JP2018507858A5 - - Google Patents
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- Publication number
- JP2018507858A5 JP2018507858A5 JP2017544629A JP2017544629A JP2018507858A5 JP 2018507858 A5 JP2018507858 A5 JP 2018507858A5 JP 2017544629 A JP2017544629 A JP 2017544629A JP 2017544629 A JP2017544629 A JP 2017544629A JP 2018507858 A5 JP2018507858 A5 JP 2018507858A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- acceptable salt
- polymorph
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 43
- 238000000034 method Methods 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 9
- UBVZQGOVTLIHLH-UHFFFAOYSA-N 4-[5-pyridin-4-yl-1h-[1,2,4]triazol-3-yl]-pyridine-2-carbonitrile Chemical compound C1=NC(C#N)=CC(C=2N=C(NN=2)C=2C=CN=CC=2)=C1 UBVZQGOVTLIHLH-UHFFFAOYSA-N 0.000 claims 6
- 229950004176 topiroxostat Drugs 0.000 claims 6
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 5
- 238000006243 chemical reaction Methods 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 239000002585 base Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000012024 dehydrating agents Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2015000430 | 2015-02-25 | ||
| EPPCT/EP2015/000430 | 2015-02-25 | ||
| PCT/EP2016/000343 WO2016134854A1 (en) | 2015-02-25 | 2016-02-24 | Methods for the preparation of topiroxostat and intermediates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018507858A JP2018507858A (ja) | 2018-03-22 |
| JP2018507858A5 true JP2018507858A5 (enExample) | 2019-04-04 |
| JP6811717B2 JP6811717B2 (ja) | 2021-01-13 |
Family
ID=55484946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544629A Expired - Fee Related JP6811717B2 (ja) | 2015-02-25 | 2016-02-24 | トピロキソスタット及びその中間体の調製のための方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6811717B2 (enExample) |
| CN (1) | CN107531677A (enExample) |
| WO (1) | WO2016134854A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108250183A (zh) * | 2016-12-29 | 2018-07-06 | 北京诚济制药有限公司 | 一种高纯度的托匹司他的制备方法 |
| CN113666909B (zh) * | 2020-05-14 | 2024-07-02 | 鲁南制药集团股份有限公司 | 一种托匹司他的制备方法 |
| CN114685451A (zh) * | 2020-12-30 | 2022-07-01 | 鲁南制药集团股份有限公司 | 马来酸托匹司他二水合物共晶及其制备方法 |
| CN114685452A (zh) * | 2020-12-31 | 2022-07-01 | 鲁南制药集团股份有限公司 | 一种托匹司他-水杨酸-乙酸三元共晶 |
| CN115925682B (zh) * | 2021-10-04 | 2025-11-25 | 山东新时代药业有限公司 | 一种托匹司他的合成方法 |
| CN115308347B (zh) * | 2022-09-01 | 2023-09-08 | 江苏知原药业股份有限公司 | 一种托吡司特中氮氧化物杂质的分析方法 |
| CN115572747B (zh) * | 2022-09-23 | 2023-05-05 | 湖南一格制药有限公司 | 托匹司他的制备方法 |
| CN115477638A (zh) * | 2022-10-09 | 2022-12-16 | 浙江神洲药业有限公司 | 一种托匹司他的制备方法 |
| CN116396275B (zh) * | 2023-03-03 | 2025-05-13 | 浙江国邦药业有限公司 | 一种托匹司他的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2252894T3 (es) * | 1998-08-10 | 2006-05-16 | F. Hoffmann-La Roche Ag | Procedimiento para la preparacion de 2-carbamoil piridinas. |
| EP1379525B1 (en) * | 2001-02-21 | 2007-10-10 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| PT1471065E (pt) | 2002-01-28 | 2008-03-13 | Fuji Yakuhin Co Ltd | Novos compostos de 1,2,4-triazole |
| KR20060037373A (ko) | 2003-07-24 | 2006-05-03 | 가부시키가이샤 후지야쿠힝 | 1,2,4-트리아졸 화합물의 제조 방법 및 그 중간체 |
| JP2005041802A (ja) * | 2003-07-25 | 2005-02-17 | Fujiyakuhin Co Ltd | １，２，４−トリアゾール化合物の製造方法 |
| US20060189811A1 (en) * | 2004-07-23 | 2006-08-24 | Fujiyakuhin Co., Ltd. | Process for producing 1,2,4-triazole compound and intermediate therefor |
| EP2878598B1 (en) | 2012-07-25 | 2019-06-19 | Fuji Yakuhin Co., Ltd. | Crystalline form of 4-[5-(pyridine-4-yl)-1h-1,2,4-triazole-3-yl]pyridine-2-carbonitrile |
| JP5827407B2 (ja) | 2012-07-25 | 2015-12-02 | 株式会社富士薬品 | ４−［５−（ピリジン−４−イル）−１ｈ−１，２，４−トリアゾール−３−イル］ピリジン−２−カルボニトリルの製造方法および中間体 |
| CN103724329B (zh) | 2013-12-23 | 2015-02-18 | 济南百诺医药科技开发有限公司 | 4-[5-(吡啶-4-基)-1h-[1,2,4]三唑-3-基]吡啶-2-甲腈的制备方法 |
-
2016
- 2016-02-24 CN CN201680023004.9A patent/CN107531677A/zh active Pending
- 2016-02-24 WO PCT/EP2016/000343 patent/WO2016134854A1/en not_active Ceased
- 2016-02-24 JP JP2017544629A patent/JP6811717B2/ja not_active Expired - Fee Related
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