JP2018507858A5 - - Google Patents

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Publication number
JP2018507858A5
JP2018507858A5 JP2017544629A JP2017544629A JP2018507858A5 JP 2018507858 A5 JP2018507858 A5 JP 2018507858A5 JP 2017544629 A JP2017544629 A JP 2017544629A JP 2017544629 A JP2017544629 A JP 2017544629A JP 2018507858 A5 JP2018507858 A5 JP 2018507858A5
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JP
Japan
Prior art keywords
formula
compound
pharmaceutically acceptable
acceptable salt
polymorph
Prior art date
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Application number
JP2017544629A
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English (en)
Japanese (ja)
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JP6811717B2 (ja
JP2018507858A (ja
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Priority claimed from PCT/EP2016/000343 external-priority patent/WO2016134854A1/en
Publication of JP2018507858A publication Critical patent/JP2018507858A/ja
Publication of JP2018507858A5 publication Critical patent/JP2018507858A5/ja
Application granted granted Critical
Publication of JP6811717B2 publication Critical patent/JP6811717B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2017544629A 2015-02-25 2016-02-24 トピロキソスタット及びその中間体の調製のための方法 Expired - Fee Related JP6811717B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2015/000430 2015-02-25
EP2015000430 2015-02-25
PCT/EP2016/000343 WO2016134854A1 (en) 2015-02-25 2016-02-24 Methods for the preparation of topiroxostat and intermediates thereof

Publications (3)

Publication Number Publication Date
JP2018507858A JP2018507858A (ja) 2018-03-22
JP2018507858A5 true JP2018507858A5 (enExample) 2019-04-04
JP6811717B2 JP6811717B2 (ja) 2021-01-13

Family

ID=55484946

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017544629A Expired - Fee Related JP6811717B2 (ja) 2015-02-25 2016-02-24 トピロキソスタット及びその中間体の調製のための方法

Country Status (3)

Country Link
JP (1) JP6811717B2 (enExample)
CN (1) CN107531677A (enExample)
WO (1) WO2016134854A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108250183A (zh) * 2016-12-29 2018-07-06 北京诚济制药有限公司 一种高纯度的托匹司他的制备方法
CN113666909B (zh) * 2020-05-14 2024-07-02 鲁南制药集团股份有限公司 一种托匹司他的制备方法
CN114685451A (zh) * 2020-12-30 2022-07-01 鲁南制药集团股份有限公司 马来酸托匹司他二水合物共晶及其制备方法
CN114685452A (zh) * 2020-12-31 2022-07-01 鲁南制药集团股份有限公司 一种托匹司他-水杨酸-乙酸三元共晶
CN115925682B (zh) * 2021-10-04 2025-11-25 山东新时代药业有限公司 一种托匹司他的合成方法
CN115308347B (zh) * 2022-09-01 2023-09-08 江苏知原药业股份有限公司 一种托吡司特中氮氧化物杂质的分析方法
CN115572747B (zh) * 2022-09-23 2023-05-05 湖南一格制药有限公司 托匹司他的制备方法
CN115477638A (zh) * 2022-10-09 2022-12-16 浙江神洲药业有限公司 一种托匹司他的制备方法
CN116396275B (zh) * 2023-03-03 2025-05-13 浙江国邦药业有限公司 一种托匹司他的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0979822T3 (da) * 1998-08-10 2006-03-27 Hoffmann La Roche Fremgangsmåde til fremstilling af 2-carbamoyl-pyridiner
KR100838447B1 (ko) * 2001-02-21 2008-06-16 아스트라제네카 아베 헤테로폴리시클릭 화합물 및 대사향성 글루타메이트수용체 길항제로서의 그의 용도
AU2002349754B2 (en) 2002-01-28 2008-01-31 Fuji Yakuhin Co., Ltd. Novel 1,2,4-triazole compound
CN1826335A (zh) * 2003-07-24 2006-08-30 株式会社富士药品 1,2,4－三唑化合物的制造方法以及其中间体
JP2005041802A (ja) * 2003-07-25 2005-02-17 Fujiyakuhin Co Ltd １，２，４−トリアゾール化合物の製造方法
US20060189811A1 (en) * 2004-07-23 2006-08-24 Fujiyakuhin Co., Ltd. Process for producing 1,2,4-triazole compound and intermediate therefor
RU2639149C2 (ru) 2012-07-25 2017-12-20 Фудзиякухин Ко., Лтд Кристаллический полиморф 4-[5-(пиридин-4-ил)-1н-1,2,4-триазол-3-ил]-пиридин-2-карбонитрила и способ его получения
CN104411686B (zh) * 2012-07-25 2016-08-31 株式会社富士药品 4-[5-(吡啶-4-基)-1h-1,2,4-三唑-3-基]吡啶-2-腈的制造方法及中间体
CN103724329B (zh) * 2013-12-23 2015-02-18 济南百诺医药科技开发有限公司 4-[5-(吡啶-4-基)-1h-[1,2,4]三唑-3-基]吡啶-2-甲腈的制备方法

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