JP2017518370A5 - - Google Patents
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- Publication number
- JP2017518370A5 JP2017518370A5 JP2017515014A JP2017515014A JP2017518370A5 JP 2017518370 A5 JP2017518370 A5 JP 2017518370A5 JP 2017515014 A JP2017515014 A JP 2017515014A JP 2017515014 A JP2017515014 A JP 2017515014A JP 2017518370 A5 JP2017518370 A5 JP 2017518370A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- pharmaceutical composition
- composition according
- eczema
- filaggrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 13
- 201000004624 Dermatitis Diseases 0.000 claims 10
- 208000010668 atopic eczema Diseases 0.000 claims 10
- 102100028314 Filaggrin Human genes 0.000 claims 9
- 101710088660 Filaggrin Proteins 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 238000004113 cell culture Methods 0.000 claims 8
- 230000001580 bacterial effect Effects 0.000 claims 7
- 230000002159 abnormal effect Effects 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 241000186429 Propionibacterium Species 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 241000186000 Bifidobacterium Species 0.000 claims 3
- 241000186146 Brevibacterium Species 0.000 claims 3
- 241000194033 Enterococcus Species 0.000 claims 3
- 241000186660 Lactobacillus Species 0.000 claims 3
- 241000194036 Lactococcus Species 0.000 claims 3
- 241000202223 Oenococcus Species 0.000 claims 3
- 241000192001 Pediococcus Species 0.000 claims 3
- 241000191940 Staphylococcus Species 0.000 claims 3
- 241000194017 Streptococcus Species 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940039696 lactobacillus Drugs 0.000 claims 3
- 241000192132 Leuconostoc Species 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000023095 Autosomal dominant epidermolytic ichthyosis Diseases 0.000 claims 1
- 108020000946 Bacterial DNA Proteins 0.000 claims 1
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 claims 1
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010013786 Dry skin Diseases 0.000 claims 1
- 201000009040 Epidermolytic Hyperkeratosis Diseases 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 206010020112 Hirsutism Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 208000002029 allergic contact dermatitis Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000000594 bullous pemphigoid Diseases 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000037336 dry skin Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 208000033286 epidermolytic ichthyosis Diseases 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 206010021198 ichthyosis Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 208000008742 seborrheic dermatitis Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462005558P | 2014-05-30 | 2014-05-30 | |
| US201462005652P | 2014-05-30 | 2014-05-30 | |
| US62/005,558 | 2014-05-30 | ||
| US62/005,652 | 2014-05-30 | ||
| PCT/US2015/032972 WO2015184134A1 (en) | 2014-05-30 | 2015-05-28 | Therapeutic tratment of skin disease with recombinant commensal skin microorganisms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205127A Division JP2021038271A (ja) | 2014-05-30 | 2020-12-10 | 組換え片利共生皮膚微生物による皮膚疾患の治療処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518370A JP2017518370A (ja) | 2017-07-06 |
| JP2017518370A5 true JP2017518370A5 (enExample) | 2018-07-12 |
| JP6810028B2 JP6810028B2 (ja) | 2021-01-06 |
Family
ID=54699800
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515014A Active JP6810028B2 (ja) | 2014-05-30 | 2015-05-28 | 組換え片利共生皮膚微生物による皮膚疾患の治療処置 |
| JP2020205127A Pending JP2021038271A (ja) | 2014-05-30 | 2020-12-10 | 組換え片利共生皮膚微生物による皮膚疾患の治療処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205127A Pending JP2021038271A (ja) | 2014-05-30 | 2020-12-10 | 組換え片利共生皮膚微生物による皮膚疾患の治療処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10702558B2 (enExample) |
| EP (2) | EP4144756A1 (enExample) |
| JP (2) | JP6810028B2 (enExample) |
| ES (1) | ES2929579T3 (enExample) |
| MA (1) | MA40057A (enExample) |
| WO (1) | WO2015184134A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2929579T3 (es) | 2014-05-30 | 2022-11-30 | Azitra Inc | Tratamiento terapéutico de enfermedades cutáneas con microorganismos cutáneos comensales recombinantes |
| WO2017184992A1 (en) | 2016-04-21 | 2017-10-26 | Naked Biome, Inc. | Compositions and methods for treatment of skin disorders |
| WO2018232300A1 (en) * | 2017-06-16 | 2018-12-20 | Azitra Inc | Compositions and methods for treatment of netherton syndrome with lekti expressing recombinant microbes |
| EP3675884A4 (en) * | 2017-08-31 | 2021-08-11 | The Regents of the University of California | MOLECULAR BACTERIOTHERAPY TO CONTROL ENZYMATIC ACTIVITY OF THE SKIN |
| KR20250111396A (ko) * | 2017-09-05 | 2025-07-22 | 아지트라 인코포레이티드 | 재조합 미생물을 사용하여 염증성 피부 질환을 치료하기 위한 방법 및 조성물 |
| JP7460531B2 (ja) | 2017-12-05 | 2024-04-02 | バイオピーエルエックス，インコーポレイティド | 微生物感染を防ぐための方法および組成物 |
| JP7121969B2 (ja) * | 2018-02-23 | 2022-08-19 | 株式会社北里コーポレーション | 培養液保護用液状物 |
| JP2021528041A (ja) * | 2018-04-05 | 2021-10-21 | アジトラ インコーポレーテッド | 組換え微生物を用いて皮膚疾患を処置するための方法および組成物 |
| AU2019203692B2 (en) * | 2018-08-30 | 2024-12-12 | Kenvue Brands Llc | Topical composition containing glycerin and yeast extract |
| AU2019346461B2 (en) * | 2018-09-26 | 2026-01-22 | Krystal Biotech, Inc. | Compositions and methods for the treatment of skin diseases |
| WO2020076770A1 (en) * | 2018-10-08 | 2020-04-16 | Yale University | Selective binding and aggregation of human keratin in the skin barrier using human filaggrin subdomains sd67 and sd150 |
| JP2022513599A (ja) * | 2018-11-16 | 2022-02-09 | アジトラ インコーポレーテッド | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ細菌の栄養要求性株 |
| CZ308231B6 (cs) * | 2019-02-11 | 2020-03-11 | BiomCare s.r.o. | Kombinované několikastupňové mikrobiální přípravky a způsob jejich aplikace |
| EP3946412A4 (en) * | 2019-04-05 | 2023-01-04 | Azitra, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ATOPIC DERMATITIS WITH RECOMBINANT MICROORGANISMS |
| US20220362358A1 (en) * | 2019-06-19 | 2022-11-17 | Chan Zuckerberg Biohub, Inc. | Bacteria-engineered to elicit antigen-specific t-cells |
| US20230087622A1 (en) * | 2020-01-29 | 2023-03-23 | The Jackson Laboratory | Bacterial admixtures |
| KR20230088803A (ko) * | 2020-10-21 | 2023-06-20 | 더 잭슨 래보라토리 | 항미생물성 바이오센서 |
| JP2024506463A (ja) * | 2021-01-05 | 2024-02-14 | ラクトバイオ アー／エス | 菌株、組成物および使用方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0637384B2 (ja) * | 1985-09-21 | 1994-05-18 | 株式会社資生堂 | 皮膚化粧料 |
| US4659774A (en) | 1985-11-01 | 1987-04-21 | American Hoechst Corporation | Support for solid-phase oligonucleotide synthesis |
| DE4221255C2 (de) | 1992-06-26 | 1994-09-15 | Lancaster Group Ag | Phospholipide enthaltendes Kosmetikum |
| DE4221268C2 (de) | 1992-06-26 | 1997-06-12 | Lancaster Group Ag | Verwendung eines Dermatikums zur Unterstützung des Sauerstofftransportes in der Haut |
| NO2480669T3 (enExample) * | 2009-09-25 | 2018-04-07 | ||
| EP2504357B1 (en) | 2009-11-23 | 2017-08-02 | Research Development Foundation | Recombinant filaggrin polypeptides for cell importation |
| US20130078275A1 (en) * | 2010-05-25 | 2013-03-28 | The Board Of Trustees Of The University Of Illinois | Novel systems, vectors, and methods for delivery of biomolecules to eukaryotic cells |
| AU2013299605A1 (en) * | 2012-08-07 | 2015-03-26 | TopGeniX, Inc. | Topical composition comprising transformed bacteria expressing a compound of interest |
| KR101491240B1 (ko) | 2013-03-15 | 2015-02-11 | 현대자동차주식회사 | 인비저블 슬라이딩 도어 링크 구조 |
| ES2929579T3 (es) | 2014-05-30 | 2022-11-30 | Azitra Inc | Tratamiento terapéutico de enfermedades cutáneas con microorganismos cutáneos comensales recombinantes |
-
2015
- 2015-05-28 ES ES15799765T patent/ES2929579T3/es active Active
- 2015-05-28 WO PCT/US2015/032972 patent/WO2015184134A1/en not_active Ceased
- 2015-05-28 MA MA040057A patent/MA40057A/fr unknown
- 2015-05-28 EP EP22182996.3A patent/EP4144756A1/en active Pending
- 2015-05-28 US US15/312,441 patent/US10702558B2/en active Active
- 2015-05-28 EP EP15799765.1A patent/EP3148569B1/en active Active
- 2015-05-28 JP JP2017515014A patent/JP6810028B2/ja active Active
-
2020
- 2020-06-02 US US16/890,552 patent/US12036248B2/en active Active
- 2020-12-10 JP JP2020205127A patent/JP2021038271A/ja active Pending
-
2024
- 2024-06-06 US US18/735,645 patent/US20250009810A1/en active Pending
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