|
WO2008027558A2
(en)
|
2006-08-31 |
2008-03-06 |
Codon Devices, Inc. |
Iterative nucleic acid assembly using activation of vector-encoded traits
|
|
EP2637780B1
(en)
|
2010-11-12 |
2022-02-09 |
Gen9, Inc. |
Protein arrays and methods of using and making the same
|
|
EP3000883B8
(en)
|
2010-11-12 |
2018-02-28 |
Gen9, Inc. |
Methods and devices for nucleic acids synthesis
|
|
AR085533A1
(es)
|
2011-03-23 |
2013-10-09 |
Pioneer Hi Bred Int |
Metodos de produccion de un locus de rasgos transgenicos complejo
|
|
CA2853829C
(en)
|
2011-07-22 |
2023-09-26 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
IL280334B2
(en)
|
2011-08-26 |
2023-09-01 |
Gen9 Inc |
Preparations and methods for high-fidelity assembly of nucleic acids
|
|
JP2014531908A
(ja)
|
2011-10-14 |
2014-12-04 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
構造アッセンブリによる配列決定
|
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US9637739B2
(en)
*
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
US9150853B2
(en)
|
2012-03-21 |
2015-10-06 |
Gen9, Inc. |
Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
|
|
EP3543350B1
(en)
|
2012-04-24 |
2021-11-10 |
Gen9, Inc. |
Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
|
|
KR101904508B1
(ko)
|
2012-04-25 |
2018-10-04 |
리제너론 파마슈티칼스 인코포레이티드 |
큰 표적화 벡터를 사용한 뉴클레아제-중재된 표적화
|
|
WO2013163628A2
(en)
|
2012-04-27 |
2013-10-31 |
Duke University |
Genetic correction of mutated genes
|
|
GB2537000C
(en)
|
2012-05-25 |
2019-10-09 |
Univ California |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
EP2861737B1
(en)
|
2012-06-19 |
2019-04-17 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
|
JP6509727B2
(ja)
|
2012-06-25 |
2019-05-15 |
ギンゴー バイオワークス， インコーポレイテッド |
核酸アセンブリおよび高処理シークエンシングのための方法
|
|
EP3808844A1
(en)
*
|
2012-07-25 |
2021-04-21 |
The Broad Institute, Inc. |
Inducible dna binding proteins and genome perturbation tools and applications thereof
|
|
EP4556564A3
(en)
*
|
2012-10-23 |
2025-09-03 |
Toolgen Incorporated |
Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
|
|
US10415024B2
(en)
|
2012-11-16 |
2019-09-17 |
Poseida Therapeutics, Inc. |
Site-specific enzymes and methods of use
|
|
CA2891347C
(en)
|
2012-12-06 |
2018-02-27 |
Sigma-Aldrich Co. Llc |
Crispr-based genome modification and regulation
|
|
US20140186919A1
(en)
*
|
2012-12-12 |
2014-07-03 |
Feng Zhang |
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
EP2931898B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
PL2771468T3
(pl)
*
|
2012-12-12 |
2015-07-31 |
Broad Inst Inc |
Inżynieria systemów, metod i zoptymalizowanych kompozycji kierujących dla manipulacji sekwencjami
|
|
KR20150105635A
(ko)
*
|
2012-12-12 |
2015-09-17 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
EP2896697B1
(en)
|
2012-12-12 |
2015-09-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
|
US8697359B1
(en)
*
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
IL239317B
(en)
|
2012-12-12 |
2022-07-01 |
Broad Inst Inc |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
US9970024B2
(en)
|
2012-12-17 |
2018-05-15 |
President And Fellows Of Harvard College |
RNA-guided human genome engineering
|
|
JP2016507244A
(ja)
|
2013-02-27 |
2016-03-10 |
ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト（ゲーエムベーハー）Ｈｅｌｍｈｏｌｔｚ Ｚｅｎｔｒｕｍ ＭｕｅｎｃｈｅｎＤｅｕｔｓｃｈｅｓ Ｆｏｒｓｃｈｕｎｇｓｚｅｎｔｒｕｍ ｆｕｅｒ Ｇｅｓｕｎｄｈｅｉｔ ｕｎｄ Ｕｍｗｅｌｔ （ＧｍｂＨ） |
Ｃａｓ９ヌクレアーゼによる卵母細胞における遺伝子編集
|
|
EP3578666A1
(en)
|
2013-03-12 |
2019-12-11 |
President and Fellows of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
|
AU2014235794A1
(en)
|
2013-03-14 |
2015-10-22 |
Caribou Biosciences, Inc. |
Compositions and methods of nucleic acid-targeting nucleic acids
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
WO2014204578A1
(en)
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
US20140273230A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
|
KR102874079B1
(ko)
|
2013-03-15 |
2025-10-22 |
더 제너럴 하스피탈 코포레이션 |
Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용
|
|
MX376838B
(es)
*
|
2013-03-15 |
2025-03-07 |
Univ Minnesota |
Ingenieria genomica de plantas utilizando sistemas crispr/cas.
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
KR20200136508A
(ko)
|
2013-04-16 |
2020-12-07 |
리제너론 파마슈티칼스 인코포레이티드 |
랫트 게놈의 표적화된 변형
|
|
WO2014172470A2
(en)
*
|
2013-04-16 |
2014-10-23 |
Whitehead Institute For Biomedical Research |
Methods of mutating, modifying or modulating nucleic acid in a cell or nonhuman mammal
|
|
WO2014186585A2
(en)
*
|
2013-05-15 |
2014-11-20 |
Sangamo Biosciences, Inc. |
Methods and compositions for treatment of a genetic condition
|
|
DK3004349T3
(en)
*
|
2013-05-29 |
2018-06-06 |
Cellectis Sa |
A method for producing precise DNA cleavage using CAS9 nickase activity
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
WO2014197568A2
(en)
*
|
2013-06-04 |
2014-12-11 |
President And Fellows Of Harvard College |
Rna-guideded transcriptional regulation
|
|
EP4435110A3
(en)
*
|
2013-06-05 |
2025-01-01 |
Duke University |
Rna-guided gene editing and gene regulation
|
|
EP3008186B1
(en)
|
2013-06-14 |
2018-11-28 |
Cellectis |
Methods for non-transgenic genome editing in plants
|
|
EP3620524A1
(en)
*
|
2013-06-17 |
2020-03-11 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
|
|
AU2014281028B2
(en)
|
2013-06-17 |
2020-09-10 |
Massachusetts Institute Of Technology |
Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy
|
|
CN105793425B
(zh)
|
2013-06-17 |
2021-10-26 |
布罗德研究所有限公司 |
使用病毒组分靶向障碍和疾病的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
CN106062197A
(zh)
*
|
2013-06-17 |
2016-10-26 |
布罗德研究所有限公司 |
用于序列操纵的串联指导系统、方法和组合物的递送、工程化和优化
|
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
WO2014204725A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
JP6718813B2
(ja)
*
|
2013-07-10 |
2020-07-08 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
Ｒｎａ誘導性遺伝子制御および編集のための直交性ｃａｓ９タンパク質
|
|
US10563225B2
(en)
|
2013-07-26 |
2020-02-18 |
President And Fellows Of Harvard College |
Genome engineering
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
MX2016002306A
(es)
|
2013-08-22 |
2016-07-08 |
Du Pont |
Promotor u6 de polimerasa iii de soja y metodos de uso.
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
ES2844174T3
(es)
*
|
2013-09-18 |
2021-07-21 |
Kymab Ltd |
Métodos, células y organismos
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
WO2015066119A1
(en)
|
2013-10-30 |
2015-05-07 |
North Carolina State University |
Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri
|
|
CN111218447B
(zh)
|
2013-11-07 |
2024-10-11 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
PL3080279T3
(pl)
|
2013-12-11 |
2019-03-29 |
Regeneron Pharmaceuticals, Inc. |
Sposoby i kompozycje do celowanej modyfikacji genomu
|
|
JP6174811B2
(ja)
|
2013-12-11 |
2017-08-02 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
ゲノムの標的改変のための方法及び組成物
|
|
CN105899657A
(zh)
|
2013-12-12 |
2016-08-24 |
布罗德研究所有限公司 |
用于改变基因产物表达的crispr-cas系统和方法、结构信息以及诱导型模块化cas酶
|
|
US20150166982A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting pi3k point mutations
|
|
WO2015089486A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
CN118813621A
(zh)
|
2013-12-12 |
2024-10-22 |
布罗德研究所有限公司 |
用于基因组编辑的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
MX374530B
(es)
|
2013-12-12 |
2025-03-06 |
Broad Inst Inc |
Suministro, uso y aplicaciones terapeuticas de los sistemas y composiciones crispr-cas para actuar sobre hbv y trastornos y enfermedades virales.
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
EP3080257A1
(en)
|
2013-12-12 |
2016-10-19 |
The Broad Institute Inc. |
Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
|
|
US10787654B2
(en)
*
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
|
WO2015123339A1
(en)
|
2014-02-11 |
2015-08-20 |
The Regents Of The University Of Colorado, A Body Corporate |
Crispr enabled multiplexed genome engineering
|
|
US10286084B2
(en)
|
2014-02-18 |
2019-05-14 |
Duke University |
Compositions for the inactivation of virus replication and methods of making and using the same
|
|
EP3114227B1
(en)
|
2014-03-05 |
2021-07-21 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
|
US9938521B2
(en)
|
2014-03-10 |
2018-04-10 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating leber's congenital amaurosis 10 (LCA10)
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
CA2943622A1
(en)
*
|
2014-03-25 |
2015-10-01 |
Editas Medicine Inc. |
Crispr/cas-related methods and compositions for treating hiv infection and aids
|
|
US11242525B2
(en)
|
2014-03-26 |
2022-02-08 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating sickle cell disease
|
|
WO2015153780A1
(en)
|
2014-04-02 |
2015-10-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
CN106460003A
(zh)
|
2014-04-08 |
2017-02-22 |
北卡罗来纳州立大学 |
用于使用crispr相关基因rna引导阻遏转录的方法和组合物
|
|
AU2015253352A1
(en)
|
2014-04-28 |
2016-12-08 |
Recombinetics, Inc. |
Multiplex Gene Editing
|
|
WO2015188056A1
(en)
*
|
2014-06-05 |
2015-12-10 |
Sangamo Biosciences, Inc. |
Methods and compositions for nuclease design
|
|
RU2704283C9
(ru)
|
2014-06-06 |
2020-02-07 |
Регенерон Фармасьютикалз, Инк. |
Способы и композиции для модификации целевого локуса
|
|
EP3674408A1
(en)
*
|
2014-06-16 |
2020-07-01 |
The Johns Hopkins University |
Compositions and methods for the expression of crispr guide rnas
|
|
JP2017518082A
(ja)
*
|
2014-06-17 |
2017-07-06 |
ポセイダ セラピューティクス， インコーポレイテッド |
ゲノム中の特異的遺伝子座にタンパク質を指向させるための方法およびその使用
|
|
CA2953499C
(en)
|
2014-06-23 |
2023-10-24 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated dna assembly
|
|
PT3161128T
(pt)
|
2014-06-26 |
2018-11-21 |
Regeneron Pharma |
Métodos e composições para modificações genéticas alvejadas e métodos de utilização
|
|
US20170198268A1
(en)
*
|
2014-07-09 |
2017-07-13 |
Gen9, Inc. |
Compositions and Methods for Site-Directed DNA Nicking and Cleaving
|
|
WO2016007839A1
(en)
|
2014-07-11 |
2016-01-14 |
President And Fellows Of Harvard College |
Methods for high-throughput labelling and detection of biological features in situ using microscopy
|
|
US11254933B2
(en)
*
|
2014-07-14 |
2022-02-22 |
The Regents Of The University Of California |
CRISPR/Cas transcriptional modulation
|
|
EP3177718B1
(en)
|
2014-07-30 |
2022-03-16 |
President and Fellows of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
CN113789317B
(zh)
|
2014-08-06 |
2024-02-23 |
基因工具股份有限公司 |
使用空肠弯曲杆菌crispr/cas系统衍生的rna引导的工程化核酸酶的基因编辑
|
|
WO2016033298A1
(en)
|
2014-08-28 |
2016-03-03 |
North Carolina State University |
Novel cas9 proteins and guiding features for dna targeting and genome editing
|
|
US10570418B2
(en)
|
2014-09-02 |
2020-02-25 |
The Regents Of The University Of California |
Methods and compositions for RNA-directed target DNA modification
|
|
WO2016040030A1
(en)
|
2014-09-12 |
2016-03-17 |
E. I. Du Pont De Nemours And Company |
Generation of site-specific-integration sites for complex trait loci in corn and soybean, and methods of use
|
|
US9943612B2
(en)
|
2014-10-09 |
2018-04-17 |
Seattle Children's Hospital |
Long poly(A) plasmids and methods for introduction of long poly(A) sequences into the plasmid
|
|
EP3998344A1
(en)
*
|
2014-10-09 |
2022-05-18 |
Life Technologies Corporation |
Crispr oligonucleotides and gene editing
|
|
EP3204496A1
(en)
|
2014-10-10 |
2017-08-16 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
EP3207124B1
(en)
|
2014-10-15 |
2019-06-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for generating or maintaining pluripotent cells
|
|
US20170306306A1
(en)
*
|
2014-10-24 |
2017-10-26 |
Life Technologies Corporation |
Compositions and Methods for Enhancing Homologous Recombination
|
|
GB201418965D0
(cg-RX-API-DMAC7.html)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
EP3212789B1
(en)
*
|
2014-10-31 |
2020-04-22 |
Massachusetts Institute of Technology |
Massively parallel combinatorial genetics for crispr
|
|
CN107406838A
(zh)
*
|
2014-11-06 |
2017-11-28 |
纳幕尔杜邦公司 |
Rna引导的内切核酸酶向细胞中的肽介导的递送
|
|
WO2016073990A2
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
|
CN107532142A
(zh)
*
|
2014-11-11 |
2018-01-02 |
应用干细胞有限公司 |
使用同源重组改造间充质干细胞
|
|
EP3222728B1
(en)
|
2014-11-19 |
2021-07-14 |
Institute for Basic Science |
Method for regulating gene expression using cas9 protein expressed from two vectors
|
|
EP3521437B1
(en)
|
2014-11-21 |
2025-01-15 |
Regeneron Pharmaceuticals, Inc. |
Methods for targeted genetic modification using paired guide rnas
|
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
KR102763527B1
(ko)
|
2014-12-03 |
2025-02-05 |
애질런트 테크놀로지스, 인크. |
화학적 변형을 갖는 가이드 rna
|
|
WO2016094679A1
(en)
|
2014-12-10 |
2016-06-16 |
Regents Of The University Of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
EP3786296A1
(en)
*
|
2014-12-18 |
2021-03-03 |
Integrated Dna Technologies, Inc. |
Crispr-based compositions and methods of use
|
|
WO2016100857A1
(en)
|
2014-12-19 |
2016-06-23 |
Regeneron Pharmaceuticals, Inc. |
Stem cells for modeling type 2 diabetes
|
|
SG11201704646YA
(en)
|
2014-12-19 |
2017-07-28 |
Regeneron Pharma |
Methods and compositions for targeted genetic modification through single-step multiple targeting
|
|
AU2015369725A1
(en)
|
2014-12-24 |
2017-06-29 |
Massachusetts Institute Of Technology |
CRISPR having or associated with destabilization domains
|
|
EP3250688B1
(fr)
|
2015-01-29 |
2021-07-28 |
Meiogenix |
Procede pour induire des recombinaisons meiotiques ciblees
|
|
WO2016130600A2
(en)
|
2015-02-09 |
2016-08-18 |
Duke University |
Compositions and methods for epigenome editing
|
|
CA2981715A1
(en)
|
2015-04-06 |
2016-10-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chemically modified guide rnas for crispr/cas-mediated gene regulation
|
|
CA2982966C
(en)
|
2015-04-24 |
2024-02-20 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
EP3289104B1
(en)
|
2015-04-29 |
2020-11-04 |
New York University |
Method for treating high-grade gliomas
|
|
EP3292219B9
(en)
|
2015-05-04 |
2022-05-18 |
Ramot at Tel-Aviv University Ltd. |
Methods and kits for fragmenting dna
|
|
JP7030522B2
(ja)
|
2015-05-11 |
2022-03-07 |
エディタス・メディシン、インコーポレイテッド |
幹細胞における遺伝子編集のための最適化ｃｒｉｓｐｒ／ｃａｓ９システムおよび方法
|
|
MX382223B
(es)
*
|
2015-05-12 |
2025-03-13 |
Sangamo Therapeutics Inc |
Regulacion de expresion genica mediada por nucleasa.
|
|
EA201792663A1
(ru)
|
2015-05-29 |
2018-04-30 |
Норт Каролина Стейт Юниверсити |
Способы скрининга бактерий, архей, водорослей и дрожжей с использованием нуклеиновых кислот crispr
|
|
CN108368502B
(zh)
|
2015-06-03 |
2022-03-18 |
内布拉斯加大学董事委员会 |
使用单链dna的dna编辑
|
|
KR102796744B1
(ko)
|
2015-06-09 |
2025-04-15 |
에디타스 메디신, 인코포레이티드 |
이식의 개선을 위한 crispr/cas-관련 방법 및 조성물
|
|
US11155823B2
(en)
|
2015-06-15 |
2021-10-26 |
North Carolina State University |
Methods and compositions for efficient delivery of nucleic acids and RNA-based antimicrobials
|
|
JP2018521689A
(ja)
*
|
2015-06-17 |
2018-08-09 |
ポセイダ セラピューティクス， インコーポレイテッド |
タンパク質をゲノム内の特定の遺伝子座に導くための組成物および方法
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
WO2016205613A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Crispr enzyme mutations reducing off-target effects
|
|
CN107949400A
(zh)
*
|
2015-06-24 |
2018-04-20 |
西格马-奥尔德里奇有限责任公司 |
细胞周期依赖性基因组调控和修饰
|
|
GB2592821B
(en)
|
2015-07-31 |
2022-01-12 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
WO2017027910A1
(en)
|
2015-08-14 |
2017-02-23 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
|
EP4345454A3
(en)
|
2015-08-25 |
2024-07-17 |
Duke University |
Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
EP3341477B1
(en)
|
2015-08-28 |
2022-03-23 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases
|
|
US11667911B2
(en)
|
2015-09-24 |
2023-06-06 |
Editas Medicine, Inc. |
Use of exonucleases to improve CRISPR/CAS-mediated genome editing
|
|
KR101795999B1
(ko)
|
2015-09-25 |
2017-11-09 |
전남대학교산학협력단 |
Crispr/cas9 시스템을 이용한 베타2-마이크로글로불린 유전자 제거용 시발체
|
|
KR101745863B1
(ko)
|
2015-09-25 |
2017-06-12 |
전남대학교산학협력단 |
Crispr/cas9 시스템을 이용한 프로히비틴2 유전자 제거용 시발체
|
|
EP3356533A1
(en)
|
2015-09-28 |
2018-08-08 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
|
WO2017066497A2
(en)
|
2015-10-13 |
2017-04-20 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
CN114629614B
(zh)
|
2015-10-22 |
2024-11-01 |
瑞典爱立信有限公司 |
与无线电信号的选择性增强有关的方法和设备
|
|
SG11201803173VA
(en)
*
|
2015-10-23 |
2018-05-30 |
Harvard College |
Nucleobase editors and uses thereof
|
|
EP3368054A4
(en)
|
2015-10-28 |
2019-07-03 |
Voyager Therapeutics, Inc. |
REGULATORY EXPRESSION USING THE ADENO-ASSOCIATED VIRUS (AAV)
|
|
HK1252878A1
(zh)
|
2015-11-03 |
2019-06-06 |
President And Fellows Of Harvard College |
用於含有基质的三维核酸的体积成像的方法和设备
|
|
CN106893739A
(zh)
|
2015-11-17 |
2017-06-27 |
香港中文大学 |
用于靶向基因操作的新方法和系统
|
|
US10240145B2
(en)
*
|
2015-11-25 |
2019-03-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
CRISPR/Cas-mediated genome editing to treat EGFR-mutant lung cancer
|
|
EP4644567A2
(en)
|
2015-11-30 |
2025-11-05 |
Duke University |
Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use
|
|
US11542466B2
(en)
|
2015-12-22 |
2023-01-03 |
North Carolina State University |
Methods and compositions for delivery of CRISPR based antimicrobials
|
|
KR102808969B1
(ko)
|
2016-01-11 |
2025-05-15 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
키메라 단백질 및 면역요법 방법
|
|
SG11201805792PA
(en)
|
2016-01-11 |
2018-08-30 |
Univ Leland Stanford Junior |
Chimeric proteins and methods of regulating gene expression
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
WO2017165826A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
EP3433364A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
EP4047092B1
(en)
|
2016-04-13 |
2025-07-30 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
|
US20170298348A1
(en)
*
|
2016-04-14 |
2017-10-19 |
The Board Of Trustees Of The Leland Stanford Junior University |
Genome editing of human neural stem cells using nucleases
|
|
JP7259182B2
(ja)
|
2016-04-25 |
2023-04-18 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ｉｎ ｓｉｔｕ分子検出のためのハイブリダイゼーション連鎖反応法
|
|
EP3448995A1
(en)
*
|
2016-04-25 |
2019-03-06 |
Universität Basel |
Allele editing and applications thereof
|
|
KR20190038479A
(ko)
*
|
2016-05-06 |
2019-04-08 |
주노 쎄러퓨티크스 인코퍼레이티드 |
유전자 조작된 세포 및 그의 제조방법
|
|
NZ747857A
(en)
|
2016-05-20 |
2023-01-27 |
Regeneron Pharma |
Methods for breaking immunological tolerance using multiple guide rnas
|
|
PL3272867T3
(pl)
|
2016-06-02 |
2020-01-31 |
Sigma-Aldrich Co. Llc |
Wykorzystanie programowalnych białek wiążących dna w celu wzmocnienia celowanej modyfikacji genomu
|
|
WO2017207797A1
(en)
*
|
2016-06-03 |
2017-12-07 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Diet controlled expression of a nucleic acid encoding cas9 nuclease and uses thereof
|
|
JP2019517503A
(ja)
*
|
2016-06-03 |
2019-06-24 |
テンプル ユニバーシティー オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション |
遺伝子編集戦略によるｈｉｖ−１のネガティブフィードバック調節
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
US10337051B2
(en)
|
2016-06-16 |
2019-07-02 |
The Regents Of The University Of California |
Methods and compositions for detecting a target RNA
|
|
US11293021B1
(en)
|
2016-06-23 |
2022-04-05 |
Inscripta, Inc. |
Automated cell processing methods, modules, instruments, and systems
|
|
US10017760B2
(en)
|
2016-06-24 |
2018-07-10 |
Inscripta, Inc. |
Methods for generating barcoded combinatorial libraries
|
|
US11603533B2
(en)
|
2016-07-12 |
2023-03-14 |
Washington University |
Incorporation of internal polya-encoded poly-lysine sequence tags and their variations for the tunable control of protein synthesis in bacterial and eukaryotic cells
|
|
WO2018017754A1
(en)
|
2016-07-19 |
2018-01-25 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
CN109563516B
(zh)
|
2016-07-28 |
2023-10-27 |
雷杰纳荣制药公司 |
Gpr156变体及其用途
|
|
SG11201901305YA
(en)
|
2016-07-29 |
2019-03-28 |
Regeneron Pharma |
Mice comprising mutations resulting in expression of c-truncated fibrillin-1
|
|
BR112019001887A2
(pt)
|
2016-08-02 |
2019-07-09 |
Editas Medicine Inc |
composições e métodos para o tratamento de doença associada a cep290
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
JP7231935B2
(ja)
|
2016-08-03 |
2023-03-08 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
アデノシン核酸塩基編集因子およびそれらの使用
|
|
CA3033327A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
KR20230155013A
(ko)
*
|
2016-08-20 |
2023-11-09 |
아벨리노 랩 유에스에이, 인크. |
단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
WO2018048827A1
(en)
*
|
2016-09-07 |
2018-03-15 |
Massachusetts Institute Of Technology |
Rna-guided endonuclease-based dna assembly
|
|
CN106636197B
(zh)
*
|
2016-09-22 |
2019-09-03 |
南京市妇幼保健院 |
一种定向敲降斑马鱼基因组中多拷贝基因的方法
|
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
|
KR20230170126A
(ko)
|
2016-09-30 |
2023-12-18 |
더 리젠츠 오브 더 유니버시티 오브 캘리포니아 |
Rna-가이드된 핵산 변형 효소 및 이의 사용 방법
|
|
EA201990860A1
(ru)
|
2016-09-30 |
2019-10-31 |
|
Рнк-направляемые модифицирующие нуклеиновые кислоты ферменты и способы их применения
|
|
JP2019534890A
(ja)
*
|
2016-10-11 |
2019-12-05 |
ステムジェニクス， インコーポレイテッド |
遺伝子編集ツールによって機能化されたナノ粒子および関連する方法
|
|
CN110290813A
(zh)
|
2016-10-14 |
2019-09-27 |
通用医疗公司 |
表观遗传学调控的位点特异性核酸酶
|
|
WO2018071868A1
(en)
|
2016-10-14 |
2018-04-19 |
President And Fellows Of Harvard College |
Aav delivery of nucleobase editors
|
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
|
CA3041068A1
(en)
|
2016-10-18 |
2018-04-26 |
Regents Of The University Of Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
|
HRP20240842T1
(hr)
*
|
2016-11-02 |
2024-10-11 |
Universität Basel |
Imunološki uočljive varijante stanične površine za upotrebu u staničnoj terapiji
|
|
EP3555297A1
(en)
|
2016-12-19 |
2019-10-23 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
KR102551664B1
(ko)
*
|
2016-12-22 |
2023-07-05 |
인텔리아 테라퓨틱스, 인크. |
알파-1 항트립신 결핍을 치료하기 위한 조성물 및 방법
|
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
|
US20200385753A1
(en)
*
|
2016-12-23 |
2020-12-10 |
Institute For Basic Science |
Composition for base editing for animal embryo and base editing method
|
|
US11859219B1
(en)
|
2016-12-30 |
2024-01-02 |
Flagship Pioneering Innovations V, Inc. |
Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA
|
|
JP7229923B2
(ja)
|
2017-01-06 |
2023-02-28 |
エディタス・メディシン、インコーポレイテッド |
ヌクレアーゼ切断を評価する方法
|
|
CA3049980A1
(en)
|
2017-01-23 |
2018-07-26 |
Regeneron Pharmaceuticals, Inc. |
Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof
|
|
US12344826B2
(en)
|
2017-01-25 |
2025-07-01 |
The George Washington University, A Congressionally Chartered Not-For-Profit Corporation |
Apparatus and methods for in vitro preclinical human trials
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
CN106978438B
(zh)
*
|
2017-02-27 |
2020-08-28 |
北京大北农生物技术有限公司 |
提高同源重组效率的方法
|
|
US12390514B2
(en)
|
2017-03-09 |
2025-08-19 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
WO2018170184A1
(en)
|
2017-03-14 |
2018-09-20 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
KR20240116572A
(ko)
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
WO2018195129A1
(en)
|
2017-04-17 |
2018-10-25 |
University Of Maryland, College Park |
Embryonic cell cultures and methods of using the same
|
|
US11834670B2
(en)
|
2017-04-19 |
2023-12-05 |
Global Life Sciences Solutions Usa Llc |
Site-specific DNA modification using a donor DNA repair template having tandem repeat sequences
|
|
CN111031790A
(zh)
|
2017-04-20 |
2020-04-17 |
E开创生物技术股份有限公司 |
产生基因修改的动物的方法
|
|
WO2018195545A2
(en)
|
2017-04-21 |
2018-10-25 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
EP3615672A1
(en)
|
2017-04-28 |
2020-03-04 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide rna molecules
|
|
WO2018209158A2
(en)
|
2017-05-10 |
2018-11-15 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
CA3063449A1
(en)
|
2017-05-25 |
2018-11-29 |
The General Hospital Corporation |
Using split deaminases to limit unwanted off-target base editor deamination
|
|
CA3065938A1
(en)
|
2017-06-05 |
2018-12-13 |
Regeneron Pharmaceuticals, Inc. |
B4galt1 variants and uses thereof
|
|
US10428319B2
(en)
|
2017-06-09 |
2019-10-01 |
Editas Medicine, Inc. |
Engineered Cas9 nucleases
|
|
MX2019015188A
(es)
|
2017-06-15 |
2020-08-03 |
Univ California |
Inserciones de adn no virales orientadas.
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
JP7278978B2
(ja)
|
2017-06-27 |
2023-05-22 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ヒト化ａｓｇｒ１座位を含む非ヒト動物
|
|
AU2018291041B2
(en)
|
2017-06-30 |
2021-08-05 |
Inscripta, Inc. |
Automated cell processing methods, modules, instruments, and systems
|
|
CN111511375A
(zh)
|
2017-06-30 |
2020-08-07 |
因提玛生物科学公司 |
用于基因治疗的腺相关病毒载体
|
|
CN111183226A
(zh)
|
2017-07-11 |
2020-05-19 |
西格马-奥尔德里奇有限责任公司 |
使用核小体相互作用蛋白结构域来增强靶向基因组修饰
|
|
US11866726B2
(en)
|
2017-07-14 |
2024-01-09 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
|
US20190032156A1
(en)
|
2017-07-31 |
2019-01-31 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for assessing crispr/cas-induced recombination with an exogenous donor nucleic acid in vivo
|
|
BR112020001364A2
(pt)
|
2017-07-31 |
2020-08-11 |
Regeneron Pharmaceuticals, Inc. |
métodos para testar e modificar a capacidade de uma crispr/cas nuclease.
|
|
WO2019028023A2
(en)
|
2017-07-31 |
2019-02-07 |
Regeneron Pharmaceuticals, Inc. |
METHODS AND COMPOSITIONS FOR EVALUATING CRISPR / CAS MEDIATED DISRUPTION OR EXCISION AND CRISPR / CAS INDUCED RECOMBINATION USING IN VIVO EXOGENIC DONOR NUCLEIC ACID
|
|
AU2018311695A1
(en)
*
|
2017-07-31 |
2020-01-16 |
Sigma-Aldrich Co. Llc |
Synthetic guide RNA for CRISPR/Cas activator systems
|
|
WO2019030695A1
(en)
*
|
2017-08-09 |
2019-02-14 |
Benson Hill Biosystems, Inc. |
Compositions and methods for modifying genomes
|
|
US10738327B2
(en)
|
2017-08-28 |
2020-08-11 |
Inscripta, Inc. |
Electroporation cuvettes for automation
|
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
|
WO2019050948A1
(en)
*
|
2017-09-05 |
2019-03-14 |
Regeneron Pharmaceuticals, Inc. |
ADMINISTRATION OF A GENE EDITION SYSTEM HAVING ONLY ONE RETROVIRAL PARTICLE AND METHODS OF GENERATING AND USING
|
|
US20210071251A1
(en)
|
2017-09-06 |
2021-03-11 |
Regeneron Pharmaceuticals, Inc. |
Single Immunoglobulin Interleukin-1 Receptor Related (SIGIRR) Variants And Uses Thereof
|
|
MX2020002644A
(es)
|
2017-09-07 |
2020-10-07 |
Regeneron Pharma |
Variantes del miembro 1 de la familia 14 del grupo portador de solutos (slc14a1) y usos de estas.
|
|
EP4276185A3
(en)
|
2017-09-29 |
2024-02-21 |
Regeneron Pharmaceuticals, Inc. |
Rodents comprising a humanized ttr locus and methods of use
|
|
WO2019068022A1
(en)
|
2017-09-30 |
2019-04-04 |
Inscripta, Inc. |
CONTINUOUS FLOW ELECTROPORATION INSTRUMENTATION
|
|
WO2019079195A1
(en)
*
|
2017-10-16 |
2019-04-25 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
GENETICALLY MODIFIED MESENCHYMAL STEM CELLS FOR USE IN CARDIOVASCULAR PROSTHESES
|
|
CN111315765A
(zh)
|
2017-10-16 |
2020-06-19 |
雷杰纳荣制药公司 |
Cornulin(CRNN)变体及其用途
|
|
AU2018352592C1
(en)
|
2017-10-16 |
2025-09-25 |
Beam Therapeutics, Inc. |
Uses of adenosine base editors
|
|
MX2020004325A
(es)
|
2017-10-27 |
2020-11-09 |
Univ California |
Reemplazo dirigido de receptores de células t endógenos.
|
|
US12227753B2
(en)
|
2017-11-01 |
2025-02-18 |
The Regents Of The University Of California |
CasY compositions and methods of use
|
|
MX2020004578A
(es)
|
2017-11-01 |
2020-12-03 |
Univ California |
Composiciones de casz y metodos de uso.
|
|
US11970719B2
(en)
|
2017-11-01 |
2024-04-30 |
The Regents Of The University Of California |
Class 2 CRISPR/Cas compositions and methods of use
|
|
WO2019090261A1
(en)
|
2017-11-03 |
2019-05-09 |
University Of Florida Research Foundation, Inc. |
Methods and compositions for plant pathogen resistance in plants
|
|
EP3585163B1
(en)
|
2017-11-10 |
2022-03-09 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising slc30a8 mutation and methods of use
|
|
CN111448313A
(zh)
*
|
2017-11-16 |
2020-07-24 |
阿斯利康(瑞典)有限公司 |
用于改善基于Cas9的敲入策略的有效性的组合物和方法
|
|
IL274740B2
(en)
|
2017-11-30 |
2024-06-01 |
Regeneron Pharma |
Non-human animals comprising a humanized trkb locus
|
|
EP3724214A4
(en)
|
2017-12-15 |
2021-09-01 |
The Broad Institute Inc. |
SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING
|
|
WO2019126578A1
(en)
*
|
2017-12-20 |
2019-06-27 |
Poseida Therapeutics, Inc. |
Compositions and methods for directing proteins to specific loci in the genome
|
|
KR102098915B1
(ko)
*
|
2017-12-22 |
2020-04-09 |
(주)지플러스 생명과학 |
키메라 게놈 조작 분자 및 방법
|
|
AU2019207409B2
(en)
|
2018-01-12 |
2023-02-23 |
Basf Se |
Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a
|
|
EP3743516A4
(en)
*
|
2018-01-26 |
2021-10-13 |
The Children's Medical Center Corporation |
TARGETING &XC9; L &XC9; MENTS R &XC9; BCL11A DISTAL GULATORS WITH CAS9-CAS9 FUSION FOR R &XC9; INDUCTION OF H &XC9; MOGLOBIN F &X152; TALE
|
|
CN111902536B
(zh)
*
|
2018-02-15 |
2024-07-30 |
西格马-奥尔德里奇有限责任公司 |
用于真核基因组修饰的改造的cas9系统
|
|
CN112020554B
(zh)
|
2018-02-23 |
2024-10-22 |
先锋国际良种公司 |
新颖cas9直系同源物
|
|
WO2019178426A1
(en)
|
2018-03-14 |
2019-09-19 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
WO2019183123A1
(en)
|
2018-03-19 |
2019-09-26 |
Regeneron Pharmaceuticals, Inc. |
Transcription modulation in animals using crispr/cas systems
|
|
EP3775159A4
(en)
|
2018-03-29 |
2022-01-19 |
Inscripta, Inc. |
AUTOMATED REGULATION OF CELL GROWTH RATES FOR INDUCTION AND TRANSFORMATION
|
|
US10376889B1
(en)
|
2018-04-13 |
2019-08-13 |
Inscripta, Inc. |
Automated cell processing instruments comprising reagent cartridges
|
|
EP3781705A4
(en)
|
2018-04-19 |
2022-01-26 |
The Regents of the University of California |
COMPOSITIONS AND METHODS OF GENE EDIT
|
|
WO2019209926A1
(en)
|
2018-04-24 |
2019-10-31 |
Inscripta, Inc. |
Automated instrumentation for production of peptide libraries
|
|
US10557216B2
(en)
|
2018-04-24 |
2020-02-11 |
Inscripta, Inc. |
Automated instrumentation for production of T-cell receptor peptide libraries
|
|
US10858761B2
(en)
|
2018-04-24 |
2020-12-08 |
Inscripta, Inc. |
Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
|
|
AU2019261385A1
(en)
*
|
2018-04-27 |
2020-11-19 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Therapeutic genome editing in X-linked hyper IgM syndrome
|
|
WO2019213430A1
(en)
*
|
2018-05-03 |
2019-11-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods for nicking target dna sequences
|
|
AU2019265916A1
(en)
|
2018-05-10 |
2020-12-10 |
Auxolytic Ltd |
Gene therapy methods and compositions using auxotrophic regulatable cells
|
|
WO2019213910A1
(en)
*
|
2018-05-10 |
2019-11-14 |
Syngenta Participations Ag |
Methods and compositions for targeted editing of polynucleotides
|
|
CA3100019A1
(en)
|
2018-05-11 |
2019-11-14 |
Beam Therapeutics Inc. |
Methods of substituting pathogenic amino acids using programmable base editor systems
|
|
WO2019222545A1
(en)
|
2018-05-16 |
2019-11-21 |
Synthego Corporation |
Methods and systems for guide rna design and use
|
|
CN108624622A
(zh)
*
|
2018-05-16 |
2018-10-09 |
湖南艾佳生物科技股份有限公司 |
一种基于CRISPR-Cas9系统构建的能分泌小鼠白细胞介素-6的基因工程细胞株
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
EP3575402A1
(en)
*
|
2018-06-01 |
2019-12-04 |
Algentech SAS |
Gene targeting
|
|
CN112384063A
(zh)
|
2018-06-07 |
2021-02-19 |
以色列国家农业部、农村发展农业研究组织·沃尔卡尼中心 |
再生及转殖大麻的方法
|
|
WO2019234754A1
(en)
|
2018-06-07 |
2019-12-12 |
The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) |
Nucleic acid constructs and methods of using same
|
|
CA3104649A1
(en)
*
|
2018-06-25 |
2020-12-21 |
Bionano Genomics, Inc. |
Labeling of dna
|
|
CA3104856A1
(en)
|
2018-06-29 |
2020-01-02 |
Editas Medicine, Inc. |
Synthetic guide molecules, compositions and methods relating thereto
|
|
AU2019292919A1
(en)
|
2018-06-30 |
2021-03-11 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
|
BR112021001904A2
(pt)
*
|
2018-08-03 |
2021-05-04 |
Beam Therapeutics Inc. |
editores de nucleobase multiefetores e métodos de usar os mesmos para modificar uma sequência alvo de ácido nucleico
|
|
GB201813011D0
(en)
|
2018-08-10 |
2018-09-26 |
Vib Vzw |
Means and methods for drought tolerance in crops
|
|
US10532324B1
(en)
|
2018-08-14 |
2020-01-14 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
|
US10752874B2
(en)
|
2018-08-14 |
2020-08-25 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
|
US11142740B2
(en)
|
2018-08-14 |
2021-10-12 |
Inscripta, Inc. |
Detection of nuclease edited sequences in automated modules and instruments
|
|
KR102103103B1
(ko)
*
|
2018-08-16 |
2020-04-21 |
(주)라트바이오 |
인위적 뉴클레아제를 생산하는 형질전환 동물 및 형질전환 배아
|
|
KR20210046001A
(ko)
*
|
2018-08-21 |
2021-04-27 |
시그마-알드리치 컴퍼니., 엘엘씨 |
시토졸 dna 센서 경로의 하향-조절
|
|
CA3108892A1
(en)
|
2018-08-30 |
2020-04-23 |
Inscripta, Inc. |
Improved detection of nuclease edited sequences in automated modules and instruments
|
|
EP3850088A4
(en)
|
2018-09-07 |
2023-07-19 |
Beam Therapeutics, Inc. |
Compositions and methods for improving base editing
|
|
CN109055379B
(zh)
*
|
2018-09-10 |
2022-04-15 |
石铭 |
一种转基因鸡输卵管生物反应器的制备方法
|
|
KR102121817B1
(ko)
*
|
2018-09-12 |
2020-06-26 |
한국화학연구원 |
Crispr 편집 기술을 이용한 재조합 항원을 발현시키는 벡터 및 이를 동시에 다중 삽입시키는 방법
|
|
EP3849304B1
(en)
|
2018-09-13 |
2024-01-10 |
Regeneron Pharmaceuticals, Inc. |
Complement factor h gene knockout rat as a model of c3 glomerulopathy
|
|
US12264330B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for killing target cells
|
|
EP3861120A4
(en)
|
2018-10-01 |
2023-08-16 |
North Carolina State University |
Recombinant type i crispr-cas system
|
|
US12203123B2
(en)
|
2018-10-01 |
2025-01-21 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for screening for variant cells
|
|
US12264313B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for genome modification and alteration of expression
|
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
|
PL3867372T3
(pl)
|
2018-10-16 |
2025-06-23 |
Blueallele Corporation |
Sposoby ukierunkowanego wprowadzania dna do genów
|
|
EP3867380A2
(en)
|
2018-10-18 |
2021-08-25 |
Intellia Therapeutics, Inc. |
Compositions and methods for expressing factor ix
|
|
US11214781B2
(en)
|
2018-10-22 |
2022-01-04 |
Inscripta, Inc. |
Engineered enzyme
|
|
CA3115534A1
(en)
|
2018-10-22 |
2020-04-30 |
Inscripta, Inc. |
Engineered nucleic acid-guided nucleases
|
|
WO2020086908A1
(en)
*
|
2018-10-24 |
2020-04-30 |
The Broad Institute, Inc. |
Constructs for improved hdr-dependent genomic editing
|
|
US12281338B2
(en)
|
2018-10-29 |
2025-04-22 |
The Broad Institute, Inc. |
Nucleobase editors comprising GeoCas9 and uses thereof
|
|
KR20200071198A
(ko)
|
2018-12-10 |
2020-06-19 |
네오이뮨텍, 인코퍼레이티드 |
Nrf2 발현 조절 기반 T 세포 항암면역치료법
|
|
CA3117228A1
(en)
|
2018-12-14 |
2020-06-18 |
Pioneer Hi-Bred International, Inc. |
Novel crispr-cas systems for genome editing
|
|
US20220062340A1
(en)
|
2018-12-19 |
2022-03-03 |
King's College London |
Immunotherapeutic methods and compositions
|
|
CA3120799A1
(en)
|
2018-12-20 |
2020-06-25 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated repeat expansion
|
|
CA3125299A1
(en)
*
|
2019-01-04 |
2020-07-09 |
The University Of Chicago |
Systems and methods for modulating rna
|
|
WO2020146899A1
(en)
*
|
2019-01-11 |
2020-07-16 |
Chan Zuckerberg Biohub, Inc. |
Targeted in vivo genome modification
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
US11946040B2
(en)
|
2019-02-04 |
2024-04-02 |
The General Hospital Corporation |
Adenine DNA base editor variants with reduced off-target RNA editing
|
|
EP3924477A4
(en)
*
|
2019-02-14 |
2023-03-29 |
Metagenomi, Inc. |
ENZYMES WITH RUVC DOMAINS
|
|
US10982200B2
(en)
|
2019-02-14 |
2021-04-20 |
Metagenomi Ip Technologies, Llc |
Enzymes with RuvC domains
|
|
JP2022520104A
(ja)
*
|
2019-02-15 |
2022-03-28 |
シグマ－アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー |
Ｃｒｉｓｐｒ／ｃａｓ融合タンパク質およびシステム
|
|
GB201902277D0
(en)
|
2019-02-19 |
2019-04-03 |
King S College London |
Therapeutic agents
|
|
WO2020181101A1
(en)
|
2019-03-07 |
2020-09-10 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
CA3127814C
(en)
|
2019-03-18 |
2024-05-14 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
|
|
KR102695765B1
(ko)
|
2019-03-18 |
2024-08-20 |
리제너론 파마슈티칼스 인코포레이티드 |
타우 시딩 또는 응집의 유전적 변형제를 식별하기 위한 CRISPR/Cas 스크리닝 플랫폼
|
|
GB2601617B
(en)
|
2019-03-19 |
2024-02-21 |
Broad Inst Inc |
Methods and compositions for editing nucleotide sequences
|
|
CN113631713A
(zh)
|
2019-03-25 |
2021-11-09 |
因思科瑞普特公司 |
酵母中的同时多重基因组编辑
|
|
US11001831B2
(en)
|
2019-03-25 |
2021-05-11 |
Inscripta, Inc. |
Simultaneous multiplex genome editing in yeast
|
|
BR112021019512A2
(pt)
|
2019-04-03 |
2022-02-15 |
Regeneron Pharma |
Métodos para inserir uma sequência de codificação de proteína de ligação ao antígeno e para tratar ou efetuar a profilaxia de uma doença em um animal, animal, célula, genoma, ácido nucleico doador exógeno, gene de porto seguro, e, agente de nuclease ou um ou mais ácidos nucleicos
|
|
CA3133359C
(en)
|
2019-04-04 |
2023-04-11 |
Regeneron Pharmaceuticals, Inc. |
Methods for scarless introduction of targeted modifications into targeting vectors
|
|
IL286905B2
(en)
|
2019-04-04 |
2024-06-01 |
Regeneron Pharma |
Non-human animals containing the human coagulation factor 12 locus
|
|
GB201905360D0
(en)
|
2019-04-16 |
2019-05-29 |
Univ Nottingham |
Fungal strains, production and uses thereof
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
EP3966334A1
(en)
|
2019-05-10 |
2022-03-16 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
US11891618B2
(en)
|
2019-06-04 |
2024-02-06 |
Regeneron Pharmaceuticals, Inc. |
Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use
|
|
EP3953477A4
(en)
|
2019-06-06 |
2022-06-22 |
Inscripta, Inc. |
HARDENING FOR RECURSIVE NUCLEIC ACID-DRIVEN CELL EDITING
|
|
US11622547B2
(en)
|
2019-06-07 |
2023-04-11 |
Regeneran Pharmaceuticals, Inc. |
Genetically modified mouse that expresses human albumin
|
|
ES3034102T3
(en)
|
2019-06-14 |
2025-08-13 |
Regeneron Pharma |
Models of tauopathy
|
|
US10907125B2
(en)
|
2019-06-20 |
2021-02-02 |
Inscripta, Inc. |
Flow through electroporation modules and instrumentation
|
|
CN114008070A
(zh)
|
2019-06-21 |
2022-02-01 |
因思科瑞普特公司 |
导致大肠杆菌赖氨酸产量增加的全基因组合理设计的突变
|
|
US10927385B2
(en)
|
2019-06-25 |
2021-02-23 |
Inscripta, Inc. |
Increased nucleic-acid guided cell editing in yeast
|
|
EP3783104A1
(en)
*
|
2019-08-20 |
2021-02-24 |
Kemijski Institut |
Coiled-coil mediated tethering of crispr-cas and exonucleases for enhanced genome editing
|
|
WO2021050398A1
(en)
*
|
2019-09-10 |
2021-03-18 |
The Regents Of The University Of California |
Synthetic lethality screening platform for cells undergoing alt
|
|
AU2020344905A1
(en)
|
2019-09-12 |
2022-04-28 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
JP2022548031A
(ja)
|
2019-09-13 |
2022-11-16 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
脂質ナノ粒子によって送達されるｃｒｉｓｐｒ／ｃａｓシステムを使用する動物における転写調節
|
|
WO2021069387A1
(en)
|
2019-10-07 |
2021-04-15 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
CN110628825A
(zh)
*
|
2019-10-14 |
2019-12-31 |
上海捷易生物科技有限公司 |
一种依赖nhej的报告基因敲入组合物及其使用方法
|
|
AU2020379046B2
(en)
|
2019-11-08 |
2025-03-13 |
Regeneron Pharmaceuticals, Inc. |
CRISPR and AAV strategies for X-linked juvenile retinoschisis therapy
|
|
US11203762B2
(en)
|
2019-11-19 |
2021-12-21 |
Inscripta, Inc. |
Methods for increasing observed editing in bacteria
|
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
|
AU2020396138A1
(en)
|
2019-12-03 |
2022-06-16 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
US10883095B1
(en)
|
2019-12-10 |
2021-01-05 |
Inscripta, Inc. |
Mad nucleases
|
|
US10704033B1
(en)
|
2019-12-13 |
2020-07-07 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US20230042273A1
(en)
|
2019-12-16 |
2023-02-09 |
BASF Agricultural Solutions Seed US LLC |
Improved genome editing using paired nickases
|
|
WO2021126886A1
(en)
|
2019-12-18 |
2021-06-24 |
Inscripta, Inc. |
Cascade/dcas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells
|
|
CA3167419A1
(en)
*
|
2020-01-09 |
2021-07-15 |
Pioneer Hi-Bred International, Inc. |
Two-step gene swap
|
|
US10689669B1
(en)
|
2020-01-11 |
2020-06-23 |
Inscripta, Inc. |
Automated multi-module cell processing methods, instruments, and systems
|
|
CN115135370A
(zh)
|
2020-01-27 |
2022-09-30 |
因思科瑞普特公司 |
电穿孔模块和仪器
|
|
CN115175559A
(zh)
|
2020-01-28 |
2022-10-11 |
瑞泽恩制药公司 |
包含人源化pnpla3基因座的非人动物及其使用方法
|
|
WO2021158883A1
(en)
|
2020-02-07 |
2021-08-12 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized klkb1 locus and methods of use
|
|
US11965161B2
(en)
|
2020-03-04 |
2024-04-23 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for sensitization of tumor cells to immune therapy
|
|
US20230102342A1
(en)
|
2020-03-23 |
2023-03-30 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
|
|
MX2022012110A
(es)
|
2020-03-31 |
2022-10-18 |
Metagenomi Inc |
Sistemas crispr clase ii tipo ii.
|
|
US12057197B2
(en)
|
2020-04-03 |
2024-08-06 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
|
US20210332388A1
(en)
|
2020-04-24 |
2021-10-28 |
Inscripta, Inc. |
Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
|
|
DE112021002672T5
(de)
|
2020-05-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
|
|
US11787841B2
(en)
|
2020-05-19 |
2023-10-17 |
Inscripta, Inc. |
Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
|
|
US20230232796A1
(en)
|
2020-06-26 |
2023-07-27 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ace2 locus
|
|
CN111849986A
(zh)
*
|
2020-07-24 |
2020-10-30 |
江苏集萃药康生物科技有限公司 |
一种减少CRISPR-Cas9基因编辑中双链DNA片段串联的方法及其应用
|
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
|
WO2022060749A1
(en)
|
2020-09-15 |
2022-03-24 |
Inscripta, Inc. |
Crispr editing to embed nucleic acid landing pads into genomes of live cells
|
|
US11512297B2
(en)
|
2020-11-09 |
2022-11-29 |
Inscripta, Inc. |
Affinity tag for recombination protein recruitment
|
|
US20240002839A1
(en)
|
2020-12-02 |
2024-01-04 |
Decibel Therapeutics, Inc. |
Crispr sam biosensor cell lines and methods of use thereof
|
|
WO2022133139A2
(en)
*
|
2020-12-16 |
2022-06-23 |
Administrators Of The Tulane Educational Fund |
Wnt+ adipocytes, exosomes from wnt+ adipocyte, and methods of making and using them
|
|
US11306298B1
(en)
|
2021-01-04 |
2022-04-19 |
Inscripta, Inc. |
Mad nucleases
|
|
WO2022150269A1
(en)
|
2021-01-07 |
2022-07-14 |
Inscripta, Inc. |
Mad nucleases
|
|
EP4281554A4
(en)
*
|
2021-01-22 |
2025-06-18 |
Metagenomi, Inc. |
NOVEL MANIPULATED AND CHIMERIC NUCLEASES
|
|
EP4288541A1
(en)
|
2021-02-05 |
2023-12-13 |
Christiana Care Gene Editing Institute, Inc. |
Methods of and compositions for reducing gene expression and/or activity
|
|
US11884924B2
(en)
|
2021-02-16 |
2024-01-30 |
Inscripta, Inc. |
Dual strand nucleic acid-guided nickase editing
|
|
GB202103131D0
(en)
|
2021-03-05 |
2021-04-21 |
Biosystems Tech Limited |
Method for preparation of research organisms
|
|
US20240247285A1
(en)
|
2021-05-10 |
2024-07-25 |
Sqz Biotechnologies Company |
Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof
|
|
WO2022251644A1
(en)
|
2021-05-28 |
2022-12-01 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
|
EP4347826A1
(en)
|
2021-06-02 |
2024-04-10 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
|
WO2023028348A1
(en)
|
2021-08-27 |
2023-03-02 |
Metagenomi, Inc. |
Enzymes with ruvc domains
|
|
JP2024534945A
(ja)
|
2021-09-10 |
2024-09-26 |
アジレント・テクノロジーズ・インク |
化学修飾を有するプライム編集のためのガイドｒｎａ
|
|
EP4405463A1
(en)
|
2021-10-14 |
2024-07-31 |
Lonza Sales AG |
Modified producer cells for extracellular vesicle production
|
|
WO2023064928A2
(en)
|
2021-10-14 |
2023-04-20 |
Arsenal Biosciences, Inc. |
Immune cells having co-expressed shrnas and logic gate systems
|
|
US20240415980A1
(en)
|
2021-10-28 |
2024-12-19 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-related methods and compositions for knocking out c5
|
|
WO2023077148A1
(en)
|
2021-11-01 |
2023-05-04 |
Tome Biosciences, Inc. |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
CN118488784A
(zh)
|
2021-11-04 |
2024-08-13 |
瑞泽恩制药公司 |
包含经修饰的cacng1基因座的非人动物
|
|
WO2023097282A1
(en)
|
2021-11-24 |
2023-06-01 |
Metagenomi, Inc. |
Endonuclease systems
|
|
WO2023108047A1
(en)
|
2021-12-08 |
2023-06-15 |
Regeneron Pharmaceuticals, Inc. |
Mutant myocilin disease model and uses thereof
|
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
|
US20250049006A1
(en)
|
2021-12-20 |
2025-02-13 |
C/O Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising humanized ace2 and tmprss loci
|
|
IL313765A
(en)
|
2021-12-22 |
2024-08-01 |
Tome Biosciences Inc |
Joint provision of a gene editor structure and a donor template
|
|
KR20240128067A
(ko)
|
2021-12-29 |
2024-08-23 |
브리스톨-마이어스 스큅 컴퍼니 |
랜딩 패드 세포주의 생성
|
|
WO2023150181A1
(en)
|
2022-02-01 |
2023-08-10 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
WO2023150623A2
(en)
|
2022-02-02 |
2023-08-10 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:gaa and anti-cd63:gaa insertion for treatment of pompe disease
|
|
WO2023150798A1
(en)
|
2022-02-07 |
2023-08-10 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for defining optimal treatment timeframes in lysosomal disease
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
JP2025514304A
(ja)
|
2022-04-29 |
2025-05-02 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
遺伝子治療法のための組織特異的遺伝子外セーフハーバーの同定
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
CA3256953A1
(en)
|
2022-05-09 |
2023-11-16 |
Regeneron Pharmaceuticals, Inc. |
VECTORS AND METHODS FOR IN VIVO ANTIBODY PRODUCTION
|
|
CA3253951A1
(en)
|
2022-05-19 |
2023-11-23 |
Lyell Immunopharma, Inc. |
NR4A3 Targeted Polynucleotides and Their Uses
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
WO2023235725A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr-based therapeutics for c9orf72 repeat expansion disease
|
|
WO2023235726A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr interference therapeutics for c9orf72 repeat expansion disease
|
|
WO2023250384A2
(en)
*
|
2022-06-22 |
2023-12-28 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
KR20250044484A
(ko)
|
2022-06-24 |
2025-03-31 |
튠 쎄라퓨틱스, 인코포레이티드 |
표적 유전자 억제를 통해 저밀도 지단백질을 감소시키기 위한 조성물, 시스템, 및 방법
|
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
|
WO2024026488A2
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a modified transferrin receptor locus
|
|
EP4561636A1
(en)
|
2022-07-29 |
2025-06-04 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
|
EP4565603A1
(en)
|
2022-08-05 |
2025-06-11 |
Regeneron Pharmaceuticals, Inc. |
Aggregation-resistant variants of tdp-43
|
|
WO2024064952A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells overexpressing c-jun
|
|
WO2024064958A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
WO2024073606A1
(en)
|
2022-09-28 |
2024-04-04 |
Regeneron Pharmaceuticals, Inc. |
Antibody resistant modified receptors to enhance cell-based therapies
|
|
WO2024077174A1
(en)
|
2022-10-05 |
2024-04-11 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
EP4605524A1
(en)
|
2022-10-20 |
2025-08-27 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
US20240182561A1
(en)
|
2022-11-04 |
2024-06-06 |
Regeneron Pharmaceuticals, Inc. |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
|
EP4619438A2
(en)
|
2022-11-14 |
2025-09-24 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
|
CN120112547A
(zh)
|
2022-11-16 |
2025-06-06 |
瑞泽恩制药公司 |
包含膜结合il-12和蛋白酶可裂解接头的嵌合蛋白
|
|
WO2024137514A1
(en)
|
2022-12-22 |
2024-06-27 |
Synthego Corporation |
Systems and method for automated oligonucleotide synthesis
|
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
|
EP4654982A1
(en)
|
2023-01-27 |
2025-12-03 |
Regeneron Pharmaceuticals, Inc. |
Modified rhabdovirus glycoproteins and uses thereof
|
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
|
WO2024259309A1
(en)
|
2023-06-15 |
2024-12-19 |
Regeneron Pharmaceuticals, Inc. |
Gene therapy for hearing disorders
|
|
AU2024309884A1
(en)
|
2023-06-30 |
2025-12-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for increasing homology-directed repair
|
|
WO2025029654A2
(en)
|
2023-07-28 |
2025-02-06 |
Regeneron Pharmaceuticals, Inc. |
Use of bgh-sv40l tandem polya to enhance transgene expression during unidirectional gene insertion
|
|
AR133385A1
(es)
|
2023-07-28 |
2025-09-24 |
Regeneron Pharma |
Inserción anti-tfr:gaa y anti-cd63:gaa para el tratamiento de la enfermedad de pompe
|
|
US20250049896A1
(en)
|
2023-07-28 |
2025-02-13 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:acid sphingomyelinase for treatment of acid sphingomyelinase deficiency
|
|
WO2025038750A2
(en)
|
2023-08-14 |
2025-02-20 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
WO2025049524A1
(en)
|
2023-08-28 |
2025-03-06 |
Regeneron Pharmaceuticals, Inc. |
Cxcr4 antibody-resistant modified receptors
|
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
|
GB202314578D0
(en)
|
2023-09-22 |
2023-11-08 |
Univ Manchester |
Methods of producing homoplasmic modified plants or parts thereof
|
|
WO2025122754A1
(en)
|
2023-12-07 |
2025-06-12 |
Regeneron Pharmaceuticals, Inc. |
Gaa knockout non-human animals
|
|
WO2025184567A1
(en)
|
2024-03-01 |
2025-09-04 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
|
|
WO2025217398A1
(en)
|
2024-04-10 |
2025-10-16 |
Lyell Immunopharma, Inc. |
Methods for culturing cells with improved culture medium
|
|
WO2025224107A1
(en)
|
2024-04-22 |
2025-10-30 |
Basecamp Research Ltd |
Method and compositions for detecting off-target editing
|
|
WO2025224182A2
(en)
|
2024-04-23 |
2025-10-30 |
Basecamp Research Ltd |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
WO2025235388A1
(en)
|
2024-05-06 |
2025-11-13 |
Regeneron Pharmaceuticals, Inc. |
Transgene genomic identification by nuclease-mediated long read sequencing
|
|
WO2025259669A1
(en)
|
2024-06-10 |
2025-12-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for characterizing modified oligonucleotides
|