|
US3547119A
(en)
|
1967-12-08 |
1970-12-15 |
Baxter Laboratories Inc |
Catheter assembly
|
|
US4360019A
(en)
|
1979-02-28 |
1982-11-23 |
Andros Incorporated |
Implantable infusion device
|
|
US4692147A
(en)
|
1980-04-02 |
1987-09-08 |
Medtronic, Inc. |
Drug administration device
|
|
US4311137A
(en)
|
1980-04-30 |
1982-01-19 |
Sherwood Medical Industries Inc. |
Infusion device
|
|
JPS57106673A
(en)
|
1980-12-24 |
1982-07-02 |
Chugai Pharmaceut Co Ltd |
Dibenzo(b,f)(1,4)oxazepin derivative
|
|
US4487603A
(en)
|
1982-11-26 |
1984-12-11 |
Cordis Corporation |
Implantable microinfusion pump system
|
|
US4531937A
(en)
|
1983-01-24 |
1985-07-30 |
Pacesetter Systems, Inc. |
Introducer catheter apparatus and method of use
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4725852A
(en)
|
1985-05-09 |
1988-02-16 |
Burlington Industries, Inc. |
Random artificially perturbed liquid apparatus and method
|
|
US4755173A
(en)
|
1986-02-25 |
1988-07-05 |
Pacesetter Infusion, Ltd. |
Soft cannula subcutaneous injection set
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US4843155A
(en)
|
1987-11-19 |
1989-06-27 |
Piotr Chomczynski |
Product and process for isolating RNA
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
JPH01167840A
(ja)
|
1987-12-24 |
1989-07-03 |
Konica Corp |
新規な写真用シアンカプラー
|
|
US5744101A
(en)
|
1989-06-07 |
1998-04-28 |
Affymax Technologies N.V. |
Photolabile nucleoside protecting groups
|
|
US5800992A
(en)
|
1989-06-07 |
1998-09-01 |
Fodor; Stephen P.A. |
Method of detecting nucleic acids
|
|
US6040138A
(en)
|
1995-09-15 |
2000-03-21 |
Affymetrix, Inc. |
Expression monitoring by hybridization to high density oligonucleotide arrays
|
|
US5143854A
(en)
|
1989-06-07 |
1992-09-01 |
Affymax Technologies N.V. |
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
|
|
CA2118806A1
(en)
|
1991-09-18 |
1993-04-01 |
William J. Dower |
Method of synthesizing diverse collections of oligomers
|
|
AU675054B2
(en)
|
1991-11-22 |
1997-01-23 |
Affymetrix, Inc. |
Combinatorial strategies for polymer synthesis
|
|
US5384261A
(en)
|
1991-11-22 |
1995-01-24 |
Affymax Technologies N.V. |
Very large scale immobilized polymer synthesis using mechanically directed flow paths
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
GB9226855D0
(en)
|
1992-12-23 |
1993-02-17 |
Erba Carlo Spa |
Vinylene-azaindole derivatives and process for their preparation
|
|
EP1302468B1
(en)
|
1992-12-29 |
2008-12-17 |
Abbott Laboratories |
Processes and intermediates for manufacturing retroviral protease inhibiting compounds
|
|
US5545143A
(en)
|
1993-01-21 |
1996-08-13 |
T. S. I. Medical |
Device for subcutaneous medication delivery
|
|
WO1995003335A1
(en)
|
1993-07-26 |
1995-02-02 |
K.O. Technology, Inc. |
Inhibitors of alternative alleles of genes as a basis for cancer therapeutic agents
|
|
US6326469B1
(en)
|
1994-04-22 |
2001-12-04 |
Sugen, Inc. |
Megakaryocytic protein tyrosine kinases
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US5556752A
(en)
|
1994-10-24 |
1996-09-17 |
Affymetrix, Inc. |
Surface-bound, unimolecular, double-stranded DNA
|
|
US5530012A
(en)
|
1994-12-22 |
1996-06-25 |
Bristol-Myers Squibb Co. |
3-alkoxybenzylpiperidine derivatives as melatonergic agents
|
|
US5643207A
(en)
|
1995-04-28 |
1997-07-01 |
Medtronic, Inc. |
Implantable techniques for infusing a therapeutic agent with endogenous bodily fluid
|
|
US5593997A
(en)
|
1995-05-23 |
1997-01-14 |
Pfizer Inc. |
4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
|
|
US6113898A
(en)
|
1995-06-07 |
2000-09-05 |
Idec Pharmaceuticals Corporation |
Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
|
|
US5994348A
(en)
|
1995-06-07 |
1999-11-30 |
Sanofi |
Pharmaceutical compositions containing irbesartan
|
|
US5545531A
(en)
|
1995-06-07 |
1996-08-13 |
Affymax Technologies N.V. |
Methods for making a device for concurrently processing multiple biological chip assays
|
|
US5856174A
(en)
|
1995-06-29 |
1999-01-05 |
Affymetrix, Inc. |
Integrated nucleic acid diagnostic device
|
|
US5854033A
(en)
|
1995-11-21 |
1998-12-29 |
Yale University |
Rolling circle replication reporter systems
|
|
EP1240899A3
(en)
|
1996-01-23 |
2004-05-19 |
Ribapharm, Inc. |
Modulation of Th1/Th2 Cytokine expression by Ribavirin and Ribavirin analogs in actived T-Lymphocytes for treating HCV infections
|
|
EP0880598A4
(en)
|
1996-01-23 |
2005-02-23 |
Affymetrix Inc |
RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
|
|
CH690773A5
(de)
|
1996-02-01 |
2001-01-15 |
Novartis Ag |
Pyrrolo(2,3-d)pyrimide und ihre Verwendung.
|
|
US5807876A
(en)
|
1996-04-23 |
1998-09-15 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme
|
|
US6054472A
(en)
|
1996-04-23 |
2000-04-25 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of IMPDH enzyme
|
|
IL126674A
(en)
|
1996-04-23 |
2005-08-31 |
Vertex Pharma |
Use of cyclic and heterocyclic compounds for preparing pharmaceutical compositions inhibiting impdh activity, pharmaceutical compositions containing the same and novel thiazole and oxazole urea derivatives
|
|
US5820589A
(en)
|
1996-04-30 |
1998-10-13 |
Medtronic, Inc. |
Implantable non-invasive rate-adjustable pump
|
|
WO1997049706A1
(en)
|
1996-06-25 |
1997-12-31 |
Novartis Ag |
SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF
|
|
EP1254911A1
(en)
|
1996-10-16 |
2002-11-06 |
ICN Pharmaceuticals, Inc. |
Monocyclic L-nucleosides, analogs and uses thereof
|
|
DE69738307T2
(de)
|
1996-12-27 |
2008-10-02 |
Canon K.K. |
Herstellungsverfahren eines Halbleiter-Bauelements und Herstellungsverfahren einer Solarzelle
|
|
US6756289B1
(en)
|
1996-12-27 |
2004-06-29 |
Canon Kabushiki Kaisha |
Method of producing semiconductor member and method of producing solar cell
|
|
ATE244717T1
(de)
|
1997-03-14 |
2003-07-15 |
Vertex Pharma |
Inhibitoren des impdh-enzyms
|
|
CA2283961A1
(en)
|
1997-03-19 |
1998-09-24 |
Basf Aktiengesellschaft |
Pyrrolo[2,3d]pyrimidines and their use as tyrosine kinase inhibitors
|
|
DE69829402T2
(de)
|
1997-10-31 |
2006-04-13 |
Affymetrix, Inc. (a Delaware Corp.), Santa Clara |
Expressionsprofile in adulten und fötalen organen
|
|
GB2332325A
(en)
|
1997-12-10 |
1999-06-16 |
Snell & Wilcox Ltd |
Video signal spatial interpolation for de-interlacing processing
|
|
US7390619B1
(en)
|
1998-02-11 |
2008-06-24 |
Maxygen, Inc. |
Optimization of immunomodulatory properties of genetic vaccines
|
|
US6200754B1
(en)
|
1998-03-19 |
2001-03-13 |
Variagenics, Inc. |
Inhibitors of alternative alleles of genes encoding products that mediate cell response to environmental changes
|
|
US6020135A
(en)
|
1998-03-27 |
2000-02-01 |
Affymetrix, Inc. |
P53-regulated genes
|
|
US6303652B1
(en)
|
1998-08-21 |
2001-10-16 |
Hughes Institute |
BTK inhibitors and methods for their identification and use
|
|
ATE269295T1
(de)
|
1998-04-17 |
2004-07-15 |
Parker Hughes Inst |
Btk inhibitoren und verfahren zur identifizierung und verwendung
|
|
SE9801799D0
(sv)
|
1998-05-20 |
1998-05-20 |
Sten Eric Lindquist |
Färgämnessensiterad nanostrukturerad fotovoltaisk tandemcell
|
|
EP1091440B1
(en)
|
1998-05-29 |
2010-06-02 |
JGC Catalysts and Chemicals Ltd. |
Method of manufacturing photoelectric cell
|
|
US20050287596A9
(en)
|
1998-06-26 |
2005-12-29 |
Braisted Andrew C |
Novel ligands and libraries of ligands
|
|
US6998233B2
(en)
|
1998-06-26 |
2006-02-14 |
Sunesis Pharmaceuticals, Inc. |
Methods for ligand discovery
|
|
US6335155B1
(en)
|
1998-06-26 |
2002-01-01 |
Sunesis Pharmaceuticals, Inc. |
Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
|
|
US7087236B1
(en)
|
1998-09-01 |
2006-08-08 |
Merrion Research I Limited |
Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
|
|
AU1096400A
(en)
|
1998-09-28 |
2000-04-17 |
Boston Medical Center Corporation |
Determining resistance to treatment for hepatitis c virus
|
|
US6824768B2
(en)
|
1998-12-18 |
2004-11-30 |
Schering Corporation |
Ribavirin-pegylated interferon alfa induction HCV combination therapy
|
|
US6198966B1
(en)
|
1999-02-26 |
2001-03-06 |
Medtronic, Inc. |
Recirculating implantable drug delivery system
|
|
US6306897B1
(en)
|
1999-03-19 |
2001-10-23 |
Parker Hughes Institute |
Calanolides for inhibiting BTK
|
|
EP1964561A1
(en)
|
1999-03-19 |
2008-09-03 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme
|
|
AR023541A1
(es)
|
1999-04-19 |
2002-09-04 |
Schering Corp |
Terapia de combinacion para vhc
|
|
PT1212327E
(pt)
|
1999-09-17 |
2004-01-30 |
Abbott Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos
|
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
|
US6506769B2
(en)
|
1999-10-06 |
2003-01-14 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Heterocyclic compounds useful as inhibitors of tyrosine kinases
|
|
WO2001025238A2
(en)
|
1999-10-06 |
2001-04-12 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Heterocyclic compounds useful as inhibitors of tyrosine kinases
|
|
HK1047109A1
(zh)
|
1999-10-15 |
2003-02-07 |
University Of Massachusetts |
作为指定基因干预工具的rna干预轨迹基因
|
|
EP1227844A2
(en)
|
1999-10-29 |
2002-08-07 |
Pharmacyclics, Inc. |
Compositions for treating atheroma and neoplastic tissue
|
|
JP2003516351A
(ja)
|
1999-11-30 |
2003-05-13 |
パーカー ヒューズ インスティテュート |
コラーゲン誘導血小板凝集阻害剤
|
|
EP1246829A1
(en)
|
1999-12-17 |
2002-10-09 |
Ariad Pharmaceuticals, Inc. |
Novel heterocycles
|
|
US6602767B2
(en)
|
2000-01-27 |
2003-08-05 |
Canon Kabushiki Kaisha |
Method for transferring porous layer, method for making semiconductor devices, and method for making solar battery
|
|
US7835970B1
(en)
|
2000-02-02 |
2010-11-16 |
Cmvt, Llc |
Method and system for automated auction and tender of complex multi-variable commodities
|
|
GB0005345D0
(en)
|
2000-03-06 |
2000-04-26 |
Mathilda & Terence Kennedy Ins |
Methods of treating sepsis septic shock and inflammation
|
|
HK1047406A1
(zh)
|
2000-03-09 |
2003-02-21 |
Schering Corporation |
Hiv免疫佐剂治疗
|
|
EP1268856A2
(de)
|
2000-04-07 |
2003-01-02 |
Epigenomics AG |
Detektion von snp's und cytosin-methylierungen
|
|
CN1152778C
(zh)
|
2000-05-19 |
2004-06-09 |
Tdk株式会社 |
具有功能性层的功能性薄膜及带有该功能性层的物体
|
|
WO2002012188A2
(en)
|
2000-08-09 |
2002-02-14 |
The Regents Of The University Of California |
Indole compounds useful for the treatment of cancer
|
|
US20020127203A1
(en)
|
2000-10-18 |
2002-09-12 |
Albrecht Janice K. |
Ribavirin-pegylated interferon alfa HCV combination therapy
|
|
WO2002038797A2
(en)
|
2000-10-23 |
2002-05-16 |
Bristol-Myers Squibb Company |
Modulators of bruton's tyrosine kinase, their identification and use
|
|
US20020094545A1
(en)
|
2000-11-30 |
2002-07-18 |
Harris Paul E. |
Growth of human dendritic cells for cancer immunotherapy in closed system using microcarrier beads
|
|
CA2436570A1
(en)
|
2000-12-06 |
2002-06-13 |
Pharmacia Corporation |
Rapidly dispersing pharmaceutical composition comprising effervescent agents
|
|
PT1355919E
(pt)
|
2000-12-12 |
2011-03-02 |
Medimmune Llc |
Moléculas com semivida longa, composições que as contêm e suas utilizações
|
|
MXPA03008560A
(es)
|
2001-03-22 |
2004-06-30 |
Abbot Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos.
|
|
AR036993A1
(es)
|
2001-04-02 |
2004-10-20 |
Wyeth Corp |
Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
|
|
US8306897B2
(en)
|
2001-05-04 |
2012-11-06 |
Stockshield, Inc. |
Method and system for insuring against investment loss
|
|
US20030103938A1
(en)
|
2001-05-09 |
2003-06-05 |
Alk-Abello A/S |
Pharmaceutical compositions for preventing or treating Th1 and Th2 cell related diseases by modulating the Th1/Th2 ratio
|
|
AU2002315389A1
(en)
|
2001-06-21 |
2003-01-08 |
Ariad Pharmaceuticals, Inc. |
Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
|
|
GB0116249D0
(en)
|
2001-07-05 |
2001-08-29 |
Imp College Innovations Ltd |
Methods
|
|
US20030124028A1
(en)
|
2001-08-10 |
2003-07-03 |
Carlson Eric D. |
Apparatuses and methods for creating and testing pre-formulations and systems for same
|
|
US20040248906A1
(en)
|
2001-08-10 |
2004-12-09 |
Donato Nicholas J |
Use of c-src inhibitors alone or in combination with st1571 for the treatment of leukaemia
|
|
WO2003016338A1
(en)
|
2001-08-15 |
2003-02-27 |
Parker Hughes Institute |
Crystal structure of the btk kinase domain
|
|
US7622260B2
(en)
|
2001-09-05 |
2009-11-24 |
The Brigham And Women's Hospital, Inc. |
Diagnostic and prognostic tests
|
|
EP1446496A4
(en)
|
2001-11-21 |
2005-03-30 |
Sunesis Pharmaceuticals Inc |
PROCESS FOR DISCOVERING LIGANDS
|
|
US20030175761A1
(en)
|
2001-12-07 |
2003-09-18 |
Sabath Daniel E. |
Identification of genes whose expression patterns distinguish benign lymphoid tissue and mantle cell, follicular, and small lymphocytic lymphoma
|
|
WO2003081210A2
(en)
|
2002-03-21 |
2003-10-02 |
Sunesis Pharmaceuticals, Inc. |
Identification of kinase inhibitors
|
|
US20050084905A1
(en)
|
2002-03-21 |
2005-04-21 |
Prescott John C. |
Identification of kinase inhibitors
|
|
WO2003087051A2
(en)
|
2002-04-08 |
2003-10-23 |
Sunesis Pharmaceuticals, Inc. |
Methods for identifying allosteric sites
|
|
JP3764402B2
(ja)
|
2002-05-02 |
2006-04-05 |
パイロットインキ株式会社 |
移動玩具セット
|
|
GB2388594A
(en)
|
2002-05-16 |
2003-11-19 |
Bayer Ag |
Imidazo-triazine PDE 4 inhibitors
|
|
KR20050037552A
(ko)
|
2002-07-15 |
2005-04-22 |
와이어쓰 |
T 헬퍼(th) 세포 발생 및 기능을 조절하는 방법 및조성물
|
|
US7138420B2
(en)
|
2002-08-08 |
2006-11-21 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Substituted benzimidazole compounds
|
|
EP2572715A1
(en)
|
2002-12-30 |
2013-03-27 |
3M Innovative Properties Company |
Immunostimulatory Combinations
|
|
GB0303910D0
(en)
|
2003-02-20 |
2003-03-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
EP1463073A1
(en)
|
2003-03-24 |
2004-09-29 |
Sony International (Europe) GmbH |
Porous film having a gradient of light scattering strength
|
|
WO2005000197A2
(en)
|
2003-04-11 |
2005-01-06 |
The Regents Of The University Of California |
Selective serine/threonine kinase inhibitors
|
|
US20050008640A1
(en)
|
2003-04-23 |
2005-01-13 |
Wendy Waegell |
Method of treating transplant rejection
|
|
EP1473039A1
(en)
|
2003-05-02 |
2004-11-03 |
Centre National De La Recherche Scientifique (Cnrs) |
Use of inhibitors and antisense oligonucleotides of BTK for the treatment of proliferative mastocytosis
|
|
WO2004110245A2
(en)
|
2003-05-16 |
2004-12-23 |
Intermune, Inc. |
Combination therapy for cancer treatment
|
|
WO2005014599A1
(en)
|
2003-06-04 |
2005-02-17 |
Cellular Genomics, Inc. |
Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds
|
|
US7393848B2
(en)
|
2003-06-30 |
2008-07-01 |
Cgi Pharmaceuticals, Inc. |
Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
|
|
US8131475B2
(en)
|
2003-09-03 |
2012-03-06 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Methods for identifying, diagnosing, and predicting survival of lymphomas
|
|
JP2005089352A
(ja)
|
2003-09-16 |
2005-04-07 |
Kissei Pharmaceut Co Ltd |
新規なイミダゾ[1,5−a]ピラジン誘導体、それを含有する医薬組成物およびそれらの用途
|
|
EP1670503A4
(en)
|
2003-09-30 |
2008-09-24 |
Telethon Inst For Child Health |
IMMUNOTHERAPY METHOD
|
|
CN1897950A
(zh)
|
2003-10-14 |
2007-01-17 |
惠氏公司 |
稠合芳基和杂芳基衍生物及其使用方法
|
|
KR100872204B1
(ko)
|
2003-10-15 |
2008-12-09 |
오에스아이 파마슈티컬스, 인코포레이티드 |
이미다조피라진 티로신 키나제 억제제
|
|
US20050288295A1
(en)
|
2003-11-11 |
2005-12-29 |
Currie Kevin S |
Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof
|
|
WO2005060956A1
(en)
|
2003-12-12 |
2005-07-07 |
University Of Maryland, Baltimore |
IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE pY+3 BINDING SITE OF TYROSENE KINASE p56 LCK SH2 DOMAIN
|
|
US20050153990A1
(en)
|
2003-12-22 |
2005-07-14 |
Watkins William J. |
Phosphonate substituted kinase inhibitors
|
|
US20070281907A1
(en)
|
2003-12-22 |
2007-12-06 |
Watkins William J |
Kinase Inhibitor Phosphonate Conjugates
|
|
RU2006122517A
(ru)
|
2004-01-08 |
2008-02-20 |
Вайет (Us) |
Фармацевтический состав для прямого прессования, предназначенный для перорального введения cci-779
|
|
GB2432834A
(en)
|
2004-01-12 |
2007-06-06 |
Cytopia Res Pty Ltd |
Selective Kinase Inhibitors
|
|
CA2554551A1
(en)
|
2004-01-26 |
2005-10-13 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of protein kinases
|
|
CA2553724A1
(en)
|
2004-02-03 |
2005-08-18 |
Abbott Laboratories |
Aminobenzoxazoles as therapeutic agents
|
|
US20080146555A1
(en)
|
2004-06-18 |
2008-06-19 |
Gpc Biotech, Inc |
Uses of Kinase Inhibitors and Compositions Thereof
|
|
ITMI20041314A1
(it)
|
2004-06-30 |
2004-09-30 |
Nuvera Fuel Cells Europ Srl |
Dispositivo di raffreddamento per celle a combustibili a membrana
|
|
TW200613306A
(en)
|
2004-07-20 |
2006-05-01 |
Osi Pharm Inc |
Imidazotriazines as protein kinase inhibitors
|
|
JP5184087B2
(ja)
|
2004-09-22 |
2013-04-17 |
トリパス イメージング, インコーポレイテッド |
ガンの予後のためのマーカー候補を分析および最適化するための方法およびコンピュータープログラム製品
|
|
CA2581375A1
(en)
|
2004-09-27 |
2006-04-06 |
Kosan Biosciences Incorporated |
Specific kinase inhibitors
|
|
WO2006036527A1
(en)
|
2004-09-28 |
2006-04-06 |
Janssen Pharmaceutica, N.V. |
Substituted dipiperdine ccr2 antagonists
|
|
KR20070083899A
(ko)
|
2004-10-01 |
2007-08-24 |
메다렉스, 인코포레이티드 |
Cd30 양성 림프종의 치료 방법
|
|
WO2006053121A2
(en)
|
2004-11-10 |
2006-05-18 |
Cgi Pharmaceuticals, Inc. |
Imidazo[1 , 2-a] pyrazin-8-ylamines useful as modulators of kinase activity
|
|
GB0425035D0
(en)
|
2004-11-12 |
2004-12-15 |
Novartis Ag |
Organic compounds
|
|
US8101770B2
(en)
|
2004-12-16 |
2012-01-24 |
Vertex Pharmaceuticals Incorporated |
Pyridones useful as inhibitors of kinases
|
|
KR100735639B1
(ko)
|
2004-12-29 |
2007-07-04 |
한미약품 주식회사 |
암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법
|
|
RU2405566C9
(ru)
|
2005-02-03 |
2012-04-27 |
Дзе Дженерал Хоспитал Корпорейшн |
Способ лечения рака, устойчивого к гефитинибу
|
|
CA2601628C
(en)
|
2005-03-10 |
2014-05-13 |
Cgi Pharmaceuticals, Inc. |
Certain substituted amides, method of making, and method of use thereof
|
|
BRPI0607579A2
(pt)
|
2005-03-23 |
2009-09-15 |
Pfizer Prod Inc |
uso de anticorpo anti-ctla4 e indolinona para a preparação de medicamentos para o tratamento de cáncer
|
|
CA2607299C
(en)
|
2005-05-13 |
2013-05-07 |
Irm, Llc |
Compounds and compositions as protein kinase inhibitors
|
|
MX2007014377A
(es)
|
2005-05-17 |
2008-02-06 |
Plexxikon Inc |
Inhibidores de proteina cinasa de derivados de pirrol (2,3-b) piridina.
|
|
WO2007002433A1
(en)
|
2005-06-22 |
2007-01-04 |
Plexxikon, Inc. |
Pyrrolo [2, 3-b] pyridine derivatives as protein kinase inhibitors
|
|
KR101411165B1
(ko)
|
2005-07-01 |
2014-06-25 |
메다렉스, 엘.엘.시. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체
|
|
WO2007027594A1
(en)
|
2005-08-29 |
2007-03-08 |
Vertex Pharmaceuticals Incorporated |
3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
|
|
US20070065449A1
(en)
|
2005-09-16 |
2007-03-22 |
Claire Verschraegen |
Method of treating cancer, especially soft tissue sarcoma utilizing gemcitabine in combination with docetaxel and anti-VEGF therapy (bevacizumab)
|
|
DK1951300T3
(da)
|
2005-11-04 |
2011-10-03 |
Novartis Vaccines & Diagnostic |
Ændring af Th1/Th2-balancen i split-influenzavacciner med adjuvanser
|
|
EP1957491A2
(en)
|
2005-11-12 |
2008-08-20 |
Boehringer Ingelheim International GmbH |
Pyrrolo (2,3-b) pyridine derivatives useful as tec kinase inhibitors
|
|
US20090197853A1
(en)
|
2005-11-16 |
2009-08-06 |
Pharmacyclics, Inc. |
Methods and compositions of treating cancer
|
|
AU2006336506B2
(en)
|
2006-01-13 |
2012-06-28 |
Pharmacyclics Llc |
Inhibitors of tyrosine kinases and uses thereof
|
|
ES2420834T3
(es)
|
2006-01-30 |
2013-08-27 |
The Scripps Research Institute |
Métodos de detección de células tumorales circulantes y métodos de diagnóstico del cáncer en un sujeto mamífero
|
|
US7908091B2
(en)
|
2006-03-17 |
2011-03-15 |
Prometheus Laboratories Inc. |
Methods of predicting and monitoring tyrosine kinase inhibitor therapy
|
|
GB0605521D0
(en)
|
2006-03-18 |
2006-04-26 |
Isis Innovation |
Adjuvant
|
|
KR20130087054A
(ko)
|
2006-04-04 |
2013-08-05 |
더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 |
키나제 길항물질
|
|
CN101415409B
(zh)
|
2006-04-05 |
2012-12-05 |
诺瓦提斯公司 |
用于治疗癌症的治疗剂的组合
|
|
MX2008012903A
(es)
|
2006-04-07 |
2008-10-13 |
Novartis Ag |
Uso de inhibidores de c-src en combinacion con un compuesto de pirimidilaminobenzamida para el tratamiento de la leucemia.
|
|
CA2651732C
(en)
|
2006-05-18 |
2014-10-14 |
Mannkind Corporation |
Intracellular kinase inhibitors
|
|
JP2010510171A
(ja)
|
2006-08-21 |
2010-04-02 |
ユナイテッド セラピューティクス コーポレーション |
ウイルス感染症の治療のための併用療法
|
|
EP2068849A2
(en)
|
2006-09-11 |
2009-06-17 |
CGI Pharmaceuticals, Inc. |
Kinase inhibitors, and methods of using and identifying kinase inhibitors
|
|
AR063946A1
(es)
|
2006-09-11 |
2009-03-04 |
Cgi Pharmaceuticals Inc |
Determinadas pirimidinas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
|
|
AR063707A1
(es)
|
2006-09-11 |
2009-02-11 |
Cgi Pharmaceuticals Inc |
Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmacéuticas que las comprenden.
|
|
EP2526934B1
(en)
|
2006-09-22 |
2015-12-09 |
Pharmacyclics LLC |
Inhibitors of bruton's tyrosine kinase
|
|
WO2008043018A1
(en)
|
2006-10-04 |
2008-04-10 |
Dana-Farber Cancer Institute, Inc. |
Tumor immunity
|
|
KR20090084891A
(ko)
|
2006-10-27 |
2009-08-05 |
시그날 파마소티칼 엘엘씨 |
4-[9-(테트라하이드로-퓨란-3-일)-8-(2,4,6-트리플루오로-페닐아미노)-9h-퓨린-2-일아미노]-사이클로헥산-1-올을 포함하는 고체 형태들, 이들의 조성물들 및 이들의 용도
|
|
EP2089391B1
(en)
*
|
2006-11-03 |
2013-01-16 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
|
EP2092075A2
(en)
|
2006-11-06 |
2009-08-26 |
Source Precision Medicine, Inc. |
Gene expression profiling for identification, monitoring and treatment of melanoma
|
|
US9408816B2
(en)
|
2006-12-26 |
2016-08-09 |
Pharmacyclics Llc |
Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
|
|
AU2008210266B2
(en)
|
2007-01-31 |
2013-09-05 |
Ym Biosciences Australia Pty Ltd |
Thiopyrimidine-based compounds and uses thereof
|
|
EP2491923A3
(en)
|
2007-02-15 |
2012-12-26 |
Novartis AG |
Combinations of therapeutic agents for treating cancer
|
|
NL2000640C2
(nl)
|
2007-03-05 |
2008-09-08 |
Stichting Wetsus Ct Of Excelle |
Werkwijze en systeem voor het zuiveren van een vloeistof.
|
|
KR101791981B1
(ko)
|
2007-03-14 |
2017-11-01 |
비온실 에스.알.엘. |
화학요법 약물-내성 상피성 종양을 치료하기 위한 siRNA-매개 유전자 침묵화
|
|
US8809273B2
(en)
|
2007-03-28 |
2014-08-19 |
Pharmacyclics, Inc. |
Inhibitors of Bruton's tyrosine kinase
|
|
US20120065201A1
(en)
|
2007-03-28 |
2012-03-15 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
SG10202107066WA
(en)
*
|
2007-03-28 |
2021-07-29 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
AU2008236634A1
(en)
|
2007-04-05 |
2008-10-16 |
Aureon Laboratories, Inc. |
Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition
|
|
US20090010911A1
(en)
|
2007-04-06 |
2009-01-08 |
Iowa State University Research Foundation, Inc. |
Methods and compositions for affecting cyclophilin a regulation of kinases in modulating cellular activities
|
|
WO2008127659A2
(en)
|
2007-04-13 |
2008-10-23 |
University Of Texas Southwestern Medical Center |
Combination therapy for cancer
|
|
ES2571533T3
(es)
|
2007-04-27 |
2016-05-25 |
Purdue Pharma Lp |
Antagonistas de TRPV1 y usos de los mismos
|
|
WO2008138578A2
(en)
|
2007-05-11 |
2008-11-20 |
Medical Prognosis Institute |
Methods, kits, and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
|
|
JP5703466B2
(ja)
|
2007-08-07 |
2015-04-22 |
パーデュー・リサーチ・ファウンデーションPurdue Research Foundation |
キナーゼ阻害薬およびその使用
|
|
JP5376780B2
(ja)
|
2007-08-08 |
2013-12-25 |
株式会社東芝 |
圧電モータおよびカメラ装置
|
|
WO2009048307A2
(en)
|
2007-10-12 |
2009-04-16 |
Electronics And Telecommunications Research Institute |
Mobile rfid reader and rfid communication method using shared system clock
|
|
US7989465B2
(en)
|
2007-10-19 |
2011-08-02 |
Avila Therapeutics, Inc. |
4,6-disubstituted pyrimidines useful as kinase inhibitors
|
|
JP5600063B2
(ja)
|
2007-10-19 |
2014-10-01 |
セルジーン アビロミクス リサーチ, インコーポレイテッド |
ヘテロアリール化合物およびその使用
|
|
CA2701275C
(en)
|
2007-10-23 |
2016-06-21 |
F. Hoffmann-La Roche Ag |
Kinase inhibitors
|
|
CN102089324B
(zh)
|
2007-11-12 |
2014-04-16 |
特罗科隆科学有限公司 |
用于对流行性感冒进行治疗以及诊断的组合物以及方法
|
|
US8426441B2
(en)
|
2007-12-14 |
2013-04-23 |
Roche Palo Alto Llc |
Inhibitors of bruton's tyrosine kinase
|
|
US20150152115A1
(en)
|
2007-12-27 |
2015-06-04 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
CN101475632B
(zh)
|
2008-01-03 |
2012-01-04 |
张喜田 |
具有抗肿瘤作用的重组灵芝免疫调节蛋白及其药物制剂
|
|
WO2009089399A2
(en)
|
2008-01-10 |
2009-07-16 |
Bausch & Lomb Incorporated |
Compositions comprising toll-like receptor or coreceptor antagonists and methods for ocular neuroprotection
|
|
ES2592312T3
(es)
|
2008-03-25 |
2016-11-29 |
Roche Glycart Ag |
Utilización de un anticuerpo anti-CD20 de tipo II con citotoxicidad celular dependiente de anticuerpos (ADCC) incrementada en combinación con ciclofosfamida, vincristina y doxorrubicina para el tratamiento de linfomas no de Hodgkin
|
|
GB0805356D0
(en)
|
2008-03-25 |
2008-04-30 |
Isis Innovation |
Vaccine adjuvant composition
|
|
WO2009137596A1
(en)
|
2008-05-06 |
2009-11-12 |
Cgi Pharmaceuticals, Inc. |
Substituted amides, method of making, and use as btk inhibitors
|
|
PE20091846A1
(es)
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
|
WO2009140853A1
(en)
|
2008-05-23 |
2009-11-26 |
The University Of Hong Kong |
Combination therapy for the treatment of influenza
|
|
WO2009149179A2
(en)
|
2008-06-03 |
2009-12-10 |
Aethlon Medical Inc. |
Enhanced antiviral therapy methods and devices
|
|
ES2383246T3
(es)
|
2008-06-05 |
2012-06-19 |
Glaxo Group Limited |
4-amino-indazoles
|
|
NZ601700A
(en)
|
2008-06-24 |
2013-02-22 |
Hoffmann La Roche |
5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives as inhibitors of Bruton's Tyrosine Kinase (Btk)
|
|
EP2361248B1
(en)
|
2008-06-27 |
2018-09-19 |
Celgene CAR LLC |
Heteroaryl compounds and uses thereof
|
|
MX2011000661A
(es)
|
2008-07-16 |
2011-05-25 |
Pharmacyclics Inc |
Inhibidores de tirosina cinasa de bruton para el tratamiento de tumores solidos.
|
|
CN102245027A
(zh)
|
2008-07-29 |
2011-11-16 |
尖端科学公司 |
四(n-烷基吡啶)-卟啉衍生物用于杀死微生物或防止微生物生长的用途
|
|
CN105574346A
(zh)
|
2008-09-05 |
2016-05-11 |
新基阿维罗米克斯研究公司 |
多肽偶联物与不可逆抑制剂的设计方法和检测方法
|
|
JP2012503619A
(ja)
|
2008-09-26 |
2012-02-09 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
Hcv感染に対する抗ウイルス治療のための標的としての宿主細胞キナーゼ
|
|
WO2010056875A1
(en)
|
2008-11-12 |
2010-05-20 |
Cgi Pharmaceuticals, Inc. |
Pyridazinones and their use as btk inhibitors
|
|
JP5794919B2
(ja)
|
2008-11-13 |
2015-10-14 |
ギリアード カリストガ エルエルシー |
血液学的な悪性疾患のための療法
|
|
UA108193C2
(uk)
|
2008-12-04 |
2015-04-10 |
|
Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
|
|
US20100160322A1
(en)
|
2008-12-04 |
2010-06-24 |
Abbott Laboratories |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
US8426428B2
(en)
|
2008-12-05 |
2013-04-23 |
Principia Biopharma, Inc. |
EGFR kinase knockdown via electrophilically enhanced inhibitors
|
|
NZ593110A
(en)
|
2008-12-09 |
2013-06-28 |
Gilead Sciences Inc |
pteridinone derivatives as MODULATORS OF TOLL-LIKE RECEPTORS
|
|
WO2010077634A1
(en)
|
2008-12-09 |
2010-07-08 |
Genentech, Inc. |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
WO2010068810A2
(en)
|
2008-12-10 |
2010-06-17 |
Cgi Pharmaceuticals, Inc. |
Certain substituted amides, method of making, and method of use thereof
|
|
WO2010068806A1
(en)
|
2008-12-10 |
2010-06-17 |
Cgi Pharmaceuticals, Inc. |
Amide derivatives as btk inhibitors in the treatment of allergic, autoimmune and inflammatory disorders as well as cancer
|
|
WO2010068788A1
(en)
|
2008-12-10 |
2010-06-17 |
Cgi Pharmaceuticals, Inc. |
Heterocyclic amides as btk inhibitors
|
|
KR20110084533A
(ko)
|
2008-12-15 |
2011-07-25 |
일라이 릴리 앤드 캄파니 |
암의 치료를 위한 엔자스타우린
|
|
CN102257159A
(zh)
|
2008-12-18 |
2011-11-23 |
弗·哈夫曼-拉罗切有限公司 |
用于hcv治疗应答的生物标志物
|
|
CN102325753B
(zh)
|
2008-12-19 |
2014-09-10 |
百时美施贵宝公司 |
用作激酶抑制剂的咔唑甲酰胺化合物
|
|
EP2396028A2
(en)
|
2009-02-12 |
2011-12-21 |
Vertex Pharmceuticals Incorporated |
Hcv combination therapies comprising pegylated interferon, ribavirin and telaprevir
|
|
US8299077B2
(en)
|
2009-03-02 |
2012-10-30 |
Roche Palo Alto Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
SG175289A1
(en)
|
2009-04-20 |
2011-11-28 |
Genentech Inc |
Adjuvant cancer therapy
|
|
EP2424368B1
(en)
|
2009-04-29 |
2014-12-31 |
Locus Pharmaceuticals, Inc. |
Pyrrolotriazine compounds
|
|
UY32668A
(es)
|
2009-05-26 |
2010-12-31 |
Abbott Lab |
Agentes inductores de la apoptosis para el tratamiento del cáncer y de enfermedades inmunes y autoinmunes
|
|
JP2012529535A
(ja)
|
2009-06-12 |
2012-11-22 |
ブリストル−マイヤーズ スクイブ カンパニー |
キナーゼモジュレーターとして有用なニコチンアミド化合物
|
|
LU91583B1
(en)
|
2009-07-03 |
2011-01-04 |
Wurth Paul Sa |
Sealing valve arrangement for a shaft furnace charging installation
|
|
TWI711610B
(zh)
|
2009-09-04 |
2020-12-01 |
美商百健Ma公司 |
布魯頓氏酪胺酸激酶抑制劑
|
|
US9556426B2
(en)
|
2009-09-16 |
2017-01-31 |
Celgene Avilomics Research, Inc. |
Protein kinase conjugates and inhibitors
|
|
GB2474748B
(en)
|
2009-10-01 |
2011-10-12 |
Amira Pharmaceuticals Inc |
Polycyclic compounds as lysophosphatidic acid receptor antagonists
|
|
US7741330B1
(en)
|
2009-10-12 |
2010-06-22 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
|
|
MY174452A
(en)
|
2009-10-14 |
2020-04-19 |
Schering Corp |
Substituted piperidines that increase p53 activity and the uses thereof
|
|
US8299070B2
(en)
|
2009-11-25 |
2012-10-30 |
Japan Tobacco Inc. |
Indole compounds and pharmaceutical use thereof
|
|
JP5802676B2
(ja)
|
2009-12-04 |
2015-10-28 |
センワ バイオサイエンシズ インコーポレイテッド |
Ck2阻害剤としてのピラゾロピリミジンおよび関連複素環化合物
|
|
US9371567B2
(en)
|
2010-04-19 |
2016-06-21 |
The Translational Genomics Research Institute |
Methods and kits to predict therapeutic outcome of BTK inhibitors
|
|
EP2566869B1
(en)
|
2010-05-07 |
2016-03-02 |
Gilead Connecticut, Inc. |
Pyridone and aza-pyridone compounds and methods of use
|
|
ES2715611T3
(es)
|
2010-05-17 |
2019-06-05 |
Incozen Therapeutics Pvt Ltd |
Compuestos novedosos de 3H-imidazo[4,5-b]piridina-3,5-disustituida y 3H-[1,2,3]triazolo[4,5-b]piridina 3,5-disustituida como moduladores de proteína cinasas
|
|
US20130184223A1
(en)
|
2010-05-20 |
2013-07-18 |
University Of Rochester |
Methods and compositions related to modulating autophagy
|
|
AU2011260961B9
(en)
|
2010-05-31 |
2015-02-26 |
Ono Pharmaceutical Co., Ltd. |
Purinone derivative
|
|
NZ604040A
(en)
|
2010-06-03 |
2015-02-27 |
Pharmacyclics Inc |
The use of inhibitors of bruton’s tyrosine kinase (btk)
|
|
US20120071497A1
(en)
|
2010-06-03 |
2012-03-22 |
Pharmacyclics, Inc. |
Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase
|
|
CA2841142C
(en)
|
2010-06-23 |
2020-12-15 |
Ryan D. Morin |
Biomarkers for non-hodgkin lymphomas and uses thereof
|
|
CA2803056C
(en)
|
2010-06-23 |
2017-05-16 |
Hanmi Science Co., Ltd. |
Fused pyrimidine derivatives for inhibition of tyrosine kinase activity
|
|
GB2481611A
(en)
|
2010-06-30 |
2012-01-04 |
Statoil Asa |
Test cell for well fluid assessment
|
|
NZ607845A
(en)
|
2010-08-10 |
2015-03-27 |
Celgene Avilomics Res Inc |
Besylate salt of a btk inhibitor
|
|
AR082590A1
(es)
|
2010-08-12 |
2012-12-19 |
Hoffmann La Roche |
Inhibidores de la tirosina-quinasa de bruton
|
|
EP2609098B1
(en)
|
2010-08-27 |
2016-07-13 |
Merck Patent GmbH |
Triazolopyrazine derivatives
|
|
CN106220614B
(zh)
|
2010-09-01 |
2019-07-16 |
吉利德康涅狄格有限公司 |
吡啶酮/吡嗪酮、其制备方法及使用方法
|
|
KR101864908B1
(ko)
|
2010-09-01 |
2018-06-05 |
질레드 코네티컷 인코포레이티드 |
피리다지논, 그의 제조 방법 및 사용 방법
|
|
NZ708508A
(en)
|
2010-11-23 |
2016-06-24 |
Abbvie Bahamas Ltd |
Methods of treatment using selective bcl-2 inhibitors
|
|
MY181439A
(en)
|
2011-02-28 |
2020-12-22 |
Sunshine Lake Pharma Co Ltd |
Substituted quinoline compounds and methods of use
|
|
CN103889962B
(zh)
|
2011-04-01 |
2017-05-03 |
犹他大学研究基金会 |
作为受体酪氨酸激酶btk抑制剂的取代的n‑(3‑(嘧啶‑4‑基)苯基)丙烯酰胺类似物
|
|
EP2710006A1
(en)
|
2011-05-17 |
2014-03-26 |
Principia Biopharma Inc. |
Azaindole derivatives as tyrosine kinase inhibitors
|
|
AU2012257802A1
(en)
|
2011-05-17 |
2013-10-31 |
F. Hoffmann-La Roche Ag |
Inhibitors of Bruton's tyrosine kinase
|
|
SI2710005T1
(sl)
|
2011-05-17 |
2017-03-31 |
Principia Biopharma Inc. |
Zaviralci tirozinske kinaze
|
|
US9376438B2
(en)
|
2011-05-17 |
2016-06-28 |
Principia Biopharma, Inc. |
Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
|
|
US20140107151A1
(en)
|
2011-05-17 |
2014-04-17 |
Principia Biophama Inc. |
Tyrosine kinase inhibitors
|
|
JP6054379B2
(ja)
|
2011-06-07 |
2016-12-27 |
クレベクセル・ファーマClevexel Pharma |
キナーゼをモジュレートするための組成物および方法
|
|
CN103765212A
(zh)
|
2011-06-27 |
2014-04-30 |
杰克逊实验室 |
治疗癌症和自体免疫性疾病的方法和组合物
|
|
CN103732596B
(zh)
|
2011-07-08 |
2016-06-01 |
诺华股份有限公司 |
吡咯并嘧啶衍生物
|
|
EP2548877A1
(en)
|
2011-07-19 |
2013-01-23 |
MSD Oss B.V. |
4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
|
|
WO2013012918A1
(en)
|
2011-07-19 |
2013-01-24 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
|
EP3495368B1
(en)
|
2011-07-19 |
2023-05-31 |
Merck Sharp & Dohme B.V. |
(s)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-2-methoxy-n-(pyridin-2-yl)benzamide as btk-inhibitor
|
|
EP2734523A1
(en)
|
2011-07-19 |
2014-05-28 |
Merck Sharp & Dohme B.V. |
4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides btk-inhibitors
|
|
PE20140865A1
(es)
|
2011-08-17 |
2014-07-19 |
Hoffmann La Roche |
Inhibidores de la tirosina-quinasa de bruton
|
|
WO2013036994A1
(en)
|
2011-09-16 |
2013-03-21 |
Biota Scientific Management Pty Ltd |
Compounds for the treatment of hcv
|
|
EP2771010A4
(en)
|
2011-10-19 |
2015-04-01 |
Pharmacyclics Inc |
USE OF BRUTON TYROSINE KINASE (BTK) INHIBITORS
|
|
CN103073508B
(zh)
|
2011-10-25 |
2016-06-01 |
北京大学深圳研究生院 |
激酶抑制剂及治疗相关疾病的方法
|
|
EP2788020A4
(en)
|
2011-12-05 |
2015-04-29 |
Immunomedics Inc |
THERAPEUTIC USE OF ANTI-CD22 ANTIBODIES FOR THE INDUCTION OF TROGO CYTOSIS
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
CN104582705A
(zh)
|
2012-01-10 |
2015-04-29 |
林伯士艾瑞斯公司 |
白介素-1受体相关激酶(irak)抑制剂和其用途
|
|
US8501724B1
(en)
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
|
US20150072988A1
(en)
|
2012-03-30 |
2015-03-12 |
The Johns Hopkins University |
Use of n-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine in combination with histone deacetylase inhibitors for treatment of cancer
|
|
GB201207305D0
(en)
|
2012-04-26 |
2012-06-13 |
E Therapeutics Plc |
Therapy
|
|
JP5514256B2
(ja)
|
2012-05-18 |
2014-06-04 |
株式会社東芝 |
磁気記憶素子及びその製造方法
|
|
EA201492082A1
(ru)
|
2012-06-04 |
2015-03-31 |
Фармасайкликс, Инк. |
Кристаллические формы ингибитора тирозинкиназы брутона
|
|
AU2013280644B2
(en)
|
2012-06-26 |
2018-08-02 |
Jeffrey A. BACHA |
Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or AHI1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
|
|
WO2014004707A1
(en)
|
2012-06-29 |
2014-01-03 |
Principia Biopharma Inc. |
Formulations comprising ibrutinib
|
|
CA3135005A1
(en)
|
2012-07-10 |
2014-01-16 |
The Regents Of The University Of California |
Methods of inducing anesthesia
|
|
US8684552B2
(en)
|
2012-07-11 |
2014-04-01 |
Agio International Company, Ltd |
Lighted furniture assembly
|
|
KR20150032340A
(ko)
|
2012-07-24 |
2015-03-25 |
파마시클릭스, 인코포레이티드 |
브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
|
|
MX2015002947A
(es)
|
2012-09-07 |
2015-09-23 |
Genentech Inc |
Terapia de combinacion de un anticuerpo ant-cd20 tipo ii con un inhibidor blc-2 selectivo.
|
|
US9944991B2
(en)
|
2012-11-02 |
2018-04-17 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies
|
|
EA201590822A1
(ru)
|
2012-11-02 |
2016-01-29 |
Фармасайкликс, Инк. |
Адъювантная терапия ингибитором киназы семейства tec
|
|
MA38183A1
(fr)
|
2012-11-15 |
2017-03-31 |
Pharmacyclics Inc |
Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase
|
|
AU2014205577A1
(en)
|
2013-01-10 |
2015-05-28 |
Nimbus Iris, Inc. |
IRAK inhibitors and uses thereof
|
|
US9481682B2
(en)
|
2013-01-23 |
2016-11-01 |
Merck Sharp & Dohme Corp. |
Substituted benzamides and substituted pyridinecarboxamides as Btk inhibitors
|
|
AU2014214843A1
(en)
|
2013-02-07 |
2015-05-21 |
Immunomedics, Inc. |
Pro-drug form (P2PDox) of the highly potent 2-pyrrolinodoxorubicin conjugated to antibodies for targeted therapy of cancer
|
|
FR3002733B1
(fr)
|
2013-03-04 |
2015-08-14 |
Servier Lab |
Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
EP2964781B1
(en)
|
2013-03-08 |
2018-01-10 |
Roche Diagnostics GmbH |
Egfr mutation blood testing
|
|
JP2016512549A
(ja)
|
2013-03-14 |
2016-04-28 |
ファーマサイクリックス エルエルシー |
ブルトン型チロシンキナーゼ阻害剤及びcyp3a4阻害剤の組み合わせ
|
|
AU2014251028A1
(en)
|
2013-04-08 |
2015-11-05 |
Janssen Pharmaceutica Nv |
Ibrutinib combination therapy
|
|
SG10201709926VA
(en)
|
2013-05-30 |
2017-12-28 |
Infinity Pharmaceuticals Inc |
Treatment of cancers using pi3 kinase isoform modulators
|
|
PL3004106T3
(pl)
|
2013-06-07 |
2018-01-31 |
Rhizen Pharmaceuticals S A |
Podwójne selektywne inhibitory kinaz pi3 delta i gamma
|
|
CA2928568A1
(en)
|
2013-07-26 |
2015-01-29 |
Update Pharma Inc. |
Combinatorial methods to improve the therapeutic benefit of bisantrene
|
|
JP6800750B2
(ja)
|
2013-08-02 |
2020-12-16 |
ファーマサイクリックス エルエルシー |
固形腫瘍の処置方法
|
|
WO2015018522A1
(en)
|
2013-08-06 |
2015-02-12 |
Oncoethix Sa |
Bet-bromodomain inhibitor shows synergism with several anti-cancer agents in pre-clinical models of diffuse large b-cell lymphoma (dlbcl)
|
|
EP3033079B1
(en)
|
2013-08-12 |
2018-10-31 |
Pharmacyclics LLC |
Methods for the treatment of her2 amplified cancer
|
|
JP2016531941A
(ja)
|
2013-09-30 |
2016-10-13 |
ファーマサイクリックス エルエルシー |
ブルトン型チロシンキナーゼの阻害剤
|
|
US20150105409A1
(en)
|
2013-10-10 |
2015-04-16 |
Acetylon Pharmaceticals, Inc. |
Hdac inhibitors, alone or in combination with btk inhibitors, for treating nonhodgkin's lymphoma
|
|
US9795604B2
(en)
|
2013-10-25 |
2017-10-24 |
Pharmacyclics Llc |
Methods of treating and preventing graft versus host disease
|
|
JP6508785B2
(ja)
|
2013-10-25 |
2019-05-08 |
ファーマサイクリックス エルエルシー |
ブルトンチロシンキナーゼ阻害剤および免疫療法を使用する処置
|
|
JP2016537345A
(ja)
|
2013-11-13 |
2016-12-01 |
ノバルティス アーゲー |
免疫応答を増強するためのmTOR阻害剤
|
|
WO2015084892A1
(en)
|
2013-12-02 |
2015-06-11 |
Cornell University |
Methods for treating b cell proliferative disorders
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
CN106008516A
(zh)
|
2014-01-29 |
2016-10-12 |
苏州晶云药物科技有限公司 |
依鲁替尼的新晶型及其制备方法
|
|
WO2015127234A1
(en)
|
2014-02-20 |
2015-08-27 |
Board Of Regents, The University Of Texas System |
Use of ibrutinib to treat egfr mutant cancer
|
|
WO2015127261A1
(en)
|
2014-02-21 |
2015-08-27 |
Pharmacyclics, Inc. |
Biomarkers for predicting response of dlbcl to treatment with ibrutinib
|
|
JP2017509336A
(ja)
|
2014-03-20 |
2017-04-06 |
ファーマサイクリックス エルエルシー |
ホスホリパーゼcガンマ2及び耐性に関連した変異
|
|
NZ724796A
(en)
|
2014-04-04 |
2019-04-26 |
Bionomics Ltd |
Method for treating chronic lymphocytic leukemia
|
|
PE20170189A1
(es)
|
2014-05-28 |
2017-03-15 |
Novartis Ag |
Nuevos derivados de pirazolo pirimidina y su uso como inhibidores de malt1
|
|
US20150361504A1
(en)
|
2014-06-13 |
2015-12-17 |
Pharmacyclics Llc |
Biomarker for predicting response of cll to treatment with a btk inhibitor
|
|
US9580418B2
(en)
|
2014-07-14 |
2017-02-28 |
Incyte Corporation |
Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
|
|
US20160022684A1
(en)
|
2014-07-25 |
2016-01-28 |
Pharmacyclics Llc |
Bet inhibitor and bruton's tyrosine kinase inhibitor combinations
|
|
AU2015296010A1
(en)
|
2014-08-01 |
2017-02-02 |
Pharmacyclics Llc |
Biomarkers for predicting response of DLBCL to treatment with a BTK inhibitor
|
|
EP3193877A4
(en)
|
2014-08-07 |
2018-04-04 |
Pharmacyclics LLC |
Novel formulations of a bruton's tyrosine kinase inhibitor
|
|
EP3177366A4
(en)
|
2014-08-08 |
2018-04-04 |
Pharmacyclics LLC |
Bruton's tyrosine kinase inhibitor combinations and uses thereof
|
|
US20170231995A1
(en)
|
2014-08-11 |
2017-08-17 |
Acerta Pharma B.V. |
BTK Inhibitors to Treat Solid Tumors Through Modulation of the Tumor Microenvironment
|
|
US9738646B2
(en)
|
2014-09-16 |
2017-08-22 |
Gilead Sciences, Inc. |
Solid forms of a toll-like receptor modulator
|
|
WO2016044774A1
(en)
|
2014-09-18 |
2016-03-24 |
Pharmacyclics Llc |
Dendritic cell based vaccine with bruton's tyrosine kinase inhibitor
|
|
EA201790737A1
(ru)
|
2014-10-03 |
2017-08-31 |
Новартис Аг |
Комбинированная терапия
|
|
US20170298446A1
(en)
|
2014-10-03 |
2017-10-19 |
Ohio State Innovation Foundation |
Biomarkers of bruton tyrosine kinase inhibitor resistance
|
|
MX391478B
(es)
|
2014-10-10 |
2025-03-21 |
Idera Pharmaceuticals Inc |
Composiciones de agonista de tlr9 e inhibidores de punto de control para usarse en la respuesta inmune contra el cáncer.
|
|
MX389663B
(es)
|
2014-10-14 |
2025-03-20 |
Novartis Ag |
Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas.
|
|
TW201628622A
(zh)
|
2014-11-17 |
2016-08-16 |
製藥公司 |
Tlr抑制劑與布魯頓氏(bruton's)酪胺酸激酶抑制劑之組合
|
|
TWI595006B
(zh)
|
2014-12-09 |
2017-08-11 |
禮納特神經系統科學公司 |
抗pd-1抗體類和使用彼等之方法
|
|
WO2016106381A1
(en)
|
2014-12-23 |
2016-06-30 |
Pharmacyclics Llc |
Btk inhibitor combinations and dosing regimen
|
|
WO2016123504A1
(en)
|
2015-01-30 |
2016-08-04 |
Pharmacyclics Llc |
Btk inhibitor combinations and multidrug-resistance
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
AU2016216673B2
(en)
|
2015-03-04 |
2017-02-02 |
Gilead Sciences, Inc. |
Toll like receptor modulator compounds
|
|
WO2016161347A1
(en)
|
2015-04-03 |
2016-10-06 |
Pharmacyclics Llc |
Combinations for generating tumor-specific immunological memory
|
|
CN106336413B
(zh)
|
2015-07-09 |
2021-04-20 |
广东东阳光药业有限公司 |
作为jak抑制剂的化合物及其用途
|
|
WO2017011314A1
(en)
|
2015-07-10 |
2017-01-19 |
Paharmacyclics Llc |
Btk and hdac combinations
|
|
CN106474143A
(zh)
|
2015-08-26 |
2017-03-08 |
长春华普生物技术有限公司 |
Toll样受体TLR7和TLR9抑制性寡核苷酸在制备用于治疗B细胞淋巴瘤的药物方面的应用
|
|
CA2996177A1
(en)
|
2015-08-31 |
2017-03-09 |
Pharmacyclics Llc |
Btk inhibitor combinations for treating multiple myeloma
|
|
US20170071962A1
(en)
|
2015-09-11 |
2017-03-16 |
Acerta Pharma B.V. |
Therapeutic Combinations of a Proteasome Inhibitor and a BTK Inhibitor
|
|
WO2017087947A2
(en)
|
2015-11-19 |
2017-05-26 |
Pharmacyclics Llc |
Method of treatment of follicular lymphoma with a btk inhibitor
|