|
DE2951135A1
(de)
|
1979-12-19 |
1981-06-25 |
Hoechst Ag, 6230 Frankfurt |
Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
|
|
US4617307A
(en)
|
1984-06-20 |
1986-10-14 |
Ciba-Geigy Corporation |
Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
|
|
US4889861A
(en)
|
1982-12-21 |
1989-12-26 |
Ciba-Geigy Corp. |
Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
|
|
DE3347565A1
(de)
|
1983-12-30 |
1985-07-11 |
Thomae Gmbh Dr K |
Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
|
|
JPS6354321A
(ja)
|
1985-03-27 |
1988-03-08 |
Ajinomoto Co Inc |
血糖降下剤
|
|
US5120712A
(en)
|
1986-05-05 |
1992-06-09 |
The General Hospital Corporation |
Insulinotropic hormone
|
|
US5118666A
(en)
|
1986-05-05 |
1992-06-02 |
The General Hospital Corporation |
Insulinotropic hormone
|
|
ES2113879T3
(es)
|
1990-01-24 |
1998-05-16 |
Douglas I Buckley |
Analogos de glp-1 utiles para el tratamiento de diabetes.
|
|
AU654331B2
(en)
|
1991-03-30 |
1994-11-03 |
Kissei Pharmaceutical Co. Ltd. |
Succinic acid compounds
|
|
US5155100A
(en)
|
1991-05-01 |
1992-10-13 |
Ciba-Geigy Corporation |
Phosphono/biaryl substituted dipeptide derivatives
|
|
RU2086544C1
(ru)
|
1991-06-13 |
1997-08-10 |
Хоффманн-Ля Рош АГ |
Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
|
|
SG43036A1
(en)
|
1991-06-21 |
1997-10-17 |
Thomae Gmbh Dr K |
(S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid
|
|
DE69217762T2
(de)
|
1991-07-30 |
1997-10-09 |
Ajinomoto Kk |
Kristalle von N-(Trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung
|
|
EP0618803A4
(en)
|
1991-12-19 |
1995-03-22 |
Southwest Found Biomed Res |
POLYPEPTIDE INHIBITING PROTEIN TRANSFER TO CHOLESTERYL ESTERS, ANTIBODIES AGAINST SYNTHETIC POLYPEPTIDE AND ANTI-ATHEROSCLEROSIS PROPHYLACTIC AND THERAPEUTIC TREATMENTS.
|
|
CA2167818A1
(en)
*
|
1993-08-02 |
1995-02-09 |
Robert George Whittaker |
Therapeutic compound - fatty acid conjugates
|
|
IL111785A0
(en)
|
1993-12-03 |
1995-01-24 |
Ferring Bv |
Dp-iv inhibitors and pharmaceutical compositions containing them
|
|
US5705483A
(en)
|
1993-12-09 |
1998-01-06 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptides, compositions and methods
|
|
US5512549A
(en)
|
1994-10-18 |
1996-04-30 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
|
|
TW313568B
(enExample)
|
1994-12-20 |
1997-08-21 |
Hoffmann La Roche |
|
|
DE122010000020I1
(de)
|
1996-04-25 |
2010-07-08 |
Prosidion Ltd |
Verfahren zur Senkung des Blutglukosespiegels in Säugern
|
|
TW492957B
(en)
|
1996-11-07 |
2002-07-01 |
Novartis Ag |
N-substituted 2-cyanopyrrolidnes
|
|
CN1283228A
(zh)
|
1997-12-24 |
2001-02-07 |
武田药品工业株式会社 |
多肽、其生产方法及应用
|
|
WO1999043357A1
(en)
*
|
1998-02-25 |
1999-09-02 |
Micrologix Biotech Inc. |
Indolicidin and cationic peptides conjugated with polymers
|
|
US6197786B1
(en)
|
1998-09-17 |
2001-03-06 |
Pfizer Inc |
4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
|
|
GT199900147A
(es)
|
1998-09-17 |
1999-09-06 |
|
1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
|
|
CO5150173A1
(es)
|
1998-12-10 |
2002-04-29 |
Novartis Ag |
Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
|
|
US6544974B2
(en)
|
1999-09-23 |
2003-04-08 |
G.D. Searle & Co. |
(R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesteryl ester transfer protein activity
|
|
US7635751B2
(en)
|
2000-03-23 |
2009-12-22 |
Takada Pharmaceutical Company Limited |
Peptides having ligand activities on APJ that is an orphan G protein-coupled receptor, and use thereof
|
|
PE20020082A1
(es)
|
2000-04-12 |
2002-02-21 |
Novartis Ag |
Composicion farmaceutica que comprende un inhibidor de aldosterona-sintasa y un antagonista del receptor de angiotensina ii (at1)
|
|
ES2464532T3
(es)
|
2001-04-19 |
2014-06-03 |
The Scripps Research Institute |
Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa
|
|
US20030138417A1
(en)
|
2001-11-08 |
2003-07-24 |
Kaisheva Elizabet A. |
Stable liquid pharmaceutical formulation of IgG antibodies
|
|
AU2003232941A1
(en)
|
2002-06-07 |
2003-12-22 |
Glaxo Group Limited |
N-mercaptoacyl phenyalanine derivatives, process for their preparation, and pharmaceutical compositions containing them
|
|
ES2270143T3
(es)
|
2002-08-07 |
2007-04-01 |
Novartis Ag |
Compuestos organicos como agentes para el tratamiento de condiciones mediadas por aldosterona.
|
|
ES2305520T3
(es)
|
2002-11-18 |
2008-11-01 |
Novartis Ag |
Derivados de imidazo(1,5a)piridina y metodos para tratar enfermedades mediadas por aldosterona.
|
|
WO2004078777A2
(en)
*
|
2003-03-04 |
2004-09-16 |
Biorexis Pharmaceutical Corporation |
Dipeptidyl-peptidase protected proteins
|
|
BRPI0508966A
(pt)
|
2004-03-26 |
2007-08-21 |
Lilly Co Eli |
composto, composição farmacêutica, e, uso de um composto
|
|
UA90269C2
(ru)
|
2004-04-02 |
2010-04-26 |
Мицубиси Танабе Фарма Корпорейшн |
Тетрагидрохинолиновые производные и способ их получения
|
|
US7612088B2
(en)
|
2004-05-28 |
2009-11-03 |
Speedel Experimenta Ag |
Heterocyclic compounds and their use as aldosterone synthase inhibitors
|
|
US20080076794A1
(en)
|
2004-05-28 |
2008-03-27 |
Peter Herold |
Heterocyclic Compounds And Their Use As Aldosterone Synthase Inhibitors
|
|
AR049126A1
(es)
|
2004-05-28 |
2006-06-28 |
Speedel Experimenta Ag |
Derivados de 5, 6, 7, 8 - tetrahidroimidazo[1,5a]piridina con actividad inhibitoria de la aldosterona sintasa, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento del hiperaldosterismo y del sindrome de cushing.
|
|
AR049711A1
(es)
|
2004-07-09 |
2006-08-30 |
Speedel Experimenta Ag |
Compuestos heterociclicos condensados como inhibidores de la aldosterona sintasa; composiciones farmaceuticas que los contienen y su uso en la preparacion de un medicamento para el tratamiento o prevencion de enfermedades relacionadas con el hiperaldosterismo y por una liberacion excesiva de cortiso
|
|
TW200716636A
(en)
|
2005-05-31 |
2007-05-01 |
Speedel Experimenta Ag |
Heterocyclic spiro-compounds
|
|
TW200716105A
(en)
|
2005-05-31 |
2007-05-01 |
Speedel Experimenta Ag |
Imidazole compounds
|
|
TW200716634A
(en)
|
2005-05-31 |
2007-05-01 |
Speedel Experimenta Ag |
Heterocyclic spiro-compounds
|
|
GT200600381A
(es)
|
2005-08-25 |
2007-03-28 |
|
Compuestos organicos
|
|
US8673848B2
(en)
*
|
2012-01-27 |
2014-03-18 |
Novartis Ag |
Synthetic apelin mimetics for the treatment of heart failure
|
|
TW200804378A
(en)
|
2005-12-09 |
2008-01-16 |
Speedel Experimenta Ag |
Organic compounds
|
|
TW200738261A
(en)
|
2005-12-20 |
2007-10-16 |
Bristol Myers Squibb Co |
Stable protein formulations
|
|
CN101415803B
(zh)
|
2006-04-04 |
2012-10-24 |
大阳日酸株式会社 |
甲烷分离方法、甲烷分离装置以及甲烷利用系统
|
|
TW200808813A
(en)
|
2006-04-12 |
2008-02-16 |
Speedel Experimenta Ag |
Imidazo compounds
|
|
TW200808812A
(en)
|
2006-04-12 |
2008-02-16 |
Speedel Experimenta Ag |
Imidazo compounds
|
|
AU2007247385B2
(en)
|
2006-05-10 |
2011-07-14 |
Novartis Ag |
Bicyclic derivatives as CETP inhibitors
|
|
EP1886695A1
(en)
|
2006-06-27 |
2008-02-13 |
Speedel Experimenta AG |
Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist
|
|
CA2657258A1
(en)
|
2006-07-20 |
2008-01-24 |
Novartis Ag |
Amino-piperidine derivatives as cetp inhibitors
|
|
WO2008027284A1
(en)
|
2006-08-25 |
2008-03-06 |
Novartis Ag |
Fused imidazole derivatives for the treatment of disorders mediated by aldosterone synthase and/or 11-beta-hydroxylase and/or aromatase
|
|
PE20081140A1
(es)
*
|
2006-10-25 |
2008-09-22 |
Amgen Inc |
Agentes terapeuticos a base de peptidos derivados de toxinas
|
|
EA200900811A1
(ru)
|
2006-12-18 |
2009-12-30 |
Новартис Аг |
Имидазолы в качестве ингибиторов альдостеронсинтазы
|
|
KR20090090395A
(ko)
|
2006-12-18 |
2009-08-25 |
노파르티스 아게 |
4-이미다졸릴-1,2,3,4-테트라히드로퀴놀린 유도체 및 알도스테론/11-베타-히드록실라제 억제제로서의 그의 용도
|
|
WO2008076862A2
(en)
|
2006-12-18 |
2008-06-26 |
Novartis Ag |
1-substituted imidazole derivatives and their use as aldosterone synthase inhibitors
|
|
AR066691A1
(es)
|
2007-03-29 |
2009-09-09 |
Speedel Experimenta Ag |
Compuestos espiro heterociclicos derivados de imidazol. composiciones farmaceuticas.
|
|
TWI448284B
(zh)
|
2007-04-24 |
2014-08-11 |
Theravance Inc |
雙效抗高血壓劑
|
|
JP2010538071A
(ja)
|
2007-09-07 |
2010-12-09 |
セラヴァンス, インコーポレーテッド |
二重作用性降圧剤
|
|
PL2207775T3
(pl)
|
2007-11-05 |
2012-08-31 |
Novartis Ag |
Pochodne 4-benzyloamino-1-karboksyacylo-piperydyny jako inhibitory CETP użyteczne do leczenia chorób, takich jak hiperlipidemia lub stwardnienie tętnic
|
|
AU2008333272B2
(en)
|
2007-12-03 |
2012-03-29 |
Novartis Ag |
1,2-disubstituted-4-benzylamino-pyrrolidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperli pidemia or arteriosclerosis
|
|
JP2011518884A
(ja)
|
2008-04-29 |
2011-06-30 |
セラヴァンス, インコーポレーテッド |
二重活性抗高血圧剤
|
|
AR072297A1
(es)
|
2008-06-27 |
2010-08-18 |
Novartis Ag |
Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
|
|
WO2010015668A1
(en)
*
|
2008-08-06 |
2010-02-11 |
Novo Nordisk A/S |
Conjugated proteins with prolonged in vivo efficacy
|
|
JP5542832B2
(ja)
|
2008-10-24 |
2014-07-09 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
生合成的に製造したピロリン−カルボキシ−リシンならびにピロリン−カルボキシ−リシンおよびピロリシン基の化学誘導体化を介する部位特異的タンパク質修飾
|
|
RU2011122482A
(ru)
*
|
2008-11-04 |
2012-12-20 |
Энкер Терапьютикс, Инк. |
Apj-рецепторы соединения
|
|
ES2459468T3
(es)
|
2009-05-15 |
2014-05-09 |
Novartis Ag |
Arilpiridinas como inhibidores de aldosterona sintasa
|
|
CA2763565A1
(en)
|
2009-05-28 |
2010-12-02 |
Novartis Ag |
Substituted aminobutyric derivatives as neprilysin inhibitors
|
|
PL2435409T3
(pl)
|
2009-05-28 |
2015-01-30 |
Novartis Ag |
Podstawione pochodne aminopropionowe jako inhibitory neprylizyny
|
|
US9345661B2
(en)
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
|
JO2967B1
(en)
|
2009-11-20 |
2016-03-15 |
نوفارتس ايه جي |
Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
|
|
PL2525834T3
(pl)
*
|
2010-01-22 |
2020-10-19 |
Novo Nordisk Health Care Ag |
Hormony wzrostu o przedłużonej skuteczności in-vivo
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
RU2012153753A
(ru)
|
2010-05-13 |
2014-06-20 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Пептиды глюкагонового суперсемейства, обладающие активностью в отношении сопряженных с g-белком рецепторов
|
|
PT3045183T
(pt)
|
2011-03-11 |
2018-11-02 |
Genzyme Corp |
Apelina peguilada e suas utilizações
|
|
CN104254540A
(zh)
*
|
2012-01-09 |
2014-12-31 |
安科治疗公司 |
Apj受体化合物
|
|
EP3907237A1
(en)
|
2012-12-20 |
2021-11-10 |
Amgen Inc. |
Apj receptor agonists and uses thereof
|
|
EA201591700A1
(ru)
|
2013-03-14 |
2015-12-30 |
Ридженерон Фармасьютикалз, Инк. |
Гибридные белки апелина и их применение
|
|
WO2015013169A2
(en)
*
|
2013-07-25 |
2015-01-29 |
Novartis Ag |
Bioconjugates of synthetic apelin polypeptides
|
|
EP3024845A1
(en)
*
|
2013-07-25 |
2016-06-01 |
Novartis AG |
Cyclic polypeptides for the treatment of heart failure
|
|
US10941182B2
(en)
|
2014-06-10 |
2021-03-09 |
Amgen Inc. |
Apelin polypeptides
|
|
US10588980B2
(en)
*
|
2014-06-23 |
2020-03-17 |
Novartis Ag |
Fatty acids and their use in conjugation to biomolecules
|
|
WO2016102648A1
(en)
|
2014-12-23 |
2016-06-30 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Metabolically stable apelin analogs in the treatment of disease mediated by the apelin receptor
|