MX341317B - Proteinas de elastasa recombinantes y metodos de fabricacion y uso de las mismas. - Google Patents
Proteinas de elastasa recombinantes y metodos de fabricacion y uso de las mismas.Info
- Publication number
- MX341317B MX341317B MX2013000540A MX2013000540A MX341317B MX 341317 B MX341317 B MX 341317B MX 2013000540 A MX2013000540 A MX 2013000540A MX 2013000540 A MX2013000540 A MX 2013000540A MX 341317 B MX341317 B MX 341317B
- Authority
- MX
- Mexico
- Prior art keywords
- elastase proteins
- methods
- recombinant
- manufacturing
- proteins
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/486—Elastase (3.4.21.36 or 3.4.21.37)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6448—Elastases, e.g. pancreatic elastase (3.4.21.36); leukocyte elastase (3.4.31.37)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21036—Pancreatic elastase (3.4.21.36)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21037—Leukocyte elastase (3.4.21.37), i.e. neutrophil-elastase
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a métodos para la fabricación, purificación, formulación y uso de proteínas elastasa recombinantes, biológicamente activas. Se describen métodos recombinantes para producir proteínas elastasa terapéuticamente útiles, así como composiciones farmacéuticas que comprenden dichas proteínas elastasa. También se describen preparaciones de proteínas elastasa recombinantes novedosas y de proteína. Se describen métodos para tratar y prevenir enfermedades de los conductos biológicos utilizando las composiciones farmacéuticas que contienen las proteínas elastasa de la invención.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99231907P | 2007-12-04 | 2007-12-04 | |
US12/327,809 US8501449B2 (en) | 2007-12-04 | 2008-12-03 | Recombinant elastase proteins and methods of manufacturing and use thereof |
PCT/US2008/085559 WO2009079220A2 (en) | 2007-12-04 | 2008-12-04 | Recombinant elastase proteins and methods of manufacturing and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX341317B true MX341317B (es) | 2016-08-15 |
Family
ID=40344763
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013000540A MX341317B (es) | 2007-12-04 | 2008-12-04 | Proteinas de elastasa recombinantes y metodos de fabricacion y uso de las mismas. |
MX2010006211A MX2010006211A (es) | 2007-12-04 | 2008-12-04 | Proteínas elastasa recombinantes y métodos de fabricación y uso de las mismas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010006211A MX2010006211A (es) | 2007-12-04 | 2008-12-04 | Proteínas elastasa recombinantes y métodos de fabricación y uso de las mismas. |
Country Status (26)
Country | Link |
---|---|
US (14) | US8501449B2 (es) |
EP (3) | EP3176262A1 (es) |
JP (3) | JP5829808B2 (es) |
KR (3) | KR101732190B1 (es) |
CN (4) | CN101918547B (es) |
AR (1) | AR069584A1 (es) |
AU (1) | AU2008338743B2 (es) |
BR (1) | BRPI0819977A2 (es) |
CA (1) | CA2707051C (es) |
CY (2) | CY1114724T1 (es) |
DK (2) | DK2229440T3 (es) |
ES (2) | ES2436783T3 (es) |
HK (1) | HK1148772A1 (es) |
HR (2) | HRP20131135T1 (es) |
HU (1) | HUE032739T2 (es) |
IL (2) | IL206157A (es) |
LT (1) | LT2666854T (es) |
MX (2) | MX341317B (es) |
NZ (2) | NZ585866A (es) |
PL (2) | PL2229440T3 (es) |
PT (2) | PT2229440E (es) |
RS (2) | RS55982B1 (es) |
RU (1) | RU2611200C2 (es) |
SI (2) | SI2229440T1 (es) |
TW (2) | TWI577385B (es) |
WO (1) | WO2009079220A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8501449B2 (en) | 2007-12-04 | 2013-08-06 | Proteon Therapeutics, Inc. | Recombinant elastase proteins and methods of manufacturing and use thereof |
CN102250863B (zh) * | 2011-04-29 | 2012-12-05 | 天津金斯坦生物科技有限公司 | 基因重组人中性粒细胞弹性蛋白酶及其制备方法和该弹性蛋白酶的医药用途 |
US10202630B2 (en) * | 2013-03-15 | 2019-02-12 | Alderbio Holdings Llc | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
TWI636136B (zh) | 2013-03-15 | 2018-09-21 | 艾爾德生物製藥股份有限公司 | 在酵母菌及其它轉型細胞中多肽高產量表現用之溫度變動技術 |
WO2018165594A1 (en) * | 2017-03-10 | 2018-09-13 | Bolt Threads, Inc. | Compositions and methods for producing high secreted yields of recombinant proteins |
EP4065167A4 (en) * | 2019-11-26 | 2024-03-27 | Children's Hospital Medical Center | INHIBITION OF CELA-1 FOR THE TREATMENT OF PULMONARY DISEASE |
WO2021146233A1 (en) * | 2020-01-14 | 2021-07-22 | Basf Se | Method for producing recombinant protein in yeast cells |
JP2023545346A (ja) * | 2020-08-18 | 2023-10-30 | オンチレス・ファーマ・インコーポレイテッド | 改変ブタ膵臓エラスターゼタンパク質 |
CA3184037A1 (en) * | 2020-08-18 | 2022-02-24 | Onchilles Pharma, Inc. | Modified serine protease proproteins |
Family Cites Families (38)
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US2508408A (en) | 1943-10-11 | 1950-05-23 | Sidney H Liebson | Averaging indicator |
US2546308A (en) | 1948-12-29 | 1951-03-27 | Kahler John | Floor marking device |
US5212068A (en) * | 1985-04-05 | 1993-05-18 | Sankyo Company Limited | Human pancreatic elastase |
DE122007000007I2 (de) | 1986-04-09 | 2010-12-30 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
JPH0673456B2 (ja) * | 1986-04-26 | 1994-09-21 | 三共株式会社 | ヒト・膵臓エラスタ−ゼ▲i▼ |
US5162205A (en) | 1986-04-26 | 1992-11-10 | Sankyo Company, Limited | Human pancreatic elastase I |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
US5543302A (en) | 1988-05-27 | 1996-08-06 | Solvay Enzymes, Inc. | Proteases of altered stability to autolytic degradation |
DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
EP0747485B1 (en) | 1989-11-06 | 1998-12-02 | Cell Genesys, Inc. | Production of proteins using homologous recombination |
GB8927722D0 (en) | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
NZ236819A (en) | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
US5503333A (en) | 1993-06-23 | 1996-04-02 | Laventure; David | Duster extension tube system with dust collecting region and tube cleaner and method of using the same |
US5811252A (en) | 1994-07-07 | 1998-09-22 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Modified proenzymes as substrates for proteolytic enzymes |
US5955072A (en) | 1994-07-13 | 1999-09-21 | Sankyo Company, Limited | Expression systems utilizing autolyzing fusion proteins and a reducing polypeptide |
US7531325B2 (en) | 1997-04-25 | 2009-05-12 | Sembiosys Genetics Inc. | Method for cleavage of fusion proteins |
US20030207402A1 (en) | 1997-08-22 | 2003-11-06 | Erhard Kopetzki | Autocatalytically activatable zymogenic precursors of proteases and their use |
GB9817909D0 (en) | 1998-08-17 | 1998-10-14 | Zeneca Ltd | DNA constructs |
GB9908458D0 (en) | 1999-04-13 | 1999-06-09 | Queen Mary & Westfield College | Enzyme |
WO2000068363A2 (en) | 1999-05-05 | 2000-11-16 | Genentech, Inc. | Elastase variants and substrates |
US7001892B1 (en) * | 1999-06-11 | 2006-02-21 | Purdue Research Foundation | Pharmaceutical materials and methods for their preparation and use |
US7063838B1 (en) | 1999-09-24 | 2006-06-20 | Proteon Therapeutics Llc | Methods for treating an artery or vein in a human subject |
AU7612100A (en) * | 1999-09-24 | 2001-04-24 | Johns Hopkins University, The | Systems and methods for opening obstructed biological conduits |
US7351549B2 (en) | 2000-01-24 | 2008-04-01 | Polymun Scientific Immunbiologische Forschung Gmbh | Method for the manufacture of recombinant trypsin |
WO2001062983A1 (en) | 2000-02-24 | 2001-08-30 | Phylos, Inc. | Improved methods for generating catalytic proteins |
US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
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JP2007525423A (ja) | 2003-02-20 | 2007-09-06 | プロテオン セラピューティクス,インコーポレーテッド | 生体導管の疾患を治療および予防するための方法 |
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US20070004658A1 (en) * | 2004-06-21 | 2007-01-04 | Nick Vandeghinste | Method and means for treatment of osteoarthritis |
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RU2299070C2 (ru) * | 2005-02-08 | 2007-05-20 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая композиция для лечения заболевания вен и способ ее получения |
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KR20140072201A (ko) * | 2006-07-05 | 2014-06-12 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제 |
US8501449B2 (en) | 2007-12-04 | 2013-08-06 | Proteon Therapeutics, Inc. | Recombinant elastase proteins and methods of manufacturing and use thereof |
PT2271767T (pt) * | 2008-04-03 | 2016-08-18 | Cb Biotechnologies Inc | Reação em cadeia de polimerase para captura de amplicões em multiplexo para amplificação de alvos múltiplos |
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2008
- 2008-12-03 US US12/327,809 patent/US8501449B2/en active Active
- 2008-12-04 SI SI200831101T patent/SI2229440T1/sl unknown
- 2008-12-04 RS RS20170443A patent/RS55982B1/sr unknown
- 2008-12-04 SI SI200831792A patent/SI2666854T1/sl unknown
- 2008-12-04 LT LTEP13181046.7T patent/LT2666854T/lt unknown
- 2008-12-04 CN CN200880124812.XA patent/CN101918547B/zh not_active Expired - Fee Related
- 2008-12-04 HU HUE13181046A patent/HUE032739T2/en unknown
- 2008-12-04 EP EP17150627.2A patent/EP3176262A1/en not_active Withdrawn
- 2008-12-04 PT PT88614672T patent/PT2229440E/pt unknown
- 2008-12-04 US US12/746,509 patent/US9057060B2/en not_active Expired - Fee Related
- 2008-12-04 DK DK08861467.2T patent/DK2229440T3/da active
- 2008-12-04 JP JP2010537075A patent/JP5829808B2/ja not_active Expired - Fee Related
- 2008-12-04 CN CN201410767370.8A patent/CN104711243B/zh not_active Expired - Fee Related
- 2008-12-04 DK DK13181046.7T patent/DK2666854T3/da active
- 2008-12-04 CA CA2707051A patent/CA2707051C/en active Active
- 2008-12-04 KR KR1020107014799A patent/KR101732190B1/ko active IP Right Grant
- 2008-12-04 EP EP08861467.2A patent/EP2229440B9/en active Active
- 2008-12-04 KR KR1020167020627A patent/KR101824350B1/ko active IP Right Grant
- 2008-12-04 CN CN201811632685.6A patent/CN109893647A/zh active Pending
- 2008-12-04 AU AU2008338743A patent/AU2008338743B2/en not_active Ceased
- 2008-12-04 TW TW097147270A patent/TWI577385B/zh not_active IP Right Cessation
- 2008-12-04 KR KR1020187002034A patent/KR20180011860A/ko not_active Application Discontinuation
- 2008-12-04 PL PL08861467T patent/PL2229440T3/pl unknown
- 2008-12-04 EP EP13181046.7A patent/EP2666854B1/en active Active
- 2008-12-04 MX MX2013000540A patent/MX341317B/es unknown
- 2008-12-04 NZ NZ585866A patent/NZ585866A/xx unknown
- 2008-12-04 RU RU2010127232A patent/RU2611200C2/ru active
- 2008-12-04 TW TW105106918A patent/TWI619726B/zh not_active IP Right Cessation
- 2008-12-04 MX MX2010006211A patent/MX2010006211A/es active IP Right Grant
- 2008-12-04 NZ NZ601592A patent/NZ601592A/en unknown
- 2008-12-04 PT PT131810467T patent/PT2666854T/pt unknown
- 2008-12-04 WO PCT/US2008/085559 patent/WO2009079220A2/en active Application Filing
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- 2008-12-04 ES ES08861467.2T patent/ES2436783T3/es active Active
- 2008-12-04 ES ES13181046.7T patent/ES2627066T3/es active Active
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- 2008-12-04 BR BRPI0819977-9A patent/BRPI0819977A2/pt not_active Application Discontinuation
- 2008-12-04 CN CN201410187187.0A patent/CN103952388B/zh not_active Expired - Fee Related
- 2008-12-05 AR ARP080105302A patent/AR069584A1/es active IP Right Grant
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2010
- 2010-06-03 IL IL206157A patent/IL206157A/en active IP Right Grant
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2011
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2013
- 2013-06-06 IL IL226771A patent/IL226771A0/en unknown
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2014
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2015
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2016
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2017
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2018
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2019
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