JP2017518370A5 - - Google Patents
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- Publication number
- JP2017518370A5 JP2017518370A5 JP2017515014A JP2017515014A JP2017518370A5 JP 2017518370 A5 JP2017518370 A5 JP 2017518370A5 JP 2017515014 A JP2017515014 A JP 2017515014A JP 2017515014 A JP2017515014 A JP 2017515014A JP 2017518370 A5 JP2017518370 A5 JP 2017518370A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- pharmaceutical composition
- composition according
- eczema
- filaggrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 13
- 201000004624 Dermatitis Diseases 0.000 claims 10
- 208000010668 atopic eczema Diseases 0.000 claims 10
- 102100028314 Filaggrin Human genes 0.000 claims 9
- 101710088660 Filaggrin Proteins 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 238000004113 cell culture Methods 0.000 claims 8
- 230000001580 bacterial effect Effects 0.000 claims 7
- 230000002159 abnormal effect Effects 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 241000186429 Propionibacterium Species 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 241000186000 Bifidobacterium Species 0.000 claims 3
- 241000186146 Brevibacterium Species 0.000 claims 3
- 241000194033 Enterococcus Species 0.000 claims 3
- 241000186660 Lactobacillus Species 0.000 claims 3
- 241000194036 Lactococcus Species 0.000 claims 3
- 241000202223 Oenococcus Species 0.000 claims 3
- 241000192001 Pediococcus Species 0.000 claims 3
- 241000191940 Staphylococcus Species 0.000 claims 3
- 241000194017 Streptococcus Species 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940039696 lactobacillus Drugs 0.000 claims 3
- 241000192132 Leuconostoc Species 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000023095 Autosomal dominant epidermolytic ichthyosis Diseases 0.000 claims 1
- 108020000946 Bacterial DNA Proteins 0.000 claims 1
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 claims 1
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010013786 Dry skin Diseases 0.000 claims 1
- 201000009040 Epidermolytic Hyperkeratosis Diseases 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 206010020112 Hirsutism Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 208000002029 allergic contact dermatitis Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000000594 bullous pemphigoid Diseases 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000037336 dry skin Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 208000033286 epidermolytic ichthyosis Diseases 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 206010021198 ichthyosis Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 208000008742 seborrheic dermatitis Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462005652P | 2014-05-30 | 2014-05-30 | |
| US201462005558P | 2014-05-30 | 2014-05-30 | |
| US62/005,652 | 2014-05-30 | ||
| US62/005,558 | 2014-05-30 | ||
| PCT/US2015/032972 WO2015184134A1 (en) | 2014-05-30 | 2015-05-28 | Therapeutic tratment of skin disease with recombinant commensal skin microorganisms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205127A Division JP2021038271A (ja) | 2014-05-30 | 2020-12-10 | 組換え片利共生皮膚微生物による皮膚疾患の治療処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518370A JP2017518370A (ja) | 2017-07-06 |
| JP2017518370A5 true JP2017518370A5 (enExample) | 2018-07-12 |
| JP6810028B2 JP6810028B2 (ja) | 2021-01-06 |
Family
ID=54699800
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515014A Active JP6810028B2 (ja) | 2014-05-30 | 2015-05-28 | 組換え片利共生皮膚微生物による皮膚疾患の治療処置 |
| JP2020205127A Pending JP2021038271A (ja) | 2014-05-30 | 2020-12-10 | 組換え片利共生皮膚微生物による皮膚疾患の治療処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205127A Pending JP2021038271A (ja) | 2014-05-30 | 2020-12-10 | 組換え片利共生皮膚微生物による皮膚疾患の治療処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10702558B2 (enExample) |
| EP (2) | EP4144756A1 (enExample) |
| JP (2) | JP6810028B2 (enExample) |
| ES (1) | ES2929579T3 (enExample) |
| MA (1) | MA40057A (enExample) |
| WO (1) | WO2015184134A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6810028B2 (ja) | 2014-05-30 | 2021-01-06 | アジトラ，インコーポレイティド | 組換え片利共生皮膚微生物による皮膚疾患の治療処置 |
| JP2019514885A (ja) | 2016-04-21 | 2019-06-06 | ネイキッド バイオーム，インク． | 皮膚障害の処置のための組成物および方法 |
| KR20200021991A (ko) * | 2017-06-16 | 2020-03-02 | 아지트라 인코포레이티드 | Lekti 발현 재조합 미생물을 사용하는 네테르톤 증후군의 치료를 위한 조성물 및 방법 |
| MX2020002013A (es) * | 2017-08-31 | 2020-07-13 | Univ California | Bacterioterapia molecular para control de la actividad enzimatica de la piel. |
| CN111278447B (zh) * | 2017-09-05 | 2024-08-06 | 阿兹特拉公司 | 用重组微生物治疗炎性皮肤疾病的方法和组合物 |
| EP3720458A4 (en) | 2017-12-05 | 2021-12-08 | BioPlx, Inc. | METHODS AND COMPOSITIONS FOR PREVENTING MICROBIAL INFECTION |
| JP7121969B2 (ja) * | 2018-02-23 | 2022-08-19 | 株式会社北里コーポレーション | 培養液保護用液状物 |
| CA3096081A1 (en) | 2018-04-05 | 2019-10-10 | Azitra Inc | Methods and compositions for treating skin disease with recombinant microorganisms |
| AU2019203692B2 (en) * | 2018-08-30 | 2024-12-12 | Kenvue Brands Llc | Topical composition containing glycerin and yeast extract |
| US20210395775A1 (en) * | 2018-09-26 | 2021-12-23 | Krystal Biotech, Inc. | Compositions and methods for the treatment of skin diseases |
| WO2020076770A1 (en) * | 2018-10-08 | 2020-04-16 | Yale University | Selective binding and aggregation of human keratin in the skin barrier using human filaggrin subdomains sd67 and sd150 |
| CN112969781A (zh) * | 2018-11-16 | 2021-06-15 | 阿兹特拉公司 | 葡萄球菌属细菌的营养缺陷型菌株 |
| CZ308231B6 (cs) * | 2019-02-11 | 2020-03-11 | BiomCare s.r.o. | Kombinované několikastupňové mikrobiální přípravky a způsob jejich aplikace |
| AU2020254753A1 (en) * | 2019-04-05 | 2021-10-28 | Azitra Inc | Methods and compositions for treating atopic dermatitis with recombinant microorganisms |
| US20220362358A1 (en) * | 2019-06-19 | 2022-11-17 | Chan Zuckerberg Biohub, Inc. | Bacteria-engineered to elicit antigen-specific t-cells |
| WO2021154938A1 (en) * | 2020-01-29 | 2021-08-05 | The Jackson Laboratory | Bacterial admixtures |
| KR20230088803A (ko) * | 2020-10-21 | 2023-06-20 | 더 잭슨 래보라토리 | 항미생물성 바이오센서 |
| EP4274435A1 (en) * | 2021-01-05 | 2023-11-15 | Lactobio A/S | Strains, compositions and methods of use |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0637384B2 (ja) | 1985-09-21 | 1994-05-18 | 株式会社資生堂 | 皮膚化粧料 |
| US4659774A (en) | 1985-11-01 | 1987-04-21 | American Hoechst Corporation | Support for solid-phase oligonucleotide synthesis |
| DE4221268C2 (de) | 1992-06-26 | 1997-06-12 | Lancaster Group Ag | Verwendung eines Dermatikums zur Unterstützung des Sauerstofftransportes in der Haut |
| DE4221255C2 (de) | 1992-06-26 | 1994-09-15 | Lancaster Group Ag | Phospholipide enthaltendes Kosmetikum |
| WO2011038210A2 (en) | 2009-09-25 | 2011-03-31 | Curna, Inc. | Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity |
| DK2504357T3 (en) | 2009-11-23 | 2017-10-23 | Res Dev Foundation | RECOMBINANT FILAGGRIN POLYPEPTIDES FOR CELL IMPORT |
| US20130078275A1 (en) * | 2010-05-25 | 2013-03-28 | The Board Of Trustees Of The University Of Illinois | Novel systems, vectors, and methods for delivery of biomolecules to eukaryotic cells |
| MX2015001751A (es) | 2012-08-07 | 2015-11-13 | Topgenix Inc | Composicion topica comprendiendo bacterias transformadas que expresan un compuesto de interes. |
| KR101491240B1 (ko) | 2013-03-15 | 2015-02-11 | 현대자동차주식회사 | 인비저블 슬라이딩 도어 링크 구조 |
| JP6810028B2 (ja) | 2014-05-30 | 2021-01-06 | アジトラ，インコーポレイティド | 組換え片利共生皮膚微生物による皮膚疾患の治療処置 |
-
2015
- 2015-05-28 JP JP2017515014A patent/JP6810028B2/ja active Active
- 2015-05-28 ES ES15799765T patent/ES2929579T3/es active Active
- 2015-05-28 EP EP22182996.3A patent/EP4144756A1/en active Pending
- 2015-05-28 WO PCT/US2015/032972 patent/WO2015184134A1/en not_active Ceased
- 2015-05-28 EP EP15799765.1A patent/EP3148569B1/en active Active
- 2015-05-28 US US15/312,441 patent/US10702558B2/en active Active
- 2015-05-28 MA MA040057A patent/MA40057A/fr unknown
-
2020
- 2020-06-02 US US16/890,552 patent/US12036248B2/en active Active
- 2020-12-10 JP JP2020205127A patent/JP2021038271A/ja active Pending
-
2024
- 2024-06-06 US US18/735,645 patent/US20250009810A1/en active Pending
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