JP2015520193A5 - - Google Patents
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- JP2015520193A5 JP2015520193A5 JP2015516220A JP2015516220A JP2015520193A5 JP 2015520193 A5 JP2015520193 A5 JP 2015520193A5 JP 2015516220 A JP2015516220 A JP 2015516220A JP 2015516220 A JP2015516220 A JP 2015516220A JP 2015520193 A5 JP2015520193 A5 JP 2015520193A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- amino acid
- acid sequence
- protein
- homologue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020001507 fusion proteins Proteins 0.000 claims 26
- 102000037865 fusion proteins Human genes 0.000 claims 26
- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 108010063954 Mucins Proteins 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 101001133059 Homo sapiens Mucin-19 Proteins 0.000 claims 5
- 102100034257 Mucin-19 Human genes 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 101000599048 Homo sapiens Interleukin-6 receptor subunit alpha Proteins 0.000 claims 2
- 101000623897 Homo sapiens Mucin-12 Proteins 0.000 claims 2
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 2
- 102100023143 Mucin-12 Human genes 0.000 claims 2
- 108010011459 Exenatide Proteins 0.000 claims 1
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 1
- 101000623900 Homo sapiens Mucin-13 Proteins 0.000 claims 1
- 101000623905 Homo sapiens Mucin-15 Proteins 0.000 claims 1
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims 1
- 101000623904 Homo sapiens Mucin-17 Proteins 0.000 claims 1
- 101001133081 Homo sapiens Mucin-2 Proteins 0.000 claims 1
- 101000972284 Homo sapiens Mucin-3A Proteins 0.000 claims 1
- 101000972285 Homo sapiens Mucin-3B Proteins 0.000 claims 1
- 101000972286 Homo sapiens Mucin-4 Proteins 0.000 claims 1
- 101000972282 Homo sapiens Mucin-5AC Proteins 0.000 claims 1
- 101000972276 Homo sapiens Mucin-5B Proteins 0.000 claims 1
- 101000972278 Homo sapiens Mucin-6 Proteins 0.000 claims 1
- 101000972273 Homo sapiens Mucin-7 Proteins 0.000 claims 1
- 101001121378 Homo sapiens Oviduct-specific glycoprotein Proteins 0.000 claims 1
- -1 MUC8 Proteins 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 102100023124 Mucin-13 Human genes 0.000 claims 1
- 102100023128 Mucin-15 Human genes 0.000 claims 1
- 102100023123 Mucin-16 Human genes 0.000 claims 1
- 102100023125 Mucin-17 Human genes 0.000 claims 1
- 102100034263 Mucin-2 Human genes 0.000 claims 1
- 102100022497 Mucin-3A Human genes 0.000 claims 1
- 102100022702 Mucin-3B Human genes 0.000 claims 1
- 102100022693 Mucin-4 Human genes 0.000 claims 1
- 102100022496 Mucin-5AC Human genes 0.000 claims 1
- 102100022494 Mucin-5B Human genes 0.000 claims 1
- 102100022493 Mucin-6 Human genes 0.000 claims 1
- 102100022492 Mucin-7 Human genes 0.000 claims 1
- 102100026327 Oviduct-specific glycoprotein Human genes 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- JUFFVKRROAPVBI-PVOYSMBESA-N chembl1210015 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@H]1[C@@H]([C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@]3(O[C@@H](C[C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C3)C(O)=O)O2)O)[C@@H](CO)O1)NC(C)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 JUFFVKRROAPVBI-PVOYSMBESA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960001519 exenatide Drugs 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657378P | 2012-06-08 | 2012-06-08 | |
| US201261657264P | 2012-06-08 | 2012-06-08 | |
| US201261657285P | 2012-06-08 | 2012-06-08 | |
| US61/657,264 | 2012-06-08 | ||
| US61/657,378 | 2012-06-08 | ||
| US61/657,285 | 2012-06-08 | ||
| US201261723081P | 2012-11-06 | 2012-11-06 | |
| US61/723,081 | 2012-11-06 | ||
| US201361778575P | 2013-03-13 | 2013-03-13 | |
| US201361778812P | 2013-03-13 | 2013-03-13 | |
| US61/778,812 | 2013-03-13 | ||
| US61/778,575 | 2013-03-13 | ||
| PCT/US2013/044552 WO2013184939A2 (en) | 2012-06-08 | 2013-06-06 | Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520193A JP2015520193A (ja) | 2015-07-16 |
| JP2015520193A5 true JP2015520193A5 (enExample) | 2016-07-21 |
| JP6234446B2 JP6234446B2 (ja) | 2017-11-22 |
Family
ID=49712642
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516219A Expired - Fee Related JP6322626B2 (ja) | 2012-06-08 | 2013-06-06 | ムチン−ドメインポリペプチドリンカーを含む融合ポリペプチド |
| JP2015516220A Expired - Fee Related JP6234446B2 (ja) | 2012-06-08 | 2013-06-06 | ムチンドメインポリペプチドに連結された活性タンパク質を含む融合ポリペプチド |
| JP2015516221A Active JP6388408B2 (ja) | 2012-06-08 | 2013-06-06 | アゴニストおよびアンタゴニストとしての循環置換により修飾されるリガンド |
| JP2017151506A Active JP6545759B2 (ja) | 2012-06-08 | 2017-08-04 | アゴニストおよびアンタゴニストとしての循環置換により修飾されるリガンド |
| JP2019113671A Active JP7048543B2 (ja) | 2012-06-08 | 2019-06-19 | アゴニストおよびアンタゴニストとしての循環置換により修飾されるリガンド |
| JP2021195887A Active JP7350041B2 (ja) | 2012-06-08 | 2021-12-02 | アゴニストおよびアンタゴニストとしての循環置換により修飾されるリガンド |
| JP2023085990A Ceased JP2023109948A (ja) | 2012-06-08 | 2023-05-25 | アゴニストおよびアンタゴニストとしての循環置換により修飾されるリガンド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516219A Expired - Fee Related JP6322626B2 (ja) | 2012-06-08 | 2013-06-06 | ムチン−ドメインポリペプチドリンカーを含む融合ポリペプチド |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516221A Active JP6388408B2 (ja) | 2012-06-08 | 2013-06-06 | アゴニストおよびアンタゴニストとしての循環置換により修飾されるリガンド |
| JP2017151506A Active JP6545759B2 (ja) | 2012-06-08 | 2017-08-04 | アゴニストおよびアンタゴニストとしての循環置換により修飾されるリガンド |
| JP2019113671A Active JP7048543B2 (ja) | 2012-06-08 | 2019-06-19 | アゴニストおよびアンタゴニストとしての循環置換により修飾されるリガンド |
| JP2021195887A Active JP7350041B2 (ja) | 2012-06-08 | 2021-12-02 | アゴニストおよびアンタゴニストとしての循環置換により修飾されるリガンド |
| JP2023085990A Ceased JP2023109948A (ja) | 2012-06-08 | 2023-05-25 | アゴニストおよびアンタゴニストとしての循環置換により修飾されるリガンド |
Country Status (20)
| Country | Link |
|---|---|
| US (8) | US9296801B2 (enExample) |
| EP (5) | EP3401402B1 (enExample) |
| JP (7) | JP6322626B2 (enExample) |
| AU (3) | AU2013271541C1 (enExample) |
| CA (3) | CA2869786A1 (enExample) |
| CY (2) | CY1120522T1 (enExample) |
| DK (2) | DK3401402T3 (enExample) |
| ES (4) | ES2675784T3 (enExample) |
| HR (2) | HRP20180914T1 (enExample) |
| HU (2) | HUE037849T2 (enExample) |
| LT (2) | LT3401402T (enExample) |
| ME (1) | ME03079B (enExample) |
| NZ (4) | NZ630851A (enExample) |
| PL (2) | PL3401402T3 (enExample) |
| PT (2) | PT3401402T (enExample) |
| RS (2) | RS57369B1 (enExample) |
| SI (2) | SI3401402T1 (enExample) |
| SM (2) | SMT202100007T1 (enExample) |
| TR (2) | TR201809046T4 (enExample) |
| WO (3) | WO2013184942A1 (enExample) |
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| HUE037849T2 (hu) * | 2012-06-08 | 2018-09-28 | Alkermes Pharma Ireland Ltd | Cirkuláris permutációval módosított ligandumok agonistaként és antagonistaként |
| MA40094B1 (fr) | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
| US20160175458A1 (en) * | 2014-12-19 | 2016-06-23 | Alkermes, Inc. | Single chain fc fusion proteins |
| WO2017120589A1 (en) * | 2016-01-08 | 2017-07-13 | Washington University | Compositions comprising chemerin and methods of use thereof |
| CA3026393C (en) | 2016-06-22 | 2023-03-14 | Alkermes, Inc. | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
| AU2017296354A1 (en) | 2016-07-11 | 2019-01-24 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Fusion proteins with extended serum half life |
| EP3600429B1 (en) * | 2017-03-20 | 2023-10-25 | Bio-Techne Corporation | Il-37 fusion protein and methods of making and using same |
| KR101784288B1 (ko) * | 2017-04-26 | 2017-10-11 | (주)넥스젠바이오텍 | 피부 세포 증식 효과가 증가한 성장 분화 인자 11과 열 충격 단백질 10의 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선용 화장료 조성물 |
| KR101800200B1 (ko) * | 2017-05-26 | 2017-11-23 | (주)넥스젠바이오텍 | 항산화 활성 및 피부 세포 증식 효과가 증가한 성장 분화 인자 11과 상피세포 성장인자의 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선용 화장료 조성물 |
| CA3064577A1 (en) | 2017-06-27 | 2019-01-03 | Codexis, Inc. | Penicillin-g acylases |
| CN107362351B (zh) * | 2017-09-04 | 2020-11-10 | 上海市儿童医院 | Il-36r的拮抗剂在制备镇痛药物中的应用 |
| IL275426B2 (en) | 2017-12-19 | 2025-03-01 | Xencor Inc | Engineered il-2 fc fusion proteins |
| EP3741774A4 (en) | 2018-01-19 | 2021-06-02 | Pepgene Inc. | N-TERMINAL FUSION APPROVED FOR THE PRODUCTION OF A RECOMBINANT POLYPEPTIDE, AND PROCESS FOR THE PRODUCTION OF A RECOMBINANT POLYPEPTIDE USING THE LATTER |
| BR112020018709A2 (pt) * | 2018-03-28 | 2021-01-05 | Bristol-Myers Squibb Company | Proteínas de fusão do receptor alfa de interleucina-2/interleucina-2 e métodos de uso |
| JP7485368B2 (ja) * | 2018-04-26 | 2024-05-16 | グッド ティー セルズ、 インコーポレイテッド | 新規な融合タンパク質およびこれを含む癌の予防または治療用薬学的組成物 |
| CN108948178A (zh) * | 2018-07-20 | 2018-12-07 | 安他杰（杭州）生物医药科技有限公司 | 一种改良的人il-37蛋白及其应用 |
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| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
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| JP7355326B2 (ja) * | 2019-08-05 | 2023-10-03 | デンカ株式会社 | 経粘膜投与薬剤 |
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