DK0506884T3 - Fremgangsmåde til afgivelse af molekyler til eukaryotiske celler - Google Patents
Fremgangsmåde til afgivelse af molekyler til eukaryotiske cellerInfo
- Publication number
- DK0506884T3 DK0506884T3 DK91903111.2T DK91903111T DK0506884T3 DK 0506884 T3 DK0506884 T3 DK 0506884T3 DK 91903111 T DK91903111 T DK 91903111T DK 0506884 T3 DK0506884 T3 DK 0506884T3
- Authority
- DK
- Denmark
- Prior art keywords
- eukaryotic cells
- delivering molecules
- delivering
- interest
- molecule
- Prior art date
Links
- 210000003527 eukaryotic cell Anatomy 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000003855 cell nucleus Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45445089A | 1989-12-21 | 1989-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0506884T3 true DK0506884T3 (da) | 1996-11-04 |
Family
ID=23804657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91903111.2T DK0506884T3 (da) | 1989-12-21 | 1990-12-21 | Fremgangsmåde til afgivelse af molekyler til eukaryotiske celler |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0506884B1 (da) |
| JP (1) | JPH05505102A (da) |
| AT (1) | ATE142266T1 (da) |
| AU (1) | AU658818B2 (da) |
| CA (1) | CA2071214C (da) |
| DE (1) | DE69028412T2 (da) |
| DK (1) | DK0506884T3 (da) |
| ES (1) | ES2091916T3 (da) |
| GR (1) | GR3021474T3 (da) |
| WO (1) | WO1991009958A2 (da) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804604A (en) * | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
| US6316003B1 (en) | 1989-12-21 | 2001-11-13 | Whitehead Institute For Biomedical Research | Tat-derived transport polypeptides |
| US5674980A (en) * | 1989-12-21 | 1997-10-07 | Biogen Inc | Fusion protein comprising tat-derived transport moiety |
| NZ239893A (en) * | 1990-09-25 | 1993-11-25 | Hoechst Japan | A method for introducing a foreign dna into a cell |
| US5633230A (en) * | 1990-10-24 | 1997-05-27 | Allelix Biopharmaceuticals, Inc. | Treatment of cytomegalovirus infection |
| WO1993012234A1 (en) * | 1991-12-13 | 1993-06-24 | Sri International | Antiviral reagents based on rna-binding proteins |
| ES2123062T3 (es) | 1992-08-21 | 1999-01-01 | Biogen Inc | Polipeptidos de transporte derivados de la proteina tat. |
| IL106760A (en) * | 1992-08-25 | 1999-12-31 | Miles Inc | Nuclear Acid Protein Hybrid Structure for Transferring Nucleic Acid from External Source to Cell and Target Nucleus |
| JP3701966B2 (ja) * | 1993-01-26 | 2005-10-05 | ウェイナー，デービッド・ビー | 遺伝物質送達のための組成物および方法 |
| US7001759B1 (en) | 1993-01-26 | 2006-02-21 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| ES2320883T3 (es) * | 1993-01-26 | 2009-05-29 | The Trustees Of The University Of Pennsylvania (A Corporation Of Pennsylvania) | Composiciones y metodos para la administracion de material genetico. |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| JP2002502376A (ja) | 1997-05-21 | 2002-01-22 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | 生物学的膜を横切る輸送を増強するための組成物および方法 |
| US5891994A (en) | 1997-07-11 | 1999-04-06 | Thymon L.L.C. | Methods and compositions for impairing multiplication of HIV-1 |
| US6348185B1 (en) | 1998-06-20 | 2002-02-19 | Washington University School Of Medicine | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
| US8038984B2 (en) | 1998-06-20 | 2011-10-18 | Washington University | Membrane-permeant peptide complexes for treatment of sepsis |
| US7306784B2 (en) | 1998-06-20 | 2007-12-11 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
| US6589503B1 (en) | 1998-06-20 | 2003-07-08 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
| EP1210121A2 (en) | 1999-08-24 | 2002-06-05 | Cellgate Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
| US6730293B1 (en) | 1999-08-24 | 2004-05-04 | Cellgate, Inc. | Compositions and methods for treating inflammatory diseases of the skin |
| US6669951B2 (en) | 1999-08-24 | 2003-12-30 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
| US7229961B2 (en) | 1999-08-24 | 2007-06-12 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into ocular tissues |
| US6399067B1 (en) | 2000-04-28 | 2002-06-04 | Thymon L.L.C. | Methods and compositions for impairing multiplication of HIV-1 |
| KR100379578B1 (ko) * | 2000-07-26 | 2003-04-08 | 최수영 | 세포침투성 티에이티-씨3 트랜스페라제 융합단백질, 이융합단백질의 발현벡터 및 티에이티-씨3 트랜스페라제를이용한 로 단백질의 생리적 기능 분석방법 |
| KR100379577B1 (ko) * | 2000-07-26 | 2003-04-08 | 최수영 | 세포침투성 티에이티 - 인간 글루탐산 탈수소효소 융합단백질, 이 융합단백질을 코딩하는 재조합폴리뉴클레오타이드, 이 융합단백질의 발현벡터 및 이융합단백질을 세포 내로 도입하는 방법 |
| EP1401473B1 (en) | 2001-02-16 | 2009-07-29 | Cellgate Inc. | Transporters comprising spaced arginine moieties |
| JP2003009883A (ja) * | 2001-07-05 | 2003-01-14 | Mitsubishi Pharma Corp | マスト細胞の細胞死誘発剤 |
| KR100495138B1 (ko) * | 2001-07-31 | 2005-06-14 | 학교법인 한림대학교 | 식물세포 투과 도메인-화물분자 복합체 |
| DE10212867B4 (de) * | 2002-03-22 | 2005-07-21 | Hans Prof. Dr. Wolf | Verwendung Harnstoff-adjuvierter Polypeptide zur Diagnose, Prophylaxe und Therapie |
| KR100472939B1 (ko) * | 2002-05-24 | 2005-03-18 | 학교법인 한림대학교 | 세포침투성 티에이티-피리독살 카이네이즈 융합단백질 및그 용도 |
| WO2004009665A2 (en) | 2002-07-19 | 2004-01-29 | The Regents Of The University Of California | Dendrimers as molecular translocators |
| KR100472937B1 (ko) * | 2002-07-25 | 2005-03-10 | 학교법인 한림대학교 | 세포침투성 티에이티-사이토신 디아미네이즈 융합단백질및 그 용도 |
| US7183066B2 (en) * | 2002-09-27 | 2007-02-27 | Allergan, Inc. | Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins |
| WO2006088740A2 (en) | 2005-02-15 | 2006-08-24 | Thymon, L.L.C. | Methods and compositions for impairing multiplication of hiv-1 |
| WO2006094200A2 (en) * | 2005-03-03 | 2006-09-08 | The Trustees Of Boston College | Method of obtaining a desired localization for cellular imaging with the use of peptidoconjugates |
| US7935816B2 (en) | 2007-10-25 | 2011-05-03 | Gene Tools, Llc | Molecular transporter compositions comprising dendrimeric oligoguanidine with a triazine core that facilitate delivery into cells in vivo |
| WO2012040295A2 (en) | 2010-09-22 | 2012-03-29 | The Regents Of The University Of Colorado | Therapeutic applications of smad7 |
| EP2964774B1 (en) | 2013-03-08 | 2020-05-06 | The Regents of The University of Colorado, A Body Corporate | Ptd-smad7 therapeutics |
| KR101835554B1 (ko) | 2014-06-24 | 2018-04-19 | 서울대학교 산학협력단 | C/ebp를 포함하는 유도성 t 조절세포 분화촉진 또는 안정화 조성물 및 방법 |
| US11466069B2 (en) | 2017-04-28 | 2022-10-11 | Auckland Uniservices Limited | Methods of treatment and novel constructs |
| EP3790571B1 (en) | 2018-05-03 | 2024-08-14 | University Of Utah Research Foundation | Peptides derived from oca-b for use in the treatment of autoimmune diseases and of leukemia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1310924C (en) * | 1986-04-24 | 1992-12-01 | Francis P. Mccormick | Infective drug delivery system |
| EP0273085A1 (en) * | 1986-12-29 | 1988-07-06 | IntraCel Corporation | A method for internalizing nucleic acids into eukaryotic cells |
| US5354844A (en) * | 1989-03-16 | 1994-10-11 | Boehringer Ingelheim International Gmbh | Protein-polycation conjugates |
-
1990
- 1990-12-21 AT AT91903111T patent/ATE142266T1/de not_active IP Right Cessation
- 1990-12-21 DE DE69028412T patent/DE69028412T2/de not_active Expired - Lifetime
- 1990-12-21 ES ES91903111T patent/ES2091916T3/es not_active Expired - Lifetime
- 1990-12-21 EP EP91903111A patent/EP0506884B1/en not_active Expired - Lifetime
- 1990-12-21 JP JP91503306A patent/JPH05505102A/ja active Pending
- 1990-12-21 DK DK91903111.2T patent/DK0506884T3/da active
- 1990-12-21 WO PCT/US1990/007607 patent/WO1991009958A2/en active IP Right Grant
- 1990-12-21 AU AU71829/91A patent/AU658818B2/en not_active Expired
- 1990-12-21 CA CA002071214A patent/CA2071214C/en not_active Expired - Lifetime
-
1996
- 1996-10-24 GR GR960402831T patent/GR3021474T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0506884B1 (en) | 1996-09-04 |
| WO1991009958A3 (en) | 1991-08-08 |
| DE69028412D1 (de) | 1996-10-10 |
| DE69028412T2 (de) | 1997-03-27 |
| AU7182991A (en) | 1991-07-24 |
| ES2091916T3 (es) | 1996-11-16 |
| EP0506884A1 (en) | 1992-10-07 |
| WO1991009958A2 (en) | 1991-07-11 |
| GR3021474T3 (en) | 1997-01-31 |
| JPH05505102A (ja) | 1993-08-05 |
| AU658818B2 (en) | 1995-05-04 |
| ATE142266T1 (de) | 1996-09-15 |
| CA2071214C (en) | 2006-06-06 |
| CA2071214A1 (en) | 1991-06-22 |
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