JP2017511133A5 - - Google Patents
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- JP2017511133A5 JP2017511133A5 JP2016559234A JP2016559234A JP2017511133A5 JP 2017511133 A5 JP2017511133 A5 JP 2017511133A5 JP 2016559234 A JP2016559234 A JP 2016559234A JP 2016559234 A JP2016559234 A JP 2016559234A JP 2017511133 A5 JP2017511133 A5 JP 2017511133A5
- Authority
- JP
- Japan
- Prior art keywords
- eza
- polypeptide
- amino acid
- seq
- infection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 229920001184 polypeptide Polymers 0.000 claims 28
- 102000004196 processed proteins & peptides Human genes 0.000 claims 28
- 102220502023 Ubiquitin-like modifier-activating enzyme 1_H25N_mutation Human genes 0.000 claims 14
- 150000001413 amino acids Chemical group 0.000 claims 14
- 102220608146 TYRO protein tyrosine kinase-binding protein_D50Q_mutation Human genes 0.000 claims 10
- 230000000694 effects Effects 0.000 claims 9
- 102220613929 Probable E3 ubiquitin-protein ligase HERC1_Y82F_mutation Human genes 0.000 claims 8
- 102000012479 Serine Proteases Human genes 0.000 claims 8
- 108010022999 Serine Proteases Proteins 0.000 claims 8
- 102220532601 Vacuolar protein sorting-associated protein 37A_I99L_mutation Human genes 0.000 claims 8
- 102220122750 rs886043192 Human genes 0.000 claims 8
- 102220482199 tRNA pseudouridine synthase A_K49E_mutation Human genes 0.000 claims 8
- 102220568693 Claudin-16_H71D_mutation Human genes 0.000 claims 6
- 108010062466 Enzyme Precursors Proteins 0.000 claims 6
- 102000010911 Enzyme Precursors Human genes 0.000 claims 6
- 230000000845 anti-microbial effect Effects 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000000813 microbial effect Effects 0.000 claims 6
- 102220286810 rs1034265990 Human genes 0.000 claims 6
- 102220080538 rs797045886 Human genes 0.000 claims 6
- 230000001747 exhibiting effect Effects 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 5
- 102220574082 Histone H3.Y_L63I_mutation Human genes 0.000 claims 4
- 102220618001 Phenylalanine-4-hydroxylase_S87R_mutation Human genes 0.000 claims 4
- 102220613921 Probable E3 ubiquitin-protein ligase HERC1_N98T_mutation Human genes 0.000 claims 4
- 102220639062 Protein Wnt-11_R74E_mutation Human genes 0.000 claims 4
- 102220490345 S-adenosylhomocysteine hydrolase-like protein 1_S85A_mutation Human genes 0.000 claims 4
- 208000036142 Viral infection Diseases 0.000 claims 4
- 102220362084 c.73C>T Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 102220215897 rs969611536 Human genes 0.000 claims 4
- 230000009385 viral infection Effects 0.000 claims 4
- 206010017533 Fungal infection Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 238000000547 structure data Methods 0.000 claims 3
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 102220492158 Homologous-pairing protein 2 homolog_K49S_mutation Human genes 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 102220632447 Mothers against decapentaplegic homolog 3_R74D_mutation Human genes 0.000 claims 2
- 208000031888 Mycoses Diseases 0.000 claims 2
- 102220543577 Polyunsaturated fatty acid 5-lipoxygenase_H25D_mutation Human genes 0.000 claims 2
- 102220509114 Sphingosine 1-phosphate receptor 1_Y97S_mutation Human genes 0.000 claims 2
- 102220489754 Ubiquitin-60S ribosomal protein L40_R74K_mutation Human genes 0.000 claims 2
- 206010052428 Wound Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000003000 inclusion body Anatomy 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 102200022232 rs387907176 Human genes 0.000 claims 2
- 102220014681 rs397517221 Human genes 0.000 claims 2
- 102220310946 rs61735157 Human genes 0.000 claims 2
- 102220243234 rs759807393 Human genes 0.000 claims 2
- 102220083748 rs863224812 Human genes 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 201000004647 tinea pedis Diseases 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 206010053555 Arthritis bacterial Diseases 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 206010006811 Bursitis Diseases 0.000 claims 1
- 241000222122 Candida albicans Species 0.000 claims 1
- 206010007134 Candida infections Diseases 0.000 claims 1
- 208000032544 Cicatrix Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000016942 Elastin Human genes 0.000 claims 1
- 108010014258 Elastin Proteins 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010061991 Grimacing Diseases 0.000 claims 1
- 241000430519 Human rhinovirus sp. Species 0.000 claims 1
- 208000004575 Infectious Arthritis Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 208000002260 Keloid Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 206010040844 Skin exfoliation Diseases 0.000 claims 1
- 206010042674 Swelling Diseases 0.000 claims 1
- 208000000491 Tendinopathy Diseases 0.000 claims 1
- 206010043255 Tendonitis Diseases 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 208000000260 Warts Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 238000001467 acupuncture Methods 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000038016 acute inflammation Diseases 0.000 claims 1
- 230000006022 acute inflammation Effects 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 230000032770 biofilm formation Effects 0.000 claims 1
- 201000003984 candidiasis Diseases 0.000 claims 1
- -1 carrier Substances 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 230000002995 comedolytic effect Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229920002549 elastin Polymers 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 230000003779 hair growth Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 210000001117 keloid Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000003300 oropharynx Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000001297 phlebitis Diseases 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 230000037387 scars Effects 0.000 claims 1
- 208000008742 seborrheic dermatitis Diseases 0.000 claims 1
- 201000001223 septic arthritis Diseases 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000004927 skin cell Anatomy 0.000 claims 1
- 201000010153 skin papilloma Diseases 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 201000004415 tendinitis Diseases 0.000 claims 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1405784.8A GB201405784D0 (en) | 2014-03-31 | 2014-03-31 | Novel methods, polypeptides and uses thereof |
| GB1405784.8 | 2014-03-31 | ||
| PCT/GB2015/051006 WO2015150799A1 (en) | 2014-03-31 | 2015-03-31 | Novel methods, polypeptides and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017511133A JP2017511133A (ja) | 2017-04-20 |
| JP2017511133A5 true JP2017511133A5 (enExample) | 2018-05-17 |
Family
ID=50737758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016559234A Pending JP2017511133A (ja) | 2014-03-31 | 2015-03-31 | 新規の方法、ポリペプチド、及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20170107503A1 (enExample) |
| EP (1) | EP3125926A1 (enExample) |
| JP (1) | JP2017511133A (enExample) |
| CN (1) | CN106257988A (enExample) |
| AU (1) | AU2015242380A1 (enExample) |
| BR (1) | BR112016022584A2 (enExample) |
| GB (1) | GB201405784D0 (enExample) |
| RU (1) | RU2016142580A (enExample) |
| WO (1) | WO2015150799A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3120866A1 (en) * | 2015-07-24 | 2017-01-25 | Zymetech ehf. | Use of marine serine proteases for removal, prevention and inhibition of formation and growth of biofilms |
| GB201701315D0 (en) | 2017-01-26 | 2017-03-15 | Enzymatica Ab | Novel treatments |
| US20200015499A1 (en) * | 2017-03-15 | 2020-01-16 | Dupont Nutrition Biosciences Aps | Trypsin-like serine proteases and uses thereof |
| GB201800274D0 (en) | 2018-01-08 | 2018-02-21 | Enzymatica Ab | Novel treatments |
| GB201801982D0 (en) | 2018-02-07 | 2018-03-28 | Enzymatica Ab | Novel treatments |
| US12325868B2 (en) | 2019-05-13 | 2025-06-10 | Bioseutica B.V. | Purified fish proteases with high specific activities and its process of production |
| WO2021191800A1 (en) | 2020-03-23 | 2021-09-30 | Kerecis Ag | Antimicrobial solutions and methods of using the same in the treatment or prevention of infections |
| JP7854397B2 (ja) * | 2020-05-13 | 2026-05-01 | ジーミキュー テクノロジー アクチエボラグ | 微生物感染治療のためのプロテアーゼ製剤 |
| CN115778864B (zh) * | 2022-12-12 | 2024-04-19 | 广州市美夫兰化妆品有限公司 | 一种祛斑净白抗皱冻干粉 |
| WO2026074475A1 (en) * | 2024-10-03 | 2026-04-09 | Onchilles Pharma, Inc. | Pharmaceutical compositions comprising protein complexes of modified a2m or a2ml |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| SE459005B (sv) | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| ATE278417T1 (de) * | 1999-06-18 | 2004-10-15 | Jon Bragi Bjarnason | Pharmazeutische- und kosmetischezusammensetzungen enthaldend serinproteasen aus kabeljau und deren pharmazeutische und kosmetische verwendung |
| WO2012104099A1 (en) * | 2011-02-04 | 2012-08-09 | Glucometrix Ag | Process for the production of recombinant trypsin |
| DK3099317T3 (en) * | 2014-01-29 | 2021-08-23 | Enzymatica Ab | Cod trypsin for use in the treatment of microbial infections in a subject with immunodeficiency |
-
2014
- 2014-03-31 GB GBGB1405784.8A patent/GB201405784D0/en not_active Ceased
-
2015
- 2015-03-31 WO PCT/GB2015/051006 patent/WO2015150799A1/en not_active Ceased
- 2015-03-31 US US15/300,567 patent/US20170107503A1/en not_active Abandoned
- 2015-03-31 JP JP2016559234A patent/JP2017511133A/ja active Pending
- 2015-03-31 AU AU2015242380A patent/AU2015242380A1/en not_active Abandoned
- 2015-03-31 CN CN201580018134.9A patent/CN106257988A/zh active Pending
- 2015-03-31 BR BR112016022584A patent/BR112016022584A2/pt not_active Application Discontinuation
- 2015-03-31 EP EP15719816.9A patent/EP3125926A1/en not_active Withdrawn
- 2015-03-31 RU RU2016142580A patent/RU2016142580A/ru not_active Application Discontinuation
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