DK1000154T3 - Identificering af humane cellelinjer til produktion af humane proteiner ved endogen genaktivering - Google Patents
Identificering af humane cellelinjer til produktion af humane proteiner ved endogen genaktiveringInfo
- Publication number
- DK1000154T3 DK1000154T3 DK98942592T DK98942592T DK1000154T3 DK 1000154 T3 DK1000154 T3 DK 1000154T3 DK 98942592 T DK98942592 T DK 98942592T DK 98942592 T DK98942592 T DK 98942592T DK 1000154 T3 DK1000154 T3 DK 1000154T3
- Authority
- DK
- Denmark
- Prior art keywords
- human
- production
- endogenous gene
- gene activation
- identification
- Prior art date
Links
- 102000003839 Human Proteins Human genes 0.000 title abstract 4
- 108090000144 Human Proteins Proteins 0.000 title abstract 4
- 230000004913 activation Effects 0.000 title abstract 2
- 210000005260 human cell Anatomy 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97112640 | 1997-07-23 | ||
| EP97121073 | 1997-12-01 | ||
| US09/113,692 US6548296B1 (en) | 1997-07-23 | 1998-07-10 | Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof |
| PCT/EP1998/004584 WO1999005267A1 (de) | 1997-07-23 | 1998-07-22 | Identifizierung humaner zellinien zur produktion humaner proteine durch endogene genaktivierung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1000154T3 true DK1000154T3 (da) | 2007-06-18 |
Family
ID=27238256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98942592T DK1000154T3 (da) | 1997-07-23 | 1998-07-22 | Identificering af humane cellelinjer til produktion af humane proteiner ved endogen genaktivering |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6395484B1 (da) |
| EP (1) | EP1000154B1 (da) |
| JP (1) | JP2001511342A (da) |
| CN (1) | CN1150319C (da) |
| AT (1) | ATE354654T1 (da) |
| AU (1) | AU737605B2 (da) |
| BR (1) | BR9811542A (da) |
| CA (1) | CA2298412C (da) |
| DE (1) | DE59813913D1 (da) |
| DK (1) | DK1000154T3 (da) |
| ES (1) | ES2281133T3 (da) |
| TR (1) | TR200000140T2 (da) |
| TW (1) | TWI224140B (da) |
| WO (1) | WO1999005267A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1000154E (pt) * | 1997-07-23 | 2007-03-30 | Roche Diagnostics Gmbh | Identificação de linhas celulares humanas para a produção de proteínas humanas por activação endógena de genes |
| GB0200977D0 (en) * | 2002-01-17 | 2002-03-06 | Lonza Biologics Plc | Glutamine-auxotrophic human cells capable of producing proteins and capable of growing in a glutamine-free medium |
| KR100982922B1 (ko) * | 2002-01-17 | 2010-09-20 | 론자 바이올로직스 피엘씨 | 단백질을 생산할 수 있으며 무글루타민 배지에서 성장할 수있는 글루타민-요구성 인간세포 |
| GB0208041D0 (en) * | 2002-04-08 | 2002-05-22 | Lonza Biologics Plc | Method of culturing animal cells |
| US11311574B2 (en) | 2003-08-08 | 2022-04-26 | Sangamo Therapeutics, Inc. | Methods and compositions for targeted cleavage and recombination |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| US7678570B2 (en) | 2004-03-01 | 2010-03-16 | Kitakyushu Foundation For The Advancement Of Industry, Science And Technology | Human cell strains for protein production, provided by selecting strains with high intracellular protein and mutating with carcinogens |
| DE102012009849A1 (de) | 2012-05-21 | 2013-11-21 | Hartwig Schwieger | Schwingungsstabilisierte Windenergieanlage-Zug-Druck-Knoten |
| JP6652334B2 (ja) | 2014-05-31 | 2020-02-19 | Ｊｃｒファーマ株式会社 | ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地 |
| AU2019301062A1 (en) * | 2018-07-09 | 2021-02-04 | NanoCav, LLC | Micro flow-through electroporation devices and methods of cell transfection |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin |
| JPS62171696A (ja) | 1986-01-23 | 1987-07-28 | Sumitomo Chem Co Ltd | ヒトエリスロポエチンの製造方法 |
| US4954437A (en) * | 1986-09-15 | 1990-09-04 | Integrated Genetics, Inc. | Cell encoding recombinant human erythropoietin |
| JP2879906B2 (ja) * | 1989-09-14 | 1999-04-05 | 鐘紡株式会社 | プロコラゲナーゼの製造方法 |
| EP0747485B1 (en) | 1989-11-06 | 1998-12-02 | Cell Genesys, Inc. | Production of proteins using homologous recombination |
| US5328844A (en) * | 1990-05-09 | 1994-07-12 | University Of Colorado Foundation, Inc. | Culture media for mammalian cells |
| US6270989B1 (en) * | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| US5641670A (en) * | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| PT101031B (pt) | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
| TW402639B (en) * | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| US5449015A (en) * | 1994-05-12 | 1995-09-12 | Petkovic; Tony | Shock-activated shut-off valve |
-
1998
- 1998-07-22 US US09/463,339 patent/US6395484B1/en not_active Expired - Lifetime
- 1998-07-22 EP EP98942592A patent/EP1000154B1/de not_active Expired - Lifetime
- 1998-07-22 WO PCT/EP1998/004584 patent/WO1999005267A1/de active IP Right Grant
- 1998-07-22 DK DK98942592T patent/DK1000154T3/da active
- 1998-07-22 ES ES98942592T patent/ES2281133T3/es not_active Expired - Lifetime
- 1998-07-22 CA CA2298412A patent/CA2298412C/en not_active Expired - Lifetime
- 1998-07-22 JP JP2000504242A patent/JP2001511342A/ja not_active Withdrawn
- 1998-07-22 AT AT98942592T patent/ATE354654T1/de active
- 1998-07-22 AU AU90674/98A patent/AU737605B2/en not_active Expired
- 1998-07-22 CN CNB988074982A patent/CN1150319C/zh not_active Expired - Lifetime
- 1998-07-22 TR TR2000/00140T patent/TR200000140T2/xx unknown
- 1998-07-22 DE DE59813913T patent/DE59813913D1/de not_active Expired - Lifetime
- 1998-07-22 BR BR9811542-1A patent/BR9811542A/pt not_active IP Right Cessation
- 1998-09-24 TW TW087115902A patent/TWI224140B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2298412C (en) | 2010-10-19 |
| WO1999005267A1 (de) | 1999-02-04 |
| CN1265144A (zh) | 2000-08-30 |
| CA2298412A1 (en) | 1999-02-04 |
| DE59813913D1 (de) | 2007-04-05 |
| EP1000154B1 (de) | 2007-02-21 |
| BR9811542A (pt) | 2000-08-22 |
| TWI224140B (en) | 2004-11-21 |
| TR200000140T2 (tr) | 2000-05-22 |
| EP1000154A1 (de) | 2000-05-17 |
| ES2281133T3 (es) | 2007-09-16 |
| US6395484B1 (en) | 2002-05-28 |
| AU9067498A (en) | 1999-02-16 |
| JP2001511342A (ja) | 2001-08-14 |
| ATE354654T1 (de) | 2007-03-15 |
| CN1150319C (zh) | 2004-05-19 |
| AU737605B2 (en) | 2001-08-23 |
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