TWI560180B - Substituted benzamides and methods of use thereof - Google Patents

Substituted benzamides and methods of use thereof

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Publication number
TWI560180B
TWI560180B TW103141262A TW103141262A TWI560180B TW I560180 B TWI560180 B TW I560180B TW 103141262 A TW103141262 A TW 103141262A TW 103141262 A TW103141262 A TW 103141262A TW I560180 B TWI560180 B TW I560180B
Authority
TW
Taiwan
Prior art keywords
methods
substituted benzamides
benzamides
substituted
Prior art date
Application number
TW103141262A
Other languages
English (en)
Chinese (zh)
Other versions
TW201533021A (zh
Inventor
Jean-Christophe Andrez
Paul Robert Bichler
Chien-An Chen
Sultan Chowdhury
Shannon Marie Decker
Christoph Martin Dehnhardt
Thilo Focken
Michael Edward Grimwood
Ivan William Hemeon
Qi Jia
Jun Li
Zhiguo Liu
Daniel F Ortwine
Brian Safina
Daniel Sutherlin
Tao Sheng
Shaoyi Sun
Andrew D White
Michael Scott Wilson
Alla Yurevna Zenova
Jiuxiang Zhu
Original Assignee
Genentech Inc
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Xenon Pharmaceuticals Inc filed Critical Genentech Inc
Publication of TW201533021A publication Critical patent/TW201533021A/zh
Application granted granted Critical
Publication of TWI560180B publication Critical patent/TWI560180B/zh

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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