NO984565L - Influensavirus replikert i pattedyrcellekultur og vaksinefremstilling - Google Patents
Influensavirus replikert i pattedyrcellekultur og vaksinefremstillingInfo
- Publication number
- NO984565L NO984565L NO984565A NO984565A NO984565L NO 984565 L NO984565 L NO 984565L NO 984565 A NO984565 A NO 984565A NO 984565 A NO984565 A NO 984565A NO 984565 L NO984565 L NO 984565L
- Authority
- NO
- Norway
- Prior art keywords
- cell culture
- mammalian cell
- influenza viruses
- vaccine production
- viruses replicated
- Prior art date
Links
- 238000004113 cell culture Methods 0.000 title 1
- 210000004962 mammalian cell Anatomy 0.000 title 1
- 241000712461 unidentified influenza virus Species 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
- C12N2760/16152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62838496A | 1996-04-05 | 1996-04-05 | |
US08/664,783 US5824536A (en) | 1994-08-23 | 1996-06-17 | Influenza virus replicated in mammalian cell culture and vaccine production |
PCT/US1997/005518 WO1997038094A1 (en) | 1996-04-05 | 1997-04-02 | Influenza virus replicated in mammalian cell culture and vaccine production |
Publications (2)
Publication Number | Publication Date |
---|---|
NO984565D0 NO984565D0 (no) | 1998-09-30 |
NO984565L true NO984565L (no) | 1998-12-03 |
Family
ID=27090697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO984565A NO984565L (no) | 1996-04-05 | 1998-09-30 | Influensavirus replikert i pattedyrcellekultur og vaksinefremstilling |
Country Status (8)
Country | Link |
---|---|
US (2) | US5824536A (no) |
EP (1) | EP0895535A4 (no) |
AU (1) | AU2722997A (no) |
CA (1) | CA2250716A1 (no) |
DE (1) | DE895535T1 (no) |
ES (1) | ES2139553T1 (no) |
NO (1) | NO984565L (no) |
WO (1) | WO1997038094A1 (no) |
Families Citing this family (81)
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DE19612967A1 (de) * | 1996-04-01 | 1997-10-02 | Behringwerke Ag | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
CA2355270A1 (en) * | 1998-12-17 | 2000-06-22 | Aventis Pasteur Limited | Multivalent immunogenic composition containing rsv subunit composition and influenza virus preparation |
IL136232A0 (en) * | 2000-05-18 | 2001-05-20 | Bar Ilan University Res Author | Measurements of enzymatic activity in a single, individual cell in population |
DE10144906B4 (de) | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
WO2003035824A1 (en) * | 2001-10-25 | 2003-05-01 | Bar-Ilan University | Interactive transparent individual cells biochip processor |
US6951752B2 (en) * | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
US6830917B2 (en) | 2001-12-10 | 2004-12-14 | Baxter Healthcare S.A. | Method of isolation and purification of trypsin from pronase protease and use thereof |
WO2003076462A1 (en) * | 2002-03-08 | 2003-09-18 | Crucell Holland B.V. | Use of recombinant trypsin for vaccine production |
US7465456B2 (en) * | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
CN103540568A (zh) * | 2002-04-26 | 2014-01-29 | 米迪缪尼有限公司 | 制备流感病毒的多质粒系统 |
KR101251902B1 (ko) | 2003-02-25 | 2013-04-08 | 메디뮨 엘엘씨 | 인플루엔자 백신 조성물의 제조 방법 |
US20060110406A1 (en) | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
IL154677A0 (en) * | 2003-02-27 | 2003-09-17 | Univ Bar Ilan | A method and apparatus for manipulating an individual cell |
WO2004110484A1 (fr) * | 2003-06-18 | 2004-12-23 | Gosudarstvenny Nauchny Tsentr Virusologii I Biotekhnologii 'vektor' | Procede de production d'un vaccin vivant de culture contre le virus de la grippe |
US7270990B2 (en) * | 2003-06-20 | 2007-09-18 | Microbix Biosystems, Inc. | Virus production |
EP1654347B1 (en) * | 2003-06-26 | 2014-06-04 | Seng Enterprises Limited | Improved materials for constructing cell-chips, cell-chip covers, cell-chip coats, processed cell-chips and uses thereof |
US8597597B2 (en) * | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
US7888110B2 (en) | 2003-06-26 | 2011-02-15 | Seng Enterprises Ltd. | Pico liter well holding device and method of making the same |
US7982751B2 (en) * | 2003-07-11 | 2011-07-19 | The University Of North Carolina | Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop |
US20050064524A1 (en) * | 2003-08-11 | 2005-03-24 | Mordechai Deutsch | Population of cells utilizable for substance detection and methods and devices using same |
US7037707B2 (en) * | 2003-09-04 | 2006-05-02 | St. Jude Children's Research Hospital | Method for generating influenza viruses and vaccines |
AU2004308328B2 (en) * | 2003-12-23 | 2009-06-04 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
US7544805B2 (en) * | 2004-02-03 | 2009-06-09 | Chemagis Ltd. | Stable amorphous forms of montelukast sodium |
WO2006003664A1 (en) * | 2004-07-07 | 2006-01-12 | Seng Enterprises Ltd. | Method and device for identifying an image of a well in an image of a well-bearing component |
US7403647B2 (en) * | 2004-09-13 | 2008-07-22 | Seng Enterprises Ltd. | Method for identifying an image of a well in an image of a well-bearing component |
EP1781404A2 (en) * | 2004-08-25 | 2007-05-09 | Seng Enterprises Limited | Method and device for isolating cells |
CA2890962A1 (en) | 2004-09-09 | 2006-03-16 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | Decreasing potential iatrogenic risks associated with influenza vaccines |
FR2878860A1 (fr) * | 2004-12-08 | 2006-06-09 | Vivalis Sa | Lignees de cellules souches humaines derivees de cellules es et utilisations pour la production de vaccins et de proteines recombinantes |
ES2526170T3 (es) * | 2004-12-23 | 2015-01-07 | Medimmune, Llc | Línea celular MDCK no tumorigénica para propagar virus |
DE602005023534D1 (de) | 2005-01-25 | 2010-10-21 | Seng Entpr Ltd | Mikrofluidische vorrichtung zur untersuchung zellen |
US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
KR20080025171A (ko) | 2005-06-21 | 2008-03-19 | 메드이뮨 백신즈 인코포레이티드 | 이종성 프로테아제를 발현시키기 위한 방법 및 조성물 |
US7790434B2 (en) * | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
DE102005034043B4 (de) * | 2005-07-18 | 2019-12-12 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Gemisch, enthaltend L-Carnitin und Trehalulose, sowie Produkt enthaltend das Gemisch |
US20070111309A1 (en) * | 2005-10-04 | 2007-05-17 | Daelli Marcelo G | Vero cell line adapted to grow in suspension |
US20070141555A1 (en) * | 2005-10-11 | 2007-06-21 | Mordechai Deutsch | Current damper for the study of cells |
NZ567817A (en) * | 2005-11-01 | 2012-01-12 | Novartis Vaccines & Diagnostic | Cell-derived viral vaccines with low levels of residual cell DNA by beta-propiolactone treatment |
US8288120B2 (en) * | 2005-11-03 | 2012-10-16 | Seng Enterprises Ltd. | Method for studying floating, living cells |
US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
DK2368572T3 (da) | 2005-11-04 | 2020-05-25 | Seqirus Uk Ltd | Adjuvansvacciner med ikke-virionantigener fremstillet fra influenza-virusser dyrket i cellekultur |
WO2007052061A2 (en) * | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines |
JP5491173B2 (ja) | 2006-04-19 | 2014-05-14 | メディミューン,エルエルシー | イヌ細胞中でマイナス鎖ウイルスrnaを発現させるための方法および組成物 |
CA3016948A1 (en) | 2006-09-11 | 2008-03-20 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
MX2009002741A (es) | 2006-09-15 | 2009-05-11 | Medimmune Llc | Lineas de celulas mdck que soportan el crecimiento viral para altos titulos y proceso de biorreactor que utiliza las mismas. |
US20080102505A1 (en) * | 2006-09-18 | 2008-05-01 | Petrie Thomas R Jr | Method of treating viral infections with ultraviolet light |
EP1911836A1 (en) | 2006-10-12 | 2008-04-16 | AVIR Green Hills Biotechnology Trading GmbH | Medium supplement for virus production |
CN101535486A (zh) * | 2006-10-23 | 2009-09-16 | 米迪缪尼有限公司 | 用于候选病毒疫苗的无血清病毒繁殖平台 |
NZ577405A (en) * | 2006-12-06 | 2012-08-31 | Novartis Ag | Vaccines including antigen from four strains of influenza virus |
UA100849C2 (ru) * | 2006-12-15 | 2013-02-11 | Шеринг-Плау Лтд. | Способ репликации вируса гриппа в культуре |
EP2091561A2 (en) * | 2006-12-15 | 2009-08-26 | Schering-Plough Ltd. | Method for replicating influenza virus in culture |
WO2008112218A2 (en) | 2007-03-12 | 2008-09-18 | Antigen Express, Inc. | Li-rnai involved li suppression in cancer immunotherapy |
WO2008128207A1 (en) * | 2007-04-13 | 2008-10-23 | Academia Sinica | Alpha-galactosyl ceramide analogs and their use as immunotherapies |
US7758867B2 (en) * | 2007-06-15 | 2010-07-20 | Biotrion Co., Ltd. | Attenuated influenza virus and a live vaccine comprising the same |
CA2690196A1 (en) | 2007-06-18 | 2008-12-24 | Medimmune, Llc | Influenza b viruses having alterations in the hemaglutinin polypeptide |
US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
US9975118B2 (en) | 2007-11-15 | 2018-05-22 | Seng Enterprises Ltd. | Device for the study of living cells |
US7928077B2 (en) * | 2008-07-11 | 2011-04-19 | Academia Sinica | Alpha-galactosyl ceramide analogs and their use as immunotherapies |
JP5689796B2 (ja) * | 2008-08-01 | 2015-03-25 | ガマ ワクチンズ ピーティワイ リミテッド | インフルエンザワクチン |
CA2738022A1 (en) | 2008-09-24 | 2010-04-01 | Medimmune, Llc | Methods for cultivating cells, propagating and purifying viruses |
CN102215865B (zh) | 2008-09-24 | 2013-10-30 | 米迪缪尼有限公司 | 病毒纯化方法 |
PL2396032T3 (pl) | 2009-02-10 | 2017-05-31 | Seqirus UK Limited | Szczepionki przeciw grypie o obniżonych zawartościach skwalenu |
CA2760657A1 (en) * | 2009-05-08 | 2010-11-11 | Glaxosmithkline Biologicals S.A. | Method for producing virus from cell culture involving homogenization |
WO2010144797A2 (en) | 2009-06-12 | 2010-12-16 | Vaccine Technologies, Incorporated | Influenza vaccines with enhanced immunogenicity and uses thereof |
CA2767392C (en) | 2009-07-06 | 2017-03-14 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
US9907746B2 (en) | 2009-07-06 | 2018-03-06 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
EP2295543A1 (en) * | 2009-09-11 | 2011-03-16 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for the preparation of an influenza virus |
US20110110975A1 (en) * | 2009-11-06 | 2011-05-12 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
AR080972A1 (es) | 2010-04-28 | 2012-05-23 | Abbott Biologicals Bv | Produccion de componentes virales |
JP6072677B2 (ja) * | 2010-05-06 | 2017-02-01 | ノバルティス アーゲー | 微生物の不活化のための有機ペルオキシド化合物 |
CA2840079C (en) | 2010-07-06 | 2018-07-03 | Variation Biotechnologies Inc. | Compositions and methods for treating influenza |
AU2012205315B2 (en) | 2011-01-13 | 2017-05-04 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
WO2012097346A1 (en) | 2011-01-13 | 2012-07-19 | Variation Biotechnologies, Inc. | Compositions and methods for treating viral infections |
EP2667891B1 (en) | 2011-01-27 | 2021-10-06 | Gamma Vaccines Pty Limited | Combination vaccines |
US9879229B2 (en) | 2011-03-14 | 2018-01-30 | National Research Council Of Canada | Method of viral production in cells |
WO2012151391A2 (en) | 2011-05-04 | 2012-11-08 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
US20140328876A1 (en) | 2011-11-18 | 2014-11-06 | Variation Biotechnologies Inc. | Synthetic derivatives of mpl and uses thereof |
EP2802353A4 (en) | 2012-01-12 | 2015-12-02 | Variation Biotechnologies Inc | COMPOSITIONS AND METHOD FOR THE TREATMENT OF VIRUS INFECTIONS |
US20150079077A1 (en) | 2012-01-27 | 2015-03-19 | Variation Biotechnologies, Inc. | Methods and compositions for therapeutic agents |
EP3740234A1 (en) * | 2018-01-18 | 2020-11-25 | Yisheng Biopharma (Singapore) Pte. Ltd. | Method for adapting influenza viruses to vero cells |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2445301A (en) * | 1941-12-05 | 1948-07-13 | Univ Pennsylvania | Influenza vaccine |
BE662899A (no) * | 1964-04-22 | |||
US4500513A (en) * | 1979-05-15 | 1985-02-19 | Miles Laboratories, Inc. | Influenza vaccine production in liquid cell culture |
ATE429246T1 (de) * | 1994-11-10 | 2009-05-15 | Baxter Healthcare Sa | Verfahren zur herstellung von biologischen produkten in protein-freiem kultur |
JPH11509081A (ja) * | 1994-11-16 | 1999-08-17 | セント ジュード チルドレンズ リサーチ ホスピタル | 新規の複製プロセス |
-
1996
- 1996-06-17 US US08/664,783 patent/US5824536A/en not_active Expired - Lifetime
-
1997
- 1997-04-02 DE DE0895535T patent/DE895535T1/de active Pending
- 1997-04-02 WO PCT/US1997/005518 patent/WO1997038094A1/en not_active Application Discontinuation
- 1997-04-02 EP EP97921094A patent/EP0895535A4/en not_active Withdrawn
- 1997-04-02 ES ES97921094T patent/ES2139553T1/es active Pending
- 1997-04-02 CA CA002250716A patent/CA2250716A1/en not_active Abandoned
- 1997-04-02 AU AU27229/97A patent/AU2722997A/en not_active Abandoned
-
1998
- 1998-06-16 US US09/097,712 patent/US6344354B1/en not_active Expired - Lifetime
- 1998-09-30 NO NO984565A patent/NO984565L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1997038094A1 (en) | 1997-10-16 |
US6344354B1 (en) | 2002-02-05 |
ES2139553T1 (es) | 2000-02-16 |
EP0895535A4 (en) | 2004-09-15 |
DE895535T1 (de) | 2000-03-02 |
NO984565D0 (no) | 1998-09-30 |
US5824536A (en) | 1998-10-20 |
CA2250716A1 (en) | 1997-10-16 |
AU2722997A (en) | 1997-10-29 |
EP0895535A1 (en) | 1999-02-10 |
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