|
US3872171A
(en)
|
1971-05-24 |
1975-03-18 |
Pfizer |
Polyamines as antiviral agents in animals
|
|
US4125544A
(en)
|
1977-06-09 |
1978-11-14 |
G. D. Searle |
20/22/23/24-Oxa-7-oxocholesterols and esters thereof
|
|
US4957735A
(en)
|
1984-06-12 |
1990-09-18 |
The University Of Tennessee Research Corporation |
Target-sensitive immunoliposomes- preparation and characterization
|
|
CA2357538A1
(en)
|
1989-03-21 |
1990-10-04 |
Wisconsin Alumni Research Foundation |
Expression of exogenous polynucleotide sequences in a vertebrate
|
|
FR2676072B1
(fr)
|
1991-05-03 |
1994-11-18 |
Transgene Sa |
Vecteur de delivrance d'arn.
|
|
JPH07503372A
(ja)
|
1992-01-23 |
1995-04-13 |
バイカル・インコーポレイテッド |
生体外遺伝子導入
|
|
US5807861A
(en)
|
1994-03-24 |
1998-09-15 |
Cell Therapeutics, Inc. |
Amine substituted xanthinyl compounds
|
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
US7288266B2
(en)
|
1996-08-19 |
2007-10-30 |
United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Liposome complexes for increased systemic delivery
|
|
US6143276A
(en)
|
1997-03-21 |
2000-11-07 |
Imarx Pharmaceutical Corp. |
Methods for delivering bioactive agents to regions of elevated temperatures
|
|
CA2304982A1
(en)
|
1997-09-19 |
1999-03-25 |
Sequitur, Inc. |
Sense mrna therapy
|
|
JP2001520889A
(ja)
|
1997-10-24 |
2001-11-06 |
バレンティス，インコーポレイティド |
ポリヌクレオチドトランスフェクション複合体を調製する方法
|
|
ATE550042T1
(de)
|
1997-11-20 |
2012-04-15 |
Vical Inc |
Behandlung von krebs mithilfe cytokin- exprimierender polynukleotide und zusammensetzungen dafür
|
|
US6432925B1
(en)
|
1998-04-16 |
2002-08-13 |
John Wayne Cancer Institute |
RNA cancer vaccine and methods for its use
|
|
GB9808268D0
(en)
|
1998-04-17 |
1998-06-17 |
Imp College Innovations Ltd |
Compound
|
|
US6395253B2
(en)
|
1998-04-23 |
2002-05-28 |
The Regents Of The University Of Michigan |
Microspheres containing condensed polyanionic bioactive agents and methods for their production
|
|
JP2000169864A
(ja)
|
1998-12-07 |
2000-06-20 |
New Japan Chem Co Ltd |
模型エンジン用燃料組成物
|
|
US8206749B1
(en)
|
1999-02-26 |
2012-06-26 |
Novartis Vaccines And Diagnostics, Inc. |
Microemulsions with adsorbed macromolecules and microparticles
|
|
AU7725500A
(en)
|
1999-09-30 |
2001-04-30 |
National Jewish Medical And Research Center |
Method for inhibition of pathogenic microorganisms
|
|
US7060291B1
(en)
|
1999-11-24 |
2006-06-13 |
Transave, Inc. |
Modular targeted liposomal delivery system
|
|
US20040142474A1
(en)
|
2000-09-14 |
2004-07-22 |
Expression Genetics, Inc. |
Novel cationic lipopolymer as a biocompatible gene delivery agent
|
|
US6696038B1
(en)
|
2000-09-14 |
2004-02-24 |
Expression Genetics, Inc. |
Cationic lipopolymer as biocompatible gene delivery agent
|
|
US7708915B2
(en)
|
2004-05-06 |
2010-05-04 |
Castor Trevor P |
Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein
|
|
US6652886B2
(en)
|
2001-02-16 |
2003-11-25 |
Expression Genetics |
Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
|
|
DE10109897A1
(de)
|
2001-02-21 |
2002-11-07 |
Novosom Ag |
Fakultativ kationische Liposomen und Verwendung dieser
|
|
US7025987B2
(en)
|
2001-05-30 |
2006-04-11 |
The Scripps Research Institute |
Delivery system for nucleic acids
|
|
DE10207178A1
(de)
|
2002-02-19 |
2003-09-04 |
Novosom Ag |
Komponenten für die Herstellung amphoterer Liposomen
|
|
US20050222064A1
(en)
|
2002-02-20 |
2005-10-06 |
Sirna Therapeutics, Inc. |
Polycationic compositions for cellular delivery of polynucleotides
|
|
US20050152980A1
(en)
|
2002-03-13 |
2005-07-14 |
Michael Ausborn |
Pharmeutical microparticles
|
|
ES2734652T3
(es)
|
2002-04-04 |
2019-12-11 |
Zoetis Belgium S A |
Oligorribonucleótidos inmunoestimulantes que contienen G y U
|
|
EP1519714B1
(en)
|
2002-06-28 |
2010-10-20 |
Protiva Biotherapeutics Inc. |
Method and apparatus for producing liposomes
|
|
US8668926B1
(en)
|
2003-09-15 |
2014-03-11 |
Shaker A. Mousa |
Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof
|
|
WO2005034979A2
(en)
|
2003-10-11 |
2005-04-21 |
Inex Pharmaceuticals Corporation |
Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity
|
|
WO2005062854A2
(en)
|
2003-12-19 |
2005-07-14 |
University Of Cincinnati |
Polyamides for nucleic acid delivery
|
|
US7745651B2
(en)
|
2004-06-07 |
2010-06-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use
|
|
WO2005121348A1
(en)
|
2004-06-07 |
2005-12-22 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering rna
|
|
AU2005260763B2
(en)
|
2004-06-30 |
2011-12-22 |
Nektar Therapeutics |
Polymer-factor IX moiety conjugates
|
|
US8663599B1
(en)
|
2004-10-05 |
2014-03-04 |
Gp Medical, Inc. |
Pharmaceutical composition of nanoparticles
|
|
CA2590098C
(en)
|
2004-12-10 |
2015-03-31 |
Justin Hanes |
Functionalized poly (ether-anhydride) block copolymers
|
|
CA2611944A1
(en)
|
2005-06-15 |
2006-12-28 |
Massachusetts Institute Of Technology |
Amine-containing lipids and uses thereof
|
|
WO2007109244A2
(en)
|
2006-03-21 |
2007-09-27 |
Morehouse School Of Medicine |
Novel nanoparticles for delivery of active agents
|
|
CA2648099C
(en)
|
2006-03-31 |
2012-05-29 |
The Brigham And Women's Hospital, Inc |
System for targeted delivery of therapeutic agents
|
|
US8367113B2
(en)
|
2006-05-15 |
2013-02-05 |
Massachusetts Institute Of Technology |
Polymers for functional particles
|
|
JP5571380B2
(ja)
|
2006-07-24 |
2014-08-13 |
ルミナス バイオサイエンシズ，インコーポレイテッド |
オストワルド熟成を減少させた水不溶性の医薬品物質の固体ナノ粒子処方物
|
|
ES2430206T3
(es)
|
2006-10-03 |
2013-11-19 |
Tekmira Pharmaceuticals Corporation |
Formulación que contiene lípidos
|
|
RU2492872C2
(ru)
|
2006-10-05 |
2013-09-20 |
Дзе Джонс Хопкинс Юниверсити |
Вододиспергируемые пероральные, парентеральные и местные композиции для плохо растворимых в воде лекарственных препаратов, включающие улучшающие их свойства полимерные наночастицы
|
|
CA2680206C
(en)
|
2007-03-05 |
2015-07-07 |
Washington University |
Nanoparticle delivery systems for membrane-integrating peptides
|
|
US8703204B2
(en)
|
2007-05-03 |
2014-04-22 |
Bend Research, Inc. |
Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
|
|
LT2494993T
(lt)
|
2007-05-04 |
2018-12-27 |
Marina Biotech, Inc. |
Aminorūgščių lipidai ir jų panaudojimas
|
|
US9144546B2
(en)
|
2007-08-06 |
2015-09-29 |
Clsn Laboratories, Inc. |
Nucleic acid-lipopolymer compositions
|
|
US20090042825A1
(en)
|
2007-08-06 |
2009-02-12 |
Majed Matar |
Composition, method of preparation & application of concentrated formulations of condensed nucleic acids with a cationic lipopolymer
|
|
EP2183390A1
(en)
|
2007-08-23 |
2010-05-12 |
Novartis Ag |
Methods for detecting oligonucleotides
|
|
WO2009030254A1
(en)
|
2007-09-04 |
2009-03-12 |
Curevac Gmbh |
Complexes of rna and cationic peptides for transfection and for immunostimulation
|
|
JP5410434B2
(ja)
|
2007-09-28 |
2014-02-05 |
バインド セラピューティックス インコーポレイテッド |
ナノ粒子を用いた癌細胞の標的化
|
|
CA2917512C
(en)
|
2007-10-12 |
2025-08-05 |
President And Fellows Of Harvard College |
VACCINE NANOTECHNOLOGY
|
|
TW200927915A
(en)
|
2007-10-25 |
2009-07-01 |
Croda Int Plc |
Laundry formulations and method of cleaning
|
|
US20110117125A1
(en)
|
2008-01-02 |
2011-05-19 |
Tekmira Pharmaceuticals Corporation |
Compositions and methods for the delivery of nucleic acids
|
|
PL2279254T3
(pl)
|
2008-04-15 |
2017-11-30 |
Protiva Biotherapeutics Inc. |
Nowe preparaty lipidowe do dostarczania kwasów nukleinowych
|
|
WO2009129395A1
(en)
|
2008-04-16 |
2009-10-22 |
Abbott Laboratories |
Cationic lipids and uses thereof
|
|
WO2009129385A1
(en)
|
2008-04-16 |
2009-10-22 |
Abbott Laboratories |
Cationic lipids and uses thereof
|
|
CA3013503A1
(en)
|
2008-04-25 |
2009-10-29 |
Northwestern University |
Nanostructures suitable for sequestering cholesterol and other molecules
|
|
US8697098B2
(en)
|
2011-02-25 |
2014-04-15 |
South Dakota State University |
Polymer conjugated protein micelles
|
|
US8613951B2
(en)
|
2008-06-16 |
2013-12-24 |
Bind Therapeutics, Inc. |
Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
|
|
DK2774608T3
(da)
|
2008-06-16 |
2020-01-13 |
Pfizer |
Lægemiddelladede polymere nanopartikler og fremgangsmåder til fremstilling og anvendelse deraf
|
|
HUE035770T2
(en)
|
2008-06-16 |
2018-05-28 |
Pfizer |
Process for the preparation of diblock copolymers functionalized with targeting material for use in the preparation of therapeutic nanoparticles
|
|
TW201019963A
(en)
|
2008-09-10 |
2010-06-01 |
Abbott Lab |
Polyethylene glycol lipid conjugates and uses thereof
|
|
WO2010042877A1
(en)
|
2008-10-09 |
2010-04-15 |
Tekmira Pharmaceuticals Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
|
JP6087504B2
(ja)
|
2008-11-07 |
2017-03-01 |
マサチューセッツ インスティテュート オブ テクノロジー |
アミノアルコールリピドイドおよびその使用
|
|
EP3757090B1
(en)
|
2008-11-10 |
2024-06-12 |
Arbutus Biopharma Corporation |
Novel lipids and compositions for the delivery of therapeutics
|
|
US8734853B2
(en)
|
2008-11-17 |
2014-05-27 |
University Of North Texas Health Science Center At Fort Worth |
HDL particles for delivery of nucleic acids
|
|
WO2010068866A2
(en)
|
2008-12-12 |
2010-06-17 |
Bind Biosciences |
Therapeutic particles suitable for parenteral administration and methods of making and using same
|
|
EA201100765A1
(ru)
|
2008-12-15 |
2012-04-30 |
Бинд Биосаиэнсис |
Наночастицы длительной циркуляции для замедленного высвобождения терапевтических средств
|
|
CA2751342C
(en)
|
2009-01-29 |
2019-05-07 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulations comprising cationic lipid and a targeting lipid comprising n-acetyl galactosamine for delivery of nucleic acid
|
|
US20140141089A1
(en)
|
2009-02-11 |
2014-05-22 |
Colorado School Of Mines |
Nanoparticles, Compositions Thereof, and Methods of Use, and Methods of Making the Same
|
|
KR101800833B1
(ko)
|
2009-03-20 |
2017-11-23 |
씨엘에스엔 래버러토리스, 인코퍼레이티드 |
폴리아민 유도체
|
|
US8287910B2
(en)
|
2009-04-30 |
2012-10-16 |
Intezyne Technologies, Inc. |
Polymeric micelles for polynucleotide encapsulation
|
|
US8715736B2
(en)
|
2009-04-30 |
2014-05-06 |
Florida Agricultural And Mechanical University |
Nanoparticle formulations for skin delivery
|
|
EP3698631A3
(en)
*
|
2009-05-05 |
2020-11-25 |
Arbutus Biopharma Corporation |
Methods of delivering oligonucleotides to immune cells
|
|
KR102229618B1
(ko)
|
2009-05-05 |
2021-03-18 |
알닐람 파마슈티칼스 인코포레이티드 |
지질 조성물
|
|
SG10201912450XA
(en)
*
|
2009-06-10 |
2020-03-30 |
Arbutus Biopharma Corp |
Improved lipid formulation
|
|
EA201270019A1
(ru)
|
2009-06-15 |
2012-06-29 |
Элнилэм Фармасьютикалз, Инк. |
Двуцепочечная рнк, включенная в липидный состав и мишенью которой является ген pcsk9
|
|
US9018187B2
(en)
|
2009-07-01 |
2015-04-28 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
JP5766188B2
(ja)
|
2009-07-01 |
2015-08-19 |
プロチバ バイオセラピューティクス インコーポレイティッド |
固形腫瘍に治療剤を送達するための脂質製剤
|
|
WO2011000106A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Improved cationic lipids and methods for the delivery of therapeutic agents
|
|
US8449916B1
(en)
|
2009-11-06 |
2013-05-28 |
Iowa State University Research Foundation, Inc. |
Antimicrobial compositions and methods
|
|
PH12012500929A1
(en)
|
2009-11-12 |
2012-11-26 |
Kao Corp |
Method for producing olefins
|
|
CA2782676C
(en)
|
2009-12-01 |
2021-06-15 |
Shire Human Genetic Therapies, Inc. |
Pharmaceutical compositions for intracellular delivery of nucleic acids and proteins and uses thereof for treatment of ureca cycle metabolic disorders
|
|
AU2010328336B2
(en)
|
2009-12-07 |
2017-03-02 |
Arbutus Biopharma Corporation |
Compositions for nucleic acid delivery
|
|
US8357401B2
(en)
|
2009-12-11 |
2013-01-22 |
Bind Biosciences, Inc. |
Stable formulations for lyophilizing therapeutic particles
|
|
CA2784568A1
(en)
|
2009-12-18 |
2011-06-23 |
Martin A. Maier |
Lipid particles for delivery of nucleic acids
|
|
SG10201407996PA
(en)
|
2009-12-23 |
2015-01-29 |
Novartis Ag |
Lipids, lipid compositions, and methods of using them
|
|
US9149432B2
(en)
|
2010-03-19 |
2015-10-06 |
Massachusetts Institute Of Technology |
Lipid vesicle compositions and methods of use
|
|
US8207290B2
(en)
|
2010-03-26 |
2012-06-26 |
Cerulean Pharma Inc. |
Methods and systems for generating nanoparticles
|
|
EP2558074B1
(en)
|
2010-04-08 |
2018-06-06 |
The Trustees of Princeton University |
Preparation of lipid nanoparticles
|
|
EP2555752B1
(en)
|
2010-04-09 |
2019-06-26 |
Pacira Pharmaceuticals, Inc. |
Method for formulating multivesicular liposomes
|
|
EP2567951B1
(en)
|
2010-04-28 |
2018-09-19 |
Kyowa Hakko Kirin Co., Ltd. |
Cationic lipid
|
|
US20130156845A1
(en)
|
2010-04-29 |
2013-06-20 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
|
WO2011143230A1
(en)
|
2010-05-10 |
2011-11-17 |
Alnylam Pharmaceuticals |
Methods and compositions for delivery of active agents
|
|
WO2011141704A1
(en)
|
2010-05-12 |
2011-11-17 |
Protiva Biotherapeutics, Inc |
Novel cyclic cationic lipids and methods of use
|
|
WO2011141705A1
(en)
|
2010-05-12 |
2011-11-17 |
Protiva Biotherapeutics, Inc. |
Novel cationic lipids and methods of use thereof
|
|
JP2013531634A
(ja)
|
2010-05-24 |
2013-08-08 |
メルク・シャープ・エンド・ドーム・コーポレイション |
オリゴヌクレオチド送達のための新規なアミノアルコールカチオン性脂質
|
|
DK2575767T3
(en)
|
2010-06-04 |
2017-03-13 |
Sirna Therapeutics Inc |
HOWEVER UNKNOWN LOW MOLECULAR CATIONIC LIPIDS TO PROCESS OIGONUCLEOTIDES
|
|
US9006417B2
(en)
*
|
2010-06-30 |
2015-04-14 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
|
JP5635690B2
(ja)
|
2010-07-01 |
2014-12-03 |
ポステック アカデミー‐インダストリー ファウンデーション |
細菌由来マイクロベシクルを用いた癌治療及び癌診断方法
|
|
US9192661B2
(en)
|
2010-07-06 |
2015-11-24 |
Novartis Ag |
Delivery of self-replicating RNA using biodegradable polymer particles
|
|
FI4005592T3
(fi)
|
2010-07-06 |
2023-01-13 |
|
Virionin kaltaisia kuljetuspartikkeleita itsereplikoituville rna-molekyyleille
|
|
AU2011276234B2
(en)
|
2010-07-06 |
2016-02-25 |
Glaxosmithkline Biologicals S.A. |
Liposomes with lipids having an advantageous pKa- value for RNA delivery
|
|
US20130142868A1
(en)
|
2010-08-20 |
2013-06-06 |
University Of Washington |
Circumferential Aerosol Device for Delivering Drugs to Olfactory Epithelium and Brain
|
|
PL4008357T3
(pl)
|
2010-08-31 |
2023-03-06 |
Glaxosmithkline Biologicals Sa |
Małe liposomy do dostarczania rna kodującego immunogen
|
|
PT3981427T
(pt)
|
2010-08-31 |
2022-06-27 |
Glaxosmithkline Biologicals Sa |
Lipossomas peguilados para entrega de arn codificador de imunogénio
|
|
AU2011295938B2
(en)
|
2010-08-31 |
2016-01-14 |
Glaxosmithkline Biologicals S.A. |
Lipids suitable for liposomal delivery of protein-coding RNA
|
|
WO2012031205A2
(en)
|
2010-09-03 |
2012-03-08 |
The Brigham And Women's Hospital, Inc. |
Lipid-polymer hybrid particles
|
|
US10307372B2
(en)
|
2010-09-10 |
2019-06-04 |
The Johns Hopkins University |
Rapid diffusion of large polymeric nanoparticles in the mammalian brain
|
|
JP5961170B2
(ja)
|
2010-09-20 |
2016-08-02 |
サーナ・セラピューティクス・インコーポレイテッドＳｉｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． |
オリゴヌクレオチドの送達のための新規な低分子量カチオン性脂質
|
|
WO2012040623A2
(en)
|
2010-09-24 |
2012-03-29 |
The Brigham And Women's Hospital, Inc. |
Nanostructured gels capable of controlled release of encapsulated agents
|
|
JP2013545723A
(ja)
|
2010-09-30 |
2013-12-26 |
メルク・シャープ・エンド・ドーム・コーポレイション |
オリゴヌクレオチドの送達のための低分子量カチオン性脂質
|
|
US9029590B2
(en)
|
2010-10-21 |
2015-05-12 |
Sirna Therapeutics, Inc. |
Low molecular weight cationic lipids for oligonucleotide delivery
|
|
EP2640700B1
(en)
|
2010-11-15 |
2018-10-31 |
Life Technologies Corporation |
Amine-containing transfection reagents and methods for making and using same
|
|
CN102068701B
(zh)
|
2011-01-18 |
2012-11-07 |
沈阳药科大学 |
可断裂peg脂质衍生物在制剂中的应用
|
|
JP2014505064A
(ja)
|
2011-01-26 |
2014-02-27 |
セニックス バイオサイエンス ゲーエムベーハー |
自然に存在する細胞内輸送経路を介して化合物を送達するための送達システム及びコンジュゲート
|
|
US10363309B2
(en)
|
2011-02-04 |
2019-07-30 |
Case Western Reserve University |
Targeted nanoparticle conjugates
|
|
EP2675918B1
(en)
|
2011-02-15 |
2017-11-08 |
Merrimack Pharmaceuticals, Inc. |
Compositions and methods for delivering nucleic acid to a cell
|
|
CN102204920B
(zh)
|
2011-03-18 |
2013-03-20 |
海南本创医药科技有限公司 |
阿司匹林钠普伐他汀钠药物组合物固体制剂
|
|
EP2688590B1
(en)
|
2011-03-24 |
2020-02-12 |
GlaxoSmithKline Biologicals SA |
Adjuvant nanoemulsions with phospholipids
|
|
WO2012142132A1
(en)
|
2011-04-11 |
2012-10-18 |
Life Technologies Corporation |
Polymer particles and methods of making and using same
|
|
WO2013158127A1
(en)
|
2012-04-16 |
2013-10-24 |
Molecular Transfer, Inc. |
Agents for improved delivery of nucleic acids to eukaryotic cells
|
|
CN103687590A
(zh)
|
2011-04-28 |
2014-03-26 |
Stc·Unm公司 |
用于靶向给药的多孔纳米颗粒支撑脂双层（原始细胞）及其使用方法
|
|
MX373641B
(es)
|
2011-04-29 |
2020-05-04 |
Selecta Biosciences Inc |
Nanoportadores sintéticos tolerogénicos para la terapia contra alergias.
|
|
EP2706988B1
(en)
|
2011-05-12 |
2019-12-04 |
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. |
Liposomes comprising polymer-conjugated lipids and related uses
|
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
|
WO2013052167A2
(en)
|
2011-06-02 |
2013-04-11 |
The Regents Of The University Of California |
Membrane encapsulated nanoparticles and method of use
|
|
CN103748078B
(zh)
|
2011-06-08 |
2016-11-09 |
夏尔人类遗传性治疗公司 |
可裂解脂质
|
|
CA3107288A1
(en)
|
2011-06-08 |
2012-12-13 |
Translate Bio, Inc. |
Lipid nanoparticle compositions and methods for mrna delivery
|
|
CN102813929B
(zh)
|
2011-06-09 |
2014-04-09 |
沈阳药科大学 |
低浓度peg脂质衍生物及其应用
|
|
CN103764121A
(zh)
|
2011-07-06 |
2014-04-30 |
诺华股份有限公司 |
用于递送rna分子的具有有用n:p比的脂质体
|
|
EP2729165B1
(en)
|
2011-07-06 |
2017-11-08 |
GlaxoSmithKline Biologicals SA |
Immunogenic combination compositions and uses thereof
|
|
US9655845B2
(en)
|
2011-07-06 |
2017-05-23 |
Glaxosmithkline Biologicals, S.A. |
Oil-in-water emulsions that contain nucleic acids
|
|
AU2012280904B2
(en)
|
2011-07-06 |
2017-02-23 |
Glaxosmithkline Biologicals S.A. |
Cationic oil-in-water emulsions
|
|
WO2013006842A2
(en)
|
2011-07-06 |
2013-01-10 |
Novartis Ag |
Immunogenic compositions and uses thereof
|
|
WO2013016058A1
(en)
|
2011-07-22 |
2013-01-31 |
Merck Sharp & Dohme Corp. |
Novel bis-nitrogen containing cationic lipids for oligonucleotide delivery
|
|
BR112014004607A2
(pt)
|
2011-08-31 |
2017-03-21 |
Novartis Ag |
lipossomas peguilados para entrega de rna codificado imunogênico
|
|
WO2013033438A2
(en)
|
2011-08-31 |
2013-03-07 |
Mallinckrodt Llc |
Nanoparticle peg modification with h-phosphonates
|
|
US9126966B2
(en)
|
2011-08-31 |
2015-09-08 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use thereof
|
|
CN107936076B
(zh)
|
2011-09-08 |
2021-10-15 |
萨奇治疗股份有限公司 |
神经活性类固醇、组合物、及其用途
|
|
WO2013072929A2
(en)
|
2011-09-23 |
2013-05-23 |
Indian Institute Of Technology |
Nanop article based cosmetic composition
|
|
WO2013049328A1
(en)
|
2011-09-27 |
2013-04-04 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted pegylated lipids
|
|
US20150272885A1
(en)
|
2011-10-14 |
2015-10-01 |
Stc.Unm |
Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof
|
|
WO2013059496A1
(en)
|
2011-10-18 |
2013-04-25 |
Dicerna Pharmaceuticals, Inc. |
Amine cationic lipids and uses thereof
|
|
EP2768528A1
(en)
|
2011-10-20 |
2014-08-27 |
Novartis AG |
Adjuvanted influenza b virus vaccines for pediatric priming
|
|
WO2013059922A1
(en)
|
2011-10-25 |
2013-05-02 |
The University Of British Columbia |
Limit size lipid nanoparticles and related methods
|
|
WO2013066903A1
(en)
|
2011-10-31 |
2013-05-10 |
Mallinckrodt Llc |
Combinational liposome compositions for cancer therapy
|
|
KR102046968B1
(ko)
|
2011-11-04 |
2019-12-02 |
닛토덴코 가부시키가이샤 |
지질-핵산입자를 멸균생성을 위한 단일 용도 시스템
|
|
US9872870B2
(en)
|
2011-11-04 |
2018-01-23 |
University Of Notre Dame Du Lac |
Multifunctional micellar nanoparticle-based drug and targeting agent system
|
|
US9579338B2
(en)
|
2011-11-04 |
2017-02-28 |
Nitto Denko Corporation |
Method of producing lipid nanoparticles for drug delivery
|
|
WO2013070872A1
(en)
|
2011-11-08 |
2013-05-16 |
The Board Of Trustees Of The University Of Arkansas |
Methods and compositions for x-ray induced release from ph sensitive liposomes
|
|
EP2785333A4
(en)
|
2011-12-02 |
2015-04-01 |
Pegasus Lab Inc |
AMPHIPATIVE COMPOSITIONS WITH DELAYED RELIEF ON LIPID BASIS
|
|
CA2856742A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Biodegradable lipids for the delivery of active agents
|
|
EP2788316B1
(en)
|
2011-12-07 |
2019-04-24 |
Alnylam Pharmaceuticals, Inc. |
Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents
|
|
WO2013086373A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Lipids for the delivery of active agents
|
|
WO2013086526A1
(en)
|
2011-12-09 |
2013-06-13 |
The Regents Of The University Of California |
Liposomal drug encapsulation
|
|
KR20140111272A
(ko)
|
2011-12-12 |
2014-09-18 |
교와 핫꼬 기린 가부시키가이샤 |
양이온성 지질의 조합을 함유하는 지질 나노 입자
|
|
WO2013089151A1
(ja)
|
2011-12-12 |
2013-06-20 |
協和発酵キリン株式会社 |
カチオン性脂質を含有するドラッグデリバリーシステムのための脂質ナノ粒子
|
|
EP2604253A1
(en)
|
2011-12-13 |
2013-06-19 |
Otto Glatter |
Water-in-oil emulsions and methods for their preparation
|
|
US9636414B2
(en)
|
2011-12-15 |
2017-05-02 |
Biontech Ag |
Particles comprising single stranded RNA and double stranded RNA for immunomodulation
|
|
DE12858350T1
(de)
|
2011-12-16 |
2021-10-07 |
Modernatx, Inc. |
Modifizierte mrna zusammensetzungen
|
|
EP4116338B1
(en)
|
2012-02-09 |
2025-06-11 |
Life Technologies Corporation |
Hydrophilic polymeric particles and methods for making same
|
|
US20140037573A1
(en)
|
2012-02-22 |
2014-02-06 |
Cerulean Pharma Inc. |
Conjugates, particles, compositions, and related methods
|
|
US20130243867A1
(en)
|
2012-02-23 |
2013-09-19 |
University Of South Florida (A Florida Non-Profit Corporation) |
Micelle compositions and methods for their use
|
|
US10322089B2
(en)
|
2012-03-14 |
2019-06-18 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nanoparticles, nanoparticle delivery methods, and systems of delivery
|
|
DK2825156T3
(en)
|
2012-03-16 |
2017-10-30 |
Merck Patent Gmbh |
TARGETED AMINO ACID LIPIDS
|
|
US9717685B2
(en)
|
2012-03-26 |
2017-08-01 |
President And Fellows Of Harvard College |
Lipid-coated nucleic acid nanostructures of defined shape
|
|
WO2013143555A1
(en)
|
2012-03-26 |
2013-10-03 |
Biontech Ag |
Rna formulation for immunotherapy
|
|
EP2830594B1
(en)
|
2012-03-27 |
2018-05-09 |
Sirna Therapeutics, Inc. |
DIETHER BASED BIODEGRADABLE CATIONIC LIPIDS FOR siRNA DELIVERY
|
|
CA2868030C
(en)
|
2012-03-29 |
2021-05-25 |
Shire Human Genetic Therapies, Inc. |
Lipid-derived neutral nanoparticles
|
|
WO2013151650A1
(en)
|
2012-04-05 |
2013-10-10 |
University Of Florida Research Foundation, Inc. |
Neurophilic nanoparticles
|
|
PL2836234T3
(pl)
|
2012-04-12 |
2020-02-28 |
Yale University |
Podłoża do kontrolowanego dostarczania różnych środków farmaceutycznych
|
|
US9402816B2
(en)
|
2012-04-19 |
2016-08-02 |
Sima Therapeutics, Inc. |
Diester and triester based low molecular weight, biodegradeable cationic lipids for oligonucleotide delivery
|
|
WO2013163234A1
(en)
|
2012-04-23 |
2013-10-31 |
Massachusetts Institute Of Technology |
Stable layer-by-layer coated particles
|
|
JP6392209B2
(ja)
|
2012-05-04 |
2018-09-19 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
粘液内層を通過する迅速な透過のための脂質ベース薬物キャリア
|
|
WO2013173693A1
(en)
|
2012-05-18 |
2013-11-21 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Nanoparticles with enhanced entry into cancer cells
|
|
BR112014029247A2
(pt)
|
2012-05-23 |
2017-06-27 |
Univ Ohio State |
nanopartícula de lipídio, composição farmacêutica, método para fazer uma nanopartícula de lipído, produto, método de tratamento de um distúrbio, e sistema de entrega
|
|
TR201816986T4
(tr)
|
2012-06-08 |
2019-01-21 |
Nitto Denko Corp |
Terapötik ajan iletim formülasyonlarına yönelik lipitler.
|
|
JP6561378B2
(ja)
|
2012-06-08 |
2019-08-21 |
トランスレイト バイオ， インコーポレイテッド |
非肺標的細胞へのｍＲＮＡの経肺送達
|
|
TW201408625A
(zh)
|
2012-07-06 |
2014-03-01 |
Kyowa Hakko Kirin Co Ltd |
陽離子性脂質
|
|
WO2014008334A1
(en)
|
2012-07-06 |
2014-01-09 |
Alnylam Pharmaceuticals, Inc. |
Stable non-aggregating nucleic acid lipid particle formulations
|
|
US9956291B2
(en)
|
2012-07-10 |
2018-05-01 |
Shaker A. Mousa |
Nanoformulation and methods of use of thyroid receptor beta1 agonists for liver targeting
|
|
EP2882706A1
(en)
|
2012-08-13 |
2015-06-17 |
Massachusetts Institute of Technology |
Amine-containing lipidoids and uses thereof
|
|
EP2884965B1
(en)
|
2012-08-14 |
2018-08-08 |
Froese, Aaron |
Internal structured self assembling liposomes
|
|
EP2885414B1
(en)
|
2012-08-15 |
2020-09-23 |
The University of Chicago |
Exosome-based therapeutics against neurodegenerative disorders
|
|
WO2014047649A1
(en)
|
2012-09-24 |
2014-03-27 |
The Regents Of The University Of California |
Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy
|
|
US20150246137A1
(en)
|
2012-09-27 |
2015-09-03 |
The University Of North Carolina At Chapel Hill |
Lipid coated nanoparticles containing agents having low aqueous and lipid solubilities and methods thereof
|
|
US20150202153A1
(en)
|
2012-10-04 |
2015-07-23 |
University Of The Witwatersrand, Johannesburg |
Liposomal drug delivery system
|
|
WO2014071072A2
(en)
|
2012-11-02 |
2014-05-08 |
Pungente Michael D |
Novel cationic carotenoid-based lipids for cellular nucleic acid uptake
|
|
US9669104B2
(en)
|
2012-11-07 |
2017-06-06 |
Council Of Scientific And Industrial Research |
Nanocomplex containing amphipathic peptide useful for efficient transfection of biomolecules
|
|
ES2968649T3
(es)
|
2012-12-07 |
2024-05-13 |
Translate Bio Inc |
Nanopartículas lipídicas para la administración de ARNm en los pulmones
|
|
WO2014160243A1
(en)
|
2013-03-14 |
2014-10-02 |
The Trustees Of The University Of Pennsylvania |
Purification and purity assessment of rna molecules synthesized with modified nucleosides
|
|
EP2971013B1
(en)
|
2013-03-15 |
2020-08-19 |
The University Of British Columbia |
Lipid nanoparticles for transfection and related methods
|
|
HUE071526T2
(hu)
|
2013-03-15 |
2025-09-28 |
Translate Bio Inc |
Nukleinsavak bejuttatásának szinergista fokozása kevert kiszerelésekkel
|
|
WO2014182661A2
(en)
|
2013-05-06 |
2014-11-13 |
Alnylam Pharmaceuticals, Inc |
Dosages and methods for delivering lipid formulated nucleic acid molecules
|
|
WO2014210356A1
(en)
|
2013-06-26 |
2014-12-31 |
Massachusetts Institute Of Technology |
Multi-tailed lipids and uses thereof
|
|
US20160151284A1
(en)
*
|
2013-07-23 |
2016-06-02 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for delivering messenger rna
|
|
US9365610B2
(en)
|
2013-11-18 |
2016-06-14 |
Arcturus Therapeutics, Inc. |
Asymmetric ionizable cationic lipid for RNA delivery
|
|
EP3556353A3
(en)
|
2014-02-25 |
2020-03-18 |
Merck Sharp & Dohme Corp. |
Lipid nanoparticle vaccine adjuvants and antigen delivery systems
|
|
US9833416B2
(en)
|
2014-04-04 |
2017-12-05 |
Ohio State Innovation Foundation |
Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same
|
|
PT3766916T
(pt)
|
2014-06-25 |
2022-11-28 |
Acuitas Therapeutics Inc |
Novos lípidos e formulações de nanopartículas lipídicas para distribuição de ácidos nucleicos
|
|
CN114146063A
(zh)
|
2014-07-02 |
2022-03-08 |
川斯勒佰尔公司 |
信使rna的包封
|
|
US9840479B2
(en)
|
2014-07-02 |
2017-12-12 |
Massachusetts Institute Of Technology |
Polyamine-fatty acid derived lipidoids and uses thereof
|
|
CN104644555A
(zh)
|
2014-11-18 |
2015-05-27 |
中国科学院过程工程研究所 |
一种避免加速血液清除现象的长循环脂质体、制备方法及应用
|
|
WO2016118697A1
(en)
|
2015-01-21 |
2016-07-28 |
Phaserx, Inc. |
Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells
|
|
EP3247363A4
(en)
|
2015-01-21 |
2018-10-03 |
Moderna Therapeutics, Inc. |
Lipid nanoparticle compositions
|
|
US20180303925A1
(en)
*
|
2015-04-27 |
2018-10-25 |
The Trustees Of The University Of Pennsylvania |
Nucleoside-Modified RNA For Inducing an Adaptive Immune Response
|
|
EP3325505B1
(en)
|
2015-07-23 |
2020-08-19 |
Modernatx, Inc. |
Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof
|
|
US11564893B2
(en)
|
2015-08-17 |
2023-01-31 |
Modernatx, Inc. |
Methods for preparing particles and related compositions
|
|
WO2017049245A2
(en)
*
|
2015-09-17 |
2017-03-23 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of therapeutic agents
|
|
EP3718565B1
(en)
|
2015-10-22 |
2022-04-27 |
ModernaTX, Inc. |
Respiratory virus vaccines
|
|
MA45209A
(fr)
|
2015-10-22 |
2019-04-17 |
Modernatx Inc |
Vaccins contre les maladies sexuellement transmissibles
|
|
LT3368507T
(lt)
|
2015-10-28 |
2023-03-10 |
Acuitas Therapeutics Inc. |
Nauji lipidai ir lipidų nanodalelių kompozicijos, skirtos nukleorūgščių tiekimui
|
|
JP7080172B2
(ja)
|
2015-12-10 |
2022-06-03 |
モデルナティエックス インコーポレイテッド |
治療薬の送達のための組成物及び方法
|
|
WO2017100744A1
(en)
|
2015-12-11 |
2017-06-15 |
Preceres Inc. |
Aminolipidoids and uses thereof
|
|
ES2913626T5
(en)
|
2015-12-22 |
2025-05-12 |
Modernatx Inc |
Compounds and compositions for intracellular delivery of agents
|
|
US20210206818A1
(en)
|
2016-01-22 |
2021-07-08 |
Modernatx, Inc. |
Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof
|
|
EP3442590A2
(en)
|
2016-04-13 |
2019-02-20 |
Modernatx, Inc. |
Lipid compositions and their uses for intratumoral polynucleotide delivery
|
|
WO2017192470A1
(en)
|
2016-05-03 |
2017-11-09 |
Merck Sharp & Dohme Corp. |
Combination therapy of anti-il-10 antibody and compositions comprising lipid nanoparticles and tlr9 agonist cpg oligonucleotides
|
|
AU2017266948B2
(en)
|
2016-05-18 |
2024-07-04 |
Fundacion Para La Investigacion Medica Aplicada |
Polynucleotides encoding porphobilinogen deaminase for the treatment of acute intermittent porphyria
|
|
WO2017201349A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Polynucleotides encoding citrin for the treatment of citrullinemia type 2
|
|
US12128113B2
(en)
|
2016-05-18 |
2024-10-29 |
Modernatx, Inc. |
Polynucleotides encoding JAGGED1 for the treatment of Alagille syndrome
|
|
US20190298657A1
(en)
|
2016-05-18 |
2019-10-03 |
Modernatx, Inc. |
Polynucleotides Encoding Acyl-CoA Dehydrogenase, Very Long-Chain for the Treatment of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency
|
|
JP7246930B2
(ja)
|
2016-05-18 |
2023-03-28 |
モデルナティエックス インコーポレイテッド |
インターロイキン－１２（ｉｌ１２）をコードするポリヌクレオチドおよびその使用
|
|
WO2017201340A2
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Polynucleotides encoding relaxin
|
|
US20190382774A1
(en)
|
2016-05-18 |
2019-12-19 |
Modernatx, Inc. |
Polyribonucleotides containing reduced uracil content and uses thereof
|
|
MA45050A
(fr)
|
2016-05-18 |
2019-03-27 |
Modernatx Inc |
Polynucléotides codant pour la lipoprotéine lipase destinés au traitement de l'hyperlipidémie
|
|
CA3024507A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Polynucleotides encoding .alpha.-galactosidase a for the treatment of fabry disease
|
|
CA3024509A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Mrna combination therapy for the treatment of cancer
|
|
WO2017201347A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis
|
|
JP7194594B2
(ja)
|
2016-05-18 |
2022-12-22 |
モデルナティエックス インコーポレイテッド |
免疫調節ポリペプチドをコードするｍＲＮＡの組み合わせ及びその使用
|
|
EP3458105B1
(en)
|
2016-05-18 |
2024-01-17 |
Modernatx, Inc. |
Polynucleotides encoding galactose-1-phosphate uridylyltransferase for the treatment of galactosemia type 1
|
|
AU2017286606A1
(en)
|
2016-06-14 |
2018-12-13 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
|
EP3532103B1
(en)
|
2016-10-26 |
2025-12-03 |
Acuitas Therapeutics, Inc. |
Lipid nanoparticle formulations
|
|
US20200163878A1
(en)
|
2016-10-26 |
2020-05-28 |
Curevac Ag |
Lipid nanoparticle mrna vaccines
|
|
US20190274968A1
(en)
|
2016-10-27 |
2019-09-12 |
The Trustees Of The University Of Pennsylvania |
Nucleoside-modified rna for inducing an adaptive immune response
|
|
EP3538067A1
(en)
|
2016-11-08 |
2019-09-18 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
|
WO2018170260A1
(en)
|
2017-03-15 |
2018-09-20 |
Modernatx, Inc. |
Respiratory syncytial virus vaccine
|
|
EP3596041B1
(en)
|
2017-03-15 |
2022-11-02 |
ModernaTX, Inc. |
Compound and compositions for intracellular delivery of therapeutic agents
|
|
WO2018170270A1
(en)
|
2017-03-15 |
2018-09-20 |
Modernatx, Inc. |
Varicella zoster virus (vzv) vaccine
|
|
WO2018170336A1
(en)
|
2017-03-15 |
2018-09-20 |
Modernatx, Inc. |
Lipid nanoparticle formulation
|
|
WO2018191719A1
(en)
|
2017-04-13 |
2018-10-18 |
Acuitas Therapeutics, Inc. |
Lipid delivery of therapeutic agents to adipose tissue
|
|
US12077501B2
(en)
|
2017-06-14 |
2024-09-03 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of agents
|
|
JP7275111B2
(ja)
|
2017-08-31 |
2023-05-17 |
モデルナティエックス インコーポレイテッド |
脂質ナノ粒子の生成方法
|
|
WO2019089828A1
(en)
|
2017-10-31 |
2019-05-09 |
Acuitas Therapeutics, Inc. |
Lamellar lipid nanoparticles
|
|
AU2019216307A1
(en)
|
2018-01-30 |
2020-07-09 |
Modernatx, Inc. |
Compositions and methods for delivery of agents to immune cells
|
|
WO2019193183A2
(en)
|
2018-04-05 |
2019-10-10 |
Curevac Ag |
Novel yellow fever nucleic acid molecules for vaccination
|
|
EP4227319B1
(en)
|
2018-04-17 |
2025-11-26 |
CureVac SE |
Novel rsv rna molecules and compositions for vaccination
|
|
US20210260178A1
(en)
|
2018-06-27 |
2021-08-26 |
Curevac Ag |
Novel lassa virus rna molecules and compositions for vaccination
|
|
US12090235B2
(en)
|
2018-09-20 |
2024-09-17 |
Modernatx, Inc. |
Preparation of lipid nanoparticles and methods of administration thereof
|
|
TW202039534A
(zh)
|
2018-12-14 |
2020-11-01 |
美商美國禮來大藥廠 |
KRAS變體mRNA分子
|
|
AU2020350759A1
(en)
|
2019-09-19 |
2022-03-31 |
Modernatx, Inc. |
Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
|