JP2017508553A - 可撓性壁を有する生物学的流体フィルタとそのフィルタを作製するための方法 - Google Patents
可撓性壁を有する生物学的流体フィルタとそのフィルタを作製するための方法 Download PDFInfo
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- 238000000034 method Methods 0.000 title description 9
- 238000001914 filtration Methods 0.000 claims abstract description 59
- 230000002093 peripheral effect Effects 0.000 claims abstract description 45
- 239000012530 fluid Substances 0.000 claims abstract description 8
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- B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
- B01D35/30—Filter housing constructions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
- A61M1/3635—Constructional details
- A61M1/3636—Constructional details having a flexible housing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/50—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D39/08—Filter cloth, i.e. woven, knitted or interlaced material
- B01D39/083—Filter cloth, i.e. woven, knitted or interlaced material of organic material
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D39/00—Filtering material for liquid or gaseous fluids
- B01D39/08—Filter cloth, i.e. woven, knitted or interlaced material
- B01D39/086—Filter cloth, i.e. woven, knitted or interlaced material of inorganic material
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D39/00—Filtering material for liquid or gaseous fluids
- B01D39/10—Filter screens essentially made of metal
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D39/00—Filtering material for liquid or gaseous fluids
- B01D39/14—Other self-supporting filtering material ; Other filtering material
- B01D39/16—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres
- B01D39/1607—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres the material being fibrous
- B01D39/1623—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres the material being fibrous of synthetic origin
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
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- B01D2201/30—Filter housing constructions
- B01D2201/301—Details of removable closures, lids, caps, filter heads
- B01D2201/306—Closures, lids, caps or filter heads forming one element with the filtering element
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/12—Special parameters characterising the filtering material
- B01D2239/1258—Permeability
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Textile Engineering (AREA)
- Inorganic Chemistry (AREA)
- External Artificial Organs (AREA)
Abstract
Description
本願は、2014年3月24日に出願され、ここに参照として内容が組み込まれる米国特許出願第14/223,511号に基づく優先権と利益とを主張する。
Claims (23)
- a)第1と第2の可撓性壁を有し、前記壁の1つは、入口ポートに関連付けられた入口ハウジング壁を含み、前記ハウジング壁の他方は、出口ポートに関連付けられた出口ハウジング壁を含むハウジングと;
b)前記可撓性壁の間に配置され、少なくとも第1、第2、第3のフィルタ要素を含むろ過媒体とを備え;
前記ろ過媒体において、
i)前記第1の要素は生物学的流体の成分または微粒子を除去するために適した材質を含み、前記入口ポートを含む前記ハウジング壁と前記第2の要素との間に配置され;
ii)前記第2の要素は前記生物学的流体の他の成分を除去するために適した材質を含み、前記第1の要素と前記第3の要素との間に配置され;
iii)前記第3の要素は有機または無機材質を含み、前記出口ポートを含む前記ハウジング壁と前記第2のフィルタ要素との間に配置され、前記第3のフィルタ要素は125Paの圧力差において厚さ1cmにつき40cm2/sより大きい通気度を有する、
生物学的流体フィルタアセンブリ。 - 前記第3のフィルタ要素は、125Paの圧力差において厚さ1cmにつき約40cm2/s〜800cm2/sの通気度を有する、請求項1に記載の生物学的流体フィルタ。
- 前記第3のフィルタ要素は約0.5〜4mmの厚みを有する、請求項1または請求項2に記載の生物学的流体フィルタ。
- 前記第3のフィルタ要素は塩化ビニルのメッシュを備える多孔質領域を含む、請求項1から請求項3までのいずれか1項に記載の生物学的流体フィルタ。
- 前記第3のフィルタ要素はさらに、前記多孔質領域を囲む実質的に非多孔質のフレームを含む、請求項4に記載の生物学的流体フィルタ。
- a)第1と第2の可撓性ハウジング壁を有し、前記壁の1つは入口ポートに関連付けられる入口ハウジング壁を含み、前記ハウジング壁の他方は出口ポートに関連付けられる出口ハウジング壁を含むハウジングと;
b)前記可撓性壁の間に配置され、少なくとも第1、第2、第3のフィルタ要素を含むろ過媒体とを備え;
前記ろ過媒体において、
i)前記第1の要素は生物学的流体から成分または微粒子を除去するために適した材質を含み、前記入口ポートを含む前記ハウジング壁と前記第2の要素との間に配置され;
ii)前記第2の要素は前記生物学的流体の別の成分を除去するために適した材質を含み、前記第1の要素と前記第3の要素との間に配置され;
iii)前記第3の要素は有機または無機材質を含み、前記出口ポートに関連付けられる前記ハウジング壁と前記第2のフィルタ要素との間に配置され、前記第3のフィルタ要素は0.04cmより小さい、または、0.25cmより大きい厚みを有し;そして、
c)さらに、外側周辺シールと、前記外側周辺シールから離間されている少なくとも1つの内側周辺シールとを備える、
生物学的流体フィルタアセンブリ。 - 前記第3のフィルタ要素は、125Paの圧力差において厚み1cmあたり40cm2/sより大きい通気度を有する、請求項6に記載の生物学的流体フィルタアセンブリ。
- 前記周辺シールは前記ハウジング壁のみを結合するシールを含む、請求項6または請求項7に記載の生物学的流体フィルタアセンブリ。
- 前記周辺シールは前記第1と第2のハウジング壁と、少なくとも第1、第2、第3の要素の1つを結合する、請求項6または請求項7に記載の生物学的流体フィルタアセンブリ。
- 第1の内側周辺シールと、前記第1の内側周辺シールから離間された第2の内周辺シールとを備える、請求項6から請求項9までのいずれか1項に記載の生物学的流体フィルタアセンブリ。
- 内側周辺シールと外側周辺シールとの間または第1と第2の内側周辺シールとの間は1〜10mmである、請求項10に記載の生物学的流体フィルタアセンブリ。
- 前記内側シールは、周辺部分の間に中心部分を含む、請求項6から請求項11までのいずれか1項に記載の生物学的流体フィルタアセンブリ。
- 前記内側シールは約0.762〜2.286mmの厚みを有する、請求項6から請求項12までのいずれか1項に記載の生物学的流体フィルタアセンブリ。
- 前記第3のフィルタ要素は、メッシュを含むシートを備える、請求項6から請求項13までのいずれか1項に記載の生物学的流体フィルタアセンブリ。
- 前記第3のフィルタ要素は、中心メッシュ部分を規定する非多孔性のフレームを備える、請求項6から請求項14までのいずれか1項に記載の生物学的流体フィルタアセンブリ。
- 前記シートは少なくとも実質的にポリ塩化ビニルによって形成されている、請求項14または請求項15に記載の生物学的流体フィルタアセンブリ。
- 前記内側周辺シールは、
a)少なくとも実質的に前記入口ハウジング壁の材質によって構成される層;
b)前記入口ハウジング壁の前記材質と前記第1と第2のフィルタ要素の材質の複合である材質を含む、前記(a)の領域に隣接した層;
c)前記層(b)と前記第2のフィルタ要素の材質によって構成される層(d)とに隣接した層;
d)前記層(c)と前記出口ハウジング壁の材質と前記第3のフィルタ要素の材質の複合である材質を含む層(e)とに隣接した層;そして
e)少なくとも実質的に前記出口ハウジングの材質によって構成される層
を含む複数の層を含む、請求項6〜16までのいずれか1項に記載の生物学的流体フィルタアセンブリ。 - 層(d)は0.15mmよりも小さい厚みを有する、請求項17に記載の生物学的流体フィルタアセンブリ。
- 前記第1、第2、第3のフィルタ要素を含む前記ろ過媒体は、積層された複数のシートを備える、請求項6から請求項18までのいずれか1項に記載の生物学的流体フィルタアセンブリ。
- 前記外側周辺シールは、
a)少なくとも実質的に前記入口ハウジング壁の材質によって構成される層;
b)入口ハウジング壁の前記材質と前記第1と第2のフィルタ要素の材質の複合である材質を含む、前記(a)の領域に隣接した層;そして
c)少なくとも実質的に前記出口ハウジングの材質によって構成される層
を含む複数の層を含む、請求項9に記載の生物学的流体フィルタアセンブリ。 - 前記第1と第2のフィルタ要素は、ポリブチレンテレフタレート、ポリエチレンテレフタレート、および、ポリプロピレンからなる群から選ばれる材質によって形成される、請求項6から請求項20までのいずれか1項に記載の生物学的流体フィルタアセンブリ。
- 前記内側周辺シールは、
a)少なくとも実質的に前記入口ハウジング壁の材質によって構成される層;
b)入口ハウジング壁の前記材質と前記第1と第2のフィルタ要素の材質の複合である材質を含む、前記(a)の領域に隣接した層;そして
c)本質的に前記出口ハウジング壁と前記第3のフィルタ要素の材質からなる前記(b)層の下流側の層
を含む複数の層を含む、請求項6から請求項16までと請求項19から請求項21までのいずれか1項に記載の生物学的流体フィルタアセンブリ。 - 前記層(c)はポリ塩化ビニルで構成されている、請求項22に記載の生物学的流体フィルタアセンブリ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/223,511 US9782707B2 (en) | 2014-03-24 | 2014-03-24 | Biological fluid filters having flexible walls and methods for making such filters |
US14/223,511 | 2014-03-24 | ||
PCT/US2014/041213 WO2015147897A1 (en) | 2014-03-24 | 2014-06-06 | Biological fluid filters having flexible walls and methods for making such filters |
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JP2019146933A Division JP2019205896A (ja) | 2014-03-24 | 2019-08-09 | 可撓性壁を有する生物学的流体フィルタとそのフィルタを作製するための方法 |
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