KR102258569B1 - 황산화 폴리굴론산 폴리사카라이드 또는 그의 제약 염, 그의 제조 방법 및 그의 용도 - Google Patents

황산화 폴리굴론산 폴리사카라이드 또는 그의 제약 염, 그의 제조 방법 및 그의 용도 Download PDF

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KR102258569B1
KR102258569B1 KR1020167002769A KR20167002769A KR102258569B1 KR 102258569 B1 KR102258569 B1 KR 102258569B1 KR 1020167002769 A KR1020167002769 A KR 1020167002769A KR 20167002769 A KR20167002769 A KR 20167002769A KR 102258569 B1 KR102258569 B1 KR 102258569B1
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inhibitor
acid sulfate
formula
polygulonic acid
pharmaceutically acceptable
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KR20160029817A (ko
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지안 딩
징 아이
이 첸
쉰 후앙
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상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00

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  • Life Sciences & Earth Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
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  • Dermatology (AREA)
  • Materials Engineering (AREA)
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  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR1020167002769A 2013-07-02 2014-07-02 황산화 폴리굴론산 폴리사카라이드 또는 그의 제약 염, 그의 제조 방법 및 그의 용도 Expired - Fee Related KR102258569B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201310275323.7 2013-07-02
CN201310275323.7A CN104277130A (zh) 2013-07-02 2013-07-02 一种硫酸酯化聚古洛糖酸多糖或其可药用盐及其制备方法和用途
PCT/CN2014/081472 WO2015000411A1 (zh) 2013-07-02 2014-07-02 一种硫酸酯化聚古洛糖酸多糖或其可药用盐及其制备方法和用途

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KR20160029817A KR20160029817A (ko) 2016-03-15
KR102258569B1 true KR102258569B1 (ko) 2021-05-28

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EP (1) EP3018147B1 (enExample)
JP (2) JP6757249B2 (enExample)
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CN (2) CN104277130A (enExample)
AU (1) AU2014286711B2 (enExample)
BR (1) BR112015032849B1 (enExample)
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104277130A (zh) * 2013-07-02 2015-01-14 中国科学院上海药物研究所 一种硫酸酯化聚古洛糖酸多糖或其可药用盐及其制备方法和用途
CN107904240A (zh) * 2017-12-04 2018-04-13 辽东学院 一种抗肝癌细胞转移的抑制剂组合物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689322A (en) 1982-07-28 1987-08-25 Algina Aktiengesellschaft Pharmaceutical products, calcium mixed salts of polymeric, anionic carboxylic acids and/or their esters of sulfuric acid, and methods for their preparation and use
CN1132209A (zh) 1995-03-27 1996-10-02 青岛海洋大学 一种新药多聚甘露糖醛酸硫酸盐
CN1473836A (zh) 2003-08-04 2004-02-11 中国海洋大学 还原端1位为羧基的古罗糖醛酸寡糖及其衍生物
CN1544475A (zh) * 2003-11-25 2004-11-10 中国海洋大学 一种古糖酯及其制备方法和应用
CN102743409A (zh) 2012-06-18 2012-10-24 中国海洋大学 聚甘露糖醛酸丙酯硫酸盐在制备抗甲型h1n1流感病毒药物中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0625304A (ja) 1992-07-06 1994-02-01 Higeta Shoyu Co Ltd ガラクトサミン重合体硫酸化物及び該物質を 含有する抗ウイルス剤
GB2317182B (en) 1996-09-11 2000-11-01 Johnson & Johnson Medical Sulfated polysaccharides and uses thereof in medical treatment
JP4897310B2 (ja) 2006-02-28 2012-03-14 理研食品株式会社 Ｌ−グルロン酸金属塩又はｄ−マンヌロン酸金属塩の製造方法
JP2008027767A (ja) 2006-07-21 2008-02-07 Aomori Prefecture 固体高分子電解質膜及び燃料電池
CN101691410B (zh) * 2009-09-18 2011-12-28 中国海洋大学 一种具有防治胰岛素抵抗作用的海洋寡糖铬配合物
RU2553348C2 (ru) 2010-03-10 2015-06-10 Айновобайолоджик, Инк. Продукт, содержащий глюкоманнан, ксантановую камедь и альгинат для лечения метаболических нарушений
CN104277130A (zh) * 2013-07-02 2015-01-14 中国科学院上海药物研究所 一种硫酸酯化聚古洛糖酸多糖或其可药用盐及其制备方法和用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689322A (en) 1982-07-28 1987-08-25 Algina Aktiengesellschaft Pharmaceutical products, calcium mixed salts of polymeric, anionic carboxylic acids and/or their esters of sulfuric acid, and methods for their preparation and use
CN1132209A (zh) 1995-03-27 1996-10-02 青岛海洋大学 一种新药多聚甘露糖醛酸硫酸盐
CN1473836A (zh) 2003-08-04 2004-02-11 中国海洋大学 还原端1位为羧基的古罗糖醛酸寡糖及其衍生物
CN1544475A (zh) * 2003-11-25 2004-11-10 中国海洋大学 一种古糖酯及其制备方法和应用
CN102743409A (zh) 2012-06-18 2012-10-24 中国海洋大学 聚甘露糖醛酸丙酯硫酸盐在制备抗甲型h1n1流感病毒药物中的应用

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EA028655B1 (ru) 2017-12-29
AU2014286711A1 (en) 2016-02-04
EA201690123A1 (ru) 2016-07-29
CA2916749C (en) 2021-03-09
MX2016000043A (es) 2016-05-31
CA2916749A1 (en) 2015-01-08
ES2674976T3 (es) 2018-07-05
CN104277130A (zh) 2015-01-14
CN105358582B (zh) 2018-09-21
MX373099B (es) 2020-03-31
JP6772318B2 (ja) 2020-10-21
JP2016523301A (ja) 2016-08-08
US10058566B2 (en) 2018-08-28
HUE038981T2 (hu) 2018-12-28
BR112015032849B1 (pt) 2021-09-14
EP3018147B1 (en) 2018-05-23
SG11201510717SA (en) 2016-01-28
KR20160029817A (ko) 2016-03-15
TR201809674T4 (tr) 2018-07-23
JP6757249B2 (ja) 2020-09-16
ZA201509353B (en) 2017-08-30
AU2014286711B2 (en) 2018-05-10
HK1220984A1 (zh) 2017-05-19
US20160367591A1 (en) 2016-12-22
JP2019090056A (ja) 2019-06-13
EP3018147A1 (en) 2016-05-11
PT3018147T (pt) 2018-07-17
WO2015000411A1 (zh) 2015-01-08
PL3018147T3 (pl) 2018-10-31
EP3018147A4 (en) 2017-04-05
DK3018147T3 (en) 2018-07-23
CN105358582A (zh) 2016-02-24
BR112015032849A2 (pt) 2020-05-12

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