|
DE2951135A1
(de)
|
1979-12-19 |
1981-06-25 |
Hoechst Ag, 6230 Frankfurt |
Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
|
|
US4617307A
(en)
|
1984-06-20 |
1986-10-14 |
Ciba-Geigy Corporation |
Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
|
|
US4889861A
(en)
|
1982-12-21 |
1989-12-26 |
Ciba-Geigy Corp. |
Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
|
|
DE3347565A1
(de)
|
1983-12-30 |
1985-07-11 |
Thomae Gmbh Dr K |
Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
|
|
JPS6354321A
(ja)
|
1985-03-27 |
1988-03-08 |
Ajinomoto Co Inc |
血糖降下剤
|
|
US5120712A
(en)
|
1986-05-05 |
1992-06-09 |
The General Hospital Corporation |
Insulinotropic hormone
|
|
US5118666A
(en)
|
1986-05-05 |
1992-06-02 |
The General Hospital Corporation |
Insulinotropic hormone
|
|
ATE164852T1
(de)
|
1990-01-24 |
1998-04-15 |
Douglas I Buckley |
Glp-1-analoga verwendbar in der diabetesbehandlung
|
|
AU654331B2
(en)
|
1991-03-30 |
1994-11-03 |
Kissei Pharmaceutical Co. Ltd. |
Succinic acid compounds
|
|
US5155100A
(en)
|
1991-05-01 |
1992-10-13 |
Ciba-Geigy Corporation |
Phosphono/biaryl substituted dipeptide derivatives
|
|
RU2086544C1
(ru)
|
1991-06-13 |
1997-08-10 |
Хоффманн-Ля Рош АГ |
Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
|
|
WO1993000337A1
(de)
|
1991-06-21 |
1993-01-07 |
Dr. Karl Thomae Gmbh |
(s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure
|
|
DE10199058I2
(de)
|
1991-07-30 |
2006-04-27 |
Alcm Co |
Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung
|
|
EP0618803A4
(en)
|
1991-12-19 |
1995-03-22 |
Southwest Found Biomed Res |
POLYPEPTIDE INHIBITING PROTEIN TRANSFER TO CHOLESTERYL ESTERS, ANTIBODIES AGAINST SYNTHETIC POLYPEPTIDE AND ANTI-ATHEROSCLEROSIS PROPHYLACTIC AND THERAPEUTIC TREATMENTS.
|
|
ATE164884T1
(de)
|
1992-11-17 |
1998-04-15 |
Icos Corp |
Neue sieben-transmembran-rezeptor v28
|
|
IL111785A0
(en)
|
1993-12-03 |
1995-01-24 |
Ferring Bv |
Dp-iv inhibitors and pharmaceutical compositions containing them
|
|
US5705483A
(en)
|
1993-12-09 |
1998-01-06 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptides, compositions and methods
|
|
US5512549A
(en)
|
1994-10-18 |
1996-04-30 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
|
|
TW313568B
(enExample)
|
1994-12-20 |
1997-08-21 |
Hoffmann La Roche |
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
US6428771B1
(en)
|
1995-05-15 |
2002-08-06 |
Pharmaceutical Discovery Corporation |
Method for drug delivery to the pulmonary system
|
|
ATE279947T1
(de)
|
1996-03-18 |
2004-11-15 |
Univ Texas |
Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
|
|
DE122010000020I1
(de)
|
1996-04-25 |
2010-07-08 |
Prosidion Ltd |
Verfahren zur Senkung des Blutglukosespiegels in Säugern
|
|
US20020052310A1
(en)
|
1997-09-15 |
2002-05-02 |
Massachusetts Institute Of Technology The Penn State Research Foundation |
Particles for inhalation having sustained release properties
|
|
TW492957B
(en)
|
1996-11-07 |
2002-07-01 |
Novartis Ag |
N-substituted 2-cyanopyrrolidnes
|
|
US6555339B1
(en)
|
1997-04-14 |
2003-04-29 |
Arena Pharmaceuticals, Inc. |
Non-endogenous, constitutively activated human protein-coupled receptors
|
|
AU1685499A
(en)
|
1997-12-24 |
1999-07-19 |
Takeda Chemical Industries Ltd. |
Polypeptide, their production and use
|
|
GT199900147A
(es)
|
1998-09-17 |
1999-09-06 |
|
1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
|
|
US6197786B1
(en)
|
1998-09-17 |
2001-03-06 |
Pfizer Inc |
4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
|
|
AU5759399A
(en)
|
1998-09-25 |
2000-04-17 |
Takeda Chemical Industries Ltd. |
Peptide derivative
|
|
CA2346064A1
(en)
|
1998-10-05 |
2000-04-13 |
Takeda Chemical Industries, Ltd. |
Method for removing n-terminal methionine
|
|
US6660843B1
(en)
*
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
CO5150173A1
(es)
|
1998-12-10 |
2002-04-29 |
Novartis Ag |
Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
|
|
US7045532B2
(en)
|
1999-04-30 |
2006-05-16 |
Millennium Pharmaceuticals, Inc. |
ACE-2 modulating compounds and methods of use thereof
|
|
US6544974B2
(en)
|
1999-09-23 |
2003-04-08 |
G.D. Searle & Co. |
(R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesteryl ester transfer protein activity
|
|
AU2001242749A1
(en)
|
2000-03-23 |
2001-10-03 |
Takeda Chemical Industries Ltd. |
Peptide derivative
|
|
KR20020089437A
(ko)
|
2000-04-12 |
2002-11-29 |
노파르티스 아게 |
유기 화합물의 배합
|
|
AU2001264937A1
(en)
|
2000-05-23 |
2001-12-03 |
Genaissance Pharmaceuticals, Inc. |
Haplotypes of the agtrl1 gene
|
|
IL158418A0
(en)
|
2001-04-19 |
2004-05-12 |
Scripps Research Inst |
In vivo incorporation of unnatural amino acids
|
|
DE60230927D1
(de)
|
2001-07-16 |
2009-03-05 |
Caprotec Bioanalytics Gmbh |
Fangverbindungen, ihre entnahme und verfahren zur analysierung des proteoms und von komplexen zusammensetzungen
|
|
WO2003063892A1
(en)
|
2002-01-29 |
2003-08-07 |
Takeda Chemical Industries, Ltd. |
Use of apelin
|
|
TW200407310A
(en)
|
2002-06-07 |
2004-05-16 |
Glaxo Group Ltd |
Compounds
|
|
CA2494636A1
(en)
|
2002-08-07 |
2004-02-19 |
Novartis Ag |
Organic compounds as agents for the treatment of aldosterone mediated conditions
|
|
CA2505752A1
(en)
|
2002-11-18 |
2004-06-03 |
Novartis Ag |
Imidazo[1,5a]pyridine derivatives and methods for treating aldosterone mediated diseases
|
|
EP1613348B1
(en)
|
2003-03-12 |
2010-06-23 |
The Arizona Board of Regents on Behalf of the University of Arizona |
Methods for modulating angiogenesis with apelin compositions
|
|
WO2005029066A2
(en)
*
|
2003-05-22 |
2005-03-31 |
Agilent Technologies, Inc. |
Diagnostic markers and pharmacological targets in heart failure and related reagents and methods of use thereof
|
|
US7947280B2
(en)
*
|
2003-05-22 |
2011-05-24 |
The Board Of Trustees Of The Leland Stanford Junior University |
Apelin and uses thereof
|
|
EP1520861A1
(en)
|
2003-09-11 |
2005-04-06 |
Aventis Pharma Deutschland GmbH |
Test system for the identification of APJ receptor ligands
|
|
EP1673395A1
(en)
*
|
2003-10-15 |
2006-06-28 |
PDL BioPharma, Inc. |
Alteration of fc-fusion protein serum half-lives by mutagenesis of positions 250, 314 and/or 428 of the heavy chain constant region of ig
|
|
EA200601785A1
(ru)
|
2004-03-26 |
2007-02-27 |
Эли Лилли Энд Компани |
Соединения и способы лечения дислипидемии
|
|
UA90269C2
(ru)
|
2004-04-02 |
2010-04-26 |
Мицубиси Танабе Фарма Корпорейшн |
Тетрагидрохинолиновые производные и способ их получения
|
|
WO2005106493A1
(en)
|
2004-04-30 |
2005-11-10 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with g protein-coupled apelin receptor (apj)
|
|
US20080076784A1
(en)
|
2004-05-28 |
2008-03-27 |
Peter Herold |
Bicyclic, Nitrogen-Containing Heterocycles and Aromatase Inhibitors
|
|
CA2568165A1
(en)
|
2004-05-28 |
2005-12-15 |
Speedel Experimenta Ag |
Heterocyclic compounds and their use as aldosterone synthase inhibitors
|
|
AR050251A1
(es)
|
2004-05-28 |
2006-10-11 |
Speedel Experimenta Ag |
Compuestos heterociclicos con nitrogeno heteroatomico y composicion farmaceutica en base al compuesto
|
|
EP1768951A4
(en)
|
2004-06-17 |
2011-06-15 |
Musc Found For Res Dev |
NON-NATURAL AMINO ACIDS
|
|
TW200611897A
(en)
|
2004-07-09 |
2006-04-16 |
Speedel Experimenta Ag |
Organic compounds
|
|
US20060045880A1
(en)
|
2004-08-23 |
2006-03-02 |
Krieg Paul A |
Methods for modulating angiogenesis and apoptosis with apelin compositions
|
|
JP2008013436A
(ja)
|
2004-10-14 |
2008-01-24 |
Kanazawa Univ |
血管形成促進剤
|
|
US20110097710A1
(en)
|
2004-10-26 |
2011-04-28 |
Macrae Calum A |
Methods for detecting atrial fibrillation and related conditions
|
|
US8431558B2
(en)
|
2004-11-01 |
2013-04-30 |
The Regents Of The University Of California |
Compositions and methods for modification of biomolecules
|
|
WO2006076736A2
(en)
|
2005-01-14 |
2006-07-20 |
Arizona Board Of Regents On Behalf Of The University Of Arizona |
Methods for modulating angiogenesis, lymphangiogenesis, and apoptosis with apelin compositions
|
|
TW200716105A
(en)
|
2005-05-31 |
2007-05-01 |
Speedel Experimenta Ag |
Imidazole compounds
|
|
TW200716636A
(en)
|
2005-05-31 |
2007-05-01 |
Speedel Experimenta Ag |
Heterocyclic spiro-compounds
|
|
TW200716634A
(en)
|
2005-05-31 |
2007-05-01 |
Speedel Experimenta Ag |
Heterocyclic spiro-compounds
|
|
BRPI0614649A2
(pt)
|
2005-08-11 |
2011-04-12 |
Amylin Pharmaceuticals Inc |
polipeptìdeos hìbridos com propriedades selecionáveis
|
|
GT200600381A
(es)
|
2005-08-25 |
2007-03-28 |
|
Compuestos organicos
|
|
US8673848B2
(en)
*
|
2012-01-27 |
2014-03-18 |
Novartis Ag |
Synthetic apelin mimetics for the treatment of heart failure
|
|
WO2007038619A2
(en)
*
|
2005-09-27 |
2007-04-05 |
Amunix, Inc. |
Proteinaceous pharmaceuticals and uses thereof
|
|
EP1876448A1
(en)
|
2005-09-30 |
2008-01-09 |
DIGILAB BioVisioN GmbH |
Method and analytical reagents for identifying therapeutics using biomarkers responsive to thiazolidinediones.
|
|
US7736346B2
(en)
|
2005-10-18 |
2010-06-15 |
Biocardia, Inc. |
Bio-interventional therapeutic treatments for cardiovascular diseases
|
|
TW200804378A
(en)
|
2005-12-09 |
2008-01-16 |
Speedel Experimenta Ag |
Organic compounds
|
|
US20080031871A1
(en)
|
2006-02-21 |
2008-02-07 |
Allen Margaret L |
Memory and learning impairments associated with disruption of Ephrin receptor A6 (EphA6) gene
|
|
WO2007116908A1
(ja)
|
2006-04-04 |
2007-10-18 |
Taiyo Nippon Sanso Corporation |
メタン分離方法、メタン分離装置及びメタン利用システム
|
|
TW200808813A
(en)
|
2006-04-12 |
2008-02-16 |
Speedel Experimenta Ag |
Imidazo compounds
|
|
TW200808812A
(en)
|
2006-04-12 |
2008-02-16 |
Speedel Experimenta Ag |
Imidazo compounds
|
|
US20090324610A1
(en)
|
2006-04-25 |
2009-12-31 |
Kyushu Univeristy, National University Corporation |
Gene associated with arteriosclerotic disease, and use thereof
|
|
WO2007128568A1
(en)
|
2006-05-10 |
2007-11-15 |
Novartis Ag |
Bicyclic derivatives as cetp inhibitors
|
|
EP1886695A1
(en)
|
2006-06-27 |
2008-02-13 |
Speedel Experimenta AG |
Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist
|
|
US20090286790A1
(en)
|
2006-07-20 |
2009-11-19 |
Hidetomo Imase |
Organic compounds
|
|
KR20090055595A
(ko)
|
2006-08-25 |
2009-06-02 |
노파르티스 아게 |
알도스테론 신타제 및/또는 11-베타-히드록실라제 및/또는 아로마타제에 의해 매개된 장애의 치료를 위한 융합 이미다졸 유도체
|
|
EA200900812A1
(ru)
|
2006-12-18 |
2009-12-30 |
Новартис Аг |
Производные 4-имидазолил-1,2,3,4-тетрагидрохинолина и их применение в качестве ингибиторов альдостерон/11-бета-гидроксилазы
|
|
WO2008076336A2
(en)
|
2006-12-18 |
2008-06-26 |
Novartis Ag |
Imidazoles as aldosterone synthase inhibitors
|
|
CN101578272A
(zh)
|
2006-12-18 |
2009-11-11 |
诺瓦提斯公司 |
1-取代的咪唑衍生物和它们作为醛固酮合酶抑制剂的用途
|
|
EP2134720B1
(en)
|
2007-03-29 |
2010-10-13 |
Novartis AG |
Heterocyclic spiro-compounds
|
|
TWI448284B
(zh)
|
2007-04-24 |
2014-08-11 |
Theravance Inc |
雙效抗高血壓劑
|
|
EP2200975A1
(en)
|
2007-09-07 |
2010-06-30 |
Theravance, Inc. |
Dual-acting antihypertensive agents
|
|
AU2008297885A1
(en)
|
2007-09-11 |
2009-03-19 |
Mondobiotech Laboratories Ag |
Use of GLP-1 as a therapeutic agent
|
|
WO2009033819A2
(en)
|
2007-09-11 |
2009-03-19 |
Mondobiotech Laboratories Ag |
Use of a peptide as a therapeutic agent
|
|
AR069165A1
(es)
|
2007-11-05 |
2010-01-06 |
Novartis Ag |
Derivados de 4-bencilamino-1-carboxacilpiperidina como inhibidores de cetp utiles para el tratamiento de hiperlipidemia
|
|
PT2404901E
(pt)
|
2007-12-03 |
2013-08-29 |
Novartis Ag |
Derivados de 4-benzilamino-pirrolidina 1,2-dissubstituídos como inibidores de cetp úteis para o tratamento de doenças tais como a hiperlipidemia ou a arteriosclerose
|
|
WO2009075566A1
(en)
|
2007-12-12 |
2009-06-18 |
Erasmus University Medical Center Rotterdam |
Biomarkers for cardiovascular disease
|
|
US20110123534A1
(en)
|
2007-12-12 |
2011-05-26 |
Erasmus University Medical Center Rotterdam |
Novel compounds for modulating neovascularisation and methods of treatment using these compounds
|
|
JP2011518884A
(ja)
|
2008-04-29 |
2011-06-30 |
セラヴァンス， インコーポレーテッド |
二重活性抗高血圧剤
|
|
CN102105487A
(zh)
*
|
2008-06-20 |
2011-06-22 |
得克萨斯大学体系董事会 |
靶向crkl的肽
|
|
AR072297A1
(es)
|
2008-06-27 |
2010-08-18 |
Novartis Ag |
Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
|
|
US8785151B2
(en)
|
2008-10-24 |
2014-07-22 |
Bernhard Geierstanger |
Biosynthetically generated pyrroline-carboxy-lysine and site specific protein modifications via chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues
|
|
CN102203117A
(zh)
|
2008-11-04 |
2011-09-28 |
安科治疗公司 |
Apj受体化合物
|
|
US20110294738A1
(en)
*
|
2008-11-04 |
2011-12-01 |
Yong Ren |
Pthr1 receptor compounds
|
|
WO2010115874A1
(en)
|
2009-04-07 |
2010-10-14 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment and the diagnosis ofpulmonary arterial hypertension
|
|
BRPI1010600A2
(pt)
|
2009-05-15 |
2016-03-15 |
Novartis Ag |
aril piridina como inibidores de aldosterona sintase
|
|
JP5420761B2
(ja)
|
2009-05-28 |
2014-02-19 |
ノバルティス アーゲー |
ネプリリシン阻害剤としての置換アミノプロピオン酸誘導体
|
|
SG176010A1
(en)
|
2009-05-28 |
2011-12-29 |
Novartis Ag |
Substituted aminobutyric derivatives as neprilysin inhibitors
|
|
US20120277144A1
(en)
|
2009-11-04 |
2012-11-01 |
Henricus Johannes Duckers |
Novel compounds for modulating neovascularisation and methods of treatment using these compounds
|
|
JO2967B1
(en)
|
2009-11-20 |
2016-03-15 |
نوفارتس ايه جي |
Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
|
|
US20110195077A1
(en)
*
|
2010-01-29 |
2011-08-11 |
Novartis Ag |
Methods and compositions using fgf23 fusion ppolypeptides
|
|
US9782454B2
(en)
|
2010-04-22 |
2017-10-10 |
Longevity Biotech, Inc. |
Highly active polypeptides and methods of making and using the same
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
RU2457216C1
(ru)
|
2010-12-21 |
2012-07-27 |
Федеральное государственное учреждение "Российский кардиологический научно-производственный комплекс" Министерства здравоохранения и социального развития Российской Федерации (ФГУ "РКНПК" Минздравсоцразвития России) |
Додекапептиды, обладающие кардиопротекторными свойствами
|
|
SI3045183T1
(sl)
*
|
2011-03-11 |
2018-11-30 |
Genzyme Corporation |
Pegiliran Apelin in njegove uporabe
|
|
CU23950B1
(es)
*
|
2011-03-21 |
2013-10-29 |
Ct De Ingeniería Genética Y Biotecnología |
Péptidos cíclicos con actividad antineoplásica y antiangiogénica
|
|
CA2838833A1
(en)
|
2011-06-10 |
2012-12-13 |
Biogen Idec Ma Inc. |
Pro-coagulant compounds and methods of use thereof
|
|
WO2013007563A1
(en)
*
|
2011-07-08 |
2013-01-17 |
Bayer Intellectual Property Gmbh |
Fusion proteins releasing relaxin and uses thereof
|
|
EP2802596A1
(en)
|
2012-01-09 |
2014-11-19 |
Anchor Therapeutics, Inc. |
Apj receptor compounds
|
|
US8921307B2
(en)
|
2012-11-20 |
2014-12-30 |
Novartis Ag |
Synthetic linear apelin mimetics for the treatment of heart failure
|
|
EP2925368B1
(en)
*
|
2012-11-30 |
2019-03-27 |
Novartis AG |
Methods for making conjugates from disulfide-containing proteins
|
|
JP6426107B2
(ja)
|
2012-12-20 |
2018-11-21 |
アムジエン・インコーポレーテツド |
Ａｐｊ受容体アゴニストおよびその使用
|
|
WO2014152955A1
(en)
|
2013-03-14 |
2014-09-25 |
Regeneron Pharmaceuticals, Inc. |
Apelin fusion proteins and uses thereof
|
|
BR112016001376A2
(pt)
*
|
2013-07-25 |
2017-10-24 |
Novartis Ag |
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|
|
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|
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|
|
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|
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|
|
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|
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|