EA025252B1 - Способы и соединения для лечения вирусных инфекций paramyxoviridae - Google Patents
Способы и соединения для лечения вирусных инфекций paramyxoviridae Download PDFInfo
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- EA025252B1 EA025252B1 EA201390152A EA201390152A EA025252B1 EA 025252 B1 EA025252 B1 EA 025252B1 EA 201390152 A EA201390152 A EA 201390152A EA 201390152 A EA201390152 A EA 201390152A EA 025252 B1 EA025252 B1 EA 025252B1
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 11
- 230000009385 viral infection Effects 0.000 title claims description 10
- 241000711504 Paramyxoviridae Species 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims abstract description 4
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims abstract description 3
- 229940079593 drug Drugs 0.000 claims abstract description 3
- 208000036142 Viral infection Diseases 0.000 claims description 9
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 6
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000006736 (C6-C20) aryl group Chemical group 0.000 claims 1
- 241000711920 Human orthopneumovirus Species 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 abstract description 2
- 150000002367 halogens Chemical class 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 208000030925 respiratory syncytial virus infectious disease Diseases 0.000 abstract 1
- 241000725643 Respiratory syncytial virus Species 0.000 description 1
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Abstract
Предложено применение соединения формулы II или его фармацевтически приемлемой соли при производстве лекарственного средства для лечения вирусных инфекций ParamyxoviridaeФормула IIгде Rявляется ОН или галогеном; Rявляется Н или ОН; Rявляется CN, (C-C) алкилом или (С-С) алкинилом; Rявляется Н иликаждый Y является О, S или NR; Wи W, каждый, является группой формулы IaФормула Iaгде каждый Yявляется независимо О, S или NR; каждый Yнезависимо является связью, О, CR, NR, S, S-S, S(O) или S(O); М2 равен 0, 1 или 2; каждый Rнезависимо является Rили имеет формулугде каждый М1а, М1с и М1d независимо равен 0 или 1; M12с равен 1 или 2; каждый Rнезависимо является Н или R; и каждый R независимо является Н, (C-C) алкилом или С-Сарилом. Представленные соединения и композиции на их основе являются особенно полезными для лечения вирусных инфекций парагриппа человека и респираторно-синцитиального вируса человека.
Description
(57) Предложено применение соединения формулы II или его фармацевтически приемлемой соли при производстве ' ' лекарственного средства для лечения вирусных инфекций Рагатухоутбае
где К2 является ОН или галогеном; К3 является Н или ОН; К6 является ΟΝ, (С1-С8) алкилом или (С2-С8) алкинилом; К7 является Н или
каждый Υ является О, 8 или ΝΚ: \У и XV , каждый, является группой формулы 1а
где каждый Υ1 является независимо О, 8 или ΝΚ; каждый Υ2 независимо является связью, О, СК2, ΝΚ, 8, 8-8, 8(Ο) или 3(О)2; М2 равен 0, 1 или 2; каждый К.х независимо является К.у или имеет формулу
где каждый М1а, М1с и М16 независимо равен 0 или 1; М12с равен 1 или 2; каждый Ку независимо является Н или К; и каждый К независимо является Н, (С1-С8) алкилом или С6-С20 арилом. Представленные соединения и композиции на их основе являются особенно полезными для лечения вирусных инфекций парагриппа человека и респираторносинцитиального вируса человека.
025252 Β1
Claims (22)
1. Применение соединения формулы II или его фармацевтически приемлемой соли при производстве лекарственного средства для лечения вирусной инфекции Рататухоутбае, где соединение формулы II имеет структуру
К3 является Н или ОН;
К6 является ΟΝ, (С1 -С8) алкилом или (С2-С8) алкинилом; К7 является Н или
Υ \л/г каждый Υ является О, δ или ΝΚ;
V1 и V2, каждый, являются группой формулы Та
- 35 025252 где каждый Υ1 является независимо О, 8 или ΝΚ;
каждый Υ2 независимо является связью, О, СК2, ΝΚ 8, 8-8, 8(0) или 8(О)2; М2 равен 0, 1 или 2;
у где каждый М1а, М1с и М1б независимо равен 0 или 1;
М12с равен 1 или 2;
каждый Ку независимо является Н или К;
каждый К независимо является Н, (С1-С8) алкилом или С6-С20 арилом.
2. Применение по п.1, где К2 является ОН или Р и К3 является ОН.
3. Применение по любому из пп.1, 2, отличающееся тем, что К6 является 0Ν, метилом или этинилом.
4. Применение по любому из пп.1-3, отличающееся тем, что К2 является ОН.
5. Применение по п.1, отличающееся тем, что К3 является ОН.
6. Применение по любому из пп.1-5, отличающееся тем, что К7 является Н.
7. Применение по любому из пп.1-3, отличающееся тем, что соединение формулы II выбрано из
- 36 025252 или его фармацевтически приемлемой соли.
8. Применение по любому из пп.1-7, отличающееся тем, что лекарственное средство дополнительно включает фармацевтически приемлемый носитель или формообразующее средство.
9. Применение по любому из пп.1-7, отличающееся тем, что вирусная инфекция Рагатухоушбае вызвана вирусом Ра^атуxον^^^ηае.
10. Применение по любому из пп.1-7, отличающееся тем, что вирусная инфекция Рагатухо¥тбае вызвана вирусом Ке8р^^ον^^и8.
11. Применение по любому из пп.1-7, отличающееся тем, что вирусная инфекция Рагатухоттбае вызвана вирусом парагриппа человека 1 или 3 типа.
12. Применение по любому из пп.1-7, отличающееся тем, что вирусная инфекция РагатухоАдпбае вызвана вирусом Рηеитον^^^ηае.
13. Применение по любому из пп.1-7 или 12, отличающееся тем, что вирусная инфекция Рагатухо¥тбае вызвана респираторно-синцитиальным вирусом человека.
14. Применение по любому из пп.1-7, 12 или 13, отличающееся тем, что ингибируется полимераза Рагатухо Адпбае.
15. Соединение, выбранное из или его фармацевтически приемлемой соли.
16. Соединение по п.15, выбранное из
- 37 025252 или его фармацевтически приемлемой соли.
17. Соединение по п.15, имеющее структуру или его фармацевтически приемлемая соль.
18. Соединение по п.15, имеющее структуру или его фармацевтически приемлемая соль.
19. Соединение формулы IV или его фармацевтически приемлемая соль, где К3 является Н или ОН;
К6 является СN или (С1-С8) алкилом;
К7 является Н или
У
II каждый Υ является О;
V1 и V2, каждый, являются группой формулы !а
УУ2 где каждый У1 является О;
каждый Υ2 независимо является связью, О или ΝΡ;
- 38 025252
М2 равен 0, 1 или 2;
каждый Кх независимо является Ку или имеет формулу где каждый М1а, М1с и М1й независимо равен 0 или 1;
М12с равен 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 или 12; каждый Ку независимо является Н или К;
каждый К независимо является Н, (С1-С8) алкилом или (С6-С20) арилом.
20. Соединение по п.19, отличающееся тем, что К7 является Н и К3 является ОН.
21. Соединение по п.19 или 20, отличающееся тем, что К6 является СN или метилом.
или его фармацевтически приемлемую соль.
23. Фармацевтическая композиция для лечения вирусных инфекций Рагатухоутйае, включающая терапевтически эффективное количество соединения по любому из пп.19-22 и фармацевтически приемлемый носитель.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36660910P | 2010-07-22 | 2010-07-22 | |
| PCT/US2011/045102 WO2012012776A1 (en) | 2010-07-22 | 2011-07-22 | Methods and compounds for treating paramyxoviridae virus infections |
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| Publication Number | Publication Date |
|---|---|
| EA201390152A1 EA201390152A1 (ru) | 2013-05-30 |
| EA025252B1 true EA025252B1 (ru) | 2016-12-30 |
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| EA201691118A EA201691118A1 (ru) | 2010-07-22 | 2011-07-22 | Способы и соединения для лечения вирусных инфекций paramyxoviridae |
| EA201390152A EA025252B1 (ru) | 2010-07-22 | 2011-07-22 | Способы и соединения для лечения вирусных инфекций paramyxoviridae |
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| RU2756921C1 (ru) * | 2020-11-20 | 2021-10-07 | Общество С Ограниченной Ответственностью "Технология Лекарств" | Способ получения ремдесивира и фосфорамидаты |
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| ES2398684T3 (es) | 2008-04-23 | 2013-03-21 | Gilead Sciences, Inc. | Análogos de carbanucleósido para el tratamiento antiviral |
| MX2012003126A (es) | 2009-09-21 | 2012-06-19 | Gilead Sciences Inc | Procesos e intermedios para la preparacion de analogos de 1'-carbonucleosidos sustituidos. |
| BR112012033117A2 (pt) | 2010-06-24 | 2016-11-22 | Gilead Sciences Inc | pirazolo[1,5-a]pirimidinas como agentes antivirais |
| BR112013001267A2 (pt) | 2010-07-19 | 2016-05-17 | Gilead Sciences Inc | métodos para a preparação de pró-fármacos de fosforamidato diasteromericamente puro |
| US20120027752A1 (en) | 2010-07-22 | 2012-02-02 | Gilead Sciences, Inc. | Methods and compounds for treating paramyxoviridae virus infections |
| PT2794611T (pt) | 2011-12-22 | 2017-12-06 | Gilead Sciences Inc | Pirazolo[1,5-a]pirimidinas como agentes antivirais |
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| WO2008089105A2 (en) * | 2007-01-12 | 2008-07-24 | Biocryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
| WO2008141079A1 (en) * | 2007-05-10 | 2008-11-20 | Biocryst Pharmaceuticals, Inc. | Tetrahydrofuro [3 4-d] dioxolane compounds for use in the treatment of viral infections and cancer |
| WO2009132135A1 (en) * | 2008-04-23 | 2009-10-29 | Gilead Sciences, Inc. | 1' -substituted carba-nucleoside analogs for antiviral treatment |
| WO2010002877A2 (en) * | 2008-07-03 | 2010-01-07 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2756921C1 (ru) * | 2020-11-20 | 2021-10-07 | Общество С Ограниченной Ответственностью "Технология Лекарств" | Способ получения ремдесивира и фосфорамидаты |
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