|
DE2951135A1
(de)
|
1979-12-19 |
1981-06-25 |
Hoechst Ag, 6230 Frankfurt |
Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
|
|
US4889861A
(en)
|
1982-12-21 |
1989-12-26 |
Ciba-Geigy Corp. |
Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
|
|
US4617307A
(en)
|
1984-06-20 |
1986-10-14 |
Ciba-Geigy Corporation |
Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
|
|
DE3347565A1
(de)
|
1983-12-30 |
1985-07-11 |
Thomae Gmbh Dr K |
Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
|
|
JPS6354321A
(ja)
|
1985-03-27 |
1988-03-08 |
Ajinomoto Co Inc |
血糖降下剤
|
|
US5118666A
(en)
|
1986-05-05 |
1992-06-02 |
The General Hospital Corporation |
Insulinotropic hormone
|
|
US5120712A
(en)
|
1986-05-05 |
1992-06-09 |
The General Hospital Corporation |
Insulinotropic hormone
|
|
WO1991011457A1
(en)
|
1990-01-24 |
1991-08-08 |
Buckley Douglas I |
Glp-1 analogs useful for diabetes treatment
|
|
AU654331B2
(en)
|
1991-03-30 |
1994-11-03 |
Kissei Pharmaceutical Co. Ltd. |
Succinic acid compounds
|
|
US5155100A
(en)
|
1991-05-01 |
1992-10-13 |
Ciba-Geigy Corporation |
Phosphono/biaryl substituted dipeptide derivatives
|
|
RU2086544C1
(ru)
|
1991-06-13 |
1997-08-10 |
Хоффманн-Ля Рош АГ |
Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
|
|
DE59109151D1
(de)
|
1991-06-21 |
1999-10-14 |
Boehringer Ingelheim Pharma |
Verwendung von (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure zur herstellung eines langzeitantidiabetikums
|
|
EP0526171B1
(en)
|
1991-07-30 |
1997-03-05 |
Ajinomoto Co., Inc. |
Crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing them
|
|
WO1993011782A1
(en)
|
1991-12-19 |
1993-06-24 |
Southwest Foundation For Biomedical Research |
Cetp inhibitor polypeptide, antibodies against the synthetic polypeptide and prophylactic and therapeutic anti-atherosclerosis treatments
|
|
DE69426629T2
(de)
*
|
1993-08-02 |
2001-08-02 |
Commonwealth Scientific And Industrial Research Organisation, Campbell |
Therapeutische verbindung - fettsäurekonjugate
|
|
IL111785A0
(en)
|
1993-12-03 |
1995-01-24 |
Ferring Bv |
Dp-iv inhibitors and pharmaceutical compositions containing them
|
|
US5705483A
(en)
|
1993-12-09 |
1998-01-06 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptides, compositions and methods
|
|
US5512549A
(en)
|
1994-10-18 |
1996-04-30 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
|
|
TW313568B
(enExample)
|
1994-12-20 |
1997-08-21 |
Hoffmann La Roche |
|
|
DE19616486C5
(de)
|
1996-04-25 |
2016-06-30 |
Royalty Pharma Collection Trust |
Verfahren zur Senkung des Blutglukosespiegels in Säugern
|
|
TW492957B
(en)
|
1996-11-07 |
2002-07-01 |
Novartis Ag |
N-substituted 2-cyanopyrrolidnes
|
|
EP1040189B1
(en)
|
1997-12-24 |
2008-01-09 |
Takeda Pharmaceutical Company Limited |
Polypeptides, their production and use
|
|
AU2605099A
(en)
*
|
1998-02-25 |
1999-09-15 |
Micrologix Biotech, Inc. |
Indolicidin and cationic peptides conjugated with polymers
|
|
US6197786B1
(en)
|
1998-09-17 |
2001-03-06 |
Pfizer Inc |
4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
|
|
GT199900147A
(es)
|
1998-09-17 |
1999-09-06 |
|
1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
|
|
CO5150173A1
(es)
|
1998-12-10 |
2002-04-29 |
Novartis Ag |
Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
|
|
US6521607B1
(en)
|
1999-09-23 |
2003-02-18 |
Pharmacia Corporation |
(R)-chiral halogenated substituted N-phenoxy N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
|
|
AU2001242749A1
(en)
|
2000-03-23 |
2001-10-03 |
Takeda Chemical Industries Ltd. |
Peptide derivative
|
|
AR032316A1
(es)
|
2000-04-12 |
2003-11-05 |
Novartis Ag |
Uso de una composicion farmaceutica para la fabricacion de medicamentos y una composicion farmaceutica
|
|
EP1490483B1
(en)
|
2001-04-19 |
2015-06-03 |
The Scripps Research Institute |
In vivo incorporation of unnatural amino acids
|
|
US20030138417A1
(en)
|
2001-11-08 |
2003-07-24 |
Kaisheva Elizabet A. |
Stable liquid pharmaceutical formulation of IgG antibodies
|
|
AR040441A1
(es)
|
2002-06-07 |
2005-04-06 |
Glaxo Group Ltd |
Compuesto de tiol, composicion farmaceutica que lo comprende, su uso para la fabricacion de un medicamento, procedimiento para prepararlo y compuesto intermediario de utilidad en dicho procedimiento
|
|
EP1537114B8
(en)
|
2002-08-07 |
2007-10-03 |
Novartis AG |
Organic compounds as agents for the treatment of aldosterone mediated conditions
|
|
JP2006508970A
(ja)
|
2002-11-18 |
2006-03-16 |
ノバルティス アクチエンゲゼルシャフト |
イミダゾ[1,5a]ピリジン誘導体およびアルデステロンにより仲介される疾患の処置方法
|
|
EP1626981A4
(en)
*
|
2003-03-04 |
2006-11-22 |
Biorexis Pharmaceutical Corp |
PROTEINS PROTECTED AGAINST DIPEPTIDYLPEPTIDASE
|
|
AU2005230915A1
(en)
|
2004-03-26 |
2005-10-20 |
Eli Lilly And Company |
Compounds and methods for treating dyslipidemia
|
|
UA90269C2
(ru)
|
2004-04-02 |
2010-04-26 |
Мицубиси Танабе Фарма Корпорейшн |
Тетрагидрохинолиновые производные и способ их получения
|
|
JP2008500998A
(ja)
|
2004-05-28 |
2008-01-17 |
シュペーデル・エクスペリメンタ・アーゲー |
複素環式化合物およびアルドステロンシンターゼ阻害薬としてのそれらの使用
|
|
DE602005025110D1
(de)
|
2004-05-28 |
2011-01-13 |
Novartis Ag |
Heterocyclische verbindungen und deren verwendung als aldosteronsynthaseinhibitoren
|
|
CA2568159A1
(en)
|
2004-05-28 |
2005-12-15 |
Speedel Experimenta Ag |
Tetrahydro-imidazo [1,5-a] pyridin derivatives as aldosterone synthase inhibitors
|
|
AR049711A1
(es)
|
2004-07-09 |
2006-08-30 |
Speedel Experimenta Ag |
Compuestos heterociclicos condensados como inhibidores de la aldosterona sintasa; composiciones farmaceuticas que los contienen y su uso en la preparacion de un medicamento para el tratamiento o prevencion de enfermedades relacionadas con el hiperaldosterismo y por una liberacion excesiva de cortiso
|
|
TW200716634A
(en)
|
2005-05-31 |
2007-05-01 |
Speedel Experimenta Ag |
Heterocyclic spiro-compounds
|
|
TW200716105A
(en)
|
2005-05-31 |
2007-05-01 |
Speedel Experimenta Ag |
Imidazole compounds
|
|
TW200716636A
(en)
|
2005-05-31 |
2007-05-01 |
Speedel Experimenta Ag |
Heterocyclic spiro-compounds
|
|
GT200600381A
(es)
|
2005-08-25 |
2007-03-28 |
|
Compuestos organicos
|
|
US8673848B2
(en)
*
|
2012-01-27 |
2014-03-18 |
Novartis Ag |
Synthetic apelin mimetics for the treatment of heart failure
|
|
TW200804378A
(en)
|
2005-12-09 |
2008-01-16 |
Speedel Experimenta Ag |
Organic compounds
|
|
CA2634547C
(en)
|
2005-12-20 |
2016-10-11 |
Bristol-Myers Squibb Company |
Stable ctla4 formulation for subcutaneous administration
|
|
CN101415803B
(zh)
|
2006-04-04 |
2012-10-24 |
大阳日酸株式会社 |
甲烷分离方法、甲烷分离装置以及甲烷利用系统
|
|
TW200808812A
(en)
|
2006-04-12 |
2008-02-16 |
Speedel Experimenta Ag |
Imidazo compounds
|
|
TW200808813A
(en)
|
2006-04-12 |
2008-02-16 |
Speedel Experimenta Ag |
Imidazo compounds
|
|
AR060873A1
(es)
|
2006-05-10 |
2008-07-16 |
Novartis Ag |
Derivados biciclicos como inhibidores de cetp
|
|
EP1886695A1
(en)
|
2006-06-27 |
2008-02-13 |
Speedel Experimenta AG |
Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist
|
|
WO2008009435A1
(en)
|
2006-07-20 |
2008-01-24 |
Novartis Ag |
Amino-piperidine derivatives as cetp inhibitors
|
|
JP2010501573A
(ja)
|
2006-08-25 |
2010-01-21 |
ノバルティス アクチエンゲゼルシャフト |
アルドステロン合成酵素および/または11−β−ヒドロキシラーゼおよび/またはアロマターゼが介在する疾患の処置のための縮合イミダゾール誘導体
|
|
WO2008088422A2
(en)
*
|
2006-10-25 |
2008-07-24 |
Amgen Inc. |
Toxin peptide therapeutic agents
|
|
CA2673119A1
(en)
|
2006-12-18 |
2008-06-26 |
Novartis Ag |
4-imidazolyl-1,2,3,4-tetrahydroquinoline derivatives and their use as aldosterone/11-beta-hydroxylase inhibitors
|
|
US20100041722A1
(en)
|
2006-12-18 |
2010-02-18 |
Qi-Ying Hu |
Organic compounds
|
|
MX2009006631A
(es)
|
2006-12-18 |
2009-06-30 |
Novartis Ag |
Imidazoles como inhibidores de sintasa de aldosterona.
|
|
ES2354008T3
(es)
|
2007-03-29 |
2011-03-09 |
Novartis Ag |
Compuestos espiroheterocíclicos.
|
|
TWI448284B
(zh)
|
2007-04-24 |
2014-08-11 |
Theravance Inc |
雙效抗高血壓劑
|
|
EP2200975A1
(en)
|
2007-09-07 |
2010-06-30 |
Theravance, Inc. |
Dual-acting antihypertensive agents
|
|
DK2207775T3
(da)
|
2007-11-05 |
2012-06-18 |
Novartis Ag |
4-Benzylamino-1-carboxyacylpiperidinderivater som CETP-inhibitorer, som er anvendelige til behandling af sygdomme som hyperlipidæmi eller arteriosclerose
|
|
JP5421282B2
(ja)
|
2007-12-03 |
2014-02-19 |
ノバルティス アーゲー |
高脂血症または動脈硬化症のような疾患の処置に有用なcetp阻害剤としての1,2−二置換−4−ベンジルアミノ−ピロリジン誘導体
|
|
US7989484B2
(en)
|
2008-04-29 |
2011-08-02 |
Theravance, Inc. |
Dual-acting antihypertensive agents
|
|
AR072297A1
(es)
|
2008-06-27 |
2010-08-18 |
Novartis Ag |
Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
|
|
MX2011000847A
(es)
*
|
2008-08-06 |
2011-02-25 |
Novo Nordisk Healthcare Ag |
Proteinas conjugadas con eficacia prolongada in vivo.
|
|
CA2742043C
(en)
|
2008-10-24 |
2014-11-25 |
Irm Llc |
Biosynthetically generated pyrroline-carboxy-lysine and site specific protein modifications via chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues
|
|
BRPI0921815A2
(pt)
*
|
2008-11-04 |
2018-10-09 |
Anchor Therapeutics Inc |
compostos receptores de apj
|
|
SG175925A1
(en)
|
2009-05-15 |
2011-12-29 |
Novartis Ag |
Aryl pyridine as aldosterone synthase inhibitors
|
|
BRPI1011657A2
(pt)
|
2009-05-28 |
2019-04-16 |
Novartis Ag |
derivados aminopropiônicos substituídos como inibidores de neprilisina
|
|
EP2435402B1
(en)
|
2009-05-28 |
2016-04-13 |
Novartis AG |
Substituted aminobutyric derivatives as neprilysin inhibitors
|
|
US9345661B2
(en)
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
|
JO2967B1
(en)
|
2009-11-20 |
2016-03-15 |
نوفارتس ايه جي |
Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
|
|
MX345736B
(es)
*
|
2010-01-22 |
2017-02-14 |
Novo Nordisk Healthcare Ag |
Hormonas de crecimiento con eficacia in vivo prolongada.
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
CN103179976A
(zh)
|
2010-05-13 |
2013-06-26 |
印第安纳大学研究及科技有限公司 |
呈现g蛋白偶联受体活性的胰高血糖素超家族肽
|
|
EP3045183B1
(en)
|
2011-03-11 |
2018-07-04 |
Genzyme Corporation |
Pegylated apelin and uses thereof
|
|
AU2013208109A1
(en)
*
|
2012-01-09 |
2014-08-14 |
Anchor Therapeutics, Inc. |
APJ receptor compounds
|
|
US20160067347A1
(en)
|
2012-12-20 |
2016-03-10 |
Amgen Inc. |
Apj receptor agonists and uses thereof
|
|
US9353163B2
(en)
|
2013-03-14 |
2016-05-31 |
Regeneron Pharmaceuticals, Inc. |
Apelin fusion proteins and uses thereof
|
|
SG11201600211XA
(en)
|
2013-07-25 |
2016-02-26 |
Novartis Ag |
Cyclic polypeptides for the treatment of heart failure
|
|
TW201518323A
(zh)
|
2013-07-25 |
2015-05-16 |
Novartis Ag |
合成apelin多肽之生物結合物
|
|
AU2015274574B2
(en)
|
2014-06-10 |
2019-10-10 |
Amgen Inc. |
Apelin polypeptides
|
|
US10588980B2
(en)
|
2014-06-23 |
2020-03-17 |
Novartis Ag |
Fatty acids and their use in conjugation to biomolecules
|
|
JP6758294B2
(ja)
|
2014-12-23 |
2020-09-23 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
アペリン受容体により媒介される疾患の処置における代謝的に安定なアペリン類似体
|