JP2017504571A5 - - Google Patents
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- JP2017504571A5 JP2017504571A5 JP2016534731A JP2016534731A JP2017504571A5 JP 2017504571 A5 JP2017504571 A5 JP 2017504571A5 JP 2016534731 A JP2016534731 A JP 2016534731A JP 2016534731 A JP2016534731 A JP 2016534731A JP 2017504571 A5 JP2017504571 A5 JP 2017504571A5
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- JP
- Japan
- Prior art keywords
- alkyl
- item
- group
- pharmaceutically acceptable
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 107
- 150000003839 salts Chemical class 0.000 claims description 37
- 239000008194 pharmaceutical composition Substances 0.000 claims description 21
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 21
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 12
- OZAYOHJGXLWETR-QGZVFWFLSA-N 4-[(3R)-1-[(2-chloro-4-fluorophenyl)methyl]piperidin-3-yl]oxy-5-cyclopropyl-2-fluoro-N-methylsulfonylbenzamide Chemical compound ClC1=C(CN2C[C@@H](CCC2)OC2=CC(=C(C(=O)NS(=O)(=O)C)C=C2C2CC2)F)C=CC(=C1)F OZAYOHJGXLWETR-QGZVFWFLSA-N 0.000 claims 3
- PRCIGHMFXRYAIG-INIZCTEOSA-N 5-cyclopropyl-N-cyclopropylsulfonyl-4-[[1-[(1S)-1-(3,5-dichlorophenyl)ethyl]piperidin-4-yl]methoxy]-2-fluorobenzamide Chemical compound C1(CC1)C=1C(=CC(=C(C(=O)NS(=O)(=O)C2CC2)C=1)F)OCC1CCN(CC1)[C@@H](C)C1=CC(=CC(=C1)Cl)Cl PRCIGHMFXRYAIG-INIZCTEOSA-N 0.000 claims 3
- KRNHAUPCKRIYSK-LJQANCHMSA-N N-(azetidin-1-ylsulfonyl)-4-[(3R)-1-[(2-chloro-4-fluorophenyl)methyl]piperidin-3-yl]oxy-5-cyclopropyl-2-fluorobenzamide Chemical compound FC1=CC=C(CN2CCC[C@H](C2)OC2=CC(F)=C(C=C2C2CC2)C(=O)NS(=O)(=O)N2CCC2)C(Cl)=C1 KRNHAUPCKRIYSK-LJQANCHMSA-N 0.000 claims 3
- 125000006125 ethylsulfonyl group Chemical group 0.000 claims 3
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 2
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- CIXVIWMKNATLIZ-CRAIPNDOSA-N 4-[(3R)-1-[(1R)-1-(5-chloro-6-cyclopropylpyridin-2-yl)ethyl]piperidin-3-yl]oxy-5-cyclopropyl-2-fluoro-N-methylsulfonylbenzamide Chemical compound ClC=1C=CC(=NC=1C1CC1)[C@@H](C)N1C[C@@H](CCC1)OC1=CC(=C(C(=O)NS(=O)(=O)C)C=C1C1CC1)F CIXVIWMKNATLIZ-CRAIPNDOSA-N 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 description 75
- 125000000217 alkyl group Chemical group 0.000 description 56
- -1 C1-8Alkyl Chemical group 0.000 description 52
- 125000003545 alkoxy group Chemical group 0.000 description 52
- 229910052739 hydrogen Inorganic materials 0.000 description 51
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 description 44
- 208000002193 Pain Diseases 0.000 description 43
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 38
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 description 35
- 125000004419 alkynylene group Chemical group 0.000 description 30
- 239000001257 hydrogen Substances 0.000 description 30
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 30
- 125000000623 heterocyclic group Chemical group 0.000 description 25
- 125000001188 haloalkyl group Chemical group 0.000 description 24
- 125000005843 halogen group Chemical group 0.000 description 24
- 238000000034 method Methods 0.000 description 20
- 125000002947 alkylene group Chemical group 0.000 description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 16
- 125000004663 dialkyl amino group Chemical group 0.000 description 15
- 125000004450 alkenylene group Chemical group 0.000 description 14
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 description 12
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 12
- 241000124008 Mammalia Species 0.000 description 12
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 12
- 201000010099 disease Diseases 0.000 description 12
- 125000004404 heteroalkyl group Chemical group 0.000 description 12
- 125000005842 heteroatom Chemical group 0.000 description 12
- 125000003282 alkyl amino group Chemical group 0.000 description 10
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 10
- 125000000753 cycloalkyl group Chemical group 0.000 description 10
- 125000004474 heteroalkylene group Chemical group 0.000 description 10
- 229910052760 oxygen Inorganic materials 0.000 description 10
- 229910052717 sulfur Inorganic materials 0.000 description 10
- 229910052799 carbon Inorganic materials 0.000 description 9
- 125000001153 fluoro group Chemical group F* 0.000 description 9
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 8
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 8
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 8
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 description 6
- 206010015150 Erythema Diseases 0.000 description 6
- 125000003342 alkenyl group Chemical group 0.000 description 6
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 6
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 125000005647 linker group Chemical group 0.000 description 6
- 201000006417 multiple sclerosis Diseases 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 description 6
- 208000033808 peripheral neuropathy Diseases 0.000 description 6
- 230000008733 trauma Effects 0.000 description 6
- 208000024172 Cardiovascular disease Diseases 0.000 description 5
- 125000001246 bromo group Chemical group Br* 0.000 description 5
- 125000001309 chloro group Chemical group Cl* 0.000 description 5
- 208000020016 psychiatric disease Diseases 0.000 description 5
- 208000023504 respiratory system disease Diseases 0.000 description 5
- FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 description 4
- 208000000094 Chronic Pain Diseases 0.000 description 4
- 206010065390 Inflammatory pain Diseases 0.000 description 4
- 231100000321 erythema Toxicity 0.000 description 4
- 208000004296 neuralgia Diseases 0.000 description 4
- 208000021722 neuropathic pain Diseases 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 208000019901 Anxiety disease Diseases 0.000 description 3
- 201000001320 Atherosclerosis Diseases 0.000 description 3
- 206010003658 Atrial Fibrillation Diseases 0.000 description 3
- 208000020925 Bipolar disease Diseases 0.000 description 3
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- 208000032131 Diabetic Neuropathies Diseases 0.000 description 3
- 208000001640 Fibromyalgia Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 101000620451 Homo sapiens Leucine-rich glioma-inactivated protein 1 Proteins 0.000 description 3
- 206010020844 Hyperthermia malignant Diseases 0.000 description 3
- 208000007914 Labor Pain Diseases 0.000 description 3
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- 102100022275 Leucine-rich glioma-inactivated protein 1 Human genes 0.000 description 3
- 208000026709 Liddle syndrome Diseases 0.000 description 3
- 208000018717 Malignant hyperthermia of anesthesia Diseases 0.000 description 3
- 208000019695 Migraine disease Diseases 0.000 description 3
- 206010028372 Muscular weakness Diseases 0.000 description 3
- 206010061533 Myotonia Diseases 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 description 3
- 206010029279 Neurogenic bladder Diseases 0.000 description 3
- 208000012075 Paroxysmal dystonia Diseases 0.000 description 3
- 208000010886 Peripheral nerve injury Diseases 0.000 description 3
- 208000004983 Phantom Limb Diseases 0.000 description 3
- 206010056238 Phantom pain Diseases 0.000 description 3
- 206010036376 Postherpetic Neuralgia Diseases 0.000 description 3
- 208000004550 Postoperative Pain Diseases 0.000 description 3
- 206010037113 Pseudoaldosteronism Diseases 0.000 description 3
- 208000005793 Restless legs syndrome Diseases 0.000 description 3
- 206010039020 Rhabdomyolysis Diseases 0.000 description 3
- 206010040744 Sinus headache Diseases 0.000 description 3
- 108010052164 Sodium Channels Proteins 0.000 description 3
- 102000018674 Sodium Channels Human genes 0.000 description 3
- 208000006011 Stroke Diseases 0.000 description 3
- 208000001871 Tachycardia Diseases 0.000 description 3
- 206010043269 Tension headache Diseases 0.000 description 3
- 208000008548 Tension-Type Headache Diseases 0.000 description 3
- 125000002252 acyl group Chemical group 0.000 description 3
- 230000036506 anxiety Effects 0.000 description 3
- 206010003119 arrhythmia Diseases 0.000 description 3
- 230000006793 arrhythmia Effects 0.000 description 3
- 206010003246 arthritis Diseases 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 208000028683 bipolar I disease Diseases 0.000 description 3
- 208000025307 bipolar depression Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 238000002512 chemotherapy Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 208000010118 dystonia Diseases 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 125000001072 heteroaryl group Chemical group 0.000 description 3
- 208000003532 hypothyroidism Diseases 0.000 description 3
- 230000002989 hypothyroidism Effects 0.000 description 3
- 208000002551 irritable bowel syndrome Diseases 0.000 description 3
- 230000000302 ischemic effect Effects 0.000 description 3
- 201000007004 malignant hyperthermia Diseases 0.000 description 3
- 206010027599 migraine Diseases 0.000 description 3
- 230000036473 myasthenia Effects 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 201000001119 neuropathy Diseases 0.000 description 3
- 230000007823 neuropathy Effects 0.000 description 3
- 230000004112 neuroprotection Effects 0.000 description 3
- 201000008482 osteoarthritis Diseases 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 230000002085 persistent effect Effects 0.000 description 3
- 206010039073 rheumatoid arthritis Diseases 0.000 description 3
- 201000000306 sarcoidosis Diseases 0.000 description 3
- 201000000980 schizophrenia Diseases 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
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- 206010044652 trigeminal neuralgia Diseases 0.000 description 3
- 208000003663 ventricular fibrillation Diseases 0.000 description 3
- 208000009935 visceral pain Diseases 0.000 description 3
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 description 2
- 150000001539 azetidines Chemical class 0.000 description 2
- 230000035606 childbirth Effects 0.000 description 2
- 206010009887 colitis Diseases 0.000 description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000009610 hypersensitivity Effects 0.000 description 2
- 208000019865 paroxysmal extreme pain disease Diseases 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010036772 Proctalgia Diseases 0.000 description 1
- 206010049447 Tachyarrhythmia Diseases 0.000 description 1
- 206010057040 Temperature intolerance Diseases 0.000 description 1
- 206010043994 Tonic convulsion Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 208000005298 acute pain Diseases 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 description 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 description 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 description 1
- 230000008543 heat sensitivity Effects 0.000 description 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 description 1
- 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013001452 | 2013-11-27 | ||
| CNPCT/CN2013/001452 | 2013-11-27 | ||
| CN2013088062 | 2013-11-28 | ||
| CNPCT/CN2013/088062 | 2013-11-28 | ||
| CN2014090171 | 2014-11-03 | ||
| CNPCT/CN2014/090171 | 2014-11-03 | ||
| PCT/CN2014/092269 WO2015078374A1 (en) | 2013-11-27 | 2014-11-26 | Substituted benzamides and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018146542A Division JP2018188466A (ja) | 2013-11-27 | 2018-08-03 | 置換ベンズアミド及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017504571A JP2017504571A (ja) | 2017-02-09 |
| JP2017504571A5 true JP2017504571A5 (enExample) | 2017-12-28 |
| JP6383418B2 JP6383418B2 (ja) | 2018-08-29 |
Family
ID=53198372
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016534731A Expired - Fee Related JP6383418B2 (ja) | 2013-11-27 | 2014-11-26 | 置換ベンズアミド及びその使用方法 |
| JP2018146542A Pending JP2018188466A (ja) | 2013-11-27 | 2018-08-03 | 置換ベンズアミド及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018146542A Pending JP2018188466A (ja) | 2013-11-27 | 2018-08-03 | 置換ベンズアミド及びその使用方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9546164B2 (enExample) |
| EP (2) | EP3074377B1 (enExample) |
| JP (2) | JP6383418B2 (enExample) |
| KR (1) | KR20160090846A (enExample) |
| CN (1) | CN105793238B (enExample) |
| AU (1) | AU2014356967A1 (enExample) |
| CA (1) | CA2931732A1 (enExample) |
| CL (1) | CL2016001287A1 (enExample) |
| CR (1) | CR20160296A (enExample) |
| EA (1) | EA201691085A1 (enExample) |
| IL (1) | IL245844A0 (enExample) |
| MX (1) | MX2016006936A (enExample) |
| PE (1) | PE20161247A1 (enExample) |
| PH (1) | PH12016501007A1 (enExample) |
| TW (1) | TWI560180B (enExample) |
| WO (1) | WO2015078374A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2586213T3 (es) | 2011-10-31 | 2016-10-13 | Xenon Pharmaceuticals Inc. | Compuestos de bencenosulfonamida y su uso como agentes terapéuticos |
| MX2014005304A (es) | 2011-10-31 | 2015-03-20 | Xenon Pharmaceuticals Inc | Biaril eter sulfonamidas y su uso como agentes terapeuticos. |
| CA2874621A1 (en) * | 2012-05-22 | 2013-11-28 | Genentech, Inc. | N-substituted benzamides and their use in the treatment of pain |
| US10071957B2 (en) | 2012-07-06 | 2018-09-11 | Genentech, Inc. | N-substituted benzamides and methods of use thereof |
| CN105263490B (zh) | 2013-03-14 | 2018-05-22 | 基因泰克公司 | 取代的三唑并吡啶及其使用方法 |
| CA2898680A1 (en) | 2013-03-15 | 2014-09-18 | Genentech,Inc. | Substituted benzoxazoles and methods of use thereof |
| JP6383418B2 (ja) | 2013-11-27 | 2018-08-29 | ジェネンテック， インコーポレイテッド | 置換ベンズアミド及びその使用方法 |
| CN106715418A (zh) | 2014-07-07 | 2017-05-24 | 基因泰克公司 | 治疗化合物及其使用方法 |
| CN107406380B (zh) * | 2015-02-04 | 2020-04-28 | 上海海雁医药科技有限公司 | 杂环取代的n-磺酰基苯甲酰胺衍生物、其制法与医药上的用途 |
| MA42118A (fr) | 2015-05-22 | 2018-03-28 | Genentech Inc | Benzamides substitués et leurs méthodes d'utilisation |
| WO2017035271A1 (en) | 2015-08-27 | 2017-03-02 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| JP6987746B2 (ja) | 2015-09-28 | 2022-01-05 | ジェネンテック， インコーポレイテッド | 治療用化合物及びその使用方法 |
| HRP20221417T1 (hr) * | 2015-11-13 | 2023-02-03 | Oppilan Pharma Ltd. | Heterociklički spojevi za liječenje bolesti |
| US10899732B2 (en) | 2015-11-25 | 2021-01-26 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| US10370368B2 (en) | 2015-11-30 | 2019-08-06 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as BLT1 antagonists |
| CN108699015A (zh) | 2015-12-18 | 2018-10-23 | 默沙东公司 | 对电压门控性钠通道具有选择性活性的羟基烷基胺-和羟基环烷基胺-取代的二胺-芳基磺胺化合物 |
| JP2019505508A (ja) | 2016-02-03 | 2019-02-28 | シャンハイ ハイヤン ファーマシューティカル テクノロジー カンパニー リミテッドＳｈａｎｇｈａｉ Ｈａｉｙａｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． | 複素環置換ｎ−スルホニルベンズアミド誘導体、その製造方法および医薬における使用 |
| US10766858B2 (en) | 2016-03-30 | 2020-09-08 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| WO2017201468A1 (en) * | 2016-05-20 | 2017-11-23 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| BR112019007763A2 (pt) * | 2016-10-17 | 2019-07-02 | Genentech Inc | composto de fórmula, composição farmacêutica, métodos para tratar uma doença ou condição, para tratar dores, para diminuir o fluxo de íons e para tratar prurido, uso de um composto e invenção |
| EP3551626B1 (en) | 2016-12-09 | 2023-10-25 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| AR111295A1 (es) | 2017-03-20 | 2019-06-26 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr) |
| EP3601273B1 (en) | 2017-03-24 | 2021-12-01 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
| EP3651762B1 (en) | 2017-07-12 | 2024-07-03 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor m4 |
| CN110300745B (zh) * | 2017-07-24 | 2023-03-31 | 上海海雁医药科技有限公司 | 钠离子通道抑制剂及其药学上可接受的盐和多晶型物及其应用 |
| JP2020532507A (ja) | 2017-08-31 | 2020-11-12 | ラクオリア創薬株式会社 | Ｔｔｘ−ｓ遮断薬としてのビアリールオキシ誘導体 |
| CN109574927A (zh) * | 2017-09-29 | 2019-04-05 | 浙江海正药业股份有限公司 | N-(取代磺酰基)苯甲酰胺类衍生物及其制备方法和医药用途 |
| JP7270989B2 (ja) | 2017-10-20 | 2023-05-11 | ヴァンダービルト ユニバーシティー | ムスカリン性アセチルコリン受容体ｍ４のアンタゴニスト |
| EP3732163A4 (en) * | 2017-12-20 | 2021-07-14 | Vanderbilt University | MUSCARIN M4 ACETYLCHOLIN RECEPTOR ANTAGONISTS |
| AR114263A1 (es) | 2018-02-26 | 2020-08-12 | Genentech Inc | Compuestos terapéuticos y métodos para utilizarlos |
| WO2019191702A1 (en) | 2018-03-30 | 2019-10-03 | F. Hoffmann-La Roche Ag | Substituted hydro-pyrido-azines as sodium channel inhibitors |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| AU2019285184B2 (en) | 2018-06-13 | 2023-11-16 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| WO2020248123A1 (en) | 2019-06-11 | 2020-12-17 | Merck Sharp & Dohme Corp. | Hydroxypyrrolidine-substituted arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
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2014
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- 2014-11-26 EP EP14865855.2A patent/EP3074377B1/en active Active
- 2014-11-26 CN CN201480064734.4A patent/CN105793238B/zh not_active Expired - Fee Related
- 2014-11-26 CA CA2931732A patent/CA2931732A1/en not_active Abandoned
- 2014-11-26 CR CR20160296A patent/CR20160296A/es unknown
- 2014-11-26 PE PE2016000696A patent/PE20161247A1/es not_active Application Discontinuation
- 2014-11-26 EP EP18197734.9A patent/EP3450428A1/en not_active Withdrawn
- 2014-11-26 KR KR1020167016643A patent/KR20160090846A/ko not_active Withdrawn
- 2014-11-26 EA EA201691085A patent/EA201691085A1/ru unknown
- 2014-11-26 WO PCT/CN2014/092269 patent/WO2015078374A1/en not_active Ceased
- 2014-11-26 AU AU2014356967A patent/AU2014356967A1/en not_active Abandoned
- 2014-11-26 MX MX2016006936A patent/MX2016006936A/es unknown
- 2014-11-27 TW TW103141262A patent/TWI560180B/zh not_active IP Right Cessation
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2015
- 2015-01-22 US US14/603,273 patent/US9546164B2/en not_active Expired - Fee Related
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2016
- 2016-05-25 IL IL245844A patent/IL245844A0/en unknown
- 2016-05-26 CL CL2016001287A patent/CL2016001287A1/es unknown
- 2016-05-27 PH PH12016501007A patent/PH12016501007A1/en unknown
- 2016-09-23 US US15/275,131 patent/US9694002B2/en not_active Expired - Fee Related
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2018
- 2018-08-03 JP JP2018146542A patent/JP2018188466A/ja active Pending
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2019
- 2019-04-22 US US16/390,957 patent/US20200108054A1/en not_active Abandoned
- 2019-11-07 US US16/677,487 patent/US20210093618A1/en not_active Abandoned
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