CN105358704B - Ptd-smad7治疗剂 - Google Patents

Ptd-smad7治疗剂 Download PDF

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CN105358704B
CN105358704B CN201480025596.9A CN201480025596A CN105358704B CN 105358704 B CN105358704 B CN 105358704B CN 201480025596 A CN201480025596 A CN 201480025596A CN 105358704 B CN105358704 B CN 105358704B
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smad7
protein
tat
cells
oral
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CN105358704A (zh
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王晓京
张庆红
优素福·里法利
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University of Colorado Boulder
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/00—Drugs for dermatological disorders
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host

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  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biomedical Technology (AREA)
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  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201480025596.9A 2013-03-08 2014-03-07 Ptd-smad7治疗剂 Active CN105358704B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361775252P 2013-03-08 2013-03-08
US61/775,252 2013-03-08
PCT/US2014/022052 WO2014138670A1 (en) 2013-03-08 2014-03-07 Ptd-smad7 therapeutics

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CN105358704A CN105358704A (zh) 2016-02-24
CN105358704B true CN105358704B (zh) 2020-01-03

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US (5) US10456448B2 (enExample)
EP (1) EP2964774B1 (enExample)
JP (1) JP6576251B2 (enExample)
CN (1) CN105358704B (enExample)
CA (1) CA2904329C (enExample)
IL (1) IL241190B (enExample)
SG (1) SG11201507045TA (enExample)
WO (1) WO2014138670A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3536337A1 (en) 2010-09-22 2019-09-11 The Regents of the University of Colorado, a body corporate Therapeutic applications of smad7
WO2014138670A1 (en) 2013-03-08 2014-09-12 The Regents Of The University Of Colorado, A Body Corporate Ptd-smad7 therapeutics
KR101853923B1 (ko) * 2016-01-25 2018-05-02 연세대학교 산학협력단 Smad 단백질을 포함하는 자가 면역 질환 치료용 조성물, Smad 단백질을 포함하는 융합 단백질, 이를 제조하기 위한 벡터, 및 이의 제조 방법
EP3731854A4 (en) * 2017-12-30 2021-10-06 The Regents of The University of Colorado, A Body Corporate THERAPEUTICS MADE FROM PTD-SMAD7 FUSION PROTEINS
WO2022191244A1 (ja) * 2021-03-10 2022-09-15 国立大学法人熊本大学 コロナウイルス感染を検出する方法
EP4401785A4 (en) * 2021-09-15 2025-11-05 Univ Colorado Regents SMAD7 POLYPEPTIDE FORMULATIONS
WO2023150743A2 (en) * 2022-02-07 2023-08-10 Aavogen Inc. Codon-optimized smad7 gene therapy to treat and prevent muscle wasting and to enhance muscle mass

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HK1219986A1 (zh) 2017-04-21
CN105358704A (zh) 2016-02-24
SG11201507045TA (en) 2015-10-29
US20170000851A1 (en) 2017-01-05
WO2014138670A1 (en) 2014-09-12
US10456448B2 (en) 2019-10-29
EP2964774A4 (en) 2016-08-10
EP2964774B1 (en) 2020-05-06
US20200023037A1 (en) 2020-01-23
JP6576251B2 (ja) 2019-09-18
US20160039894A1 (en) 2016-02-11
CA2904329C (en) 2021-11-30
JP2016510596A (ja) 2016-04-11
IL241190A0 (en) 2015-11-30
IL241190B (en) 2019-09-26
US20140288006A1 (en) 2014-09-25
EP2964774A1 (en) 2016-01-13
CA2904329A1 (en) 2014-09-12
US20220370560A1 (en) 2022-11-24
US9422352B2 (en) 2016-08-23

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