-07-02 SG SG11201510717SA patent/SG11201510717SA/en unknown
- 2014-07-02 AU AU2014286711A patent/AU2014286711B2/en not_active Ceased
- 2014-07-02 JP JP2016522246A patent/JP6757249B2/ja not_active Expired - Fee Related
- 2014-07-02 EP EP14819337.8A patent/EP3018147B1/en not_active Not-in-force
- 2014-07-02 PL PL14819337T patent/PL3018147T3/pl unknown
- 2014-07-02 CA CA2916749A patent/CA2916749C/en not_active Expired - Fee Related
- 2014-07-02 EA EA201690123A patent/EA028655B1/ru unknown
- 2014-07-02 TR TR2018/09674T patent/TR201809674T4/tr unknown
- 2014-07-02 PT PT148193378T patent/PT3018147T/pt unknown
-
2015
- 2015-12-23 ZA ZA2015/09353A patent/ZA201509353B/en unknown
-
2019
- 2019-02-22 JP JP2019030255A patent/JP6772318B2/ja not_active Expired - Fee Related
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