BR122020020745B8 - Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende - Google Patents

Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende

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Publication number
BR122020020745B8
BR122020020745B8 BR122020020745A BR122020020745A BR122020020745B8 BR 122020020745 B8 BR122020020745 B8 BR 122020020745B8 BR 122020020745 A BR122020020745 A BR 122020020745A BR 122020020745 A BR122020020745 A BR 122020020745A BR 122020020745 B8 BR122020020745 B8 BR 122020020745B8
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BR
Brazil
Prior art keywords
treatment
pharmaceutical composition
antiviral compound
paramyxoviridae infections
paramyxoviridae
Prior art date
Application number
BR122020020745A
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English (en)
Other versions
BR122020020745B1 (pt
Inventor
S Ray Adrian
Agnes Theodore Dorothy
P Parrish Jay
L Mackman Richard
Original Assignee
Gilead Sciences Inc
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Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of BR122020020745B1 publication Critical patent/BR122020020745B1/pt
Publication of BR122020020745B8 publication Critical patent/BR122020020745B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

a presente invenção se refere a métodos para tratar infecções por vírus paramyxoviridae administrando ribosídeos, fosfatos de ribosídeos e pró-fármacos dos mesmos, de fórmula (i): em que a posição 1? do açúcar de nucleosídeo é substituída. os compostos, composições e métodos fornecidos são particularmente úteis para o tratamento de infecções por vírus de parainfluenza humana e sincicial respiratório.
BR122020020745A 2010-07-22 2011-07-22 Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende BR122020020745B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36660910P 2010-07-22 2010-07-22
US61/366,609 2010-07-22
PCT/US2011/045102 WO2012012776A1 (en) 2010-07-22 2011-07-22 Methods and compounds for treating paramyxoviridae virus infections
BR112013001553-5A BR112013001553B1 (pt) 2010-07-22 2011-07-22 compostos antivirais para o tratamento de infecções por paramyxoviridae e composições farmacêuticas que os compreendem

Publications (2)

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BR122020020745B1 BR122020020745B1 (pt) 2023-07-11
BR122020020745B8 true BR122020020745B8 (pt) 2023-10-31

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ID=44534635

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BR122020020745A BR122020020745B8 (pt) 2010-07-22 2011-07-22 Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende
BR112013001553-5A BR112013001553B1 (pt) 2010-07-22 2011-07-22 compostos antivirais para o tratamento de infecções por paramyxoviridae e composições farmacêuticas que os compreendem

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Country Status (30)

Country Link
US (6) US20120027752A1 (pt)
EP (1) EP2595980B1 (pt)
JP (2) JP5969471B2 (pt)
KR (2) KR101924765B1 (pt)
CN (2) CN103052631B (pt)
AP (1) AP3269A (pt)
AU (4) AU2011280910B2 (pt)
BR (2) BR122020020745B8 (pt)
CA (1) CA2804840C (pt)
CL (1) CL2013000077A1 (pt)
CO (1) CO6690740A2 (pt)
CR (2) CR20170278A (pt)
EA (2) EA025252B1 (pt)
EC (1) ECSP13012458A (pt)
ES (1) ES2524356T3 (pt)
HK (2) HK1183487A1 (pt)
IL (2) IL224043A (pt)
MA (1) MA34470B1 (pt)
ME (1) ME01924B (pt)
MX (1) MX2013000744A (pt)
NL (1) NL301084I2 (pt)
NO (1) NO2020047I1 (pt)
NZ (1) NZ606156A (pt)
PE (2) PE20130400A1 (pt)
PL (1) PL2595980T3 (pt)
PT (1) PT2595980E (pt)
SG (1) SG186830A1 (pt)
SI (1) SI2595980T1 (pt)
UA (1) UA111163C2 (pt)
WO (1) WO2012012776A1 (pt)

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