JP2018507858A5 - - Google Patents
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- Publication number
- JP2018507858A5 JP2018507858A5 JP2017544629A JP2017544629A JP2018507858A5 JP 2018507858 A5 JP2018507858 A5 JP 2018507858A5 JP 2017544629 A JP2017544629 A JP 2017544629A JP 2017544629 A JP2017544629 A JP 2017544629A JP 2018507858 A5 JP2018507858 A5 JP 2018507858A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- acceptable salt
- polymorph
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2015/000430 | 2015-02-25 | ||
| EP2015000430 | 2015-02-25 | ||
| PCT/EP2016/000343 WO2016134854A1 (en) | 2015-02-25 | 2016-02-24 | Methods for the preparation of topiroxostat and intermediates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018507858A JP2018507858A (ja) | 2018-03-22 |
| JP2018507858A5 true JP2018507858A5 (enExample) | 2019-04-04 |
| JP6811717B2 JP6811717B2 (ja) | 2021-01-13 |
Family
ID=55484946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544629A Expired - Fee Related JP6811717B2 (ja) | 2015-02-25 | 2016-02-24 | トピロキソスタット及びその中間体の調製のための方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6811717B2 (enExample) |
| CN (1) | CN107531677A (enExample) |
| WO (1) | WO2016134854A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108250183A (zh) * | 2016-12-29 | 2018-07-06 | 北京诚济制药有限公司 | 一种高纯度的托匹司他的制备方法 |
| CN113666909B (zh) * | 2020-05-14 | 2024-07-02 | 鲁南制药集团股份有限公司 | 一种托匹司他的制备方法 |
| CN114685451A (zh) * | 2020-12-30 | 2022-07-01 | 鲁南制药集团股份有限公司 | 马来酸托匹司他二水合物共晶及其制备方法 |
| CN114685452A (zh) * | 2020-12-31 | 2022-07-01 | 鲁南制药集团股份有限公司 | 一种托匹司他-水杨酸-乙酸三元共晶 |
| CN115925682B (zh) * | 2021-10-04 | 2025-11-25 | 山东新时代药业有限公司 | 一种托匹司他的合成方法 |
| CN115308347B (zh) * | 2022-09-01 | 2023-09-08 | 江苏知原药业股份有限公司 | 一种托吡司特中氮氧化物杂质的分析方法 |
| CN115572747B (zh) * | 2022-09-23 | 2023-05-05 | 湖南一格制药有限公司 | 托匹司他的制备方法 |
| CN115477638A (zh) * | 2022-10-09 | 2022-12-16 | 浙江神洲药业有限公司 | 一种托匹司他的制备方法 |
| CN116396275B (zh) * | 2023-03-03 | 2025-05-13 | 浙江国邦药业有限公司 | 一种托匹司他的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69928610T2 (de) * | 1998-08-10 | 2006-08-10 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von 2-Carbamoyl-Pyridinen |
| CA2438991C (en) * | 2001-02-21 | 2010-08-17 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| MXPA04004037A (es) * | 2002-01-28 | 2004-07-23 | Fuji Yakuhin Co Ltd | Compuestos novedosos de 1, 2, 4-de triazol. |
| CN1826335A (zh) * | 2003-07-24 | 2006-08-30 | 株式会社富士药品 | 1,2,4－三唑化合物的制造方法以及其中间体 |
| JP2005041802A (ja) * | 2003-07-25 | 2005-02-17 | Fujiyakuhin Co Ltd | １，２，４−トリアゾール化合物の製造方法 |
| US20060189811A1 (en) * | 2004-07-23 | 2006-08-24 | Fujiyakuhin Co., Ltd. | Process for producing 1,2,4-triazole compound and intermediate therefor |
| CA2876268C (en) | 2012-07-25 | 2016-12-20 | Fujiyakuhin Co., Ltd. | Method for producing 4-[5-(pyridin-4-yl)-1h-1,2,4-triazol-3-yl]pyridine-2-carbonitrile |
| TWI598346B (zh) | 2012-07-25 | 2017-09-11 | Fujiyakuhin Co Ltd | Crystallographic polymorphism of 4- [5- (pyridin-4-yl) -1H-1,2,4-triazol-3-yl] pyridine-2-carbonitriles and process for producing the same |
| CN103724329B (zh) * | 2013-12-23 | 2015-02-18 | 济南百诺医药科技开发有限公司 | 4-[5-(吡啶-4-基)-1h-[1,2,4]三唑-3-基]吡啶-2-甲腈的制备方法 |
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2016
- 2016-02-24 JP JP2017544629A patent/JP6811717B2/ja not_active Expired - Fee Related
- 2016-02-24 CN CN201680023004.9A patent/CN107531677A/zh active Pending
- 2016-02-24 WO PCT/EP2016/000343 patent/WO2016134854A1/en not_active Ceased