JP2016510596A5 - - Google Patents

Info

Publication number

JP2016510596A5

JP2016510596A5 JP2015561737A JP2015561737A JP2016510596A5 JP 2016510596 A5 JP2016510596 A5 JP 2016510596A5 JP 2015561737 A JP2015561737 A JP 2015561737A JP 2015561737 A JP2015561737 A JP 2015561737A JP 2016510596 A5 JP2016510596 A5 JP 2016510596A5

Authority

JP

Japan

Prior art keywords

fusion protein

seq

acid sequence

amino acid

protein according

Prior art date

2014-03-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108020001507 fusion proteins Proteins 0.000 claims 21
• 102000037865 fusion proteins Human genes 0.000 claims 21
• 125000003275 alpha amino acid group Chemical group 0.000 claims 9
• 102100030608 Mothers against decapentaplegic homolog 7 Human genes 0.000 claims 5
• 101700026522 SMAD7 Proteins 0.000 claims 5
• 150000001413 amino acids Chemical class 0.000 claims 5
• 230000004071 biological effect Effects 0.000 claims 5
• 230000004663 cell proliferation Effects 0.000 claims 3
• 230000002265 prevention Effects 0.000 claims 3
• 230000001737 promoting effect Effects 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 102000004169 proteins and genes Human genes 0.000 claims 3
• 230000026683 transduction Effects 0.000 claims 3
• 238000010361 transduction Methods 0.000 claims 3
• 230000003110 anti-inflammatory effect Effects 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 230000006378 damage Effects 0.000 claims 2
• 230000005764 inhibitory process Effects 0.000 claims 2
• 230000005855 radiation Effects 0.000 claims 2
• 230000004083 survival effect Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
• 230000005778 DNA damage Effects 0.000 claims 1
• 231100000277 DNA damage Toxicity 0.000 claims 1
• 201000004624 Dermatitis Diseases 0.000 claims 1
• 206010016654 Fibrosis Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 102100025751 Mothers against decapentaplegic homolog 2 Human genes 0.000 claims 1
• 101710143123 Mothers against decapentaplegic homolog 2 Proteins 0.000 claims 1
• 101710149951 Protein Tat Proteins 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 206010052428 Wound Diseases 0.000 claims 1
• 208000027418 Wounds and injury Diseases 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 230000033115 angiogenesis Effects 0.000 claims 1
• 230000003172 anti-dna Effects 0.000 claims 1
• 230000006907 apoptotic process Effects 0.000 claims 1
• 230000012292 cell migration Effects 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000010393 epithelial cell migration Effects 0.000 claims 1
• 230000004761 fibrosis Effects 0.000 claims 1
• 230000003176 fibrotic effect Effects 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 230000005937 nuclear translocation Effects 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 230000026731 phosphorylation Effects 0.000 claims 1
• 238000006366 phosphorylation reaction Methods 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1
• 238000001959 radiotherapy Methods 0.000 claims 1
• 230000004044 response Effects 0.000 claims 1
• 230000037390 scarring Effects 0.000 claims 1
• 208000003265 stomatitis Diseases 0.000 claims 1
• 230000000451 tissue damage Effects 0.000 claims 1
• 231100000827 tissue damage Toxicity 0.000 claims 1
• 230000029663 wound healing Effects 0.000 claims 1