JP2017513849A5 - - Google Patents

Info

Publication number

JP2017513849A5

JP2017513849A5 JP2016562764A JP2016562764A JP2017513849A5 JP 2017513849 A5 JP2017513849 A5 JP 2017513849A5 JP 2016562764 A JP2016562764 A JP 2016562764A JP 2016562764 A JP2016562764 A JP 2016562764A JP 2017513849 A5 JP2017513849 A5 JP 2017513849A5

Authority

JP

Japan

Prior art keywords

composition

seq

fragment

variant

amino acid

Prior art date

2015-04-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000012634 fragment Substances 0.000 claims 18
• 125000003275 alpha amino acid group Chemical group 0.000 claims 14
• 210000000440 neutrophil Anatomy 0.000 claims 13
• 241000124008 Mammalia Species 0.000 claims 10
• 101710085938 Matrix protein Proteins 0.000 claims 10
• 101710127721 Membrane protein Proteins 0.000 claims 10
• 230000000694 effects Effects 0.000 claims 10
• 108090000765 processed proteins & peptides Proteins 0.000 claims 10
• 241001505901 Streptococcus sp. 'group A' Species 0.000 claims 6
• 239000003795 chemical substances by application Substances 0.000 claims 6
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 5
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 5
• 108020004707 nucleic acids Proteins 0.000 claims 5
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 108090000623 proteins and genes Proteins 0.000 claims 5
• 241000894006 Bacteria Species 0.000 claims 4
• 102100032965 Myomesin-2 Human genes 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 208000035143 Bacterial infection Diseases 0.000 claims 2
• 108091005804 Peptidases Proteins 0.000 claims 2
• 239000004365 Protease Substances 0.000 claims 2
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
• 208000022362 bacterial infectious disease Diseases 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 230000002068 genetic effect Effects 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 102000004890 Interleukin-8 Human genes 0.000 claims 1
• 108090001007 Interleukin-8 Proteins 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 230000036039 immunity Effects 0.000 claims 1
• 230000003053 immunization Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
• 229940096397 interleukin-8 Drugs 0.000 claims 1
• 230000011242 neutrophil chemotaxis Effects 0.000 claims 1
• 238000011084 recovery Methods 0.000 claims 1