EP0743981A4 - High performance cell culture bioreactor and method - Google Patents

High performance cell culture bioreactor and method

Info

Publication number
EP0743981A4
EP0743981A4 EP94915758A EP94915758A EP0743981A4 EP 0743981 A4 EP0743981 A4 EP 0743981A4 EP 94915758 A EP94915758 A EP 94915758A EP 94915758 A EP94915758 A EP 94915758A EP 0743981 A4 EP0743981 A4 EP 0743981A4
Authority
EP
European Patent Office
Prior art keywords
cell culture
high performance
culture bioreactor
performance cell
bioreactor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94915758A
Other languages
German (de)
French (fr)
Other versions
EP0743981A1 (en
Inventor
Randal A Goffe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genespan Corp
Original Assignee
UniSyn Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UniSyn Technologies Inc filed Critical UniSyn Technologies Inc
Publication of EP0743981A1 publication Critical patent/EP0743981A1/en
Publication of EP0743981A4 publication Critical patent/EP0743981A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP94915758A 1994-02-09 1994-02-09 High performance cell culture bioreactor and method Withdrawn EP0743981A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/002140 WO1995021911A1 (en) 1994-02-09 1994-02-09 High performance cell culture bioreactor and method

Publications (2)

Publication Number Publication Date
EP0743981A1 EP0743981A1 (en) 1996-11-27
EP0743981A4 true EP0743981A4 (en) 1999-09-08

Family

ID=22242305

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94915758A Withdrawn EP0743981A4 (en) 1994-02-09 1994-02-09 High performance cell culture bioreactor and method

Country Status (4)

Country Link
EP (1) EP0743981A4 (en)
JP (1) JPH09511392A (en)
AU (1) AU687059B2 (en)
WO (1) WO1995021911A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882918A (en) * 1995-08-08 1999-03-16 Genespan Corporation Cell culture incubator
US5622857A (en) * 1995-08-08 1997-04-22 Genespan Corporation High performance cell culture bioreactor and method
US6680166B1 (en) * 1995-06-07 2004-01-20 Claudy Jean Paul Mullon Dual fiber bioreactor
KR19990022612A (en) * 1995-06-08 1999-03-25 퍼니스 챨스 엠 DNA Extraction Method and Extraction Apparatus
DE69633189T2 (en) * 1995-10-06 2005-08-11 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Solid support for use in cell culture, in particular for the cultivation of liver cells, bioreactor containing the solid support, and the use thereof in a bio-artificial liver system
US5993406A (en) * 1997-05-14 1999-11-30 Cedars-Sinai Medical Center Artificial gut
US6027937A (en) * 1998-08-18 2000-02-22 Harper; William Method for propagation of insecta germ cells
CN1316014C (en) * 2004-04-09 2007-05-16 华东理工大学 Method for preparing stem cell of mesenchyme in marrow in large scale
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
CA2680130C (en) 2007-03-05 2016-01-12 Caridianbct, Inc. Cell expansion system and methods of use
US8906688B2 (en) 2007-04-13 2014-12-09 Terumo Bct, Inc. Cell expansion system and methods of use
US9057045B2 (en) 2009-12-29 2015-06-16 Terumo Bct, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
CN102869762B (en) 2010-05-05 2015-09-02 泰尔茂比司特公司 The method of the attached cell grown in renewed vaccination hollow-fiber bioreactor system
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US20120308531A1 (en) 2011-06-06 2012-12-06 ReGenesys BVBA Expansion of Stem Cells in Hollow Fiber Bioreactors
SG11201404608WA (en) 2012-02-13 2014-09-26 Gamida Cell Ltd Mesenchymal stem cells conditioned medium and methods of generating and using the same
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
EP2885393A1 (en) 2012-08-20 2015-06-24 Terumo BCT, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
JP2014117190A (en) * 2012-12-13 2014-06-30 Mitsubishi Rayon Co Ltd Device, module and method for non-adherent cell cultivation
US9617506B2 (en) 2013-11-16 2017-04-11 Terumo Bct, Inc. Expanding cells in a bioreactor
EP3613841B1 (en) 2014-03-25 2022-04-20 Terumo BCT, Inc. Passive replacement of media
US10077421B2 (en) 2014-04-24 2018-09-18 Terumo Bct, Inc. Measuring flow rate
EP3198006B1 (en) 2014-09-26 2021-03-24 Terumo BCT, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656842A1 (en) 2017-03-31 2020-05-27 Terumo BCT, Inc. Cell expansion

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63240774A (en) * 1987-03-27 1988-10-06 Ube Ind Ltd Bioreactor
JPS63317075A (en) * 1987-06-19 1988-12-26 Nok Corp Bubbling type bioreactor
JPH01222768A (en) * 1988-03-01 1989-09-06 Ube Ind Ltd Bioreactor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
US4220725A (en) * 1978-04-03 1980-09-02 United States Of America Capillary cell culture device
FR2580514B1 (en) * 1985-04-17 1989-08-18 Lyonnaise Eaux COMPOSITE ASSEMBLY OF FILTRATION MEMBRANES AND ITS USE IN A BIOREACTOR
US4720462A (en) * 1985-11-05 1988-01-19 Robert Rosenson Culture system for the culture of solid tissue masses and method of using the same
US5399493A (en) * 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
GB8921458D0 (en) * 1989-09-22 1989-11-08 Univ Strathclyde Cell culture apparatus
US5278063A (en) * 1989-09-28 1994-01-11 Board Of Regents The University Of Texas System Chemical modification of promote animal cell adhesion on surfaces

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63240774A (en) * 1987-03-27 1988-10-06 Ube Ind Ltd Bioreactor
JPS63317075A (en) * 1987-06-19 1988-12-26 Nok Corp Bubbling type bioreactor
JPH01222768A (en) * 1988-03-01 1989-09-06 Ube Ind Ltd Bioreactor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 013, no. 042 (C - 564) 30 January 1989 (1989-01-30) *
PATENT ABSTRACTS OF JAPAN vol. 013, no. 169 (C - 587) 21 April 1989 (1989-04-21) *
PATENT ABSTRACTS OF JAPAN vol. 013, no. 546 (C - 661) 6 December 1989 (1989-12-06) *
See also references of WO9521911A1 *

Also Published As

Publication number Publication date
EP0743981A1 (en) 1996-11-27
AU6765594A (en) 1995-08-29
JPH09511392A (en) 1997-11-18
WO1995021911A1 (en) 1995-08-17
AU687059B2 (en) 1998-02-19

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