JP2018510914A5 - - Google Patents
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- Publication number
- JP2018510914A5 JP2018510914A5 JP2018503718A JP2018503718A JP2018510914A5 JP 2018510914 A5 JP2018510914 A5 JP 2018510914A5 JP 2018503718 A JP2018503718 A JP 2018503718A JP 2018503718 A JP2018503718 A JP 2018503718A JP 2018510914 A5 JP2018510914 A5 JP 2018510914A5
- Authority
- JP
- Japan
- Prior art keywords
- carboplatin
- solvent
- combining step
- molar ratio
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 23
- 190000008236 carboplatin Chemical compound 0.000 claims 9
- 229960004562 carboplatin Drugs 0.000 claims 9
- 239000002904 solvent Substances 0.000 claims 7
- CCQPAEQGAVNNIA-UHFFFAOYSA-N cyclobutane-1,1-dicarboxylic acid Chemical compound OC(=O)C1(C(O)=O)CCC1 CCQPAEQGAVNNIA-UHFFFAOYSA-N 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- IIJQICKYWPGJDT-UHFFFAOYSA-L azane;cyclobutane-1,1-dicarboxylate;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound N.N.[Pt+2].OC(=O)C1(C([O-])=O)CCC1.OC(=O)C1(C([O-])=O)CCC1 IIJQICKYWPGJDT-UHFFFAOYSA-L 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 2
- 235000019439 ethyl acetate Nutrition 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- GJRQTCIYDGXPES-UHFFFAOYSA-N iso-butyl acetate Natural products CC(C)COC(C)=O GJRQTCIYDGXPES-UHFFFAOYSA-N 0.000 claims 1
- FGKJLKRYENPLQH-UHFFFAOYSA-M isocaproate Chemical compound CC(C)CCC([O-])=O FGKJLKRYENPLQH-UHFFFAOYSA-M 0.000 claims 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims 1
- 229940011051 isopropyl acetate Drugs 0.000 claims 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 1
- OQAGVSWESNCJJT-UHFFFAOYSA-N isovaleric acid methyl ester Natural products COC(=O)CC(C)C OQAGVSWESNCJJT-UHFFFAOYSA-N 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2015/025334 WO2016164040A1 (en) | 2015-04-10 | 2015-04-10 | Process for the preparation of dicycloplatin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510914A JP2018510914A (ja) | 2018-04-19 |
| JP2018510914A5 true JP2018510914A5 (enExample) | 2018-06-07 |
| JP6925318B2 JP6925318B2 (ja) | 2021-08-25 |
Family
ID=56895556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503718A Active JP6925318B2 (ja) | 2015-04-10 | 2015-04-10 | ジシクロプラチンの製造方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9447130B1 (enExample) |
| EP (1) | EP3280408B1 (enExample) |
| JP (1) | JP6925318B2 (enExample) |
| KR (1) | KR102432526B1 (enExample) |
| CN (1) | CN106132408B (enExample) |
| AU (1) | AU2015390714B2 (enExample) |
| CA (1) | CA2981158C (enExample) |
| DK (1) | DK3280408T3 (enExample) |
| ES (1) | ES2765648T3 (enExample) |
| IL (1) | IL254894B (enExample) |
| MX (1) | MX2017012985A (enExample) |
| RU (1) | RU2676269C1 (enExample) |
| WO (1) | WO2016164040A1 (enExample) |
| ZA (1) | ZA201706795B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016279099B2 (en) | 2015-06-19 | 2021-09-23 | Syn-Nat Products Enterprise LLC | Pharmaceutical composition of carboplatin based co-crystals and use thereof |
| CN108697093A (zh) | 2015-06-19 | 2018-10-23 | 新纳特产品公司 | 含卡铂的组合物及其用途 |
| EP3297640A4 (en) | 2015-06-25 | 2019-01-02 | Syn-Nat Products Enterprise LLC | Pharmaceutical co-crystal composition and use thereof |
| CN106995467B (zh) * | 2017-05-03 | 2019-06-21 | 江苏大红鹰恒顺药业有限公司 | 一种微波催化合成双环铂的方法 |
| CN109053808B (zh) * | 2017-06-21 | 2020-12-29 | 宋勤华 | 一种高纯度双环铂针状晶体的工业化制备方法 |
| EP3714881A4 (en) * | 2017-11-21 | 2021-09-01 | Medoncare Pharmaceutical Co., Ltd | COMBINATION PRODUCT INCLUDING DICYCLOPLATIN, ITS PREPARATION PROCESS AND ITS USE |
| CN108780053A (zh) * | 2018-02-09 | 2018-11-09 | 北京索普兴大医药研究有限公司 | 双环铂药物检测方法 |
| CN108884119A (zh) * | 2018-02-22 | 2018-11-23 | 昆明贵研药业有限公司 | 一种双二羧酸二氨络铂(ii)衍生物的制备方法 |
| WO2019161526A1 (zh) * | 2018-02-22 | 2019-08-29 | 昆明贵研药业有限公司 | 一锅法制备双二羧酸二氨络铂(ii)衍生物的方法 |
| CN112262123B (zh) * | 2018-09-18 | 2023-12-15 | 昆明贵研药业有限公司 | 一种双二羧酸二氨络铂(ii)衍生物的纯化方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT65220A (en) * | 1991-03-23 | 1994-05-02 | Sunkyong Ind Ltd | Process for producing new platinum(ii) complexes |
| US5455270A (en) * | 1993-08-11 | 1995-10-03 | Bristol-Myers Squibb Co. | Stabilized solutions of platinum(II) antitumor agents |
| CN1121380C (zh) * | 2000-03-03 | 2003-09-17 | 北京兴大豪斯科技有限公司 | 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物 |
| DE60138739D1 (de) * | 2001-11-30 | 2009-06-25 | Jingzun Wang | Supermolekulare carboplatinderivate, deren herstellung und pharmazeutische zusammensetzungen, die diese als wirkstoffe enthalten, sowie anwendungen der zusammensetzungen |
| US20090082438A1 (en) * | 2005-03-18 | 2009-03-26 | Kazunori Kataoka | Coordination Compound Composed of Diaminocyclohexane Platinum (II) and Block Copolymer and Anti-Cancer Agent Comprising the Same |
| AU2005329764B2 (en) * | 2005-03-28 | 2010-08-12 | Dabur Pharma Ltd. | Stable pharmaceutical compositions of platinum (II) antitumour agents |
| JP2009525273A (ja) | 2006-01-30 | 2009-07-09 | プラットコー テクノロジーズ （プロプライエタリー） リミテッド | 白金（ｉｉ）錯体の調製 |
| CA2691047A1 (en) * | 2007-06-18 | 2008-12-24 | Platco Technologies (Proprietary) Limited | Platinum (iv) complexes |
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2015
- 2015-04-10 EP EP15888686.1A patent/EP3280408B1/en active Active
- 2015-04-10 AU AU2015390714A patent/AU2015390714B2/en active Active
- 2015-04-10 ES ES15888686T patent/ES2765648T3/es active Active
- 2015-04-10 WO PCT/US2015/025334 patent/WO2016164040A1/en not_active Ceased
- 2015-04-10 CA CA2981158A patent/CA2981158C/en active Active
- 2015-04-10 CN CN201580002750.5A patent/CN106132408B/zh active Active
- 2015-04-10 KR KR1020177032550A patent/KR102432526B1/ko active Active
- 2015-04-10 MX MX2017012985A patent/MX2017012985A/es unknown
- 2015-04-10 DK DK15888686.1T patent/DK3280408T3/da active
- 2015-04-10 RU RU2017136078A patent/RU2676269C1/ru active
- 2015-04-10 JP JP2018503718A patent/JP6925318B2/ja active Active
-
2016
- 2016-04-12 US US15/097,071 patent/US9447130B1/en active Active
-
2017
- 2017-10-03 IL IL254894A patent/IL254894B/en active IP Right Grant
- 2017-10-09 ZA ZA2017/06795A patent/ZA201706795B/en unknown