JP2017186358A5 - - Google Patents

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JP2017186358A5
JP2017186358A5 JP2017111470A JP2017111470A JP2017186358A5 JP 2017186358 A5 JP2017186358 A5 JP 2017186358A5 JP 2017111470 A JP2017111470 A JP 2017111470A JP 2017111470 A JP2017111470 A JP 2017111470A JP 2017186358 A5 JP2017186358 A5 JP 2017186358A5
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JP2017111470A 2014-10-29 2017-06-06 フィロウイルス科ウイルス感染症を処置するための方法 Active JP6757294B2 (ja)

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US201462072331P 2014-10-29 2014-10-29
US62/072,331 2014-10-29
US201562105619P 2015-01-20 2015-01-20
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JP2017520934A Active JP6487547B2 (ja) 2014-10-29 2015-10-29 リボシドの調製のための方法
JP2017520938A Active JP6220484B1 (ja) 2014-10-29 2015-10-29 フィロウイルス科ウイルス感染症を処置するための方法
JP2017111470A Active JP6757294B2 (ja) 2014-10-29 2017-06-06 フィロウイルス科ウイルス感染症を処置するための方法
JP2018129006A Active JP6671424B2 (ja) 2014-10-29 2018-07-06 リボシドの調製のための方法
JP2019000664A Withdrawn JP2019048901A (ja) 2014-10-29 2019-01-07 リボシドの調製のための方法
JP2020023613A Withdrawn JP2020090536A (ja) 2014-10-29 2020-02-14 フィロウイルス科ウイルス感染症を処置するための方法
JP2020038878A Active JP7158428B2 (ja) 2014-10-29 2020-03-06 リボシドの調製のための方法
JP2022019651A Withdrawn JP2022065066A (ja) 2014-10-29 2022-02-10 フィロウイルス科ウイルス感染症を処置するための方法
JP2022024119A Pending JP2022068297A (ja) 2014-10-29 2022-02-18 リボシドの調製のための方法

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JP2019000664A Withdrawn JP2019048901A (ja) 2014-10-29 2019-01-07 リボシドの調製のための方法
JP2020023613A Withdrawn JP2020090536A (ja) 2014-10-29 2020-02-14 フィロウイルス科ウイルス感染症を処置するための方法
JP2020038878A Active JP7158428B2 (ja) 2014-10-29 2020-03-06 リボシドの調製のための方法
JP2022019651A Withdrawn JP2022065066A (ja) 2014-10-29 2022-02-10 フィロウイルス科ウイルス感染症を処置するための方法
JP2022024119A Pending JP2022068297A (ja) 2014-10-29 2022-02-18 リボシドの調製のための方法

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EP (7) EP3366295B1 (enrdf_load_stackoverflow)
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KR (6) KR102453808B1 (enrdf_load_stackoverflow)
CN (6) CN107074902A (enrdf_load_stackoverflow)
AR (2) AR102468A1 (enrdf_load_stackoverflow)
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CL (2) CL2017001040A1 (enrdf_load_stackoverflow)
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CR (2) CR20170483A (enrdf_load_stackoverflow)
CU (2) CU20170056A7 (enrdf_load_stackoverflow)
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EC (2) ECSP17025261A (enrdf_load_stackoverflow)
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SV (2) SV2017005424A (enrdf_load_stackoverflow)
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TW (4) TWI767201B (enrdf_load_stackoverflow)
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Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102596979B (zh) 2009-09-21 2014-12-10 吉里德科学公司 用于制备1’-取代碳核苷类似物的方法和中间体
AP3269A (en) 2010-07-22 2015-05-31 Gilead Sciences Inc Methods and compounds for treating paramyxoviridaevirus infections
TWI767201B (zh) * 2014-10-29 2022-06-11 美商基利科學股份有限公司 絲狀病毒科病毒感染之治療
CN108348526B (zh) * 2015-09-16 2025-04-25 吉利德科学公司 治疗沙粒病毒科和冠状病毒科病毒感染的方法
WO2018089306A1 (en) * 2016-11-10 2018-05-17 Oyagen, Inc. Methods of treating and inhibiting ebola virus infection
AU2017361855A1 (en) * 2016-11-18 2019-05-30 Neurovive Pharmaceutical Ab Liver prodrugs of mitochondrial proton ionophores
EP3595672B1 (en) * 2017-03-14 2023-09-06 Gilead Sciences, Inc. Compounds for use in methods of treating feline coronavirus infections
JP6923112B2 (ja) * 2017-03-31 2021-08-18 国立大学法人北海道大学 フィロウイルスの細胞侵入阻害活性を有するビアリールスルフォンアミド誘導体
US10836787B2 (en) 2017-05-01 2020-11-17 Gilead Sciences, Inc. Crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5- (4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
EP4512475A3 (en) 2017-07-11 2025-05-14 Gilead Sciences, Inc. Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections
EP3684782A1 (en) 2017-09-18 2020-07-29 Janssen BioPharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CN109535200A (zh) * 2017-09-21 2019-03-29 杭州和正医药有限公司 一种核苷类似物的磷酰胺酯前药、药物组合物及其应用
CN109748944B (zh) * 2017-11-03 2021-12-10 中国科学院上海药物研究所 5’-脱氧-5’-异丙基取代氨基核苷类化合物、其制备方法和用途
CN109748943A (zh) * 2017-11-03 2019-05-14 中国科学院上海药物研究所 2’-c-甲基取代核苷类化合物及其制备与用途
CN110330540A (zh) * 2019-08-08 2019-10-15 木天(济南)生物科技有限公司 核苷盐及其制备方法
CN110613726B (zh) * 2019-09-25 2020-10-16 广州六顺生物科技股份有限公司 核苷化合物的应用
WO2021095091A1 (ja) * 2019-11-11 2021-05-20 藤本化学製品株式会社 アミノアリール誘導体及びその中間体、並びにそれらの製造方法
CN110776512A (zh) * 2019-11-28 2020-02-11 成都傲飞生物化学品有限责任公司 一种核苷类似物的制备方法
CA3163424A1 (en) 2020-01-27 2021-08-05 Gilead Sciences, Inc. Methods for treating sars cov-2 infections
US11738025B2 (en) 2020-02-04 2023-08-29 Oyagen, Inc. Method for treating coronavirus infections
CN113214263B (zh) * 2020-02-06 2022-09-30 北京桦冠医药科技有限公司 瑞德西韦关键中间体的一种合成方法
US20210244705A1 (en) * 2020-02-07 2021-08-12 Centre For Digestive Diseases Therapeutic compositions, products of manufacture and methods for ameliorating or preventing coronavirus infection
CN111205327B (zh) * 2020-02-17 2022-05-31 南京法恩化学有限公司 一种瑞德西韦的制备方法
AU2021224588B2 (en) 2020-02-18 2024-07-18 Gilead Sciences, Inc. Antiviral compounds
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
TWI775313B (zh) * 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
TWI884403B (zh) * 2020-02-18 2025-05-21 美商基利科學股份有限公司 抗病毒化合物
CN113292565B (zh) * 2020-02-24 2023-01-31 浙江森科建设有限公司 核苷类化合物及其制备方法和应用
CN111187269A (zh) * 2020-02-27 2020-05-22 江苏阿尔法药业有限公司 一种瑞德西韦中间体的合成方法
CN111171078B (zh) * 2020-02-27 2022-04-22 江苏阿尔法药业股份有限公司 一种瑞德西韦的合成方法
CN111205294B (zh) * 2020-02-27 2021-10-01 江苏阿尔法药业股份有限公司 一种瑞德西韦中间体的制备方法
CN111233930B (zh) * 2020-03-04 2022-05-13 江苏阿尔法药业股份有限公司 一种瑞德西韦的制备方法
WO2021175296A1 (zh) * 2020-03-04 2021-09-10 中国科学院上海药物研究所 瑞德西韦的中间体及其制备方法
CN111269248A (zh) * 2020-03-05 2020-06-12 江苏福瑞康泰药业有限公司 一种核苷氨基磷酸酯类药物母液回收的新方法
CN111269263A (zh) * 2020-03-09 2020-06-12 上海龙翔生物医药开发有限公司 一种瑞德西韦侧链中间体及其制备方法
CN111233870A (zh) * 2020-03-11 2020-06-05 中国科学技术大学 用于快速制备瑞德西韦药物中间体的方法
CN113387954B (zh) * 2020-03-11 2024-03-19 上海特化医药科技有限公司 一种瑞德西韦中间体的制备方法
CN111233869B (zh) * 2020-03-12 2022-09-16 杭州新博思生物医药有限公司 用于制备瑞德西韦关键中间体的新化合物及其制备方法
CA3169340A1 (en) 2020-03-12 2021-09-16 Pavel R. Badalov Methods of preparing 1'-cyano nucleosides
CN113402546A (zh) * 2020-03-17 2021-09-17 浙江四维医药科技有限公司 一种瑞德西韦磷酸中间体尾链动态动力学拆分方法
JP2023518812A (ja) 2020-03-23 2023-05-08 ジェネンテック, インコーポレイテッド Covid19肺炎を治療するための、トシリズマブとレムデシビルとの組み合わせ
WO2021194861A1 (en) 2020-03-23 2021-09-30 Genentech, Inc. Biomarkers for predicting response to il-6 antagonist in covid-19 pneumonia
CN111233931B (zh) * 2020-03-26 2022-03-22 宿迁盛基医药科技有限公司 一种瑞德西韦的合成方法
CN111398464B (zh) * 2020-04-02 2022-03-08 广州隽沐生物科技股份有限公司 2-乙基丁基((全氟苯氧基)(苯氧基)磷酰基)-l-丙氨酸酯的检测方法
CN111423443A (zh) * 2020-04-03 2020-07-17 广州科锐特生物科技有限公司 一种4-氨基-7-碘吡咯并[2,1-f][1,2,4]三嗪的制备方法
CN113493480B (zh) * 2020-04-03 2025-04-15 南京正大天晴制药有限公司 一种瑞德西韦异构体的制备及其分析方法
KR20220164784A (ko) * 2020-04-06 2022-12-13 길리애드 사이언시즈, 인코포레이티드 1'-시아노 치환된 카르바뉴클레오시드 유사체의 흡입 제형
US20230158054A1 (en) * 2020-04-07 2023-05-25 Biocryst Pharmaceuticals, Inc. Methods, compositions, and dosing regimens for treatment of sars-cov-2 infections
WO2021208910A1 (zh) * 2020-04-13 2021-10-21 山东华铂凯盛生物科技有限公司 用于治疗病毒感染的聚合物制剂及制备方法和用途
CN111393494A (zh) * 2020-04-17 2020-07-10 广东帕派恩生物科技有限公司 基于核苷酸结构的化合物、制备方法、用途
CN112778310B (zh) 2020-04-20 2025-05-30 中国科学院上海药物研究所 核苷类似物或含有核苷类似物的组合制剂在抗病毒中的应用
KR20230004716A (ko) * 2020-04-21 2023-01-06 리간드 파마슈티칼스 인코포레이티드 뉴클레오티드 프로드러그 화합물
CN111471070B (zh) * 2020-04-26 2022-05-13 江苏阿尔法药业股份有限公司 瑞德西韦的合成方法
CN111454270B (zh) * 2020-04-27 2024-05-14 南通伟顺生物科技有限公司 一种含六元环的核苷类化合物及其制备方法
CN111440176B (zh) * 2020-04-28 2022-04-26 江苏大学 金属配合物促进的瑞德西韦中间体的合成方法
US10988503B1 (en) * 2020-05-06 2021-04-27 Nantong Weishun Biotechnology Co., Ltd Six-membered ring-containing nucleoside compound and preparation method thereof
CN113637041B (zh) * 2020-05-11 2024-02-27 上海科胜药物研发有限公司 一种核糖核苷的制备方法
RU2740660C1 (ru) * 2020-05-20 2021-01-19 Общество С Ограниченной Ответственностью "Промомед Рус" Противовирусная композиция
WO2021237109A1 (en) 2020-05-22 2021-11-25 Trailhead Biosystems Inc. Combination therapy for treatment of viral infections
CN111961057A (zh) * 2020-05-26 2020-11-20 李小冬 一种α构型核苷及其在治疗猫冠状病毒感染的应用
WO2021240543A1 (en) 2020-05-29 2021-12-02 Jubilant Generics Limited Transmucosal pharmaceutical compositions of antiviral drugs
JP7664287B2 (ja) 2020-05-29 2025-04-17 ギリアード サイエンシーズ, インコーポレイテッド レムデシビル治療方法
IN202011022634A (enrdf_load_stackoverflow) 2020-05-29 2020-10-09 Jubilant Generics Limited
CN113754692B (zh) * 2020-06-03 2022-06-10 上海交通大学 瑞德西韦中间体(s,s)-氨基磷酸酯的不对称催化合成方法
CN113754693B (zh) * 2020-06-03 2022-09-09 上海交通大学 一种磷手性核苷衍生物的不对称催化合成方法及催化剂
CN113754694B (zh) * 2020-06-03 2022-10-25 上海交通大学 一种不对称催化无保护基核苷合成瑞德西韦的方法
WO2021257569A1 (en) * 2020-06-15 2021-12-23 Metro International Biotech, Llc Anti-viral compounds and methods of use
US20230241225A1 (en) 2020-06-15 2023-08-03 Metro International Biotech, Llc Anti-viral compounds and methods of use
CN111620903A (zh) * 2020-06-17 2020-09-04 安徽贝克联合制药有限公司 C-核苷类似物以及用于合成瑞德西韦合成的含腈c-核苷类化合物的制备方法及其应用
WO2021262715A1 (en) * 2020-06-23 2021-12-30 Anovent Pharmaceutical (U.S.), Llc Pharmaceutical formulation containing active metabolites of remdesivir or its analog for inhalation
TW202417008A (zh) 2020-06-24 2024-05-01 美商基利科學股份有限公司 1'-氰基核苷類似物及其用途
CN111732618A (zh) * 2020-07-03 2020-10-02 镇江巨杰新材料技术研发中心(有限合伙) 瑞德西韦关键片段的合成方法
CN111961079A (zh) * 2020-07-17 2020-11-20 南京正济医药研究有限公司 一种瑞德西韦有关物质及其制备方法和应用
EP4185300A4 (en) 2020-07-24 2024-09-25 The Regents of the University of California ANTIVIRAL PRODRUGS, PHARMACEUTICAL FORMULATIONS AND METHODS
EP4192839A1 (en) 2020-08-06 2023-06-14 Richter Gedeon Nyrt. Remdesivir intermediates
CN113004330A (zh) * 2020-08-22 2021-06-22 齐鲁制药有限公司 一种高纯度瑞德西韦的制备方法
CR20230100A (es) * 2020-08-24 2023-04-28 Gilead Sciences Inc Compuestos fosfolípidos y usos de los mismos
CN116568688A (zh) * 2020-08-27 2023-08-08 吉利德科学公司 用于治疗病毒感染的化合物和方法
IL300453A (en) 2020-08-27 2023-04-01 Gilead Sciences Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
CN114105989A (zh) * 2020-08-31 2022-03-01 中国科学院大连化学物理研究所 一种碘代吡咯并三嗪胺类化合物的制备方法和应用
US20230357418A1 (en) 2020-09-17 2023-11-09 Genentech, Inc. Results of empacta: a randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of tocilizumab in hospitalized patients with covid-19 pneumonia
CN112321642A (zh) * 2020-09-28 2021-02-05 南京正济医药研究有限公司 一种瑞德西韦有关物质及其制备方法和用途
WO2022074630A1 (en) * 2020-10-09 2022-04-14 Auxilla Pharmaceuticals And Research Llp Liquid oral suspension of favipiravir
CN112194661B (zh) * 2020-10-22 2021-06-08 威海同丰海洋生物科技有限公司 一种4-氨基-7-碘吡咯并[2,l-f][l,2,4]三嗪的制备方法
CN114391016B (zh) * 2020-10-26 2023-06-30 苏州旺山旺水生物医药有限公司 一种核苷类似物的盐及其晶型、药物组合物和用途
CN114507256B (zh) * 2020-11-16 2025-02-28 上海医药集团股份有限公司 一种瑞德西韦工艺手性异构体、其制备方法及其应用
RU2756921C1 (ru) * 2020-11-20 2021-10-07 Общество С Ограниченной Ответственностью "Технология Лекарств" Способ получения ремдесивира и фосфорамидаты
CA3200885A1 (en) 2020-11-23 2022-05-27 Genentech, Inc. Methods for modulating host cell surface interactions with sars-cov-2
CN112358513A (zh) * 2020-12-02 2021-02-12 上海朴颐化学科技有限公司 一种利用连续流反应器制备瑞德西韦中间体的方法
CN114621229B (zh) * 2020-12-11 2024-07-02 嘉兴金派特生物科技有限公司 治疗或预防猫传染性腹膜炎的化合物或组合物
CN114644666A (zh) * 2020-12-18 2022-06-21 上海特化医药科技有限公司 5’-核苷前药的制备方法及中间体
CN114685511A (zh) * 2020-12-25 2022-07-01 上海科胜药物研发有限公司 一种瑞德西韦中间体的纯化方法
CN114685558A (zh) * 2020-12-28 2022-07-01 尚科生物医药(上海)有限公司 一种瑞德西韦中间体的制备方法
CN113754665B (zh) * 2020-12-30 2022-08-19 南方科技大学 一种核苷类化合物的制备方法
CN116874490A (zh) * 2020-12-30 2023-10-13 南方科技大学 化合物atv014或其药学可接受的盐及其药物组合物
US11998562B2 (en) 2021-01-25 2024-06-04 University Of South Florida Ophthalmological formulations for the prevention of a coronavirus infection
WO2022166581A1 (zh) * 2021-02-07 2022-08-11 石家庄迪斯凯威医药科技有限公司 一种核苷酸衍生物及其药物组合物和用途
CN117157081A (zh) * 2021-02-19 2023-12-01 南京赛弗斯医药科技有限公司 一种具有抗肿瘤活性的核苷酸衍生物及其药物组合物和用途
CN112979736B (zh) * 2021-03-04 2022-03-25 南京欧信医药技术有限公司 一种瑞德西韦的制备方法
CN115109077A (zh) * 2021-03-18 2022-09-27 上海医药集团股份有限公司 瑞德西韦中间体的制备方法
KR20230170745A (ko) 2021-04-16 2023-12-19 길리애드 사이언시즈, 인코포레이티드 아미드를 사용한 카르바뉴클레오시드를 제조하는 방법
KR20230170948A (ko) 2021-04-16 2023-12-19 길리애드 사이언시즈, 인코포레이티드 아미드를 사용한 카르바뉴클레오시드를 제조하는 방법
US20230000873A1 (en) 2021-05-26 2023-01-05 Gilead Sciences, Inc. Phospholipid formulations of 1'-cyano substituted carba-nucleoside analogs
CN113683640B (zh) * 2021-08-10 2025-01-14 浙江华海药业股份有限公司 一种丁基瑞德西韦的制备方法
KR20240049311A (ko) 2021-08-18 2024-04-16 길리애드 사이언시즈, 인코포레이티드 인지질 화합물 및 이의 제조 및 사용 방법
MX2024002116A (es) 2021-08-20 2024-03-06 Shionogi & Co Derivados de nucleosido y profarmacos de los mismos que tienen accion inhibidora del crecimiento viral.
CN113999237B (zh) * 2021-10-29 2023-08-08 润佳(苏州)医药科技有限公司 一种核苷类前药及其用途
KR102675967B1 (ko) 2021-11-02 2024-06-17 충남대학교산학협력단 렘데시비르를 함유하는 나노지질담체, 이의 제조방법 및 이를 포함하는 약학적 조성물
CN114409655A (zh) * 2022-01-26 2022-04-29 郑州大学 3′,4′-不饱和核糖c-核苷类似物及其制备方法
TWI867455B (zh) 2022-03-02 2024-12-21 美商基利科學股份有限公司 用於治療病毒感染的化合物及方法
CN115028672A (zh) * 2022-06-14 2022-09-09 南京正济医药研究有限公司 瑞德西韦中间体晶体及其制备方法
CN116874491A (zh) * 2022-07-12 2023-10-13 深圳安泰维生物医药有限公司 一种n-保护的吡咯并三嗪碳苷类化合物及其制备方法
US11655255B2 (en) 2022-10-17 2023-05-23 Sph No.1 Biochemical & Pharmaceutical Co., Ltd. Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein
WO2024108130A1 (en) 2022-11-18 2024-05-23 Gilead Sciences, Inc. Methods for treating poxvirus infections
CN115737675B (zh) * 2022-11-28 2024-03-08 安徽农业大学 氧化型硒代硫酸钠的制备及其在治疗冠状病毒感染中的应用
CN115947759A (zh) * 2022-12-13 2023-04-11 安徽大学 一种治疗新冠药物瑞德西韦的制备方法
CN116332996B (zh) * 2023-05-04 2025-04-01 南京颐媛生物医学研究院有限公司 L-呋喃核糖型抗冠状病毒化合物及其制备方法和应用
CN116284135B (zh) * 2023-05-04 2025-03-21 南京颐媛生物医学研究院有限公司 抗冠状病毒核苷类化合物的制备方法及其应用
HUP2300153A1 (hu) 2023-05-09 2024-11-28 Rotachrom Tech Zrt Eljárás remdesivir foszfor sztereoizomereinek elválasztására akirális folyadék-folyadék kromatográfiával
CN116554176A (zh) * 2023-05-11 2023-08-08 南京正济医药研究有限公司 一种核苷类化合物的制备方法
CN117126199B (zh) * 2023-05-17 2024-12-06 江西师范大学 一种氟代瑞德西韦合成方法
US20250109157A1 (en) 2023-09-28 2025-04-03 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
US12357577B1 (en) 2024-02-02 2025-07-15 Gilead Sciences, Inc. Pharmaceutical formulations and uses thereof

Family Cites Families (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816570A (en) 1982-11-30 1989-03-28 The Board Of Regents Of The University Of Texas System Biologically reversible phosphate and phosphonate protective groups
US4968788A (en) 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
EP0533833B1 (en) 1990-06-13 1995-12-20 GLAZIER, Arnold Phosphorous produgs
ATE167679T1 (de) 1990-09-14 1998-07-15 Acad Of Science Czech Republic Wirkstoffvorläufer von phosphonaten
JPH1017629A (ja) 1996-07-04 1998-01-20 Kayaku Akzo Kk ハードコート用樹脂組成物及びその硬化方法
US6887707B2 (en) 1996-10-28 2005-05-03 University Of Washington Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
BR9908399A (pt) 1998-03-03 2000-10-31 Novo Nordisk As Composto, processo para preparação do composto, composição farmacêutica, uso de um composto, e, processo para estimular a liberação do hormÈnio de crescimento em um paciente
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
US6475985B1 (en) 1998-03-27 2002-11-05 Regents Of The University Of Minnesota Nucleosides with antiviral and anticancer activity
WO2000023449A1 (en) 1998-10-16 2000-04-27 Merck Sharp & Dohme Limited Pyrazolo-triazine derivatives as ligands for gaba receptors
DE19912636A1 (de) 1999-03-20 2000-09-21 Aventis Cropscience Gmbh Bicyclische Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und pharmazeutische Mittel
AU3418800A (en) * 1999-03-24 2000-10-09 Exiqon A/S Improved synthesis of (2.2.1)bicyclo nucleosides
EP1181301A1 (en) * 1999-06-03 2002-02-27 Abbott Laboratories Oligonucleotide synthesis with lewis acids as activators
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
AU7490600A (en) 1999-09-15 2001-04-17 Biocryst Pharmaceuticals, Inc. Inhibiting t-cell proliferation
US6566365B1 (en) 1999-11-04 2003-05-20 Biochem Pharma Inc. Method for the treatment of Flaviviridea viral infection using nucleoside analogues
CN1427722A (zh) 2000-02-18 2003-07-02 希拉生物化学股份有限公司 用核苷类似物治疗或预防黄病毒感染的方法
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
AP1727A (en) 2000-05-26 2007-03-06 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses.
JP4651264B2 (ja) 2000-07-21 2011-03-16 ギリアード サイエンシーズ, インコーポレイテッド ホスホネートヌクレオチドアナログのプロドラッグならびにこれを選択および作製するための方法。
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
EP1411954B1 (en) 2000-10-18 2010-12-15 Pharmasset, Inc. Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
SI1355916T1 (sl) 2001-01-22 2007-04-30 Merck & Co Inc Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
DE10145223A1 (de) 2001-09-13 2003-04-03 Basf Ag Verfahren zur Herstellung von meso-Zeaxanthin
WO2003026675A1 (en) 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
AT410792B (de) 2001-12-28 2003-07-25 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung
US7285658B2 (en) 2002-02-28 2007-10-23 Biota, Inc. Nucleotide mimics and their prodrugs
EP1485396A2 (en) 2002-02-28 2004-12-15 Biota, Inc. Nucleoside 5'-monophosphate mimics and their prodrugs
US20040138170A1 (en) 2002-03-06 2004-07-15 Montgomery John A. Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
GB0210127D0 (en) 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
GB0210124D0 (en) 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
CN1653077A (zh) 2002-05-06 2005-08-10 健亚生物科技公司 治疗c型肝炎病毒感染的核苷衍生物
WO2003100009A2 (en) 2002-05-23 2003-12-04 Biocryst Pharmaceuticals, Inc. Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
JP2006519753A (ja) 2002-11-15 2006-08-31 イデニクス(ケイマン)リミテツド 2’−分枝ヌクレオシドおよびフラビウイルス科ウイルス突然変異
WO2004096286A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Antiviral phosphonate analogs
WO2004112687A2 (en) 2003-06-26 2004-12-29 Biotron Limited Antiviral acylguanidine compounds and methods
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
DE602004028841D1 (de) 2003-07-25 2010-10-07 Centre Nat Rech Scient Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c
US7713941B2 (en) 2003-08-27 2010-05-11 Biota Scientific Management Pty Ltd Tricyclic nucleosides or nucleotides as therapeutic agents
JP2005187428A (ja) * 2003-12-26 2005-07-14 Univ Of Tokyo 抗mgl抗体によるフィロウイルス治療薬
JP2005185235A (ja) * 2003-12-26 2005-07-14 Univ Of Tokyo ウイルス感染に対する感受性診断のための方法およびキット。
KR20120007088A (ko) 2004-03-16 2012-01-19 베링거 인겔하임 인터내셔날 게엠베하 글루코피라노실-치환된 벤졸 유도체, 당해 화합물을 함유하는 약제, 이의 용도 및 이의 제조 방법
AU2005254057B2 (en) 2004-06-15 2011-02-17 Isis Pharmaceuticals, Inc. C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase
US7560434B2 (en) 2004-06-22 2009-07-14 Biocryst Pharmaceuticals, Inc. AZA nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
EP1809301B1 (en) 2004-09-14 2019-11-06 Gilead Pharmasset LLC 2-fluoro-2-alkyl-substituted d-ribonolactone intermediates
EP1804812A4 (en) 2004-10-21 2009-09-02 Merck & Co Inc FLUORINATED PYRROLO [2,3-D] PYRIMIDIN NUCLEOSIDES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRUS INFECTIONS
CN101043893A (zh) 2004-10-21 2007-09-26 默克公司 治疗RNA-依赖性RNA病毒感染的氟化吡咯并[2,3-d]嘧啶核苷
NZ555441A (en) 2004-10-29 2010-12-24 Biocryst Pharm Inc Therapeutic furopyrimidines and thienopyrimidines
EP1828216B1 (en) 2004-12-16 2008-09-10 Boehringer Ingelheim International GmbH Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
CA2600886A1 (en) 2005-03-08 2006-09-14 Biota Scientific Management Pty Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
US7514410B2 (en) 2005-03-29 2009-04-07 Biocryst Pharmaceuticals, Inc. Hepatitis C therapies
US7405204B2 (en) 2005-04-25 2008-07-29 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
WO2006121820A1 (en) 2005-05-05 2006-11-16 Valeant Research & Development Phosphoramidate prodrugs for treatment of viral infection
WO2007027248A2 (en) 2005-05-16 2007-03-08 Valeant Research & Development 3', 5' - cyclic nucleoside analogues for treatment of hcv
NZ610715A (en) 2005-06-24 2014-07-25 Biotron Ltd Antiviral compounds and methods
ES2436404T3 (es) 2005-10-03 2013-12-30 University Health Network Inhibidores ODCasa para el tratamiento de malaria
ES2401099T3 (es) 2005-11-02 2013-04-16 Bayer Intellectual Property Gmbh Pirrolo[2,1-F] [1,2,4]-triazin-4-ilaminas como inhibidores de la quinasa IGF-1R para el tratamiento del cáncer y de otras enfermedades hiperproliferativas
EP1954264B1 (en) 2005-12-01 2009-10-07 Basilea Pharmaceutica AG Process for the manufacture of epoxybutanol intermediates
WO2007064931A2 (en) 2005-12-02 2007-06-07 Bayer Healthcare Llc Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
PE20070855A1 (es) 2005-12-02 2007-10-14 Bayer Pharmaceuticals Corp Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
RU2422454C2 (ru) 2005-12-09 2011-06-27 Ф. Хоффманн-Ля Рош Аг Антивирусные нуклеозиды
EP1971331A2 (en) 2005-12-09 2008-09-24 Basilea Pharmaceutica AG 4-oxo-(iso)tretinoin for the topical treatment of severe dermatological disorders
WO2007097991A2 (en) 2006-02-16 2007-08-30 Pharmasset, Inc. Methods and kits for dosing of antiviral agents
DE102006015378A1 (de) 2006-04-03 2007-10-04 Ludwig-Maximilians-Universität München Verfahren zur Synthese von Organoelementverbindungen
AR061024A1 (es) 2006-05-22 2008-07-30 Novartis Ag Maleato de 5-amino-3- (2'3'-di-o-acetil-beta-d-ribofuranosil)-3h-tiazolo[4,5-d] pirimidin-2-ona.
WO2008005542A2 (en) 2006-07-07 2008-01-10 Gilead Sciences, Inc., Antiviral phosphinate compounds
WO2008033466A2 (en) 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
US7879806B2 (en) * 2006-11-06 2011-02-01 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzyl-benzonitrile derivates, medicaments containing such compounds, their use and process for their manufacture
AU2007338899A1 (en) 2006-12-20 2008-07-03 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Nucleoside cyclic phosphoramidates for the treatment of RNA-dependent RNA viral infection
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
CA2673649A1 (en) 2007-01-05 2008-07-17 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection
EP2535345A1 (en) * 2007-01-12 2012-12-19 BioCryst Pharmaceuticals, Inc. Anticancer nucleoside analogs
US8188272B2 (en) 2007-03-21 2012-05-29 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8242085B2 (en) 2007-05-10 2012-08-14 Biocryst Pharmaceuticals, Inc. Tetrahydrofuro [3,4-D] dioxolane compounds for use in the treatment of viral infections and cancer
CN100532388C (zh) 2007-07-16 2009-08-26 郑州大学 2’-氟-4’-取代-核苷类似物、其制备方法及应用
EP2659885B1 (en) 2007-08-03 2016-11-09 Biotron Limited Hepatitis C Antiviral Compositions and Methods
KR101502533B1 (ko) 2007-11-22 2015-03-13 에스케이케미칼주식회사 우수한 안정성을 갖는 택산 유도체 함유 주사제용동결건조 조성물 및 이의 제조방법
TW200942243A (en) 2008-03-05 2009-10-16 Biocryst Pharm Inc Antiviral therapeutic agents
US8227431B2 (en) 2008-03-17 2012-07-24 Hetero Drugs Limited Nucleoside derivatives
US7863291B2 (en) 2008-04-23 2011-01-04 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
HUE038946T2 (hu) 2008-04-23 2018-12-28 Gilead Sciences Inc 1'-szubsztituált carba-nukleozid analógok antivirális kezelésre
WO2010036407A2 (en) 2008-05-15 2010-04-01 Biocryst Pharmaceuticals, Inc. Antiviral nucleoside analogs
EP2313102A2 (en) 2008-07-03 2011-04-27 Biota Scientific Management Bycyclic nucleosides and nucleotides as therapeutic agents
KR101834707B1 (ko) 2009-02-10 2018-03-05 길리애드 사이언시즈, 인코포레이티드 항바이러스 치료를 위한 카르바-뉴클레오시드 유사체
AR075584A1 (es) 2009-02-27 2011-04-20 Intermune Inc COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.
CA2755642A1 (en) 2009-03-20 2010-09-23 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
KR101763672B1 (ko) 2009-03-24 2017-08-01 바이오크리스트파마슈티컬즈,인코포레이티드 7―[(3r,4r)―3―하이드록시―4―하이드록시메틸―피롤리딘―1―일메틸]―3,5―디하이드로―피롤로[3,2―d]피리미딘―4―온의 유용한 약학적 염
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
US8569302B2 (en) 2009-07-21 2013-10-29 Gilead Sciences, Inc. Inhibitors of flaviviridae viruses
SG179194A1 (en) 2009-09-21 2012-05-30 Gilead Sciences Inc 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment
CN102596979B (zh) 2009-09-21 2014-12-10 吉里德科学公司 用于制备1’-取代碳核苷类似物的方法和中间体
US7973013B2 (en) 2009-09-21 2011-07-05 Gilead Sciences, Inc. 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
US8455451B2 (en) 2009-09-21 2013-06-04 Gilead Sciences, Inc. 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
CA2785618C (en) 2009-12-28 2015-03-17 Development Center For Biotechnology Pyrimidine compounds as mtor and pi3k inhibitors
JP6058528B2 (ja) 2010-03-31 2017-01-11 ギリアド ファーマセット エルエルシー ヌクレオシドホスホルアミデート
EP2609923B1 (en) 2010-03-31 2017-05-24 Gilead Pharmasset LLC Process for the crystallisation of (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate
TW201201815A (en) 2010-05-28 2012-01-16 Gilead Sciences Inc 1'-substituted-carba-nucleoside prodrugs for antiviral treatment
KR102108864B1 (ko) * 2010-07-19 2020-05-12 길리애드 사이언시즈, 인코포레이티드 부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법
AP3269A (en) 2010-07-22 2015-05-31 Gilead Sciences Inc Methods and compounds for treating paramyxoviridaevirus infections
TW201305185A (zh) * 2010-09-13 2013-02-01 Gilead Sciences Inc 用於抗病毒治療之2’-氟取代之碳-核苷類似物
SG188223A1 (en) 2010-09-20 2013-04-30 Gilead Sciences Inc 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment
US8871737B2 (en) 2010-09-22 2014-10-28 Alios Biopharma, Inc. Substituted nucleotide analogs
EP3345605B1 (en) 2010-10-15 2019-11-20 BioCryst Pharmaceuticals, Inc. Pyrrolopyrimidine derivatives for use in the inhibition of polymerase
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
US20130273005A1 (en) 2010-12-20 2013-10-17 Gilead Sciences, Inc. Methods for treating hcv
WO2012142523A2 (en) 2011-04-13 2012-10-18 Gilead Sciences, Inc. 1'-substituted pyrimidine n-nucleoside analogs for antiviral treatment
PH12013502141A1 (en) 2011-04-13 2014-01-06 Merck Sharp & Dohme 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
UA114086C2 (xx) * 2011-05-13 2017-04-25 Імуногенна композиція глікопротеїну g вірусу hendra і/або nipah
EP2755693A4 (en) * 2011-09-12 2015-05-20 Moderna Therapeutics Inc MANIPULATED NUCLEIC ACIDS AND METHOD OF APPLICATION THEREFOR
SI2709613T2 (sl) 2011-09-16 2020-12-31 Gilead Pharmasset LLC c/o Gilead Sciences, Inc. Postopki za zdravljenje HCV
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
WO2013084165A1 (en) 2011-12-05 2013-06-13 Medivir Ab Hcv polymerase inhibitors
US20130143835A1 (en) * 2011-12-05 2013-06-06 Medivir Ab HCV Polymerase Inhibitors
WO2013096680A1 (en) * 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
MX355708B (es) 2012-05-22 2018-04-27 Idenix Pharmaceuticals Llc Compuestos de d-aminoacidos para enfermedades del higado.
EP2890704B1 (en) 2012-08-31 2018-02-28 Novartis AG 2'-ethynyl nucleoside derivatives for treatment of viral infections
EP2892893B2 (en) 2012-09-10 2019-10-16 F.Hoffmann-La Roche Ag 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
WO2014042433A2 (en) * 2012-09-14 2014-03-20 Kainos Medicine, Inc. Compounds and compositions for modulating adenosine a3 receptor activity
AU2013344422A1 (en) 2012-11-16 2015-07-02 Biocryst Pharmaceuticals, Inc. Antiviral azasugar-containing nucleosides
AU2013344757A1 (en) 2012-11-19 2015-05-21 Merck Sharp & Dohme Corp. 2 -alkynyl substituted nucleoside derivatives for treating viral diseases
PE20151433A1 (es) * 2012-12-21 2015-10-16 Alios Biopharma Inc Nucleosidos sustituidos, nucleotidos y analogos de los mismos
WO2014116755A1 (en) 2013-01-22 2014-07-31 Massachusetts Institute Of Technology Uses of dihydro bases
US10034893B2 (en) 2013-02-01 2018-07-31 Enanta Pharmaceuticals, Inc. 5, 6-D2 uridine nucleoside/tide derivatives
BR112015025716A2 (pt) 2013-04-12 2017-07-18 Achillion Pharmaceuticals Inc pró-fármacos de nucleosídeo submetidos a deutério úteis para o tratamento de hcv
US9542154B2 (en) 2013-06-25 2017-01-10 Intel Corporation Fused multiply add operations using bit masks
UA117375C2 (uk) * 2013-09-04 2018-07-25 Медівір Аб Інгібітори полімерази hcv
EP3043865B1 (en) 2013-09-11 2020-11-04 Institut National de la Sante et de la Recherche Medicale (INSERM) Methods and pharmaceutical compositions for the treatment of hepatitis b virus infection
UA119050C2 (uk) * 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
AU2015212903A1 (en) 2014-01-30 2016-05-19 F. Hoffmann-La Roche Ag Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
RS58384B1 (sr) 2014-03-07 2019-04-30 Hoffmann La Roche Novi 6-fuzionisani heteroarildihidropirimidini za lečenje i profilaksu infekcije virusom hepatitisa b
RU2016146365A (ru) 2014-05-13 2018-06-19 Ф. Хоффманн-Ля Рош Аг Новые дигидрохинолизиноны для лечения и профилактики заражения вирусом гепатита b
US9504701B2 (en) 2014-06-02 2016-11-29 The Board Of Regents Of The University Of Texas System Methods for treating viral infections using hydrogen sulfide donors
US9616076B2 (en) * 2014-06-02 2017-04-11 The Board Of Regents Of The University Of Texas Systems Methods for treating viral infections using hydrogen sulfide donors
WO2016012470A1 (en) 2014-07-25 2016-01-28 F. Hoffmann-La Roche Ag New amorphous and crystalline forms of (3s)-4-[[(4r)-4-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1, 4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
RU2664329C1 (ru) 2014-08-14 2018-08-16 Ф. Хоффманн-Ля Рош Аг Новые пиридазоны и триазиноны для лечения и профилактики заражения вирусом гепатита b
TWI767201B (zh) 2014-10-29 2022-06-11 美商基利科學股份有限公司 絲狀病毒科病毒感染之治療
US9637485B2 (en) 2014-11-03 2017-05-02 Hoffmann-La Roche Inc. 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
AR103222A1 (es) 2014-12-23 2017-04-26 Hoffmann La Roche Procedimiento para la preparación de análogos de 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidina
US9676793B2 (en) 2014-12-23 2017-06-13 Hoffmann-Laroche Inc. Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
EP3240537B1 (en) 2014-12-30 2020-09-09 F. Hoffmann-La Roche AG Novel tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis b virus infection
EP3240913A1 (en) 2014-12-31 2017-11-08 F. Hoffmann-La Roche AG A novel high-throughput method for quantification of hbv cccdna from cell lysate by real-time pcr
MA41338B1 (fr) 2015-01-16 2019-07-31 Hoffmann La Roche Composés de pyrazine pour le traitement de maladies infectieuses
CN107208102B (zh) 2015-01-27 2021-07-06 豪夫迈·罗氏有限公司 重组hbv cccdna、其产生方法及其用途
WO2016128335A1 (en) 2015-02-11 2016-08-18 F. Hoffmann-La Roche Ag Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
CN108348526B (zh) 2015-09-16 2025-04-25 吉利德科学公司 治疗沙粒病毒科和冠状病毒科病毒感染的方法
WO2017184668A1 (en) 2016-04-20 2017-10-26 Gilead Sciences, Inc. Methods for treating flaviviridae virus infections
AU2018218179B2 (en) 2017-02-08 2023-05-04 Biotron Limited Methods of treating influenza
EP3595672B1 (en) 2017-03-14 2023-09-06 Gilead Sciences, Inc. Compounds for use in methods of treating feline coronavirus infections
US10836787B2 (en) 2017-05-01 2020-11-17 Gilead Sciences, Inc. Crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5- (4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
EP4512475A3 (en) 2017-07-11 2025-05-14 Gilead Sciences, Inc. Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections
CN111265532A (zh) 2020-01-21 2020-06-12 中国人民解放军军事科学院军事医学研究院 取代氨基丙酸酯类化合物在治疗2019-nCoV感染中的应用
CA3163424A1 (en) 2020-01-27 2021-08-05 Gilead Sciences, Inc. Methods for treating sars cov-2 infections
CA3169340A1 (en) * 2020-03-12 2021-09-16 Pavel R. Badalov Methods of preparing 1'-cyano nucleosides

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