ME01924B - Metode i jedinjenja za lečenje infekcija izazvanih Paramyxoviridae virusom - Google Patents

Metode i jedinjenja za lečenje infekcija izazvanih Paramyxoviridae virusom

Info

Publication number
ME01924B
ME01924B MEP-2014-148A MEP14814A ME01924B ME 01924 B ME01924 B ME 01924B ME P14814 A MEP14814 A ME P14814A ME 01924 B ME01924 B ME 01924B
Authority
ME
Montenegro
Prior art keywords
compounds
methods
virus infections
paramyxoviridae virus
treating paramyxoviridae
Prior art date
Application number
MEP-2014-148A
Other languages
English (en)
Inventor
Richard L Mackman
Jay P Parrish
Adrian S Ray
Dorothy Agnes Theodore
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44534635&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME01924(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of ME01924B publication Critical patent/ME01924B/me

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06Heterocyclic radicals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MEP-2014-148A 2010-07-22 2011-07-22 Metode i jedinjenja za lečenje infekcija izazvanih Paramyxoviridae virusom ME01924B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36660910P 2010-07-22 2010-07-22
PCT/US2011/045102 WO2012012776A1 (en) 2010-07-22 2011-07-22 Methods and compounds for treating paramyxoviridae virus infections
EP11743709.5A EP2595980B1 (en) 2010-07-22 2011-07-22 Methods and compounds for treating paramyxoviridae virus infections

Publications (1)

Publication Number Publication Date
ME01924B true ME01924B (me) 2015-05-20

Family

ID=44534635

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2014-148A ME01924B (me) 2010-07-22 2011-07-22 Metode i jedinjenja za lečenje infekcija izazvanih Paramyxoviridae virusom

Country Status (30)

Country Link
US (6) US20120027752A1 (me)
EP (1) EP2595980B1 (me)
JP (2) JP5969471B2 (me)
KR (2) KR101924765B1 (me)
CN (2) CN105343098B (me)
AP (1) AP3269A (me)
AU (4) AU2011280910B2 (me)
BR (2) BR122020020745B8 (me)
CA (1) CA2804840C (me)
CL (1) CL2013000077A1 (me)
CO (1) CO6690740A2 (me)
CR (2) CR20170278A (me)
EA (2) EA025252B1 (me)
EC (1) ECSP13012458A (me)
ES (1) ES2524356T3 (me)
HK (2) HK1183487A1 (me)
IL (2) IL224043A (me)
MA (1) MA34470B1 (me)
ME (1) ME01924B (me)
MX (1) MX2013000744A (me)
NL (1) NL301084I2 (me)
NO (1) NO2020047I1 (me)
NZ (1) NZ606156A (me)
PE (2) PE20130400A1 (me)
PL (1) PL2595980T3 (me)
PT (1) PT2595980E (me)
SG (1) SG186830A1 (me)
SI (1) SI2595980T1 (me)
UA (1) UA111163C2 (me)
WO (1) WO2012012776A1 (me)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP3237A (en) 2008-04-23 2015-04-30 Gilead Sciences Inc 1'-Substituted carba-nucleoside analogs for antiviral treatment
AU2010295392B2 (en) 2009-09-21 2015-10-22 Gilead Sciences, Inc. Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs
JP5878171B2 (ja) 2010-06-24 2016-03-08 ギリアード サイエンシーズ, インコーポレイテッド 抗ウイルス剤としてのピラゾロ[1,5−a]ピリミジン
MX2013000656A (es) 2010-07-19 2013-04-03 Gilead Sciences Inc Metodos para la preparacion de profarmacos de fosforamidato diastereomericamente puros.
ME01924B (me) 2010-07-22 2015-05-20 Gilead Sciences Inc Metode i jedinjenja za lečenje infekcija izazvanih Paramyxoviridae virusom
ES2647486T3 (es) 2011-12-22 2017-12-21 Gilead Sciences, Inc. Pirazolo[1,5-a]pirimidinas como agentes antivirales
KR102072041B1 (ko) 2011-12-22 2020-01-31 앨리오스 바이오파마 인크. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체
EA028928B9 (ru) * 2012-03-13 2018-05-31 Джилид Сайэнс, Инк. 2'-замещенные карбануклеозидные аналоги для противовирусного лечения
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
UA113980C2 (uk) * 2012-03-21 2017-04-10 Аліос Біофарма, Інк. Заміщені нуклеозиди, нуклеотиди і їх аналоги
CA2870024C (en) 2012-04-17 2020-04-07 Gilead Sciences, Inc. Compounds and methods for antiviral treatment
CN103232507B (zh) * 2012-04-27 2016-07-06 北京大学 修饰核苷单体及其合成方法和应用
KR20150014457A (ko) 2012-05-25 2015-02-06 얀센 알 앤드 디 아일랜드 우라실 스피로옥세탄 뉴클레오시드
WO2014035140A2 (en) * 2012-08-30 2014-03-06 Kainos Medicine, Inc. Compounds and compositions for modulating histone methyltransferase activity
WO2014042433A2 (en) * 2012-09-14 2014-03-20 Kainos Medicine, Inc. Compounds and compositions for modulating adenosine a3 receptor activity
BR112015014457A2 (pt) 2012-12-21 2017-11-21 Alios Biopharma Inc composto ou sal farmaceuticamente aceitável do mesmo e composição farmacêutica e respectivos usos e processos para melhorar ou tratar infecção de hcv, para inibir a atividade da ns5b polimerase do vírus da hepatite c e a replicação de vírus da hepatite c
UA119050C2 (uk) * 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
TWI678369B (zh) * 2014-07-28 2019-12-01 美商基利科學股份有限公司 用於治療呼吸道合胞病毒感染之噻吩並[3,2-d]嘧啶、呋喃並[3,2-d]嘧啶及吡咯並[3,2-d]嘧啶化合物類
TWI673283B (zh) 2014-08-21 2019-10-01 美商基利科學股份有限公司 2’-氯胺基嘧啶酮及嘧啶二酮核苷類
TWI740546B (zh) 2014-10-29 2021-09-21 美商基利科學股份有限公司 製備核糖苷的方法
RS62434B1 (sr) 2014-12-26 2021-11-30 Univ Emory Antivirusni n4-hidroksicitidin derivati
EA039561B1 (ru) * 2015-01-20 2022-02-10 Джилид Сайэнс, Инк. Соединения для лечения вирусных инфекций filoviridae
WO2016117622A1 (ja) * 2015-01-22 2016-07-28 国立大学法人岐阜大学 テトラゾール誘導体及び抗ウイルス剤
DK3324977T3 (da) 2015-07-22 2022-10-17 Enanta Pharm Inc Benzodiazepinderivater som rsv-inhibitorer
EP3349758B1 (en) * 2015-09-16 2022-04-06 Gilead Sciences, Inc. Methods for treating arenaviridae virus infections
JP6768796B2 (ja) 2015-09-23 2020-10-14 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 4’−置換ヌクレオシド逆転写酵素阻害剤及びその調製
WO2017172596A1 (en) 2016-03-28 2017-10-05 Incyte Corporation Pyrrolotriazine compounds as tam inhibitors
WO2017184668A1 (en) 2016-04-20 2017-10-26 Gilead Sciences, Inc. Methods for treating flaviviridae virus infections
WO2017184670A2 (en) 2016-04-22 2017-10-26 Gilead Sciences, Inc. Methods for treating zika virus infections
CN106083962B (zh) * 2016-06-08 2018-12-18 成都倍特药业有限公司 一种具有环磷酰胺结构的化合物及其制备方法
US10202412B2 (en) 2016-07-08 2019-02-12 Atea Pharmaceuticals, Inc. β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
WO2018169946A1 (en) * 2017-03-14 2018-09-20 Gilead Sciences, Inc. Methods of treating feline coronavirus infections
CN110636884B (zh) 2017-05-01 2022-10-04 吉利德科学公司 新结晶形式
US10675296B2 (en) 2017-07-11 2020-06-09 Gilead Sciences, Inc. Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections
EP3684782A1 (en) 2017-09-18 2020-07-29 Janssen BioPharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CN111386118B (zh) * 2017-09-29 2023-05-09 英安塔制药有限公司 作为rsv抑制剂的组合药物剂
BR112020010581A2 (pt) 2017-12-07 2020-11-10 Emory University composição farmacêutica, recipiente pressurizado, e, métodos para tratar ou prevenir uma infecção viral e de tratamento ou prevenção de coronavírus humano, sars, coronavírus mers, vírus da encefalite equina oriental, vírus da encefalite equina ocidental, vírus da encefalite equina venezuelana, vírus chikungunya e infecção por infecção de ross river, vírus orthomyxoviridae ou vírus paramyxoviridae ou vírus rsv, ou infecção pelo vírus influenza a e vírus influenza b ou vírus filoviridae ou vírus ebola.
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
MX2021011144A (es) 2019-03-18 2022-01-18 Enanta Pharm Inc Derivados de las benzodiazepinas como inhibidores del vsr.
CA3137119A1 (en) 2019-05-09 2020-11-12 Aligos Therapeutics, Inc. Modified cyclic dinucleoside compounds as sting modulators
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
CN110776512A (zh) * 2019-11-28 2020-02-11 成都傲飞生物化学品有限责任公司 一种核苷类似物的制备方法
AU2021214911A1 (en) 2020-01-27 2022-07-21 Gilead Sciences, Inc. Methods for treating SARS CoV-2 infections
CN113214262B (zh) * 2020-02-05 2023-07-07 华创合成制药股份有限公司 一种含有胍基的化合物及其制备方法和用途
CN113214263B (zh) * 2020-02-06 2022-09-30 北京桦冠医药科技有限公司 瑞德西韦关键中间体的一种合成方法
WO2021158851A1 (en) * 2020-02-07 2021-08-12 Cai Gu Huang Pharmaceutical formulation containing remdesivir
TW202315607A (zh) 2020-02-18 2023-04-16 美商基利科學股份有限公司 抗病毒化合物
TW202245800A (zh) 2020-02-18 2022-12-01 美商基利科學股份有限公司 抗病毒化合物
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
KR20220143064A (ko) 2020-02-18 2022-10-24 길리애드 사이언시즈, 인코포레이티드 항바이러스 화합물
CN113292565B (zh) * 2020-02-24 2023-01-31 浙江森科建设有限公司 核苷类化合物及其制备方法和应用
WO2021168930A1 (zh) * 2020-02-25 2021-09-02 顾世海 一种瑞德西韦的片剂及其制备方法
CN113354699B (zh) * 2020-03-04 2023-07-18 中国科学院上海药物研究所 瑞德西韦的中间体及其制备方法
WO2021183750A2 (en) 2020-03-12 2021-09-16 Gilead Sciences, Inc. Methods of preparing 1'-cyano nucleosides
AR121620A1 (es) 2020-03-20 2022-06-22 Gilead Sciences Inc Profármacos de nucleósidos 4’-c-sustituidos-2-halo-2’-deoxiadenosina y métodos de preparación y uso de los mismos
CN113493480A (zh) * 2020-04-03 2021-10-12 南京正大天晴制药有限公司 一种瑞德西韦异构体的制备及其分析方法
US11701372B2 (en) 2020-04-06 2023-07-18 Gilead Sciences, Inc. Inhalation formulations of 1'-cyano substituted carba-nucleoside analogs
WO2021208910A1 (zh) * 2020-04-13 2021-10-21 山东华铂凯盛生物科技有限公司 用于治疗病毒感染的聚合物制剂及制备方法和用途
US20230158074A1 (en) * 2020-04-16 2023-05-25 The General Hospital Corporation B cell immunomodulatory therapy for acute respiratory distress syndrome
US20230173077A1 (en) * 2020-04-30 2023-06-08 AJK Biopharmaceutical, LLC Fatty acyl and fatty ether conjugates of remdesivir and its active metabolites as antivirals
CN111494349A (zh) * 2020-04-30 2020-08-07 中国人民解放军空军军医大学 一种瑞德西韦口腔速溶膜及制备方法
US20210346416A1 (en) * 2020-05-05 2021-11-11 Ralph Lipp Pharmaceutical Compositions and Methods for their Use in Antiviral Therapy
CN111961057A (zh) * 2020-05-26 2020-11-20 李小冬 一种α构型核苷及其在治疗猫冠状病毒感染的应用
CA3179226A1 (en) 2020-05-29 2021-12-02 Tomas Cihlar Remdesivir treatment methods
US11377456B2 (en) 2020-06-11 2022-07-05 Apotex Inc. Crystalline form of Remdesivir
IL299202A (en) * 2020-06-24 2023-02-01 Gilead Sciences Inc 1'-cyano nucleoside analogs and uses thereof
US20230263816A1 (en) * 2020-07-17 2023-08-24 Board Of Regents, The University Of Texas System Pharmaceutical compositions for delivery of remdesivir by inhalation
EP4192839A1 (en) 2020-08-06 2023-06-14 Richter Gedeon Nyrt. Remdesivir intermediates
AU2021331214B2 (en) 2020-08-27 2024-01-04 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
WO2022086840A1 (en) 2020-10-19 2022-04-28 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
TW202406932A (zh) 2020-10-22 2024-02-16 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
KR20230107288A (ko) 2020-11-11 2023-07-14 길리애드 사이언시즈, 인코포레이티드 gp120 CD4 결합 부위-지향 항체를 이용한 요법에 감수성인 HIV 환자를 식별하는 방법
CN114507256A (zh) * 2020-11-16 2022-05-17 上海医药集团股份有限公司 一种瑞德西韦工艺手性异构体、其制备方法及其应用
JPWO2022107463A1 (me) 2020-11-18 2022-05-27
RU2756921C1 (ru) * 2020-11-20 2021-10-07 Общество С Ограниченной Ответственностью "Технология Лекарств" Способ получения ремдесивира и фосфорамидаты
EP4267582A4 (en) * 2020-12-30 2024-06-05 Southern University of Science and Technology METHODS AND MODIFIED NUCLEOSIDES FOR THE TREATMENT OF CORONAVIRUS INFECTIONS
WO2022166581A1 (zh) * 2021-02-07 2022-08-11 石家庄迪斯凯威医药科技有限公司 一种核苷酸衍生物及其药物组合物和用途
CN112843073A (zh) * 2021-03-30 2021-05-28 山东省农业科学院畜牧兽医研究所 瑞德西韦(Remdesivir)在制备抗牛副流感病毒3型药物中的应用
AU2022256476A1 (en) 2021-04-16 2023-10-12 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides
US20230000873A1 (en) 2021-05-26 2023-01-05 Gilead Sciences, Inc. Phospholipid formulations of 1'-cyano substituted carba-nucleoside analogs
AU2022328698A1 (en) 2021-08-18 2024-02-01 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
WO2023102472A1 (en) * 2021-12-01 2023-06-08 The Scripps Research Institute Antiviral prodrugs and formulations thereof
AU2022399845A1 (en) 2021-12-03 2024-05-23 Gilead Sciences, Inc. Therapeutic compounds for hiv virus infection
TW202412779A (zh) 2021-12-03 2024-04-01 美商基利科學股份有限公司 用於hiv病毒感染之治療性化合物
TW202342447A (zh) 2021-12-03 2023-11-01 美商基利科學股份有限公司 用於hiv病毒感染之治療性化合物
WO2023161427A1 (en) 2022-02-24 2023-08-31 Eisbach Bio Gmbh Viral combination therapy
EP4320128A1 (en) 2022-03-02 2024-02-14 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
CN118843629A (zh) * 2022-03-03 2024-10-25 吉利德科学公司 抗病毒化合物及其制备和使用方法
TWI843506B (zh) 2022-04-06 2024-05-21 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
US20240051962A1 (en) * 2022-06-29 2024-02-15 Gilead Sciences, Inc. Solid forms of a nucleoside analogue and uses thereof
WO2024006461A1 (en) * 2022-06-30 2024-01-04 Gilead Sciences, Inc. Solid forms of a nucleoside analogue and uses thereof
US20240034724A1 (en) 2022-07-01 2024-02-01 Gilead Sciences, Inc. Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection
US20240083984A1 (en) 2022-08-26 2024-03-14 Gilead Sciences, Inc. Dosing and scheduling regimen for broadly neutralizing antibodies
US20240226130A1 (en) 2022-10-04 2024-07-11 Gilead Sciences, Inc. 4'-thionucleoside analogues and their pharmaceutical use
TW202421167A (zh) 2022-11-18 2024-06-01 美商基利科學股份有限公司 用於治療痘病毒感染之方法
WO2024220624A1 (en) 2023-04-19 2024-10-24 Gilead Sciences, Inc. Dosing regimen of capsid inhibitor

Family Cites Families (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1003489A (en) 1911-04-10 1911-09-19 Minnie Moritz Barber's reversible hair-cloth.
US3361306A (en) 1966-03-31 1968-01-02 Merck & Co Inc Aerosol unit dispensing uniform amounts of a medically active ingredient
US3565070A (en) 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
FR2224175B1 (me) 1973-04-04 1978-04-14 Isf Spa
US4069819A (en) 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
IT1017153B (it) 1974-07-15 1977-07-20 Isf Spa Apparecchio per inalazioni
SE438261B (sv) 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
US4816570A (en) 1982-11-30 1989-03-28 The Board Of Regents Of The University Of Texas System Biologically reversible phosphate and phosphonate protective groups
US4805811A (en) 1985-03-29 1989-02-21 Aktiebolaget Draco Dosage device
SE448277B (sv) 1985-04-12 1987-02-09 Draco Ab Indikeringsanordning vid en doseringsanordning for lekemedel
US4968788A (en) 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
US4955371A (en) 1989-05-08 1990-09-11 Transtech Scientific, Inc. Disposable inhalation activated, aerosol device for pulmonary medicine
EP0533833B1 (en) 1990-06-13 1995-12-20 GLAZIER, Arnold Phosphorous produgs
DK0481214T3 (da) 1990-09-14 1999-02-22 Acad Of Science Czech Republic Prolægemidler af phosphonater
EP1693080A3 (en) 1991-07-02 2007-07-25 Nektar Therapeutics Method and device for delivering aeroslized medicaments
US5261538A (en) 1992-04-21 1993-11-16 Glaxo Inc. Aerosol testing method
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US5388572A (en) 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5522385A (en) 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5622163A (en) 1994-11-29 1997-04-22 Iep Group, Inc. Counter for fluid dispensers
US5544647A (en) 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator
US6887707B2 (en) 1996-10-28 2005-05-03 University Of Washington Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
JP2002505340A (ja) 1998-03-03 2002-02-19 ノボ ノルディスク アクティーゼルスカブ (2e)−5−アミノ−5−メチルヘキセ−2−エン酸n−メチル−n−((1r)−1−(n−メチル−n−((1r)−1−(メチルカルバモイル)−2−フェニルエチル)カルバモイル)−2−(2−ナフチル)エチル)アミドの新規な塩
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
WO1999049873A1 (en) 1998-03-27 1999-10-07 Regents Of The University Of Minnesota Nucleosides with antiviral and anticancer activity
US6476030B1 (en) 1998-10-16 2002-11-05 Merck Sharp & Dohme Ltd. Pyrazolo-triazine derivatives as ligands for GABA receptors
US6116234A (en) 1999-02-01 2000-09-12 Iep Pharmaceutical Devices Inc. Metered dose inhaler agitator
DE19912636A1 (de) 1999-03-20 2000-09-21 Aventis Cropscience Gmbh Bicyclische Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und pharmazeutische Mittel
WO2000075157A1 (en) 1999-06-03 2000-12-14 Abbott Laboratories Oligonucleotide synthesis with lewis acids as activators
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
US6656915B1 (en) 1999-09-15 2003-12-02 Biocryst Pharmaceuticals, Inc. Inhibiting T-cell proliferation
WO2001032153A2 (en) 1999-11-04 2001-05-10 Shire Biochem Inc. Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
WO2001060315A2 (en) 2000-02-18 2001-08-23 Shire Biochem Inc. Method for the treatment or prevention of flavivirus infections using nucleoside analogues
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
AP2006003708A0 (en) 2000-05-26 2006-08-31 Idenix Cayman Ltd Methods and compositions for treating flavivirusesand pestiviruses
EP1301519B2 (en) 2000-07-21 2021-11-10 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
US20030087873A1 (en) 2000-10-18 2003-05-08 Lieven Stuyver Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
ATE526339T1 (de) 2001-01-22 2011-10-15 Merck Sharp & Dohme Nukleosidderivate als inhibitoren der rna- abhängigen viralen rna-polymerase
DE10145223A1 (de) 2001-09-13 2003-04-03 Basf Ag Verfahren zur Herstellung von meso-Zeaxanthin
US20040006002A1 (en) 2001-09-28 2004-01-08 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
AT410792B (de) 2001-12-28 2003-07-25 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung
EP1485395A4 (en) 2002-02-28 2011-04-13 Biota Scient Management NUCLEOTIDE MIMETICS AND PRODRUGS THEREOF
US20040023901A1 (en) 2002-02-28 2004-02-05 Cook Phillip D. Nucleoside 5'-monophosphate mimics and their prodrugs
US20040138170A1 (en) 2002-03-06 2004-07-15 Montgomery John A. Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
GB0210127D0 (en) 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
GB0210124D0 (en) 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
US20040063658A1 (en) 2002-05-06 2004-04-01 Roberts Christopher Don Nucleoside derivatives for treating hepatitis C virus infection
WO2003100009A2 (en) 2002-05-23 2003-12-04 Biocryst Pharmaceuticals, Inc. Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
DK1576138T3 (en) 2002-11-15 2017-05-01 Idenix Pharmaceuticals Llc 2'-METHYL NUCLEOSIDES IN COMBINATION WITH INTERFERON AND FLAVIVIRIDAE MUTATION
EP2359833A1 (en) 2003-04-25 2011-08-24 Gilead Sciences, Inc. Antiviral phosphonate analogs
NZ544671A (en) 2003-06-26 2009-02-28 Biotron Ltd Antiviral compounds and methods
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
DE602004028841D1 (de) 2003-07-25 2010-10-07 Centre Nat Rech Scient Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c
BRPI0414019A (pt) 2003-08-27 2006-10-24 Biota Inc nucleosìdios ou nucleotìdio tricìclicos como agentes terapêuticos
CN103030617A (zh) 2004-03-16 2013-04-10 贝林格尔.英格海姆国际有限公司 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
US7534767B2 (en) 2004-06-15 2009-05-19 Merck & Co., Inc. C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase
US7560434B2 (en) 2004-06-22 2009-07-14 Biocryst Pharmaceuticals, Inc. AZA nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
KR101177590B1 (ko) 2004-09-14 2012-08-27 파마셋 인코포레이티드 2'-플루오로-2'-알킬 치환되거나 또는 다른 선택적으로치환된 리보퓨라노실 피리미딘 및 퓨린 및 그 유도체의제조
US20080280842A1 (en) 2004-10-21 2008-11-13 Merck & Co., Inc. Fluorinated Pyrrolo[2,3-D]Pyrimidine Nucleosides for the Treatment of Rna-Dependent Rna Viral Infection
CN101043893A (zh) 2004-10-21 2007-09-26 默克公司 治疗RNA-依赖性RNA病毒感染的氟化吡咯并[2,3-d]嘧啶核苷
CN101166750A (zh) 2004-10-29 2008-04-23 拜奥克里斯特制药公司 治疗用呋喃并嘧啶类化合物和噻吩并嘧啶类化合物
ATE407938T1 (de) 2004-12-16 2008-09-15 Boehringer Ingelheim Int Glucopyranosyl-substituierte benzen-derivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür
EP1858889A1 (en) 2005-03-08 2007-11-28 Biota Scientific Management Pty. Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
CA2602533A1 (en) 2005-03-29 2006-10-05 Biocryst Pharmaceuticals, Inc. Use of c-nucleoside analogs for treatment of hepatitis c related viral infections
WO2006116557A1 (en) 2005-04-25 2006-11-02 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
WO2006121820A1 (en) 2005-05-05 2006-11-16 Valeant Research & Development Phosphoramidate prodrugs for treatment of viral infection
WO2007027248A2 (en) 2005-05-16 2007-03-08 Valeant Research & Development 3', 5' - cyclic nucleoside analogues for treatment of hcv
CA2612403C (en) 2005-06-24 2014-03-25 Biotron Limited Antiviral compounds and methods
CN101321775B (zh) 2005-10-03 2012-05-23 大学健康网络 用于治疗疟疾的odcase抑制剂
EP1945222B1 (en) 2005-11-02 2012-12-26 Bayer Pharma Aktiengesellschaft Pyrrolo[2,1-f] [1,2,4]-triazin-4-ylamines as igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases
ATE444747T1 (de) 2005-12-01 2009-10-15 Basilea Pharmaceutica Ag Verfahren zur herstellung von expoxybutanol- zwischenprodukten
PE20070855A1 (es) 2005-12-02 2007-10-14 Bayer Pharmaceuticals Corp Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
US8143393B2 (en) 2005-12-02 2012-03-27 Bayer Healthcare Llc Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
EP1971331A2 (en) 2005-12-09 2008-09-24 Basilea Pharmaceutica AG 4-oxo-(iso)tretinoin for the topical treatment of severe dermatological disorders
KR101238461B1 (ko) 2005-12-09 2013-03-05 길리어드 파마셋 엘엘씨 항바이러스성 뉴클레오시드
JP2009526850A (ja) 2006-02-14 2009-07-23 メルク エンド カムパニー インコーポレーテッド Rna依存性rnaウイルス感染を治療するためのヌクレオシドアリールホスホルアミデート
WO2007097991A2 (en) 2006-02-16 2007-08-30 Pharmasset, Inc. Methods and kits for dosing of antiviral agents
DE102006015378A1 (de) 2006-04-03 2007-10-04 Ludwig-Maximilians-Universität München Verfahren zur Synthese von Organoelementverbindungen
AR061024A1 (es) 2006-05-22 2008-07-30 Novartis Ag Maleato de 5-amino-3- (2'3'-di-o-acetil-beta-d-ribofuranosil)-3h-tiazolo[4,5-d] pirimidin-2-ona.
WO2008005542A2 (en) 2006-07-07 2008-01-10 Gilead Sciences, Inc., Antiviral phosphinate compounds
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
EP2079753A1 (en) 2006-11-06 2009-07-22 Boehringer Ingelheim International GmbH Glucopyranosyl-substituted benzyl-benzonitrile derivatives, medicaments containing such compounds, their use and process for their manufacture
WO2008079206A1 (en) 2006-12-20 2008-07-03 Merck & Co., Inc. Nucleoside cyclic phosphoramidates for the treatment of rna-dependent rna viral infection
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
WO2008085508A2 (en) 2007-01-05 2008-07-17 Merck & Co., Inc. Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection
WO2008089105A2 (en) * 2007-01-12 2008-07-24 Biocryst Pharmaceuticals, Inc. Antiviral nucleoside analogs
JP2010522241A (ja) 2007-03-21 2010-07-01 ブリストル−マイヤーズ スクイブ カンパニー 増殖性疾患、アレルギー性疾患、自己免疫疾患または炎症性疾患として有用な縮合ヘテロ環化合物
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
AU2008251555B2 (en) 2007-05-10 2012-08-30 Biocryst Pharmaceuticals, Inc. Tetrahydrofuro [3 4-D] dioxolane compounds for use in the treatment of viral infections and cancer
CN100532388C (zh) 2007-07-16 2009-08-26 郑州大学 2’-氟-4’-取代-核苷类似物、其制备方法及应用
BRPI0814737B8 (pt) 2007-08-03 2021-05-25 Biotron Ltd composição para o tratamento de hcv, e, uso de uma composição
KR101502533B1 (ko) 2007-11-22 2015-03-13 에스케이케미칼주식회사 우수한 안정성을 갖는 택산 유도체 함유 주사제용동결건조 조성물 및 이의 제조방법
US20090176732A1 (en) * 2007-12-21 2009-07-09 Alios Biopharma Inc. Protected nucleotide analogs
TW200942243A (en) 2008-03-05 2009-10-16 Biocryst Pharm Inc Antiviral therapeutic agents
US8227431B2 (en) 2008-03-17 2012-07-24 Hetero Drugs Limited Nucleoside derivatives
US7863291B2 (en) 2008-04-23 2011-01-04 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
AP3237A (en) * 2008-04-23 2015-04-30 Gilead Sciences Inc 1'-Substituted carba-nucleoside analogs for antiviral treatment
WO2010036407A2 (en) 2008-05-15 2010-04-01 Biocryst Pharmaceuticals, Inc. Antiviral nucleoside analogs
WO2010002877A2 (en) * 2008-07-03 2010-01-07 Biota Scientific Management Bycyclic nucleosides and nucleotides as therapeutic agents
KR101834707B1 (ko) 2009-02-10 2018-03-05 길리애드 사이언시즈, 인코포레이티드 항바이러스 치료를 위한 카르바-뉴클레오시드 유사체
AR075584A1 (es) 2009-02-27 2011-04-20 Intermune Inc COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.
EP2623104A1 (en) * 2009-03-20 2013-08-07 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
NZ595590A (en) 2009-03-24 2013-11-29 Biocryst Pharm Inc Useful pharmaceutical salts of 7-[(3r,4r)-3-hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one
TWI583692B (zh) 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
UY32793A (es) 2009-07-21 2011-01-31 Gilead Sciences Inc Compuestos inhibidores de los virus flaviviridae, composición farmacéutica que los contiene y sus usos
AU2010295392B2 (en) 2009-09-21 2015-10-22 Gilead Sciences, Inc. Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs
SI2480552T1 (sl) 2009-09-21 2017-02-28 Gilead Sciences, Inc. 2'-fluoro substituirani karba-nukleozidni analogi za protivirusno obravnavo
US7973013B2 (en) 2009-09-21 2011-07-05 Gilead Sciences, Inc. 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
US8455451B2 (en) 2009-09-21 2013-06-04 Gilead Sciences, Inc. 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
TWI555746B (zh) 2009-12-28 2016-11-01 財團法人生物技術開發中心 作為mTOR及PI3K抑制劑之新穎嘧啶化合物
JP2013527145A (ja) 2010-03-31 2013-06-27 ギリード・ファーマセット・エルエルシー リン含有活性化剤の立体選択的合成
UY33310A (es) 2010-03-31 2011-10-31 Pharmasset Inc Sintesis estereoselectiva de activos que contienen fosforo
TW201201815A (en) 2010-05-28 2012-01-16 Gilead Sciences Inc 1'-substituted-carba-nucleoside prodrugs for antiviral treatment
MX2013000656A (es) 2010-07-19 2013-04-03 Gilead Sciences Inc Metodos para la preparacion de profarmacos de fosforamidato diastereomericamente puros.
ME01924B (me) * 2010-07-22 2015-05-20 Gilead Sciences Inc Metode i jedinjenja za lečenje infekcija izazvanih Paramyxoviridae virusom
TW201305185A (zh) 2010-09-13 2013-02-01 Gilead Sciences Inc 用於抗病毒治療之2’-氟取代之碳-核苷類似物
MX2013003179A (es) 2010-09-20 2013-04-24 Gilead Sciences Inc Analogos de carba-nucleosidos sustituidos con 2 '-fluoro para tratamiento antiviral.
PE20140608A1 (es) 2010-09-22 2014-06-12 Alios Biopharma Inc Analogos de nucleotidos sustituidos
MX348759B (es) 2010-10-15 2017-06-28 Biocryst Pharm Inc Metodos y composiciones para inhibicion de polimerasa.
TW201701876A (zh) 2010-12-20 2017-01-16 吉李德科學股份有限公司 治療c型肝炎病毒(hcv)之方法
CN103476783A (zh) 2011-04-13 2013-12-25 吉里德科学公司 用于抗病毒治疗的1’-取代的嘧啶n-核苷类似物
ES2963147T3 (es) 2011-05-13 2024-03-25 Zoetis Services Llc Composiciones inmunogénicas de glucoproteína G de virus Hendra y Nipah
MX354958B (es) 2011-09-16 2018-03-27 Gilead Pharmasset Llc Metodos para el tratamiento de vhc.
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US20130143835A1 (en) 2011-12-05 2013-06-06 Medivir Ab HCV Polymerase Inhibitors
WO2013084165A1 (en) 2011-12-05 2013-06-13 Medivir Ab Hcv polymerase inhibitors
US8980865B2 (en) 2011-12-22 2015-03-17 Alios Biopharma, Inc. Substituted nucleotide analogs
AU2013266393B2 (en) 2012-05-22 2017-09-28 Idenix Pharmaceuticals Llc D-amino acid compounds for liver disease
ES2671478T3 (es) 2012-08-31 2018-06-06 Novartis Ag Derivados de 2'-etinil nucleósidos para el tratamiento de infecciones virales
EA201590384A1 (ru) 2012-09-10 2015-10-30 Ф. Хоффманн-Ля Рош Аг 6-аминокислота-гетероарилдигидропиримидины для лечения и профилактики инфекции вируса гепатита в
WO2014042433A2 (en) 2012-09-14 2014-03-20 Kainos Medicine, Inc. Compounds and compositions for modulating adenosine a3 receptor activity
MX2015005949A (es) 2012-11-16 2015-09-08 Biocryst Pharm Inc Nucleosidos que contienen aza-azucar antiviral.
AU2013344757A1 (en) 2012-11-19 2015-05-21 Merck Sharp & Dohme Corp. 2 -alkynyl substituted nucleoside derivatives for treating viral diseases
BR112015014457A2 (pt) 2012-12-21 2017-11-21 Alios Biopharma Inc composto ou sal farmaceuticamente aceitável do mesmo e composição farmacêutica e respectivos usos e processos para melhorar ou tratar infecção de hcv, para inibir a atividade da ns5b polimerase do vírus da hepatite c e a replicação de vírus da hepatite c
WO2014116755A1 (en) 2013-01-22 2014-07-31 Massachusetts Institute Of Technology Uses of dihydro bases
US10034893B2 (en) 2013-02-01 2018-07-31 Enanta Pharmaceuticals, Inc. 5, 6-D2 uridine nucleoside/tide derivatives
EP2984097B1 (en) 2013-04-12 2017-03-29 Achillion Pharmaceuticals, Inc. Highly active nucleoside derivative for the treatment of hcv
UA117375C2 (uk) 2013-09-04 2018-07-25 Медівір Аб Інгібітори полімерази hcv
EP3711762A1 (en) 2013-09-11 2020-09-23 INSERM (Institut National de la Santé et de la Recherche Médicale) A farnesoid x receptor agonsits foruse and pharmaceutical compositions for the treatment of chronic hepatitis b virus infection
UA119050C2 (uk) 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
CN105899508B (zh) 2014-01-30 2017-07-04 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的新型二氢喹嗪酮类化合物
CR20160337A (es) 2014-03-07 2016-09-20 Hoffmann La Roche Nuevas heteroarildihidropirimidinas 6-fusionadas para el tratamiento y la profilaxis de la infección por virus de la hepatitis b
EP3143020B1 (en) 2014-05-13 2019-08-21 F. Hoffmann-La Roche AG Dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
US9616076B2 (en) 2014-06-02 2017-04-11 The Board Of Regents Of The University Of Texas Systems Methods for treating viral infections using hydrogen sulfide donors
US9504701B2 (en) 2014-06-02 2016-11-29 The Board Of Regents Of The University Of Texas System Methods for treating viral infections using hydrogen sulfide donors
WO2016012470A1 (en) 2014-07-25 2016-01-28 F. Hoffmann-La Roche Ag New amorphous and crystalline forms of (3s)-4-[[(4r)-4-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1, 4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
BR112017002970B1 (pt) 2014-08-14 2023-04-11 F. Hoffmann-La Roche Ag Novas piridazonas e triazinonas para o tratamento e profilaxia da infecção pelo vírus da hepatite b
TWI740546B (zh) 2014-10-29 2021-09-21 美商基利科學股份有限公司 製備核糖苷的方法
US9637485B2 (en) 2014-11-03 2017-05-02 Hoffmann-La Roche Inc. 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
AR103222A1 (es) 2014-12-23 2017-04-26 Hoffmann La Roche Procedimiento para la preparación de análogos de 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidina
US9676793B2 (en) 2014-12-23 2017-06-13 Hoffmann-Laroche Inc. Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
JP6506845B2 (ja) 2014-12-30 2019-04-24 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft B型肝炎ウイルス感染症の治療及び予防のための新規テトラヒドロピリドピリミジン類及びテトラヒドロピリドピリジン類
EP3240913A1 (en) 2014-12-31 2017-11-08 F. Hoffmann-La Roche AG A novel high-throughput method for quantification of hbv cccdna from cell lysate by real-time pcr
MA41338B1 (fr) 2015-01-16 2019-07-31 Hoffmann La Roche Composés de pyrazine pour le traitement de maladies infectieuses
WO2016120186A1 (en) 2015-01-27 2016-08-04 F. Hoffmann-La Roche Ag Recombinant hbv cccdna, the method to generate thereof and the use thereof
JP6435054B2 (ja) 2015-02-11 2018-12-05 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft B型肝炎ウイルス感染の治療及び予防のための新規2−オキソ−6,7−ジヒドロベンゾ[a]キノリジン−3−カルボン酸誘導体
EP3349758B1 (en) 2015-09-16 2022-04-06 Gilead Sciences, Inc. Methods for treating arenaviridae virus infections
WO2017184668A1 (en) 2016-04-20 2017-10-26 Gilead Sciences, Inc. Methods for treating flaviviridae virus infections
MX2019009443A (es) 2017-02-08 2019-12-16 Biotron Ltd Metodos para tratar la influenza.
WO2018169946A1 (en) 2017-03-14 2018-09-20 Gilead Sciences, Inc. Methods of treating feline coronavirus infections
CN110636884B (zh) 2017-05-01 2022-10-04 吉利德科学公司 新结晶形式
US10675296B2 (en) 2017-07-11 2020-06-09 Gilead Sciences, Inc. Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections
CN111265532A (zh) 2020-01-21 2020-06-12 中国人民解放军军事科学院军事医学研究院 取代氨基丙酸酯类化合物在治疗2019-nCoV感染中的应用
AU2021214911A1 (en) 2020-01-27 2022-07-21 Gilead Sciences, Inc. Methods for treating SARS CoV-2 infections
WO2021183750A2 (en) 2020-03-12 2021-09-16 Gilead Sciences, Inc. Methods of preparing 1'-cyano nucleosides
US11701372B2 (en) 2020-04-06 2023-07-18 Gilead Sciences, Inc. Inhalation formulations of 1'-cyano substituted carba-nucleoside analogs
CA3179226A1 (en) 2020-05-29 2021-12-02 Tomas Cihlar Remdesivir treatment methods
AU2021331214B2 (en) 2020-08-27 2024-01-04 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections

Also Published As

Publication number Publication date
ES2524356T3 (es) 2014-12-05
UA111163C2 (uk) 2016-04-11
AU2019208167A1 (en) 2019-08-08
AU2011280910A1 (en) 2013-02-07
CL2013000077A1 (es) 2013-04-19
AU2019208167B2 (en) 2021-05-06
EP2595980A1 (en) 2013-05-29
WO2012012776A1 (en) 2012-01-26
PT2595980E (pt) 2014-11-27
US20120027752A1 (en) 2012-02-02
CN103052631A (zh) 2013-04-17
CO6690740A2 (es) 2013-06-17
ECSP13012458A (es) 2013-03-28
KR20130091743A (ko) 2013-08-19
SG186830A1 (en) 2013-02-28
EP2595980B1 (en) 2014-09-03
US20190055251A1 (en) 2019-02-21
EA025252B1 (ru) 2016-12-30
AP2013006680A0 (en) 2013-01-31
MA34470B1 (fr) 2013-08-01
US20150152116A1 (en) 2015-06-04
HK1221657A1 (zh) 2017-06-09
AU2011280910B2 (en) 2015-07-09
CR20130073A (es) 2013-03-25
AU2017201230A1 (en) 2017-03-16
KR20180012336A (ko) 2018-02-05
US20150111839A1 (en) 2015-04-23
MX2013000744A (es) 2013-03-07
CN103052631B (zh) 2015-11-25
US20230125751A1 (en) 2023-04-27
BR122020020745B8 (pt) 2023-10-31
NZ606156A (en) 2015-01-30
AU2017201230B2 (en) 2019-05-02
BR122020020745B1 (pt) 2023-07-11
BR112013001553B1 (pt) 2021-01-12
KR101924765B1 (ko) 2018-12-03
US11492353B2 (en) 2022-11-08
EA201691118A1 (ru) 2017-01-30
NO2020047I1 (no) 2020-12-23
JP2013535453A (ja) 2013-09-12
US20210061806A1 (en) 2021-03-04
EA201390152A1 (ru) 2013-05-30
HK1183487A1 (en) 2013-12-27
IL224043A (en) 2016-05-31
CA2804840C (en) 2018-09-11
CN105343098A (zh) 2016-02-24
IL245348B (en) 2019-07-31
AP3269A (en) 2015-05-31
JP5969471B2 (ja) 2016-08-17
NL301084I2 (nl) 2021-01-28
IL245348A0 (en) 2016-06-30
BR112013001553A2 (pt) 2020-05-26
PL2595980T3 (pl) 2015-03-31
CN105343098B (zh) 2018-07-13
PE20130400A1 (es) 2013-04-10
US10696679B2 (en) 2020-06-30
US10065958B2 (en) 2018-09-04
CA2804840A1 (en) 2012-01-26
PE20171155A1 (es) 2017-08-16
SI2595980T1 (sl) 2014-11-28
JP2016216480A (ja) 2016-12-22
KR101821680B1 (ko) 2018-01-24
CR20170278A (es) 2017-09-29
AU2015238851A1 (en) 2015-10-29

Similar Documents

Publication Publication Date Title
HK1221657A1 (zh) 用於治療副黏病毒科病毒感染的方法和化合物
IL273194B (en) Methods, compounds and preparations for the treatment of parainfluenza virus in patients with a deficiency in the immune system
AP2013007263A0 (en) Substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenesuseful for treating HCV infections
ZA201404061B (en) Compositions and methods for treating the hepatitis c virus
EP2757887A4 (en) PYRROLOPYRIDINONE COMPOUNDS AND METHOD FOR THE TREATMENT OF HIV
HK1189884A1 (zh) 用於治療呼吸道合胞病毒感染的化合物
EP2254582A4 (en) METHOD FOR THE TREATMENT OF VIRUS INFECTIONS
HK1200096A1 (en) Methods for treating intrapulmonary infections
EP2869821A4 (en) COMPOSITIONS AND METHODS FOR TREATING AND INHIBITING VIRAL INFECTIONS
EP2534150A4 (en) METHODS OF TREATING A VIRAL INFECTION
EP2802353A4 (en) COMPOSITIONS AND METHOD FOR THE TREATMENT OF VIRUS INFECTIONS
IL221320A0 (en) Compounds for treating respiratory syncytial virus infections
EP2663327A4 (en) COMPOSITIONS AND METHOD FOR THE TREATMENT OF VIRUS INFECTIONS
EP2536282A4 (en) METHOD FOR THE TREATMENT OF INFECTIONS
ZA201501601B (en) Virus purification and formulation process
HK1206238A1 (en) Composition for preventing and treating aids and preparation method thereof
EP2838903A4 (en) METHOD AND COMPOSITIONS FOR TREATING VIRUS INFECTIONS
EP2739629A4 (en) COMPOUNDS FOR THE TREATMENT OF SYNCYTIAL RESPIRATORY VIRUS INFECTIONS
EP2685820A4 (en) COMPOSITIONS AND METHODS FOR TREATING INFECTIONS
AU2010905234A0 (en) Compounds for treating respiratory syncytial virus infections
IL232889A0 (en) Compounds and methods for treating hepatitis c virus
AU2012905097A0 (en) Agents and methods for inhibiting virus infection
AU2010900494A0 (en) Compound for treating respiratory syncytial virus infections
GB201012168D0 (en) Treatment of viral infections
GB201001821D0 (en) Treatment of viral infections