MX2020006151A - Mutaciones asociadas a resistencia a inhibidores de la tirosina cinasa de bruton (btk). - Google Patents

Mutaciones asociadas a resistencia a inhibidores de la tirosina cinasa de bruton (btk).

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Publication number
MX2020006151A
MX2020006151A MX2020006151A MX2020006151A MX2020006151A MX 2020006151 A MX2020006151 A MX 2020006151A MX 2020006151 A MX2020006151 A MX 2020006151A MX 2020006151 A MX2020006151 A MX 2020006151A MX 2020006151 A MX2020006151 A MX 2020006151A
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MX
Mexico
Prior art keywords
btk
polypeptides
modified
methods
inhibitors
Prior art date
Application number
MX2020006151A
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English (en)
Inventor
Joseph J Buggy
Betty Y Chang
Susanne M Steggerda
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Pharmacyclics Llc
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Publication date
Application filed by Pharmacyclics Llc filed Critical Pharmacyclics Llc
Publication of MX2020006151A publication Critical patent/MX2020006151A/es

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
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    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase
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    • C12Y301/04—Phosphoric diester hydrolases (3.1.4)
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Abstract

En el presente documento se describen mutaciones que confieren resistencia al tratamiento con un inhibidor de BTK. En el presente documento se describen polipéptidos de BTK modificada que presentan disminución de la inhibición (es decir, son resistentes) a un inhibidor de BTK covalente y/o irreversible. En el presente documento también se describen modificaciones de polipéptidos de PLC?2 y CARD11 que confieren resistencia al tratamiento con un inhibidor de BTK. En el presente documento se describen procedimientos de diagnóstico para detectar los polipéptidos y ácidos nucleicos modificados que codifican los polipéptidos modificados y aplicaciones de los procedimientos de los mismos. En el presente documento se describen composiciones, combinaciones y kits que contienen los polipéptidos modificados y procedimientos de uso de los polipéptidos modificados. En el presente documento también se describen procedimientos de uso de polipéptidos de BTK modificada como agentes de exploración para la identificación y diseño de inhibidores de BTK de segunda generación.
MX2020006151A 2012-07-24 2015-01-23 Mutaciones asociadas a resistencia a inhibidores de la tirosina cinasa de bruton (btk). MX2020006151A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261675303P 2012-07-24 2012-07-24
US201261682688P 2012-08-13 2012-08-13
US201361780652P 2013-03-13 2013-03-13

Publications (1)

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MX2020006151A true MX2020006151A (es) 2020-08-13

Family

ID=48948511

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Application Number Title Priority Date Filing Date
MX2015001081A MX2015001081A (es) 2012-07-24 2013-07-23 Mutaciones asociadas a resistencia a inhibidores de la tirosina cinasa de bruton (btk).
MX2020006151A MX2020006151A (es) 2012-07-24 2015-01-23 Mutaciones asociadas a resistencia a inhibidores de la tirosina cinasa de bruton (btk).

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MX2015001081A MX2015001081A (es) 2012-07-24 2013-07-23 Mutaciones asociadas a resistencia a inhibidores de la tirosina cinasa de bruton (btk).

Country Status (11)

Country Link
US (1) US10954567B2 (es)
EP (2) EP3550031A1 (es)
JP (2) JP6575950B2 (es)
KR (2) KR20180088926A (es)
CN (1) CN104704129A (es)
AU (1) AU2013293087B2 (es)
BR (1) BR112015001690A2 (es)
CA (1) CA2879570A1 (es)
HK (1) HK1206073A1 (es)
MX (2) MX2015001081A (es)
WO (1) WO2014018567A1 (es)

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JP2015530080A (ja) 2015-10-15
CA2879570A1 (en) 2014-01-30
JP2020000239A (ja) 2020-01-09
AU2013293087A1 (en) 2015-03-05
MX2015001081A (es) 2015-10-14
WO2014018567A1 (en) 2014-01-30
AU2013293087B2 (en) 2017-08-31
KR20150032340A (ko) 2015-03-25
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JP6575950B2 (ja) 2019-09-18
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